Scientific Program

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  • Session TrackBiomaterials design
  • Session TitleBiomaterial Design for Immunoengineering
  • Session CodeSP-T01-0026
  • Date & Time / RoomMay 31 (Fri) 9:30~11:00 / Room 306-B
Organizer

Abhinav Acharya (Arizona State University, USA)

Chair

Abhinav Acharya (Arizona State University, USA)

Junsang Doh (Seoul National University, Korea, Republic of)

Keynote Speaker

9:30~9:55 : Multidimensional immunoengineering approaches to enhanced cancer immunotherapy Li Tang (EPFL, Switzerland)

Invited Speaker

9:55~10:10 : Research on the extrahepatic targeting delivery of siRNA therapeutics Huining He (School of Pharmacy, Tianjin Medical University, China)

10:10~10:25 : One stone fourbirds: application of ginsenosides to prepare multifunctional liposomal delivery system for cancer therapy Jianxin Wang (School of Pharmacy, Fudan University, China)

Oral Presenter

10:25~10:35 : Evaluation of an osteoinductive bone graft with submicron surface topography in a clinically-relevant sheep posterolateral lumbar spine fusion model Nathan Kucko (Kuros Biosciences, Netherlands)

10:35~10:45 : One Produces Multi: A Drug-free Cardiovascular Stent Functionalized with Tailored Collagen Supports in-situ Healing of Vascular Tissues Haoshuang Wu (Sichuan University, China)

10:45~10:55 : Photocrosslinked silk fibroin microgels and microgel scaffolds for biomedical applications Jelena Rnjak-Kovacina (University of New South Wales, Australia)

Description

1) Objectives or purposes - This symposia will focus on bringing together scientists from various different areas of research that deal with immunoengineering-based biomaterials. This will include the development of novel biomaterials, and utilization of said biomaterials for the treatment of autoimmune diseases, cancer, infection, and other inflammation-associated diseases. 



2) Proposed program and intended audience - The intended audience will be the international biomaterial community focused on understanding the effect of biomaterials on the immune system. 



3) Expected outcomes and relevance to the main topic of WBC 2024 - The expected outcome is to foster new collaboration and increase the exchange of ideas in a symposia format.

Keywords : immunoengineering, biomaterials, drug delivery

  • Session TrackBiomaterials design
  • Session TitleFunctionalization and commercialization of nano/micro-structured materials
  • Session CodeSP-T01-0036
  • Date & Time / RoomMay 30 (Thu) 16:30~18:00 / Room 306-B
Organizer

Sung Yun Yang (Chungnam National University, Korea, Republic of)

Chair

Sung Yun Yang (Chungnam National University, Korea, Republic of)

Nguyen Kim Nga (Hanoi University of Science & Technology, Vietnam)

Keynote Speaker

16:30~16:55 : Factory-on-a-Chip: Scaling-up Microfluidics for Large-Scale Biomaterials Synthesis Daeyeon Lee (University of Pennsylvania, USA)

Invited Speaker

16:55~17:10 : Machine Deep-Learning Analysis of Living Cell Morphology on 2D versus Psuedo-3D Polymeric Surface Sung Yun Yang (Chungnam National University, Korea, Republic of)

17:10~17:25 : Addressing boron neutron capture therapy’s bottlenecks: The synthesis, functionalization, and therapeutic potential of boron-based nanoparticles Pei Yuin Keng (National Tsing Hua University, Chinese Taipei)

17:25~17:40 : Optical Assessment of Tear Glucose by Smart Biosensor based on Chromophoric Cerium Oxide Nanoparticle Dong Yun Lee (Hanyang University, Korea, Republic of)

Oral Presenter

17:40~17:50 : Cell Painting with supramolecular assemblies: exploring biomimicry via high-throughput screening. Victor Veenbrink (Eindhoven University of Technology, Netherlands)

17:50~18:00 : Functionalized hydrogels interface with inflamed mucosa for material-tissue interaction in murine models of inflammatory bowel disease Sufeng Zhang (Brigham and Women's Hospital and Harvard Medical School, USA)

Description

Microfluidic systems have been used for analysis, purification, and controlled bioreactor system which is a highly prominent nano-biotechnology. Recent studies involve industrial approaches not only academic research. In this symposium, we like to introduce the recent technology in the functionalization of biomaterials by using microsystems to meet the requirements for their commercialization.

This will be interesting to audiences who are interested in cutting-edge research that could be realized to become a product.

 

Keywords : nano/micro material, microfluidics, surface functionality

  • Session TrackBiomaterials design
  • Session TitleNext Generation Biomaterials for Stem Cell Culture and Differentiation
  • Session CodeSP-T01-0038
  • Date & Time / RoomMay 30 (Thu) 9:30~11:00 / Room 306-B
Organizer

Akon Higuchi (National Central University, Chinese Taipei)

Chair

Akon Higuchi (National Central University, Chinese Taipei)

Guoping Chen (National Institute for Materials Science, Japan)

Keynote Speaker

9:30~9:55 : Biomimetic ECM scaffolds and their influences on stem cell differentiation Guoping Chen (National Institute for Materials Science, Japan)

Invited Speaker

9:55~10:10 : Cell sorting biomaterials for purification of cardiomyocytes differentiated from human pluripotent stem cells Akon Higuchi (National Central University, Chinese Taipei)

Yinghong Zhou (The University of Queensland, Australia)

10:25~10:40 : Extracellular matrix (ECM)-inspired biomaterial for hPSC-MSCs isolation and iPSCs reprogramming Byung-Hyun Cha (Kangwon National University, Korea, Republic of)

10:40~10:55 : Cell-adaptable dynamic hydrogels for tissue engineering Liming Bian (South China University of Technology, China)

Description

1. Objectives or purposes

There is a shortage of tissues and organs for patients who suffer damage or loss of their tissues and organs. Stem cells hold promise for drug discovery and regenerative medicine. We would like to propose the symposium of “Biomaterials for Stem Cell Culture and Differentiation for Stem Cell Therapy”. The development of a fully defined microenvironment for culturing and differentiating human stem cells will have a great effect on the use of stem cells in cell therapy and tissue engineering. In this symposium, we will discuss the design and strategy of biomaterials for stem cell culture and differentiation. Especially, we will discuss biomaterial design and preparation that can not only maintain the pluripotency and stemness of human stem cells, but also guide differentiation of stem cells (adult stem cells, fetal stem cells, human embryonic stem cells and human induced pluripotent stem cells) into specific lineages of cells (osteoblasts, chondrocytes, adipocytes, mesenchymal stem cells (from human pluripotent stem cells), hematopoietic stem cells (from human pluripotent stem cells), retinal pigment epithelium (from human pluripotent stem cells) and cardiomyocytes). We will further focus on the effects of physical cues (elasticity, micropatterning, electrical field and mechanical force), together with the biomaterials used in clinical application using stem cells and the translational development of stem cell therapies in various catastrophic illnesses.



2. Proposed program and intended audience

Proposed program: 1 Keynote speaker, 2 Invited speaker, 2-4 oral presentation selected by session chairs.

Intended audience: Polymer Scientist, Bioengineer, Biomaterial researcher, Material Scientist



3. Expected outcomes and relevance to the main topic of WBC 2024

This symposium will bridge between material scientist and clinical application, which should be one of the main topics of WBC2024.

Keywords : Stem cells, Design of cell culture biomaterials, Stem cell differentiation

  • Session TrackBiomaterials design
  • Session TitleBiomaterial strategies for delivering biologics and therapeutic cells to transform cancer immunotherapy
  • Session CodeSP-T01-0294
  • Date & Time / RoomMay 31 (Fri) 9:30~11:00 / Room 325-AB
Organizer

Sergio Moya (CIC biomaGUNE, Spain)

Chair

Horacio Cabral (University of Tokyo, Japan)

Sergio Moya (CIC biomaGUNE, Spain)

Keynote Speaker

9:30~9:55 : Engineering cells for cancer immunotherapy Quanyin Hu (University of Wisconsin-Madison, USA)

Invited Speaker

9:55~10:10 : Multiscale design of 3D hydrogel bioink with ROS scavenging and inner retina tissue regeneration Jiashing Ju (National Taiwan University, Chinese Taipei)

10:10~10:25 : Bioengineering approaches to elucidate interactions between immune cells and cancer cells at the nanoscale Hae Lin Jang (Brigham and Women's Hospital, Harvard Medical School, USA)

Oral Presenter

10:25~10:35 : Enhancing Tumor-Targeting Bacteria Efficacy via Smart Polymer Shield Encapsulation Diego Cattoni (Center of Structural Biology, CNRS UMR 5048 - UM - INSERM U 1054, France)

10:35~10:45 : Injectable granular hydrogels enable avidity-controlled cytokine delivery Arielle D'Elia (Drexel University, USA)

10:45~10:55 : Optimising the formulation of hydrogel-based non-viral carrier for gene delivery in the treatment of epidermolysis bullos SeyedehZohreh MousaviNejad (Dublin City University, Ireland)

Description







Immunotherapy has become a key weapon in the fight against cancer. Biologics, such as antibodies and cytokines, have shown potential for eliciting curative responses in many patients. Viral-induced oncolysis is also an extremely promising approach because it induces immunogenic cell death that enhances the release of tumour antigens and synergises with other immunotherapies. Therapeutic bacteria have potential as powerful antitumor agents by carrying tumoricidal compounds and immunotherapeutic agents, and benefiting from genetically engineered functionalities, and metabolism,  and controlled tumour penetration, specially towards hypoxic regions. However, the therapeutic efficacy of these agents is restricted by the difficulties to reach tumours once administrated. While the main goal of many of these therapeutics is to boost immunity at the tumour, the immune system prevents them from reaching the tumour site and result in their rapid clearance and severe toxicities.

Major efforts have been made to bypass the immune system and lead the biologics/virus/bacteria to the tumour site by encapsulating them into polymeric and lipid matrices that prevent the action of the immune systems and in some cases direct them toward the tumour. Thus, the design of these coating biomaterials is critical for the function and the therapeutic action of the payloads,  representing a major challenge.

The aim of this symposium is to revise the different strategies for protecting and delivering, biologics, oncolytic virus and therapeutic bacteria to tumours, bypassing the immune system through polymeric or self-assembled coatings or the chemical modification of viral capsids or bacterial glycocalyces. The symposium aims to discuss and foster research and innovation on biomaterials for encapsulating and engineering biologics/viruses/bacteria and their potentiality in the treatment of cancer, and other diseases. The symposius will target the broad audience interested in inmunotherapy, biologics, therapeutic cells,  self assembly, polymer biomaterials and target delivery.

 

Keywords : biologics; therapeutic cells; biomaterial design

  • Session TrackBiomaterials design
  • Session TitleLeveraging cell microenvironment and immune system to heal and regenerate
  • Session CodeSP-T01-0300
  • Date & Time / RoomMay 30 (Thu) 13:40~15:10 / Room 325-AB
Organizer

Matteo D'Este (AO Research Institute Davos, Switzerland)

Chair

Claudia Loebel (University of Michigan, USA)

Matteo D'Este (AO Research Institute Davos, Switzerland)

Keynote Speaker

13:40~14:05 : Engineering the cell-matrix interface - understanding and guiding cell function Claudia Loebel (University of Michigan, USA)

Invited Speaker

14:05~14:20 : Towards understanding neutrophils role in biomaterials-mediated immunomodulation Matteo D'Este (AO Research Institute Davos, Switzerland)

Oral Presenter

14:20~14:30 : Engineering immunomodulatory materials for regenerative medicine Daniel Salthouse (Newcastle University, United Kingdom)

14:30~14:40 : Alkaline hydrogels initiate endogenous TGFβ signaling for in situ tissue regeneration Yuting Niu (Peking University, China)

14:40~14:50 : Synthesis and characterization of binary mesoporous bioactive glass submicron particles containing cobalt and curcumin for wound healing applications Amanda Maria Almeida Coco (Friedrich Alexander Universität Erlangen-Nürnberg, Germany, Germany)

14:50~15:00 : Conductive double network eutectogel cooperates with electrical stimulation to facilitate burn wound healing by mimicking physiological properties of natural skin Yu Tian (Ocean Univertisy of China, China)

Description

Immunomodulatory properties of biomaterials are increasingly being recognized as a key towards their function. When the first biomaterials were introduced in the 50s and 60s, the emphasis was on replacing human tissues or their function while avoiding undesired reactions. In contrast, biomaterials are now designed to stimulate cellular and molecular responses that facilitate regeneration of diseased or damaged tissue. In particular, today’s biomaterials mobilize the body's endogenous cells to stimulate a regenerative healing response, and supplement or replace body functions. These advances have been possible due to the widely recognized biological activity of biomaterials and a plethora of design parameters that can be leveraged for successful repair. However, development of regenerative biomaterials necessitates a thorough understanding of the biological responses upon implantation. In particular, the success of biomaterial-guided tissue regeneration closely relies on the wound healing response, which is mostly driven by the body's innate immune system and by how cells interact with their environments. In this symposium the keynote speaker will illustrate her pioneering work on utilizing metabolic labeling techniques to visualize secreted matrix and investigate its dynamic nature.

The invited speaker will complement this topic by illustrating  the role of neutrophils in cell-biomaterial interaction and immunomodulation. The topics are highly complementary and will attract the attention of a large portion of the audience.

Keywords : immunomodulation, reprogramming, nascent matrix

  • Session TrackBiomaterials design
  • Session TitleMateriobiology
  • Session CodeSP-T01-0307
  • Date & Time / RoomMay 30 (Thu) 9:30~11:00 / Room 320-B
Organizer

Changsheng Liu (Shanghai University, China)

Chair

Changsheng Liu (Shanghai University, China)

Joachim Kohn (Rutgers University, USA)

Keynote Speaker

9:30~9:55 : Decoding biomaterial-mediated regeneration: from the perspective of materiobiology Changsheng Liu (Shanghai University, China)

9:55~10:20 : Nanoengineered biomaterials for medicine and beyond Krasimir Vasilev (College of Medicine and Public Health, Flinders University, Australia)

Invited Speaker

10:20~10:35 : Tissue-Anchored Indoleamine 2,3 Dioxygenase Locally Suppresses Inflammation Benjamin Keselowsky (University of Florida, USA)

Young Jang (Georgia Tech/Emory, USA)

Oral Presenter

10:50~11:00 : Exploring the blood-contacting response of biodegradable metals Deirdre Anderson (Oregon Health and Science University, USA)

Description

    There is considerable interest in developing bioactive materials having a self-regenerative capacity to stimulate tissue regeneration, instead of attempting to recreate the complexity of living tissues or tissue constructs ex vivo. "Materiobiology", proposed first by Prof. Changsheng Liu in 2017, is an emerging scientific discipline that advocates systematic studying of the biological effects of biomaterials at diverse levels, including cell, tissue, organ, and the whole organism. The principles of materiobiology may benefit from establishing the relationship between material properties and biological functions, and developing novel biomaterials providing combinative bioactive cues to activate the migration of stem cells from endogenous reservoirs (i.e., cell niches), stimulate robust and scalable self-healing mechanisms, and unlock the body's innate powers of regeneration. Based on this, Prof. Changsheng Liu (Shanghai University, China), Prof. Joachim Kohn (IUSBSE, US) and Prof. Yin Xiao (Griffith University, Australia) co-propose to organize a special symposium entitled “Materiobiology” that may include themes on materials’ features on cellular response, immune response, microenvironmental regulation, tissue regeneration, and database of biomaterials genomes etc. And also we hope to arract the audience in the related research fields. We believe that the successful application and holding of the symposium will provide rational guidance for biomaterial design. 

Keywords : Materiobiology, biological response, microenvironmental regulation

  • Session TrackBiomaterials design
  • Session TitleEngineering regenerative biomaterials through bioinspired and biocooperative approaches
  • Session CodeSP-T01-0322
  • Date & Time / RoomMay 29 (Wed) 13:40~15:10 / Room 325-AB
Organizer

Tiziano Serra (AO Research Institute Davos, Switzerland)

Chair

Matteo D'Este (AO Research Institute Davos, Switzerland)

Keynote Speaker

Alvaro Mata (Nottingham University, United Kingdom)

Invited Speaker

14:05~14:20 : Novel Fibrous Biomaterials: Nano-Hybridization and Biomimetic Fabrication Meifang Zhu (Donghua University, China)

Oral Presenter

14:20~14:30 : Novel Ti-10Mo-Mn system alloys for biomedical applications Carlos Roberto Grandini (UNESP - Univ Estadual Paulista, Brazil)

14:30~14:40 : On the communication between nuclei and mitochondria in a hydrogel environment  Cathrine Abild Meyer (Aarhus University, Denmark)

14:40~14:50 : A bilayer membrane containing intrafibrillarly mineralized collagen and pure zinc enhanced bone regeneration Dandan Xia (Peking University School and Hospital of Stomatology, China)

Description

There is increasing need for more effective and accessible regenerative therapies that can enhance the function and quality of life of a growing older demographic, the majority of which will not have access to sophisticated or costly treatments. However, despite advances in regenerative medicine, their societal impact remains limited. As a result, autografts remain the gold-standard choice for the regeneration of many tissues (bone, skin, tendon, nerve, muscle) and animal-derived matrixes the material of choice in many in vitro applications.

Living systems have evolved to grow and heal through self-assembling and self-organization processes coordinating and organizing a wide variety of molecular and cellular building-blocks at multiple size-scales. It is increasingly evident that recreation of such structural complexity and functionality will require new ways of thinking about tissue regeneration that go beyond current paradigms.

Biomaterials hold a unique opportunity to communicate with and regulate key biological processes. These materials should incorporate features of living systems such as selectivity, specificity, dynamicity, hierarchy, and multifunctionality but, simultaneously, must operate within regulatory and financial constraints that are required for clinical translation. Furthermore, there is a need for innovative fabrication methods that can transform these materials into practical regenerative devices that are reproducible and scalable while being physiologically relevant and capable to communicate with living systems.

This session will present new ways to design and fabricate innovative bioinspired and biocooperative materials that aim to overcome major challenges in regenerative medicine. Bioinspired approaches harness mechanisms that biology has evolved to enhance the repair or regeneration of tissues, while biocooperative approaches aim to achieve these goals by working with biological processes and endogenous molecules. The session will provide a space to integrate biomaterials and biofabrication.

Keywords : biomaterials, biofabrication, living systems

  • Session TrackBiomaterials design
  • Session TitleElectrically conductive polymers for bioelectrode applications
  • Session CodeSP-T01-0078
  • Date & Time / RoomMay 29 (Wed) 9:30~11:00 / Room 325-AB
Organizer

Jae Young Lee (Gwangju Institute of Science and Technology, Korea, Republic of)

Chair

Jae Young Lee (Gwangju Institute of Science and Technology, Korea, Republic of)

Elisa Castagnola (Louisiana Tech University, USA)

Keynote Speaker

9:30~9:55 : Conducting Polymers and Biomaterial Strategies Towards Seamless Neural Tissue-Device Interface Tracy X. Cui (University of Pittsburgh, USA)

Invited Speaker

9:55~10:10 : Integration of poly(3,4-ethylenedioxythiophene)/carbon nanotube (PEDOT/CNT) coating on flexible implantable neural devices to achieve multimodality and implant stability Elisa Castagnola (Louisiana Tech University, USA)

10:10~10:25 : Why do we still need better electrode materials for bioelectronic medicine? Maria Asplund (Chalmers University of Technology, Sweden)

Oral Presenter

10:25~10:35 : Electrically induced shape memory hydrogels and their biomedical application Georgios Mikalef (University of Birmingham, United Kingdom)

10:35~10:45 : A multimodal approach with magnetic and piezoelectric activation in injectable hydrogel therapy for functional skeletal muscle regeneration Silvia Panseri (National Research Council of Italy, Italy)

Description

The symposia includes the recent achievements of conductive polymer-based bioelectrodes, focusing on material design and applictions for bioelectrode applications

Keywords : Conductive polymers, bioelectrodes,

  • Session TrackBiomaterials design
  • Session TitleFunctional materials for nerve regeneration
  • Session CodeSP-T01-0079
  • Date & Time / RoomMay 28 (Tue) 16:30~18:00 / Room 325-AB
Organizer

Jae Young Lee (Gwangju Institute of Science and Technology, Korea, Republic of)

Chair

Jae Young Lee (Gwangju Institute of Science and Technology, Korea, Republic of)

Young Hye Song (University of Arkansas, USA)

Keynote Speaker

16:30~16:55 : Harnessing the regenerative power of brain using injectable peptide hydrogels John Forsythe (Monash University, Australia)

Invited Speaker

16:55~17:10 : Nervous system regeneration using tissue engineering strategies Tzu-Wei Wang (National Tsing Hua University, Chinese Taipei)

17:10~17:25 : Understanding Neuro-Regenerative Behavior of Adipose-Derived Stem Cells as a Function of Extracellular Matrix Parameters Young Hye Song (University of Arkansas, USA)

Oral Presenter

17:25~17:35 : The effect of bioactive scaffolds with enhanced supramolecular motion on neuronal regeneration
 
Zaida Alvarez (Institute for Bioengineering of Catalonia (IBEC), Spain)

17:35~17:45 : Fully biodegradable self-powered electronics for neurological diseases treatment Liu Wang (Beihang University, China)

17:45~17:55 : Semi-Interpenetrated Network Structure of Collagen/PEG/PPy Hydrogel with Enhanced Mechanical Strength, Biostability, and Electrical Conductivity for Potential Neural Tissue Regeneration Application Nur Hidayah Shahemi (Universiti Teknologi MARA, Malaysia)

Description

The symposia includes recent achivements of functional biomaterials for nerve regeneration, focusing on ne material design, characterization, and applications.

Keywords : Biomaterials, Nerve regeneration

  • Session TrackBiomaterials design
  • Session TitleMicrogels for Microtissues
  • Session CodeSP-T01-0086
  • Date & Time / RoomMay 30 (Thu) 9:30~11:00 / Room 325-AB
Organizer

Youngmee Jung (Korea Institute of Science and Technology, Korea, Republic of)

Chair

Tae-Hyung Kim (Chung-Ang University, Korea, Republic of)

Youngmee Jung (Korea Institute of Science and Technology, Korea, Republic of)

Keynote Speaker

9:30~9:55 : Microfabricated Biomaterials for Extracellular Vesicle (EV) Manufacturing Hyunjoon Kong (University of Illinois at Urbana-Champaign, USA)

Invited Speaker

9:55~10:10 : Engineering next-generation bioactive materials to promote tissue regeneration through the modulation of skeletal interoceptive circuit Wei Qiao (The University of Hong Kong, Hong Kong SAR, China)

Hyeon-Yeol Cho (Kookmin University, Korea, Republic of)

10:25~10:40 : Rational design of microgels as organ-on-a-chip components Baeckkyoung Sung (KIST Europe, Germany)

Oral Presenter

10:40~10:50 : Encapsulation of Multiple Enzymes within a Microgel via Water-in-Water Emulsion for Enzymatic Cascade Reaction YOTA Okuno (Kansai University, Japan)

10:50~11:00 : Enzyme-living microgels for precise channel customization in hydrogel-based tissue mimetic Ana Silva (University of Aveiro, Portugal)

Description

The tissues of our bodies are arranged in three dimensions by two or more different cells and ECM rather than single cells and perform their functions through interaction between them. Therefore, microtissues based on multicellular spheroids and designed biomaterials recapitulate three-dimensional tissues in vivo enabling cell–cell and cell–matrix interactions. These microtissues can be applied for therapeutics for tissue regeneration as well as in vitro models for screening platforms.  The main objective of the symposium on “Microgels for Microtissues” is to provide the attendees with the latest developments in the field. This symposium will highlight recent trends in developing functional microtissues based on designing microgels including multicellular spheroids or tissue organoids. Furthermore, recent technologies producing microtissues of uniform quality by microfluidics, self-assemblies, or 4D printing technics will be introduced. Therefore, this symposium will define the disciplines crucial for building new tissue and organs for a wide range of applications. Furthermore, we can construct complex systems to perform new tasks that have never been explored before.

Keywords : microfluidics, microgels, spheroid

  • Session TrackBiomaterials design
  • Session TitleAdvanced Biomaterials for Wet Tissue Adhesion
  • Session CodeSP-T01-0372
  • Date & Time / RoomMay 27 (Mon) 13:00~14:30 / Room 325-AB
Organizer

Terry Steele (Nanyang Technological University, Singapore)

Chair

Terry Steele (Nanyang Technological University, Singapore)

Bruce Lee (Michigan Tech, USA)

Keynote Speaker

13:00~13:25 : Adhesive elastic materials for wet tissue Anthony Weiss (University of Sydney, Australia)

Invited Speaker

Nasim Annabi (UCLA, USA)

Oral Presenter

13:40~13:50 : Polyelectrolyte association of natural polymers for the preparation of adhesive hydrogels. Emilie-Rose Dode (Ingénierie des Matériaux Polymères Lyon 1, France)

13:50~14:00 : Thermoresponsive bioadhesive hydrogel with dopamine-modified hyperbranched polymer crosslinker for enhanced wound healing Jiseok Han (UNIST, Korea, Republic of)

14:00~14:10 : Enhancing moist adhesion and wound healing with dopamine contained gelatin-silica hybrid dressings Ren-Jei Chung (Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Chinese Taipei)

14:10~14:20 : calcium ion exchanged carboxymethyl cellulose self-gelling powder with superwettability and tissue adhesion for hemorrhage control Shuyang LI (the Affiliated Hospital of Southwest Medical University, China)

14:20~14:30 : An injectable hydrogel of derivatized Enteromorpha prolifera polysaccharide and gelatin for cascade modulation and promotion of diabetes chronic wound healing Fei Jiang (Ocean University of China, China)

Description

The lack of suitable tissue adhesives has resulted in a range of unmet clinical needs in regards to tissue/biomaterial fixation.  Tissue adhesives are needed that allow for facile manipulation and  on-demand adhesion on wet tissue surfaces.  The development of tissue adhesives with novel biological mimicry, polymer chemistry, and/or stimuli activation attempts to fill this clinical gap.  This programm will highlight the latest developments of both preclinical and commercial tissue adhesives to address the replacement of legacy mechanical tissue fixatives. Objectives of this symposium is to bring together clinicians, early stage researchers, and experienced entrepreneurs to highlight current unmet medical applciations and address the technical/engineering/regulatory hurdles within the field of bioadhesives. We aim to have 5 session talks of: 1x commercially-relevant development (Anthony Weiss, Metro(R), 2 x latest preclinical research developments, and 2 x clinical-based unmet need presentations. Relevance is the overlapping of stimuli-sensitive biomaterials, insights of dynamic material properties needed, and structure property relationships needed for a variety of soft tissue substrates to be addressed.

 

Keywords : adhesion, fixation, preclinical

  • Session TrackBiomaterials design
  • Session TitleMaterial Symbiosis: Beyond Biocompatibility
  • Session CodeSP-T01-0119
  • Date & Time / RoomMay 29 (Wed) 13:40~15:10 / Room 306-B
Organizer

Mitsuhiro Ebara (National Institute for Materials Science (NIMS), Japan)

Chair

Mitsuhiro Ebara (National Institute for Materials Science (NIMS), Japan)

Koichi Shiraishi (Jikei University School of Medicine, Japan)

Keynote Speaker

13:40~14:05 : Biomaterial-driven osmosis for advanced biomarker analysis James Lai (National Taiwan University of Science and Technology, Chinese Taipei)

Invited Speaker

14:05~14:20 : Polymeric prodrugs for immune therapy and infectious disease
Patrick S. Stayton (University of Washington, USA)

14:20~14:35 : Anti-PEG antibodies: Analysis, incidence and biological functions Steve Roffler (Academia Sinica, Chinese Taipei)

Oral Presenter

14:35~14:45 : Structure-driven osteoimmunomodulation of 3D printed biodegradable Zn-based scaffold for bone repair Hongtao Yang (Beihang University, China)

14:45~14:55 : Synergistic interactions of semi-stable domains in biosystem Yuhe Yang (National Center for Nanoscience and Technology, China)

Description

1) The purposes; Although many different types of functional molecules, including biological drugs and biocompatible materials, have been developed, symbiosis between humans and non-self molecules/materials has not fully been established. This symposium will provide the opportunity to discuss about the new design of immune-modulating biomaterials from the viewpoint of material symbiosis.

2) Proposed program and intended audience; The mother does not reject her fetus, even though the fetus is completely another organism. This symbiosis is achieved via “symbiotic communications” between mother and fetus using an intricate and fascinating system, the placenta. Another intriguing example is the relationship between humans and our intestinal bacteria, which is also based on a “symbiotic communication” to form the intestinal microbiota unique to individuals. The program consists of immune-inert, immune-active, and immune-tolerant biomaterials. This symposium will cover a broad audience such as material chemistry, biophysical chemistry, immunology, cell/molecular biology etc.

3) Expected outcomes; The Immunogenicity has recently become a major challenge for many biopharmaceuticals. The primary goal of this symposium is to delineate previously-neglected, weak but specific interactions between living cells/biomolecules and materials, and eventually find ways to achieve material symbiosis in our body. Throughout this symposium, a new concept "material symbiosis” will open the way for biomaterials society.

Keywords : Immune-modulating biomaterials, Bioinspired materials, Immune tolerance

  • Session TrackBiomaterials design
  • Session TitleRoles of interfacial water states on cells/proteins/materials interactions and Biomaterials design
  • Session CodeSP-T01-0125
  • Date & Time / RoomMay 28 (Tue) 13:40~15:10 / Room 325-AB
Organizer

Masaru Tanaka (Kyushu University, Japan)

Chair

Masaru Tanaka (Kyushu University, Japan)

Takuya Matsumoto (Okayama University, Japan)

Keynote Speaker

13:40~14:05 : State of water in biofilms Liraz Chai (Institute of Chemistry, The Hebrew University of Jerusalem, Israel)

Invited Speaker

14:05~14:20 : Unraveling the Role of Intermediate Water in the Biocompatibility of Elastin-like Polypeptides Seung-Wuk Lee (University of California, Berkeley, USA)

Manuel Salmeron-Sanchez (University of Glasgow, United Kingdom)

14:35~14:50 : Design of cell adhesive/non-adhesive synthetic polymers based on the intermediate water concept Masaru Tanaka (Kyushu University, Japan)

Oral Presenter

14:50~15:00 : Surface coatings on biodegradable magnesium alloys for orthopedic applications IULIAN ANTONIAC (National University of Science and Technology POLITEHNICA Bucharest, Romania)

15:00~15:10 : Implications of bioactive glass surface modification on protein adsorption. Virginia Alessandra Gobbo (Tampere University, Finland)

Description

Understanding and controlling the interfacial interactions of biomaterials with biological elements, such as water, ions, proteins, bacteria, fungai and cells, are essential toward their successful implementation in biomedical applications. When biomaterials come into contact with body fluids, the first event that occurs on the material surface is hydration. Water molecules play a crucial role in bio-interfacial interactions, including protein adsorption/desorption and cell adhesion behavior. The mechanisms underlying material/protein/cell interactions at the molecular and cellular level have not been clearly demonstrated, although many experimental and theoretical efforts have been made to understand these mechanisms. Analysis of the water states of hydrated materials is complicated and remains controversial; however, knowledge about interfacial water is useful for the design of advanced biomaterials. To understand the role of water in the interaction of proteins and cells at biological interfaces, it is important to compare the states of hydration water with various physicochemical properties of hydrated biomaterials. This session covers the fundamental concepts for determining the interactions of proteins and cells with hydrated materials including organic and inorganic biomaterials. We share recent findings on the hydration of synthetic polymers, supramolecular materials, inorganic materials, and biomolecules. Furthermore, we discuss recent advances in our understanding of the classification of interfacial water and advanced biomaterials. Our discussion provides novel insights and helps develop novel experimental models for understanding protein adsorption in a wide range of materials, such as those used in biomedical applications. The scientific motivation for this session is to give an overview of the recent progress in the quantitative description, modeling and simulation of mechanism of biocompatibility driven by novel approaches. We will summarize the roles of interfacial water in the biointerfaces as well as biomaterials design.

Keywords : Bio-interfacial Water, Biointerphases, Biomedical Material Design

  • Session TrackBiomaterials design
  • Session TitleNature-inspired solutions: Bio-inspired hydrogels for new therapies and additive manufacturing
  • Session CodeSP-T01-0130
  • Date & Time / RoomMay 29 (Wed) 16:30~18:00 / Room 306-B
Organizer

Hongji Yan (Uppsala University and Karolinska Institutet, Sweden)

Chair

Hongji Yan (Uppsala University and Karolinska Institutet, Sweden)

Ying Yang (School of Pharmacy and Bioengineering, Guy Hilton Research Centre, Keele University, United Kingdom)

Keynote Speaker

16:30~16:55 : Bio-Inspired Self-Assembling Hydrogels for Tissue Engineering and Drug Delivery Aline F Miller (School of Chemical Engineering and Analytical Science, Manchester Institute of Biotechnology, United Kingdom)

Invited Speaker

16:55~17:10 : Creation of advanced hydrogel structures using microtechnology and acoustics Maria Tenje (Uppsala University, Sweden)

17:10~17:25 : Topical reinforcement of the cervical mucus barrier to sperm Thomas Crouzier (Cirqle Biomedical, Denmark)

17:25~17:40 : Microgel-based clickable granular hydrogel bioinks for 3D bioprinting of skin constructs Daniel Aili (Linköping University, Sweden)

Oral Presenter

17:40~17:50 : Self-assembling peptide hydrogel coating with biomimetic immune-escape function for advanced implantable devices Lei Lu (Wenzhou Medical University, China)

17:50~18:00 : Biomimetic semi-flexible hydrogel with reduced inflammation for bone remodeling Jae Seo Lee (Harvard Medical School, USA)

Description

Bio-inspired hydrogels have a wide range of biomedical applications. These gels are often built up using both natural and synthetic polymers using various crosslinking reactions, including Nobel Prize-winning 'clickable chemistry & bioorthogonal chemistry. In our bodies, hydrogels harbor cells and interact bidirectionally with cells. For instance, mucus gels are self-healing gels, in which mucins, the main non-aqueous components, are multifunctional. Mucus moisturizes, lubricates our epithelium, protects us from invaders such as bacteria and viruses, and maintains the hemostasis of tissues. Generation of mucus gel with the alterations in its composition, crosslinking capacity, and physical properties can mimic disease status and develop new therapies because the complexity and structural integrity of components such as extracellular matrix molecules or mucins and formed gels with specific material properties are important for their function. Bioinspired hydrogels can also be used to create advanced in vitro models or grafts composed of highly heterogeneous tissues using microfluidic technologies and additive manufacturing. Bioinspired hydrogels are biocompatible with living cells and tissues, as well as with the immune system. In addition, bioinspired hydrogels can elicit an anti-tumor immune response for tumor therapy or suppress a foreign body response for transplantation.

This symposium aims to gather world-leading scientists, and students at different levels who are designing and applying such bioinspired hydrogels by controlling their synthesis and characterization, including theoretical and fundamental aspects. The scope of the abstract in this symposium will be the state-of-the-art research and discussion in bio-inspired hydrogels for new therapies and additive manufacturing


  • The synthesis of new bio-inspired hydrogels 

  • The new characterization tools for physicochemical properties of hydrogel e.g. rheology, tribology, microscopy techniques, and sensors. 

  • The new applications of hydrogel for disease modeling and therapies

  • The recent development of biomimetic functional hydrogels for use in tissue engineering and regenerative medicine, immunotherapy, and infections will be addressed.

Keywords : Immunomodulating hydrogels, compartmentalization of microtissues, in situ mucus engineering

  • Session TrackBiomaterials design
  • Session TitleThermo responsive hydrogels and their biomedical applications
  • Session CodeSP-T01-0137
  • Date & Time / RoomMay 29 (Wed) 9:30~11:00 / Room 306-B
Organizer

Byeongmoon Jeong (Ewha Womans University, Korea, Republic of)

Chair

Kang Moo Huh (Chung-Nam University, Korea, Republic of)

Younsoo Kim (POSTECH, Korea, Republic of)

Keynote Speaker

9:30~9:55 : Block copolymer thermogel for medical applications Jiandong Ding (Fudan University, China)

Invited Speaker

9:55~10:10 : Development of functional hydrogels of imidazolium-based zwitterionic polymers for bioelectronics Younsoo Kim (POSTECH, Korea, Republic of)

10:10~10:25 : Thermogels as cell storage and drug screening platforms Byeongmoon Jeong (Ewha Womans University, Korea, Republic of)

Oral Presenter

10:25~10:35 : Thermosensitive chitosan-grafted-fibronectin for injectable bioactive macroporous cell-laden hydrogels Pierre Marquaille (ESPCI Paris PSL, France)

10:35~10:45 : Biomedical Tubes of Hydrogels Lidong Zhang (East China Normal University, China)

10:45~10:55 : Injectable dopamine-alginate/pluronic based hydrogel reinforced by peroxidase mimicking bioglass for bone regeneratio Le Hang Dang (Institute of Applied Materials Science, Vietnam)

Description

1) Objectives or purposes

Thermo-responsive hydrogels that undergo solution-to-gel transition upon increasing temperature have been extensively investigated for last decades. They have a balanced structure of hydrophilicity and hydrophobicity. By changing temperature, the delicate balance is broken and they begins to undergo significant conformational changes such as unimer-to-micelle transition, micellar aggregation, secondary structural changes, etc. Poly(lactic-co-glycolic acid), chitosan, polycaprolactone, polyphosphazene,  poly(ethylene glycol)/poly(propylene glycol) multiblocks, poly(trimethylene carbonate), polycyanoacrylate, poly(N-isopropylacrylamide), polypeptides, etc. have been developed as a thermo-responsive hydrogel. In this session, the characteristics of various thermo-responsive hydrogel will  be discussed focusing on unique structures, transition mechanisms, biomedical applications, and future perspectives of the thermogels among various groups.



2) Proposed program and intended audience

The program belong to biomaterials design and the audience cover scientists and students working on hydrogel, thermo-responsive polymers, and drug delivery, tissue engineering, etc.



3) Expected outcomes and relevance to the main topic of WBC 2024

Based on the symposium, recent research results on thermogels among the leading groups in this field will be presented. In addition, trends and perspectives on thermo-responsive hydrogel will be discussed for further research and collaboration on the thermogels which perfectly match to the WBC2024.

Keywords : thermosensitivity, hydrogel, biomedical application

  • Session TrackBiomaterials design
  • Session TitleBioadhesive Biomaterials
  • Session CodeSP-T01-0139
  • Date & Time / RoomMay 28 (Tue) 16:30~18:00 / Room 306-B
Organizer

Jayakumar Rangasamy (Amrita Vishwa Vidyapeetham, India)

Chair

Jayakumar Rangasamy (Amrita Vishwa Vidyapeetham, India)

Nathaniel Hwang (Seoul National University, Korea, Republic of)

Keynote Speaker

16:30~16:55 : Antibacterial Bioadhesives in Mediastinitis Jayakumar Rangasamy (Amrita Vishwa Vidyapeetham, India)

Invited Speaker

16:55~17:10 : Development of Bio-polysaccharide-based Biomimetic Hemostatic Bone Adhesives Arun Kumar Rajendran (Seoul National University, Korea, Republic of)

Oral Presenter

17:10~17:20 : Injectable asymmetric adhesive-antifouling bifunctional hydrogel for peritoneal adhesion prevention Zhongming Zhao (tianjin university, China)

17:20~17:30 : Anisotropic hydrogel-based engineered extracellular matrices for promoting regenerative tendon healing Tayler Hebner (University of Oregon, USA)

17:30~17:40 : Biodegradable bottlebrush polymer with salt-tunable adhesion properties Hoyong Chung (FAMU-FSU College of Engineering, USA)

17:40~17:50 : Alginate (ALG)-g-maleic anhydride-chitosan particles as potential mucoadhesive oral drug delivery devices Adley Forti Rubira (Maringá State University, Brazil)

17:50~18:00 : Tissue adhesive materials based on hydrophobically-modified Alaska pollock-derived gelatin for biomedical applications Tetsushi Taguchi (NIMS, Japan)

18:00~18:10 : A chitosan-optimized polyethyleneimine/polyacrylic acid multifunctional hydrogel for reducing the risk of ulcerative arterial bleeding Panxianzhi Ni (Sichuan University, China)

Description

1) Objectives or Purposes



Adhesive biomaterials, historically, have had a wide range of applications in all medical fields. With the extensive variety of biomaterials with adhesion properties, the field of tissue regeneration & regenerative medicine benefits from using adhesives which can provide superior biocompatibility, resorbability, and low immunogenicity. The goal of this symposia is to serve as a place for idea exchange by world biomaterials experts on functional tissue adhesives.  In addition, we intend to invite experts from multiple countries who are currently investigating clinically applicable tissue adhesive biomaterials in the field of tissue engineering & regenerative medicine.  We hope this symposium would bring next breakthrough research ideas in the field of adhesive biomaterials and provide platform for networking and collaboration as well as devlopement of new adhesive biomaterials for clinics. 



2) Proposed Program and intended audience

The proposed program is that one Keynote talk and 2 invited was included. If WBC2024 commitee permitss we can able to 2 or 3 speakers in this session. The intended audience are that researchers and students community who are working in the area of bioadhesvie biomaterials, hemostasis and surgical tissue sealants. 



3) Expected outcomes and relevance to the main topic of WBC 2024

The main outcome of this symposium would bring a designing of new bioadhesive biomaterails which can be used in the clinics. This topic is relvance to the main topic "Biomaterial Design" and also fulfill the conference objective "A vision for the future of Healthcare" 

Keywords : Bioadhesevies, Tissue Sealants, Regenerative Medicine

  • Session TrackBiomaterials design
  • Session TitleMolecular assembly control for supramolecular nano-biomaterials
  • Session CodeSP-T01-0141
  • Date & Time / RoomMay 31 (Fri) 11:20~12:50 / Room 306-B
Organizer

Jun Shik Choi (Korea Institute of Radiological and Medical Sciences (KIRAMS), Korea, Republic of)

Chair

Jun Shik Choi (Korea Institute of Radiological and Medical Sciences (KIRAMS), Korea, Republic of)

Kohei Sato (Kwansei Gakuin University, Japan)

Keynote Speaker

11:20~11:45 : Self-Assembled Peptide Biomaterials for Delivery and Responsiveness Yong-beom Lim (Yonsei University, Korea, Republic of)

Invited Speaker

11:45~12:00 : Development of supramolecular transmembrane channels and transporters Kohei Sato (Kwansei Gakuin University, Japan)

12:00~12:15 : Two-dimensional supramolecular materials Yongju Kim (Korea University, Korea, Republic of)

Oral Presenter

12:15~12:25 : Facilitated transdermal delivery using self-assembled skin-penetrating peptides Woo-jin Jeong (Inha University, Korea, Republic of)

12:25~12:35 : Supramolecular peptide nanofiber modifications for improving oral delivery Mia Woodruff (Duke University, USA)

12:35~12:45 : C/H-π interaction between cucurbituril[7] and Ibuprofen triggers the fast assembly of supramolecular hydrogel Yuxiao Zhang (South China University of Technology, China)

Description

Molecular self-assembly provides a facile way to synthesize biofunctional nanomaterials. Biological nanomaterials via biomolecular self-assembly have a variety of applications ranging from material science to biomedical engineering, nanotechnology, and tissue engineering due to the unique structure and function of biomolecules. This symposium presents the results of recent research on the synthesis of supramolecular nanobiomaterials by controlling molecular self-assembly. The program consists of self-assembly mechanisms using molecular interactions (hydrogen bonding, electrostatic interaction, hydrophobic interaction, etc.) of various biomolecules such as peptides, proteins, DNA, and polymers, and research on strategies for synthesizing and applying new biofunctional nanomaterials. This allows audiences to understand the self-assembly mechanisms and strategies of biomolecules and to help design and develop novel biological nanostructures or nanomaterials for desired applications. In addition, this symposium presents a method of developing novel biomaterials through the convergence of nanomaterials and biomaterials, so it is deeply related to the main theme of WBC 2024.

Keywords : self-assembly, nano-biomaterial, supramolecular structure

  • Session TrackBiomaterials design
  • Session TitleBiomaterials with micro/nano patterns
  • Session CodeSP-T01-0152
  • Date & Time / RoomMay 27 (mon) 14:40~16:10 / Room 325-AB
Organizer

Won-Gun Koh (Yonsei University, Korea, Republic of)

Chair

David Myung (Stanford University, USA)

Wonjae Lee (Duke University, USA)

Keynote Speaker

14:40~15:05 : Designing bioactive microcapsules for scalable cultivation of stem cells Alexander Revzin (Mayo Clinic, USA)

Invited Speaker

15:05~15:20 : Micro- and nanopatterning modification of biomaterials to enhance vascular cell responses for vascular tissue engineering applications Evelyn Yim (University of Waterloo, Canada)

15:20~15:35 : Designing Biomimetic Soft Materials with Tailored Nanostructures and Properties for Advanced Functional Applications Yeongseon Jang (University of Florida, USA)

Oral Presenter

15:35~15:45 : Hydrogels with Magnetic Gradients/Patterns for Tissue Engineering Applications Ángel Viteri (Polytechnic University of Catalonia, Spain)

15:45~15:55 : Multiscale biomechanical investigation of porous Mg-based WZM211 alloys for bone regeneration: from in vitro to in vivo Roxane Bonithon (University of Portsmouth, United Kingdom)

Description

Stimulated by the development of various multlscale fabrication techniques, various patterns on the biomaterials with micro or nanometer scale has been playing important role in biomedical engineering. This session will cover the use of various fabrication techniques to produce biomaterials or devices incorporating micro/nano patterns. Fabrication methods include 2D or 3D printing techniques, while application areas include miniaturized biosensor, tissue engineering scaffold, lab on a chip devices and other micro or nanofabricated biomedical systems.

Keywords : Micro

  • Session TrackBiomaterials design
  • Session TitleAdvanced hemocompatible coatings
  • Session CodeSP-T01-0158
  • Date & Time / RoomMay 27 (Mon) 14:40~16:10 / Room 306-B
Organizer

Manfred Maitz (Leibniz Institute of Polymer Research Dresden, Germany)

Chair

Manfred Maitz (Leibniz Institute of Polymer Research Dresden, Germany)

Mario Barbosa (Universidade do Porto, Portugal)

Keynote Speaker

14:40~15:05 : Working at the interface of thromboinflammation and biomaterials: what we know and don't know quite yet Maud Gorbet (University of Waterloo, Canada)

Invited Speaker

15:05~15:20 : Platelet Membrane Coating on Macro-Scale Blood-Contacting Material Enables Multifunctional Biointerfacing Rifang Luo (Sichuan University, Chengdu, China)

15:20~15:35 : Hemocompatible endothelium-inspired synthetic coating for medical devices to reduce coagulation by catalytically releasing nitric oxide Jenny Englert (DWI - Leibniz Institute for Interactive Materials, Germany)

15:35~15:50 : Reimagining hemocompatible coatings: modulation of hemostasis by interactive polymer brushes César Rodriguez-Emmenegger (DWI - Leibniz-Institut für Interaktive Materialien, Germany)

Oral Presenter

15:50~16:00 : Functional coatings accelerate endothelialization on left atrial appendage occluder

 
Xingwang Wang (Zhejiang University, China)

16:00~16:10 : The Impact of Different Cellulose Derivatives on the Anti-Adhesive Hydrogels YIXIN LIU (National Taipei University of Technology, Chinese Taipei)

Description

The combined activation of multiple pathways of hemostasis and inflammation, and the risk of bacterial colonization challenge blood-contacting medical devices and are the targets of hemocompatible surface modifications. These modifications strongly advanced in recent years from passive or purely anticoagulant to multifunctional and responsive coatings. Drugs with better-targeted selectivity inhibit thrombus formation at early rather than terminal steps and do not interfere with general hemostasis. Feedback-controlled systems can release anticoagulant or anti-inflammatory drugs dose adjusted to the actual requirements in blood. NO-generating coatings act as catalysts; they moderate platelet activity perpetually and provide additional antimicrobial activity. The intelligent combination of bioactive mechanisms addresses the complex interaction of thromboinflammation pathways on foreign surfaces and allows superior effects with minimal application of drugs.

This symposium shall present recent developments in hemocompatible coatings and identify synergistic modes of action for further development of totally hemocompatible surfaces.

 

Keywords : Hemocompatibility; Coagulation; Inflammation

  • Session TrackBiomaterials design
  • Session TitleBioinspired Biomaterials and Strategies for Tissue Engineering
  • Session CodeSP-T01-0160
  • Date & Time / RoomMay 27 (Mon) 13:00~14:30 / Room 306-B
Organizer

Nuno Neves (3B's Research Group, University of Minho, Portugal)

Chair

Rui Reis (3B's Research Group, University of Minho, Portugal)

Keynote Speaker

Rui Reis (3B's Research Group/University of Minho, Portugal)

Invited Speaker

13:25~13:40 : Polyacrylamide/Gel-based Self-healing Artificial Tympanic Membrane for Drug Delivery of Otitis Treatment Hwan Kim (Korea National University of Transportation, Korea, Republic of)

13:40~13:55 : Design principles toward the development of biomimetic red blood cells Minkyu Kim (University of Arizona, USA)

Ganesan Krishnamoorthy (R&D Cell, Department of Biochemistry, Muthayammal College of Arts and Science, India)

Oral Presenter

14:10~14:20 : In situ artificial enamel formation via laser-assisted rapid pseudo-biomineralization Ayako Oyane (National Institute of Advanced Industrial Science and Technology (AIST), Japan)

14:20~14:30 : Next generation of biomimetic materials for cornea repair Aidan MacAdam (University of Ottawa, Canada)

Description

1. Biologically derived polymers and composites offer excellent opportunities in the biomaterials field. This versatile class of materials includes biopolymers (polyhydroxy alkanoates, hyaluronic acid), polysaccharides (starch, chitin/chitosan, alginate) or proteins (collagen, fibrin, silk fibroin) enabling developing engineered systems with outstanding biological performance. The innovative use of its characteristics, taking advantage of the similar structure or composition with respect to biological tissues, enables designing high performance solutions for biocompatibility, biodegradability and bioactivity of biomaterials. Also the advanced areas of tissue engineering, drug delivery and smart/active/adaptative systems may benefit from the wealth of natural polymers existing in nature. This Symposium will be the primary forum to present and discuss the progress in this important class of biomaterials for Tissue Engineering and Regenerative Medicine.



2. The Keynote Speaker (Rui Reis) is one of the world leaders in this research field and for sure will attract the interest of the community attending the WBC 2024.



3. It is expected to attract a large number of high quality abstract submissions for this Symposium, enabling to have a high level scientific session with a large participation from the WBC delegates. The topic is of high relevance for the attendance of the WBC.

Keywords : Biomaterials; Bioinspired; Tissue Engineering

  • Session TrackBiomaterials design
  • Session TitleSmart zwitterionic polymer biomaterials
  • Session CodeSP-T01-0172
  • Date & Time / RoomMay 31 (Fri) 11:20~12:50 / Room 306-A
Organizer

Yasuhiko Iwasaki (Kansai University, Japan)

Chair

Yasuhiko Iwasaki (Kansai University, Japan)

Akifumi Kawamura (Kansai University, Japan)

Keynote Speaker

11:20~11:45 : Bio-inspired Zwitterionic Polymer Biomaterials for Advanced Medical Applications Yung Chang (Deputy director, R&D center for membrane technology and Department of chemical engineering, Chung Yuan Christian University, Chinese Taipei)

Invited Speaker

11:45~12:00 : Effect of hydrated structure of zwitterionic polymer on ice and frost formation from the hydrogel-coated surfaces Ji-Hun Seo (Department of Materials Science and Engineering, Korea University, Korea, Republic of)

12:00~12:15 : Zwitterionic materials that resist the foreign body response Peng Zhang (Department of Polymer Science and Engineering, Zhejiang University, China)

Oral Presenter

12:15~12:25 : Self-healing property of phospholipid polymer micro-hydrogel pieces with seamless biointerface technology Tomohiro KONNO (Tohoku University, Japan)

12:25~12:35 : Design of submicron-scale smart capsules for intracellular delivery Akifumi Kawamura (Kansai University, Japan)

12:35~12:45 : Reduction of osteoclastic resorption by bone-targeting polyphosphoesters Yasuhiko Iwasaki (Kansai University, Japan)

Description

For over 30 decades, the application of zwitterionic polymers, which mimic the phospholipids which are components of biomembranes, has been studied and they have been employed to improve the performance, durability, and biocompatibility of various medical devices, including those in the fields of cardiology, orthopedics, and ophthalmology. Especially, ventricular assist devices, contact lenses, and artificial hip joints constructed using phosphorylcholine polymers are now on a market. Recently, in addition to phosphorylcholine polymers, various zwitterionic polymers including carboxybetaine and sulfobetaine polymers have been proposed to generate not only anti-fouling surfaces but also highly lubricant- and selective molecular recognition surfaces, as well as to develop materials that control immunity. Furthermore, zwitterionic polymers that can respond to external physical, chemical, and biological stimuli are being actively studied, and are expected to bring innovation to the field of drug delivery systems. The zwitterionic polymers are a promising candidate to open the door for constructing the next generation of polymer biomaterials beyond PEGs. This symposium will focus on new designs, functions, and applications of zwitterionic polymers and discuss their new possibilities as biomaterials.

Keywords : Zwitterionic polymer, Anti-biofouling, Surface modification

  • Session TrackBiomaterials design
  • Session TitleCalcium phosphate biomaterials design: Bioactivity, materials property and mechanisms of biomineralization
  • Session CodeSP-T01-0177
  • Date & Time / RoomMay 31 (Fri) 9:30~11:00 / Room 306-A
Organizer

Nicola Doebelin (RMS Foundation, Switzerland)

Chair

Nicola Doebelin (RMS Foundation, Switzerland)

Takahisa Anada (Kyushu University, Japan)

Keynote Speaker

9:30~9:55 : Involvement of inorganic ion exchange and protein accumulation during spontaneous hydrolysis of octacalcium phosphate with enhancing new bone formation Osamu Suzuki (Tohoku University, Japan)

Invited Speaker

9:55~10:10 : Calcium phosphate-based biomineralizations: the physico-chemical point of vue Christele Combes (Institut National Polytechnique de Toulouse, France)

10:10~10:25 : In vivo mineralization to induce ectopic bone formation Marc Bohner (RMS Foundation, Switzerland)

Oral Presenter

10:25~10:35 : Chitosan-apatite wollastonite composites for bone tissue engineering formulated using chitosan solutions varied in ionic strength. Meng Pan (Newcastle University, United Kingdom)

Description

Bone is a unique mineralized tissue that is highly organized and formed through interaction with organic molecules in a series of biomineralization processes. Bone graft substitutes, such as octacalcium phosphate (OCP), β-tricalcium phosphate (β-TCP), biphasic calcium phosphate (BCP) and bone apatite crystal prototype (poorly crystallized non-stoichiometric Ca-deficient hydroxyapatite, CDHA), have been shown to exhibit bioactivity and are of increasing interest to researchers worldwide in biomaterials science and application in tissue engineering. However, the mechanism of calcium phosphate formation in the absence or the presence of biomolecules in physiological environments, the material's precise property, chemical reaction, and the bioactivity in vitro and in vivo have not yet been fully elucidated. In recent years, research on the crystal growth of OCP in the presence of biomolecules, such as non-collagenous proteins and collagenous proteins (e.g. gelatin molecules), has been conducted [1]. It was apparent that a higher bioactivity of the materials can be obtained through such organic-inorganic interactions and brought about in relation to the structural defects in the crystals. The importance of the mechanism of biomineralization due to ionic dissolution and nano-crystal agglomeration and maturation gradually became clear in the calcium phosphate materials science [2, 3]. In this symposium, we will give keynote lectures and invited lectures by experts in biomaterials application of OCP, materials science, and biomineralization. In addition, as regular presentation, young and mid-career researchers related to this field will be presented. Through this symposium, we will discuss the development and design of next-generation bioactive materials using calcium phosphates by providing the chemical, structural, and biological information on calcium phosphate materials.



[1] Suzuki O et al. Acta Biomater 2023 (10.1016/j.actbio.2022.12.046)

[2] Maazouz Y et al. Biomaterials 275:120912, 2021 (10.1016/j.biomaterials.2021.120912)

[3] Habraken WJ et al. Nat Commun 4:1507, 2013 (10.1038/ncomms2490)

Keywords : biomineralization, calcium phosphate materials, bioactivity

  • Session TrackBiomaterials design
  • Session TitleHierarchical biomaterials from particulate building blocks
  • Session CodeSP-T01-0184
  • Date & Time / RoomMay 27 (Mon) 13:00~14:30 / Room 306-A
Organizer

Mani Diba (Radboud University Medical Center, Netherlands)

Chair

Mani Diba (Radboud University Medical Center, Netherlands)

Marian Hettiaratchi (University of Oregon, USA)

Keynote Speaker

Laura De Laporte (DWI - Leibniz Institute for Interactive Materials, Germany)

Invited Speaker

13:25~13:40 : Biopolymer Networks Packed with Microgels: Metastable Strain Stiffening and Shaping Thomas E. Angelini (University of Florida, USA)

13:40~13:55 : Micro- and nanomodules for the legolization of organ fabrication Huanan Wang (Dalian University of Technology, China)

Oral Presenter

13:55~14:05 : Host–guest chemistry for the design of modular functional polymer–nanoparticle hydrogels Stéphane Bernhard (ETH Zürich, Switzerland)

14:05~14:15 : Guest-host interlinked microporous annealed particle hydrogels as an injectable scaffold for islet transplantation Edward Phelps (University of Florida, USA)

14:15~14:25 : Fabrication and characterization of bismuth-doped bioactive glasses for tissue engineering: from micro to nano Meng Li (Institute of Biomaterials, University of Erlangen-Nuremberg, Germany)

Description

1) Objectives or purposes:

Recent advances in materials synthesis and processing as well as our improved understanding of cell-material interactions provide new opportunities for the design of novel biomaterials. More recently, bottom-up assembly of biomaterials from particulate building blocks have gained interest for a wide range of applications including tissue engineering, regenerative medicine, 3D printing, and drug delivery. By employing nano- and/or microparticles as material building blocks, this approach has been shown as a promising route for both acellular or cellular biomaterials design strategies.



2) Proposed program and intended audience:

This session aims to provide an overview of the most recent advances in biomaterials design strategies based on particulate building blocks. Areas of interest include, but are not limited to: 1) methods for development and characterization of nano- and micro-particulate building blocks, 2) methods for controlling interactions of particulate materials, 3) design of colloidal and granular biomaterials, 4) design of polymer-(nano)particle networks, 5) biofabrication strategies based on particulate assemblies, and 6) 3D printing enabled by particle-based support baths.



3) Expected outcomes and relevance to the main topic of WBC 2024:

This symposium will bring together biomaterials researchers from different backgrounds and methodological frameworks who focus on the use of particulate materials for biomaterial design.

The session intends to highlight opportunities and remaining challenges in this field, and showcase the state-of-the-art capabilities of this material design approach for the wider biomaterials community.

The focus on particulate materials for biomaterial design is particularly relevant to the main topic of WBC2024, as it highlights the potential of this innovative biomaterial design strategy in areas such as biofabrication, drug delivery, and regenerative medicine. Overall, this symposium is expected to generate new insights and ideas that will drive the advancement of biomaterials research and contribute to the development of new biomaterials-based therapies.

Keywords : Hierarchical materials; bottom-up design; particulate biomaterials

  • Session TrackBiomaterials design
  • Session TitleProgramming dynamic materials for engineering functional tissues
  • Session CodeSP-T01-0186
  • Date & Time / RoomMay 28 (Tue) 13:40~15:10 / Room 306-B
Organizer

Roxanne Kieltyka (Leiden University, Netherlands)

Chair

Khoon Lim (University of Sydney, Australia)

Matt Baker (Maastricht University, Netherlands)

Keynote Speaker

13:40~14:05 : Encoding Interactions and Printability into Biomaterials – It’s Time to get Hairy and Open the Window! Justin Cooper-White (The University of Queensland, Australia)

Invited Speaker

14:05~14:20 : Exploration of photo-responsive biodegradable shape-memory polymers in the biomedical realm Sandra Van Vlierberghe (Ghent University, Belgium)

Oral Presenter

14:20~14:30 : Advancing corrosion control in biodegradable magnesium implants through dual-layer calcium phosphate coatings for enhanced bone remodelling Tina Sadat Hashemi (Dublin City University, Ireland)

14:30~14:40 : Emulating physical dynamicity of arterial blood vessels and neighbouring tissue interaction Cécile Bosmans (University of Twente, Netherlands)

14:40~14:50 : Spinal disc repair with tunable ultrasound-triggered in situ hydrogel formation Veerle Brans (University of Oxford, United Kingdom)

14:50~15:00 : Hydrogel loaded 3D printed bone graft for reconstruction of the segmental bone defect Anupama Devi V. K. (Vellore Institute of Technology, India)

15:00~15:10 : Macrophage reprogramming modulated by piezoelectric hydrogels for enhancing bone regeneration Xin Liu (Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, China)

Description

Cells communicate chemically and physically with the natural extracellular matrix in a reciprocal manner to guide a wealth of processes from the cell to tissue level. To recapitulate the dynamic responses of this natural matrix, the field of synthetic polymer biomaterials has developed a wide range of chemical strategies that are dynamic or responsive to various stimuli (e.g. light, redox, heat). These strategies have engendered structural, mechanical or biochemical changes in materials to interact with cells over several length and time scales. This symposium will showcase the latest in dynamic and responsive biomaterials design based on supramolecular and (dynamic)covalent polymers, looking forward towards the development of advanced 3D cellular models through biofabrication strategies. We will share the design features, synthesis, structure-property-function relationships, and processability needed to prepare biomaterials that enable the engineering of functional tissues. The symposium aligns with the main theme of WBC 2024 of convergence, bringing together experts from the polymer, bioengineering, and biofabrication communities that work with responsive polymer systems to develop functional tissues for healthcare providing a forum for synergy. We will approach journals for a themed special issue related to the symposium as an additional outcome. The symposium is open to several possible formats such as multisession, multiday.

Keywords : Dynamic biomaterials, Biofabrication, Tissue engineering

  • Session TrackBiomaterials design
  • Session TitleBiomimetic surface design for implantable devices
  • Session CodeSP-T01-0209
  • Date & Time / RoomMay 30 (Thu) 9:30~11:00 / Room 306-A
Organizer

Sachiro Kakinoki (Kansai University, Japan)

Chair

Marta Cerruti (McGill University, Canada)

Sachiro Kakinoki (Kansai University, Japan)

Keynote Speaker

9:30~9:55 : Bioactive surface modification and characterization strategies for improving blood contacting polymeric materials and devices Kyla Sask (McMaster University, Canada)

Invited Speaker

9:55~10:10 : Bioinspired solutions at surfaces and interfaces to prevent transepithelial implant infections ​Conrado Aparicio (UIC Barcelona International University of Catalonia, Spain)

10:10~10:25 : Anti-thrombus and cell-capturing technology on decellularized tissue for medical applications Atsushi Mahara (National cerebral and cardiovascular research institute, Japan)

Oral Presenter

10:25~10:35 : Anti-biofouling surface provided by collagen backbone-inspired oligoproline immobilization Sachiro Kakinoki (Kansai University, Japan)

10:35~10:45 : Biomimetic Electrospun Scaffold-Based In Vitro Model of Human Myocardial Fibrotic Tissue Irene Carmagnola (Politecnico di Torino, Italy)

Description

Polymeric materials have long been used for implantable devices such as vascular grafts and bone implants because of their ease of fabrication, biocompatibility, and wide range of mechanical properties. Despite these advantages, polymeric materials are often hydrophobic and do not have specific cues on their surface that enhance tissue integration around them. This can lead to unfavorable foreign body reactions including thrombosis and inflammation. Biomimetic surface design inspired by biological reactions and extracellular matrix-cell interactions can be a solution, and lead to functional polymeric devices that better integrate with the body.

This symposium will bring together experts of surface modifications of polymeric biomaterials, whose work aims at improving tissue integration around polymeric prostheses through cutting-edge biomimetic methods. Applications will include cardiovascular, bone, dental, percutaneous, etc; the talks will discuss both surface modification methods and methods to characterize surfaces before and after implantation. Examples of biomimetic surface modifications leading to successful in-vivo outcomes will be showcased, and related issues and requirements discussed. In line with the spirit of WBC 2024, this symposium will highlight the convergence of biomaterial development and clinical needs, by promoting the inclusion of perspectives of materials science researchers and clinicians, who are both meant to be the target audience of this symposium.

Our keynote speaker is Professor Kyla Sask, emerging star in biomimetic blood contacting and bone-interfacing devices. Invited speakers include Professor Thomas Groth, leading expert in Layer-by-Layer multi-functional surfaces on polymeric implant materials, and Dr Atsushi Mahara, running the forefront of preclinical trials of decellularized vascular grafts with biomimetic surfaces.

It is expected that this symposium will help biomimetic surfaces play a greater role in the development of implantable devices, especially polymeric ones, with the overall goal of improving healthcare for many. Submissions from members of underrepresented groups in science, engineering and medicine are especially welcome.

Keywords : Biomimetic surface, Polymeric materials, Implantable devices

  • Session TrackBiomaterials design
  • Session TitleSelf-assembling polymeric biomaterials for healthcare
  • Session CodeSP-T01-0212
  • Date & Time / RoomMay 29 (Wed) 9:30~11:00 / Room 306-A
Organizer

João Borges (University of Aveiro, Portugal)

Chair

João F. Mano (University of Aveiro, Portugal)

Jeroen Leijten (University of Twente, Netherlands)

Keynote Speaker

9:30~9:55 : Biofunctional supramolecular polymeric biomaterials and their interaction with living systems João Borges (CICECO - Aveiro Institute of Materials, University of Aveiro, Portugal)

Invited Speaker

9:55~10:10 : Glycopolymers for the delivery of drugs Martina Stenzel (University of New South Wales, Australia)

10:10~10:25 : Hydrogels of Brain-Derived Decellularized Extracellular Matrices for 3D Astrocyte Culture Insung Choi (KAIST, Korea, Republic of)

10:25~10:40 : Biomimetic materials presenting extracellular matrix components to study bone morphogenetic protein bioactivity Elisa Migliorini (CEA, France)

Oral Presenter

10:40~10:50 : Self-assembling hydrogels with tunable stiffness instruct tumour cell phenotypes and therapy resistance in pancreatic cancer model Babatunde Okesola (University of Nottingham, United Kingdom)

10:50~11:00 : Surface-assembled optoelectronic assemblies for directing electrogenic tissue anisotropy Herdeline Ann Ardoña (University of California, Irvine, USA)

Description

Biological systems are intrinsically complex and dynamic supramolecular landscapes formed by the non-covalent molecular self-assembly of the basic building blocks of life, namely peptides, carbohydrates, nucleobases and phospholipids. Those include the complex native cell microenvironment, i.e., the natural extracellular matrices (ECM) of tissues and organs that works as an unprecedented source of inspiration towards the supramolecular self-assembly of next-generation dynamic biofunctional materials to emulate the composition, structure, properties and functions of the native ECM, direct cell behavior and support advanced regenerative therapies.

In this symposium, we will showcase several examples on rationally designed high-performance multiscale self-assembled biomaterials, denoting emergent properties and multifunctionalities, for applications in biomedicine, biotechnology, and healthcare. In particular, the symposium will highlight recent advances in the supramolecular self-assembly of biomimetic polysaccharide-, peptide- and protein-based bioactive nanostructured multilayered films, dynamic, adaptive and responsive supramolecular hydrogels, and self-assembled glycopolymer nanoparticles for 3D cell culture, controlled drug/cell delivery, bioimaging, diagnostics, tissue engineering and regenerative medicine. Insights into the molecular design, synthesis, and characterization tools for elucidating the cell-biomaterial and drug-polymer interactions, morphology, structure-property-function relationships, and biological properties of a library of biofunctional supramolecular biomaterial architectures will be presented. Moreover, their intrinsic potential to enable innovative biomaterial products/devices with enhanced therapeutic efficacy for addressing unmet needs in human health and improve the quality of life, the key challenges hampering their clinical translation, and future perspectives of the field will be discussed.

This symposium is of great interest to all scientists working at the interface of supramolecular chemistry, polymer chemistry, materials science, biomedical engineering, bioengineering and biotechnology, nanoscience, biomaterials and cell biology. It is also highly relevant to the topic of the congress, being expected to inspire the scientific community, launch fruitful exchanges of knowledge and expertise, and open new perspectives on the development of next-generation supramolecular polymer biomaterials for healthcare.

Keywords : self-assembly, supramolecular polymeric biomaterials, biomedical applications

  • Session TrackBiomaterials design
  • Session TitleAdvanced sustainable hydrogels for smart wearable technologies
  • Session CodeSP-T01-0215
  • Date & Time / RoomMay 28 (Tue) 9:30~11:00 / Room 306-B
Organizer

Kindness Uyanga (City University of Hong Kong, Hong Kong SAR, China)

Chair

Kindness Uyanga (City University of Hong Kong, Hong Kong SAR, China)

Hong Zhao (School of Materials Science and Hydrogen Energy, Foshan University, China)

Keynote Speaker

9:30~9:55 : Advanced sustainable hydrogels for smart wearable technologies Walid A. Daoud (Department of Mechanical Engineering, City University of Hong Kong, Hong Kong SAR, China)

Invited Speaker

9:55~10:10 : Conductive Hydrogels for Biomechanical Energy Harvesting and Wearable Sensing Lingyun Wang (School of Microelectronics, Shandong University, China)

10:10~10:25 : Self-healing, Stretchable, and Tissue-adhesive Materials for Stable Bioelectronic Donghee Son (Sungkyunkwan University, Korea, Republic of)

Oral Presenter

10:25~10:35 : Carboxymethyl cellulose-chitosan composite hydrogel: Modelling and experimental study of the effect of composition on microstructure and swelling response Kindness Uyanga (City University of Hong Kong, Hong Kong SAR, China)

10:35~10:45 : Multifunctional bioengineered active 3D hydrogels Carolina Vargas Estevez (Universitat Politècnica de Catalunya - BarcelonaTech (UPC), Spain)

10:45~10:55 : Temperature responsive polymer, poly(N-acryloyl-piperidine-carboxamide) and its application to the preparation of smart hydrogel Yoshikatsu AKIYAMA (Tokyo Women's Medical University, Japan)

Description

Following increasing social, ethical and environmental concerns, there is a growing demand for sustainable materials and technologies. One such material is natural polymer-based hydrogels, recently being explored in multi-disciplines, including wearable technology as delivery systems, absorbents, biosensing and bioresponsive systems. The draw is attributable to hydrogel properties such as biocompatibility, degradability, environmental friendliness, affordability, ease of processing and tunability. However, challenges such as poor mechanical properties and durability limit hydrogel advancement for wearables.



In this symposium, we highlight the benefits of exploring hydrogel for wearable energy technology, present successes achieved in recent years, report associated challenges and recommend methods/approaches for advancing hydrogel-wearable technology. The three-part symposium will feature (1) a keynote address that introduces the concept of hydrogel, highlighting recent progress and successes attained in hydrogel-based smart wearable technologies and (2) paper presentations reporting hydrogel-based smart textiles and sensors developed. Some of the successes to be featured in the keynote address include hydrogel applications in batteries, triboelectric nanogenerators, and functional textiles. The keynote address will also enumerate approaches necessary to address the current challenges. The symposium will conclude with a presentation of selected abstract submissions and group discussions on ways to advance hydrogel-wearable technology, proffering solutions to achieve up-scaling, user comfort/no burden and product durability. The expected audience includes experts, researchers and exhibitors in physical sciences and engineering, health sciences and life sciences.



It is expected that at the symposium end, participants will be able to discuss progress in hydrogel-wearable technology and ways of addressing present challenges. This symposium is relevant as its content falls under the WBC 2024 topic category of composites and relates to hydrogels, nano-biomaterials, smart materials, textiles and fibers, and nano-/microstructured materials. It will benefit biomaterials researchers applying hydrogel technology for smart wearable textiles/devices for sensing, delivery or responsive systems.

Keywords : hydrogel, wearable textiles/devices, sustainable biomaterials

  • Session TrackBiomaterials design
  • Session TitleDynamic Hydrogels
  • Session CodeSP-T01-0221
  • Date & Time / RoomMay 27 (Mon) 16:30~18:00 / Room 306-B
Organizer

Matthew Webber (University of Notre Dame, USA)

Chair

Matthew Webber (University of Notre Dame, USA)

Patricia Dankers (TU Eindhoven, Netherlands)

Sei Kwang Hahn (POSTECH, Korea, Republic of)

Keynote Speaker

Tanja Weil (Max Planck Institute for Polymer Research, Germany)

Invited Speaker

16:55~17:10 : Photocrosslinkable biopolymers for enhanced tissue adhesion and local drug delivery Seung Yun Yan (Pusan National University, Korea, Republic of)

Oral Presenter

17:10~17:20 : Dynamic Hydrogel Biomaterials with Supramolecular Crosslinking Matthew Webber (University of Notre Dame, USA)

17:20~17:30 : Enzymatically Crosslinked Collagen as a Versatile Matrix for In Vitro and In Vivo Co-Engineering of Blood and Lymphatic Vasculature Dominic Ruetsche (ETH Zurich, University Hospital Zurich, University Zurich, Switzerland)

Description

An expanding focus in biomaterials science has included the preparation of hydrogels that rely on precisely engineered network dynamics by molecular-scale tuning of junction chemistry. Using crosslinking motifs that include host–guest complexation, hydrogen bonding interactions, dynamic-covalent associations, metal-ligand coordination, and other non-covalent modes of recognition and/or self-assembly, rationally designed materials have been designed that capture dynamic features of natural matrix materials using tractable synthetic analogues. Due to the dynamic, reversible, and equilibrium-governed nature of their crosslinking chemistry, these hydrogels demonstrate tunable mechanical and viscoelastic properties, can be designed for reversible response to specific biological stimuli, exhibit biomimetic activity, and enable generalizable platforms for customizable therapies that are injectable/moldable. Emerging uses for this class of materials in the areas of bioelectronics and soft robotics promise tissue-mimetic dynamic biointerfaces. It is envisioned that future biomaterials will therefore continue to leverage defined, non-covalent interactions to empower hydrogel materials with superior properties and enhanced function rooted in molecular-scale design of dynamic junction chemistries.



This proposed program is responsive to a growing focus in the biomaterials community wherein researchers are moving from traditional (static) covalent polymer hydrogels to those affording more dynamic mechanical properties rooted in molecular engineering of the underlying dynamic crosslinking chemistries. This community has seen growth globally, and the envisioned symposium would capture this enthusiasm in its area of focus. Moreover, the symposium organizers have organized previous symposia at several regional, national, and global scientific conferences (including WBC 2016, SFB 2017 & 2018, MRS 2019, and ACS 2020), with each of these symposia being oversubscribed on the basis of abstracts submitted and thereby awarded additional sessions to accommodate an enthusiastic response from the community. We expect that with strong advertising within our respective global networks, this symposium will be similarly well-received.

Keywords : Hydrogels; Molecular Engineering; Dynamic Networks

  • Session TrackBiomaterials design
  • Session TitleSupramolecular Nanomaterials
  • Session CodeSP-T01-0225
  • Date & Time / RoomMay 28 (Tue) 13:40~15:10 / Room 306-A
Organizer

Bret Ulery (University of Missouri, USA)

Co-organizer

Eunji Chung (University of Southern California, USA)

Adrianne Rosales (University of Texas at Austin, USA)

Mark Tibbit (ETH Zurich, Switzerland)

Chair

Bret Ulery (University of Missouri, USA)

Eunji Chung (University of Southern California, USA)

Keynote Speaker

13:40~14:05 : Designing bioinspired materials to heal the body and detect diseases earlier Molly Stevens (Imperial College London, United Kingdom)

Invited Speaker

14:05~14:20 : Hydrogels as cell culture platforms to determine sex chromosome regulation of myofibroblast phenotypes Brian Aguado (University of California San Diego, USA)

14:20~14:35 : Supramolecular Biomaterials for Localized Biotherapeutic Delivery Greg Hudalla (University of Florida, USA)

Oral Presenter

14:35~14:45 : Hydrogel for aptamer selection in a single step Yong Wang (Penn State, USA)

14:45~14:55 : Assembly drives regioselective azide-alkyne cycloaddition reaction Qiaochu Jiang (Southeast University, China)

Description

Due to the versatility and diversity in materials properties, a wide range of biomedical applications have emerged in recent years using supramolecular nanomaterials. By leveraging specific, tunable, and non-covalent interactions, the rational design of functional objects at the nanoscale has been used to develop individual nanoparticles or to produce highly oriented materials for a growing number of applications including but not limited to drug delivery, imaging, theranostics, and vaccines. Leaders in this field (like the proposed Keynote and Invited Speakers) as well as emerging experts who will submit abstracts to this session are making significant contributions to not only fundamental biomaterials science, but also to addressing real world clinical problems for both animals and humans. By working collaboratively with basic and applied scientists and engineers as well as veterinarians and clinicians, supramolecular nanomaterial researchers are at the forefront of convergent research to generate next generation technologies capable of transforming global healthcare. The intended audience for this work will not only be those currently conducting research in this area, but introducing the field and its potential to other biomaterials researchers will allow for them to consider incorporating complex non-covalent interactions into their research. Through hosting this session, we believe that we will be able to bring together crosscutting researchers in the supramolecular nanomaterials field to share ideas and build new personal and professional networks across geographical, experiential, and topic area boundaries. The excitement associated with this field is complemented by the involvement of Adrianne Rosales (UT Austin Assistant Professor, arosales@che.utexas.edu) and Mark Tibbitt (ETH Zurich Assistant Professor, mtibbitt@ethz.ch) as two additional co-chairs for this session.

Keywords : Supramolecular Interactions, Nanomaterials

  • Session TrackBiomaterials design
  • Session TitleSynthetic protein-complexing hydrogel materials to direct cell fate
  • Session CodeSP-T01-0229
  • Date & Time / RoomMay 28 (Tue) 9:30~11:00 / Room 306-A
Organizer

Uwe Freudenberg (Leibniz Institute of Polymer Research Dresden, Germany)

Chair

Carsten Werner (Leibniz Institute of Polymer Research Dresden, Germany)

Uwe Freudenberg (Leibniz Institute of Polymer Research Dresden, Germany)

Keynote Speaker

9:30~9:55 : Chitosan scaffolds containing engineered short forms of perlecan promote angiogenesis via the potentiation of growth factors Megan Lord (University of New South Wales, Australia)

Invited Speaker

9:55~10:10 : A cell-instructive hydrogel library with variable sulf(on)ation pattern to tune protein affinity Passant Atallah (Leibniz-Institut f. Polymerforschung Dresden e.V., Germany)

Oral Presenter

10:10~10:20 : Hybrid supramolecular-covalent gelatin bioresins as dynamic matrices for enhanced cell migration and self-assembly in light-based volumetric bioprinted constructs Marc Falandt (University Utrecht, Netherlands)

10:20~10:30 : Hyaluronan topography impacts epithelial to mesenchymal transition Katherine Ballard (South Dakota School of Mines and Technology, USA)

10:30~10:40 : Inflammation-triggered hydrogels to remodel pathological microenvironment for lessening cerebral ischemia injury wen zhang (sichuan university, China)

10:40~10:50 : Dynamic protein-based G-quadruplex-derived supramolecular hydrogels as stable bioinks for healthcare Vera Sousa (CICECO - Aveiro Institute of Materials, University of Aveiro, Portugal)

10:50~11:00 : Spatiotemporal Regulation of Injectable Heterogeneous Silk Gel Scaffolds for Accelerating Guided Vertebral Repair Tianji Wang (Xijing Hospital, China)

Description

Sulfated glycosaminoglycans (GAGs) govern the spatiotemporal distribution and activity of soluble signaling molecules in living tissues and therefore inspired the design of cell-instructive hydrogel systems (1). Utilizing the underlying principle of electrostatically controlled protein complexation, fully synthetic hydrogels were recently demonstrated to allow for the holistic adjustment of cytokine affinity, even beyond the characteristics of GAG-based materials. The special symposium will summarize and discuss recent progress in the preparation of the respective hydrogels as well as their use in tissue engineering and therapeutic applications.

 

Keywords : hydrogels, protein affinity, cell-culture

  • Session TrackBiomaterials design
  • Session TitlePlant and Polysaccharide-based biomaterials
  • Session CodeSP-T01-0233
  • Date & Time / RoomMay 27 (Mon) 16:30~18:00 / Room 306-A
Organizer

Feng Jiang (The University of British Columbia, Canada)

Chair

Feng Jiang (, Canada)

Guang Yang (Huazhong University of Science and Technology, China)

Keynote Speaker

16:30~16:55 : Direct 3D biofabrication of bacterial nanocellulose via soft matter templating Orlando Rojas (The University of British Columbia, Canada)

Invited Speaker

16:55~17:10 : Cellulose nanofibrils-based ionic conductive gel as wearable sensors for physiological monitoring Feng Jiang (The University of British Columbia, Canada)

Oral Presenter

17:10~17:20 : Controllable construction and biomedical applications of functional natural polysaccharide hydrogels Guang Yang (Huazhong University of Science and Technology, China)

17:20~17:30 : Dynamic covalently crosslinked alginate hydrogels for biomedical applications Yi-Cheun Yeh (National Taiwan University, Chinese Taipei)

17:30~17:40 : Development of a novel plant-derived polysaccharide-based hydrogel for bone tissue engineering Xinyu Li (university of Glasgow, United Kingdom)

17:40~17:50 : Lubricant-infused cellulose-based biomaterials for biomedical applications Maryam Badv (University of Calgary, Canada)

17:50~18:00 : Chitosan@Puerarin hydrogel for accelerated wound healing in diabetic subjects by miR-29ab1 mediated inflammatory axis suppression Xiaoling Zeng (Department of Pharmacy, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, China)

Description

The proposed symposium “Plant and Polysaccharide-based biomaterials” of the WBC 2024 offers the recent developments in plant and polysaccharides-based-based biomaterials, including cellulose, hemicellulose, lignin, chitin, and alginate, and their diverse applications in the cutting-edge areas that contribute to minimizing the impact on the global environment and climate. The special issues emphasizes the synthesis, modification, and advanced application of the plant and polysaccharides -based biomaterials. More specifically, the areas of interest include,



• Novel nanotechnologies to fabricate plant and polysaccharides-based biomaterials on the sub-100-nanometer scale, showing unique optical, mechanical, physical, and electrical characteristics;



• Enabling technologies for the modification of plant and polysaccharides-based biomaterials for novel material properties;



• Emerging applications of plant and polysaccharides-based biomaterials in biomedical applications (theranostics, tissue engineering, specific medical applications, in vitro analysis, pre-clinical and clinical translation).



• The proposed symposium also highlights the advantages and challenges in the commercialization of such materials in the given applications. 



The intended audience include those from academia and industry. It will attract audience who use these plant and polysaccharides-based materials for the application in the areas of biomedical applications.



These plant and polysaccharides-based materials are vastly available and has great potential for biomedical applications. This program can help to promote the interest in seeking alternative natural polymers for such applications.  

 

Keywords : polysaccharides, lignin, biomedical applications

  • Session TrackBiomaterials design
  • Session TitleBiomimetic structured materials
  • Session CodeSP-T01-0236
  • Date & Time / RoomMay 30 (Thu) 13:40~15:10 / Room 306-A
Organizer

Hao Bai (Zhejiang University, China)

Chair

Hao Bai (Zhejiang University, China)

In-Seop Lee (Institute of Human Materials, Korea, Republic of)

Keynote Speaker

13:40~14:05 : Ice-templating technique and its application in bioinspired macroporous materials Hao Bai (Zhejiang University, China)

Invited Speaker

14:05~14:20 : Multiscale biomimetic approaches for regulation of cell function and tissue regeneration Jangho Kim (Chonnam National University, Korea, Republic of)

Oral Presenter

14:20~14:30 : 3D printed porous titanium filled with mineralized UV-responsive chitosan hydrogel promotes cell proliferation and osteogenesis in vitro Cen Chen (Zhejiang Sci-Tech University, China)

14:30~14:40 : The structure of osseointegration Anders Palmquist (University of Gothenburg, Sweden)

14:40~14:50 : Biomimetic Solutions Derived from Simulated Body Fluid for Hydroxyapatite Coating Kazumasa Suzuki (Nagoya Univeristy, Japan)

14:50~15:00 : Spatiotemporal control of fiber alignment within fiber-hydrogel composites using magnetic fields Julianne Holloway (Arizona State University, USA)

15:00~15:10 : Defined phosphate-based cement structures processed via 3D printing such as digital light processing (DLP) for biomedical applications Juliane Kade (University of Würzburg, Germany)

Description

Built with limited components in mild environments, natural materials exhibit outstanding properties which always surpass synthetic ones. The sophisticated multiscale structure of natural materials is believed to be largely responsible for their extraordinary properties. For example, to sustain dynamic movements that occur millions of times per year, natural tissues such as muscles, tendons, and heart valves exhibit outstanding fatigue resistance, which arises from highly ordered and partially crystallized collagen fibrous structures. Bone and sea shells achieve low density and high strength to provide protection and support, due to their complex hierarchical microstructure comprised of soft and hard phases. Taking the elegant multiscale structure of natural materials as inspiration, biomimetic structured materials have been developed with bioinspired microstructures, and have shown a large range of application perspectives in fields such as tissue prostheses, artificial muscles, and tissue engineering scaffolds. Specifically, anti-fatigue hydrogels inspired by natural tissues and biomimetic high-strength porous scaffolds are competing candidates for the applications of tissue prostheses and tissue engineering scaffolds, respectively. This symposium will focus on the advances in biomimetic structured materials and aims to bring together researchers in this field to present current and further developments in the structural and functional design of biomimetic structured materials, reveal their structure-function relationships, and explore their applications as biomaterials.

Keywords : biomimetic materials, structured materials, bioinspiration,

  • Session TrackBiomaterials design
  • Session TitleEnzyme and Protease-responsive biomaterials
  • Session CodeSP-T01-0239
  • Date & Time / RoomMay 27 (Mon) 14:40~16:10 / Room 306-A
Organizer

Tommy Pashuck (Lehigh University, USA)

Chair

Tommy Pashuck (Lehigh University, USA)

Rona Chandrawati (University of New South Wales, Australia)

Keynote Speaker

14:40~15:05 : Introduction of dynamic reciprocity in supramolecular elastomeric materials and coatings Patricia Dankers (Eindhoven University of Technology, Netherlands)

Invited Speaker

15:05~15:20 : Design of Glucose-Responsive Biomaterials Matthew Webber (University of Notre Dame, USA)

Oral Presenter

15:20~15:30 : Nanozymes and polymers for nitric oxide delivery from prodrugs Rona Chandrawati (University of New South Wales, Australia)

15:30~15:40 : Identifying membrane-specific protease substrate peptides for improved hydrogel design Tommy Pashuck (Lehigh University, USA)

15:40~15:50 : Alkaline phosphatase responsive disassembly and intracellular polymerization for the supramolecular senolytics with high selectivity Sangpil Kim (UNIST, Korea, Republic of)

15:50~16:00 : Pepsin-digested ECM hydrogels promote inflammation and migration Carolina Herranz-Diez (Universitat de Barcelona, Spain)

16:00~16:10 : Targeted Delivery and Enzyme-responsive Release of Inorganic Polyphosphate from Platelet-inspired Synthetic Nanoparticles to Augment Hemostasis Norman Luc (Case Western Reserve University, USA)

Description

Enzymes account for over 10% of the human proteome and are involved in almost all cellular functions. This group of proteins includes the subclass of proteases which, hydrolyze peptide bonds and play key roles in tissue regeneration and cancer progression. The past 15 years has seen an explosion of research in the area of enzyme and protease responsive biomaterials, including protease degradable cross linked hydrogels, enzyme-assisted self-assembly, and enzyme prodrug therapies. Enzymes have a key advantage over other classes of biomolecule in that they catalyze chemical reactions, and thus are useful tools for modifying the bioactivity of biomaterials in a cell-responsive manner.



This symposia will focus on many ways that research groups have utilized enzymes and proteases within the field of biomaterials. This includes applications in detection and diagnostics, therapeutic delivery, modification of material properties, cell-responsive systems, tissue engineering, and activation of drugs and biomolecules. By focusing on enzymes on as a route to biomaterial change this symposium will be of interest to researchers from a variety of disciplines, with an array of different classes of biomaterials, and applications ranging from drug delivery to tissue engineering.

Keywords : Enzymes, proteases, cell-responsive

  • Session TrackBiomaterials design
  • Session TitleBioinspired supramolecular Biomaterials
  • Session CodeSP-T01-0240
  • Date & Time / RoomMay 31 (Fri) 11:20~12:50 / Room 325-AB
Organizer

Chris Sammon (Sheffield Hallam University & RSC Biomaterials Chemistry Interest Grouo, United Kingdom)

Chair

Sanjukta Deb (King’s College London, United Kingdom)

Jacek Wychowaniec (AO Research Institute Davos, Switzerland)

Keynote Speaker

11:20~11:45 : Designing Peptide Based Hydrogels Scaffolds for Biomedical Apllications. Alberto Saiani (University of Manchester, United Kingdom)

Invited Speaker

11:45~12:00 : DNA-based Superstructures via Module-assembly of DNA Scaffolds for Biomedical Applications
Jong Bum Lee (University of Seoul, Korea, Republic of)

12:00~12:15 : Self-assembled hyaluronic acid nanomedicine for treatment of chronic inflammatory diseases: Beyond drug carriers Wook Kim (Ajou University, Korea, Republic of)

Oral Presenter

12:15~12:25 : Self-assembly of Tyrosine-containing Peptides into Distinct Nanostructures is Key in Determining Inflammatory Response of Macrophages Jacek Wychowaniec (AO Research Institute Davos, Switzerland)

12:25~12:35 : Modular protein hydrogels for biofabrication Dalia Dranseike (ETH Zurich, Switzerland)

12:35~12:45 : Tumor microenvironment targeting for glioblastoma multiforme treatment via hybrid cell membrane coating supramolecular micelles Xiaobei Huang (Chinese Academy of Sciences, China)

Description

Nature has evolved a variety of creative approaches to many aspects of biomaterials design. One such approach is biomolecular self-assembly, which represents a simple and efficient route to the construction of large, complex and functional materials. This phenomenon is also a key process in all living organisms where many of the building blocks exhibit a hierarchy of structures that are critical to their function.

One area that is currently receiving significant attention is design of nanostructured supramolecular biomaterials exploiting the self-assembling properties of nature’s building blocks including peptides, oligonucleotides, protein, DNA and RNA. The use of these biological building blocks is very attractive as it allows the design of materials that can be made intrinsically biocompatible and biofunctional. As our understanding of these building blocks’ physicochemical properties and biological roles and functions improves our ability to build novel functional biomaterials expand. This has led in the last decade to the design of a new generation of functional and responsive biomaterials for a diverse range of applications, including tissue engineering, drug/cell delivery, biosensing and regenerative medicine.

This interdisciplinary symposium will bring together scientist from a wide range of scientific fields including physics, chemistry and biology working on biomaterial design exploiting bio-inspired self-assembly of biological molecules including polypeptides, protein, DNA and RNA as well as their hybrids. It will allow the exchange of information on recent progress and contribute to this fast-growing biomaterial field.

The symposia is organised under the hospices of the Royal Society of Chemistry (RSC) Biomaterials Chemistry Interest Group and will be advertised to the RSC large network of members in the UK and internationally. The RSC Biomaterials Chemistry Interest Group will also contribute towards the registration fees of the invited speaker and chairperson.

 

Keywords : Supramolecular, bioinspired, biomaterials

  • Session TrackBiomaterials processing and biofabrication
  • Session TitleMicrofabrication techniques for vascularization of tissue engineered constructs
  • Session CodeSP-T02-0326
  • Date & Time / RoomMay 31 (Fri) 9:30~11:00 / Room 323
Organizer

Gulden Camci-Unal (University of Massachusetts Lowell, USA)

Chair

Gulden Camci-Unal (University of Massachusetts Lowell, USA)

Syam Nukavarapu (University of Connecticut, USA)

Keynote Speaker

9:30~9:55 : 3D EXTRUDABLE HYBRID BIO(MATERIAL) INK FORMULATION: PROCESS SCIENCE AND BIOCOMPATIBILITY Bikramjit Basu (Indian Institute of Science, Bangalore, India)

Invited Speaker

9:55~10:10 : The Integration of Tailored Peptides into Bioinks via Photo Induced Crosslinking of Unmodified Proteins Yeong-Jin Choi (Korea Institute of Materials Science, Korea, Republic of)

10:10~10:25 : Application of advanced, various tissue-specific bioinks for engineering vascularized in vitro multiorgan/disease constructs Jungbin Yoon (POSTECH, Korea, Republic of)

Oral Presenter

10:25~10:35 : The use of proteomics in extrusion and volumetric-based biofabrication for optimal bone regeneration Laurens Parmentier (Ghent University, Belgium)

10:35~10:45 : Coaxial 3D Bioprinting of Blood Vessel Grafts and Vascular Disease Models Ge Gao (School of Medical Technology, Beijing Institute of Technology, China)

10:45~10:55 : Mimicking the vascularized cortical bone: an advanced in vitro osteon model to study bone (patho)physiological conditions clarissa tomasina (Maastricht University, Netherlands)

Description

Tissue engineered scaffolds that include cells, biomaterials and small molecules are widely employed in biomaterials and regenerative medicine research. However, lack of vascularization is a significant hurdle in fabrication of properly functioning tissue mimetics due to potential mass transport limitations. The success of tissue engineering relies on formation of highly vascularized and functional three dimensional constructs. Toward this aim, various microfabrication techniques (e.g. 3D bioprinting, microfluidics, micromolding, photolithography) were utilized to develop prevascularized constructs or generate vascular geometries within scaffolds. The session will cover the basics of these technologies as well as their cellular applications. This session will be of great significance for the efforts towards fabrication of vascularized off-the-shelf tissue products to replace lost tissue function. It is also expected that the session will be of interest to the biomedical industry going forward with clinical translation and commercialization. This session will facilitate sharing the latest information and knowledge in biomaterials research and aligns well with the aims of the WBC 2024.

Keywords : biomaterials, microfabrication, vascularization

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WBC 2024 SECRETARIAT

Address
6F, 11-13, Hwarang-ro 8-gil, suseong-gu, Daegu, Republic of Korea (42038)
E-MAIL
(Congress)info.wbc2024@gmail.com
(Sponsorship & Exhibit) exhibition.wbc2024@gmail.com
(Accommodation) wbc2024hotel@gmail.com
(Tour) wbc2024tour@gmail.com

PHONE+82-53-740-0424, 0405

FAX+82-53-742-9007

REGISTRATION NO.138-82-76927

REPRESENTATIVEKi Dong Park

THE KOREAN SOCIETY FOR BIOMATERIALS

Address
502, 22, Teheran-ro 7-gil, Gangnam-gu, Seoul, Republic of Korea (06130)

REGISTRATION NO.209-82-61032

REPRESENTATIVEKun Na

PHONE+82-02-554-9977

FAX+82-02-554-9978

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