Scientific Program

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  • Session TrackBiomaterials for tissue engineering
  • Session TitleLearning from Successful Failures in Tissue Engineering & Regenerative Medicine
  • Session CodeSP-T04-0282
  • Date & Time / RoomMay 28 (Tue) 9:30~11:00 / Room 324-B
Organizer

Sing Yian Chew (Nanyang Technological University, Singapore)

Chair

Sing Yian Chew (Nanyang Technological University, Singapore)

Catherine Le Visage (Inserm; University of Nantes, France)

Keynote Speaker

9:30~9:55 : That’s not right, it is not even wrong Michael Sefton (University of Toronto, Canada)

9:55~10:20 : Neglecting complexity when extrapolating from cell culture to the human Viola Vogel (ETH Zurich, Switzerland)

Catherine Le Visage (University of Nantes; Inserm, France, France)

Oral Presenter

10:45~10:55 : Improving stem cell differentiation potency using simulated microgravity Jeremy Teo (New York University Abu Dhabi, United Arab Emirates)

Description

The advancement of science traditionally relies heavily on the positive results and outcomes from the scientific community. Indeed, the field of Tissue Engineering & Regenerative Medicine (TERM) has advanced greatly in the past 2 decades due to positive contributions and reports in the field. On the other hand, the lack of positive experimental outcomes, such as the absence of correlation of in vitro cellular responses with in vivo treatment efficacies, is often seen as failures and frequently remains unreported. This is a great loss to the field since failures have undeniably taught us a great deal and may in fact be more helpful than the typically defined successful experimentations.



In this symposium, we have invited successful scientists to share the truth of science and how they have learnt from failures and lack of efficacy as observed in vivo and moved ahead. The symposium aims to gather scientists from different aspects of TERM to share their journey in learning from successful failures to inspire the current and next generation of scientists. 

Keywords : In vivo tissue regeneration; Biomaterials; Cell therapy

  • Session TrackBiomaterials for tissue engineering
  • Session TitleNanofiberous scaffold for tissue engineering
  • Session CodeSP-T04-0285
  • Date & Time / RoomMay 30 (Thu) 13:40~15:10 / Room 324-B
Organizer

Xiumei Mo (Donghua University, China)

Chair

Xiumei Mo (Donghua University, China)

Gary L. Bowlin (University of Memphis, USA)

Keynote Speaker

13:40~14:05 : Nanofiberous scaffolds for peripheral nerve repair Younan Xia (Georgia Institute of Technology, USA)

Invited Speaker

14:05~14:20 : Electrospun organic and inorganic nanofiber for tissue engineering Xiumei Mo (Donghua University, China)

14:20~14:35 : Semi-unstable Near-field Electrospinning: Providing Capacity for Cellular Interactions and Ingrowth within the Template Superstructure Framework Voids/Pores Gary L. Bowlin (University of Memphis, USA)

Oral Presenter

14:35~14:45 : Electronspun polycaprolactone-silk fibroin nanofiber scaffolds for the differentiation of mesenchymal stem cells into vascular cells Zhongkui Hong (Texas Tech University, USA)

14:45~14:55 : Advanced 3D Spacer Textile Scaffolds for Tubular Tissue Regeneration using an engineered nanofiber PCL-PLA core-sheath yarn Anna Doersam (University of Manchester, United Kingdom)

Description

1) Objectives or purposes

to bring nanofiber researchers from all of the world to Korea to discuss the application for tissue engineeringto bring nanofiber researchers from all of the world to Korea to discuss the application for tissue engineering.



2) Proposed program and intended audience

Native extracellular matrix(ECM) is in nanofibrous network, to biomemic the native ECM nanofibrous scaffold have been developed for tissue repairing and tissue engineering. In this symposium electrospinning, phase separation and  selfassembling nanofibers and regenerative medicine will be discussed. That include the preparation of nanofiberous scaffolds, characterization of nanofibers, biocompatibility of nanofibers, nanofibrous scaffold application in the tissue engineering of bone, cartilage, skin, blood vessel, nerve conduit, tendon and so on. Intended audience include tissue engineering researchers of  bone, cartilage, skin, blood vessel, nerve conduit, tendon and so on, electrospinning researchers and nanofiber researchers.



3) Expected outcomes and relevance to the main topic of WBC 2024

Nanofiber scaffolds for tissue engineering is most relevance to the main topic of WBC 2024 of Biomaterials for tissue engineering, the running of this symposium will give expected outcoming

Keywords : nanofiber, electrospinning

  • Session TrackBiomaterials for tissue engineering
  • Session TitleTranslational Regenerative Medicine
  • Session CodeSP-T04-0289
  • Date & Time / RoomMay 30 (Thu) 16:30~18:00 / Room 324-B
Organizer

Sang Jin Lee (Wake Forest Institute for Regenerative Medicine, USA)

Chair

Sang Jin Lee (Wake Forest Institute for Regenerative Medicine, USA)

Alvaro Mata (Nottingham University, United Kingdom)

Keynote Speaker

16:30~16:55 : Translational approaches in designing bioactive materials for regeneration of dense connective tissues Chang Hun Lee (Columbia University, USA)

Invited Speaker

16:55~17:10 : Bioengineered strategies for augmenting skeletal muscle function in rotator cuff injuries Woojin Han (Icahn School of Medicine at Mount Sinai, USA)

17:10~17:25 : Photocrosslinkable bioinks for light-based 3D bioprinting to fabricate multiscale tissue constructs Keekyung Kim (University of Calgary, Canada)

Deok-Ho Kim (Johns Hopkins Biomedical Engineering, USA)

17:40~17:55 : Pre-clinical and clinical translation of tissue engineered tendons to regenerate human extensor tendon for functional recovery Wei Liu (Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, China)

Oral Presenter

17:55~18:05 : Self-feeding living tissues via nutritional nanoparticles enables long-term stem cell functionality under anoxia Niels Willemen (University of Twente, Netherlands)

Description

This session will report on state-of-the-art regenerative medicine applications, including cell-based and scaffold-based tissue engineering approaches, by addressing science, engineering, development, regulatory, biomanufacturing, and clinical aspects of the field. The biomaterial-based scaffolding system must meet mechanical, biological, chemical, and morphological demands. While some of these demands are met by adjusting the composition and formulation of the biomaterials, advances rely on the development of a scaffolding system that can utilize the microenvironment for efficient tissue regeneration and better integration with host tissue. Generally, attendees who are involved in stem cells, biomedical engineering, cell biology, molecular biology, material science, and biofabrication may well be interested in this topic.

Keywords : Regenerative medicine, Scaffold, Translational research

  • Session TrackBiomaterials for tissue engineering
  • Session Title3D Organoids for Disease Modeling and Tissue Regeneration
  • Session CodeSP-T04-0292
  • Date & Time / RoomMay 27 (Mon) 13:00~14:30 / Room 324-B
Organizer

Yongsung Hwang (Soonchunhyang University, Korea, Republic of)

Chair

Yongsung Hwang (Soonchunhyang University, Korea, Republic of)

Yu Suk Choi (The University of Western Australia, Australia)

Keynote Speaker

13:00~13:25 : CRISPR/Cas-assisted genetics in organoids and pluripotent stem cell Bon-Kyoung Koo (Institute for Basic Science (IBS), Korea, Republic of)

Invited Speaker

13:25~13:40 : 3D-bioprinted tissue and cancer models - a revolution in preclinical drug research? Michał Wszoła (Polbionica Sp. z o.o., Poland)

Oral Presenter

13:40~13:50 : Bioengineered airway organoids using proteinaceous artificial extracellular matrix for regeneration of traumatic airway injury SeongMin Han (Kyungpook National University, Korea, Republic of)

13:50~14:00 : A seamless intervascular encapsulation device for transplantation of pancreatic islets Jonathan Brassard (McGill university, Canada)

14:00~14:10 : Bioinspired Hydrogel for Highly Effective Transplantation of Hepatic Organoids to Treat Liver Failure Dongchang Kim (Kyungpook National University, Korea, Republic of)

14:10~14:20 : Permeability of the blood brain barrier in brain organoids under normoxic and hypoxic conditions as stroke model Kathrin Kostka (University of Duisburg-Essen, Germany)

Description

Recent advances in stem cell-derived 3D human organoids have been used to study various diseases, including genetic disorders, rare and degenerative diseases, and cancers. Furthermore, the enabling organoid technology can provide researchers with new opportunities to understand the pathophysiology of human diseases. Therefore, in this session, we aim to introduce novel methods to fully recapitulate the structural and functional properties of human tissues and to highlight the emerging understanding of multiple aspects of the pathophysiology of various human diseases using patient-derived 3D organoids. In addition, this session will cover the potential applications of 3D organoids in treating devasting human diseases. In summary, this session will feature expert speakers working in the field of 3D-engineered organoids for modeling various diseases and their potential applications in regenerative medicine. 

Keywords : Organoids, Stem cells, In vitro models

  • Session TrackBiomaterials for tissue engineering
  • Session TitleAdvanced Nanobiomaterials for Biomedical Applications
  • Session CodeSP-T04-0039
  • Date & Time / RoomMay 31 (Fri) 11:20~12:50 / Room 314
Organizer

Dong-Wook Han (Pusan National University, Korea, Republic of)

Chair

Dong-Wook Han (Pusan National University, Korea, Republic of)

Yu Suk Choi (The University of Western Australia, Australia)

Keynote Speaker

11:20~11:45 : Phage as a Nanobiomaterial for Disease Diagnosis and Treatment Chuanbin Mao (The Chinese University of Hong Kong, Hong Kong SAR, China)

Invited Speaker

11:45~12:00 : M13 Bacteriophage: Advanced Nanobiomaterials as a complex gas receptor Jin-Woo Oh (Pusan National University, Korea, Republic of)

12:00~12:15 : Gradient Hydrogel platforms for 2D and 3D cell mechanotransduction Samuel Maher (University of Western Australia, Australia)

Oral Presenter

12:15~12:25 : Fibrin scaffold stabilization promotes natural anterior cruciate ligament repair despite the surrounding thrombolytic milieu. Grant Scull (The Joint Department of Biomedical Engineering at UNC-Chapel Hill and NC State University, USA)

12:25~12:35 : Mechanically Engineered Polymeric Nanoneedle Arrays for Guided Neuronal Differentiation Yerim Jang (KIST, Korea, Republic of)

12:35~12:45 : Multifunctional nanoparticles regulate neuronal differentiation of neural stem cells and M2 polarization of microglia for PD treatment Shuping Wang (University of Jinan, China)

Description

This symposium is expected to serve as a bridge for the exchange of the latest trends and information among basic and applied researchers related to the biomedical applications of nanobiomaterials such as nanostructured ceramics, metals, polymers, composites, self-assembled materials, and biomacromolecules.

Keywords : nanobiomaterials, biomedical applications

  • Session TrackBiomaterials for tissue engineering
  • Session Title3D bioprinting of multiple cell lineages and organoids for tissue regeneration
  • Session CodeSP-T04-0102
  • Date & Time / RoomMay 30 (Thu) 9:30~11:00 / Room 314
Organizer

Chengtie Wu (Shanghai Institute of Ceramics, Chinese Academy of Science, China)

Chair

Michael Gelinsky (Dresden University of Technology, Germany)

Hongxu Lu (Shanghai Institute of Ceramics, Chinese Academy of Science, China)

Keynote Speaker

9:30~9:55 : Bioengineered Hydrogels for Human Organoids in Regenerative Medicine Andrés J. García (Georgia Institute of Technology, USA)

Invited Speaker

9:55~10:10 : 3D printing of biomimetic biomaterials: from hard tissue to soft tissue regeneration Chengtie Wu (Shanghai Institute of Ceramics, Chinese Academy of Science, China)

10:10~10:25 : Using coaxial extrusion bioprinting for fabrication of complex liver models Michael Gelinsky (Dresden University of Technology, Germany)

Oral Presenter

10:25~10:35 : Development of bioactive materials for intestine and liver organoid culture Hongxu Lu (Shanghai Institute of Ceramics, Chinese Academy of Science, China)

10:35~10:45 : Stem cell-based spheroids for vascularized bone regeneration and their potential for 3d bioprinting  Filipa Teixeira (MERLN Institute, Maastricht University, Netherlands)

10:45~10:55 : Machine learning-enabled constrained multi-objective design of bone scaffolds Yu Qin (peking university, China)

Description

The recent advances in 3D bioprinting, especially the simultaneous printing of multiple cell lineages, bring tremendous opportunities in repairing large and complex tissues/organs. By printing bioactive materials with different cell types (such as stem, stromal, endothelial, and neural cells), the 3D living constructs show a relatively similar structure and functionality to the native tissue/organ. Organoid technologies equip researchers with a powerful resource for regenerative medicine due to the high capacity of self-renewal, similar cell composition, and organ-like functionality. Integrating bioprinting with organoids will extend the power for tissue/organ repair.



The symposium is expected to boost the development of 3D bioprinting, stem cells, and organoids for tissue/organ regeneration. It may generate new ideas, thoughts, and threads for tissue/organ repair via 3D bioprinting, cell therapy, and stem cell technologies. The technology will also bring useful 3D in vitro models to investigate disease mechanisms and screen therapeutics for personalized medicine. Bringing researchers together will significantly increase global collaboration. In addition, the industrial stakeholders in 3D printing, biotech, and biomaterials sciences, may also benefit from the emerging new tech and methodologies from the proposed symposium.



Here, we proposed this symposium to invite world-known experts in this area and attract a bundle of researchers together to boost this research topic. The symposium is planned to have one keynote speaker and two invited speakers. The other time slots will be given to candidates after the abstract screening. It is expected to attract a large variety of audiences from multidisciplinary areas, including biomaterials, tissue engineering, and biofabrication experts, chemists, stem cell biologists, biophysicists, clinicians, and industrial partners.

Keywords : 3D Bioprinting; multiple cell types; organoids

  • Session TrackBiomaterials for tissue engineering
  • Session TitleGranular Hydrogels in Biology and Medicine
  • Session CodeSP-T04-0369
  • Date & Time / RoomMay 28 (Tue) 16:30~18:00 / Room 324-B
Organizer

Amir Sheikhi (Penn State University, USA)

Chair

Amir Sheikhi (Penn State University, USA)

Tatiana Segura (Duke University, USA)

Keynote Speaker

16:30~16:55 : Engineering hydrogel microparticle-based materials for bioprinting, tissue regeneration, and biosensing Daniel L. Alge (Texas A&M University, USA)

Invited Speaker

16:55~17:10 : Gelatin Methacryloyl (GelMA) Granular Biomaterials for Patterning Soft Tissues Amir Sheikhi (Penn State University, USA)

Oral Presenter

17:10~17:20 : Functionalized injectable microgels for the treatment of osteoarthritis Yiting Lei (The First Affiliated Hospital of Chongqing Medical University, China)

17:20~17:30 : Developing vascularized in vitro 3D jammed microgel scaffolds without RGD Natasha Claxton (University of Virginia, USA)

17:30~17:40 : Mineralized Collagen Building Blocks Fabrication for Bottom-Up Bone Tissue Engineering Esra Güben Kaçmaz (Maastricht University, Netherlands)

17:40~17:50 : Granular hydrogel model of hematopoietic stem cells in bone marrow Gunnar Thompson (University of Illinois Urbana-Champaign, USA)

Description

Granular biomaterials, including hydrogel scaffolds assembled from hydrogel microparticle (microgels), have received tremendous attention in the past few years due to their modularity, versatility, unique in vitro capabilities, and unprecedented in vivo performance, e.g., improving wound healing via immunomodulation. These platforms outperform bulk hydrogels in many aspects as a result of their unique microarchitecture. The unique features of granular biomaterials, such as injectability and microscale porosity, have enabled them to secure a promising place in tissue engineering, regenerative medicine, in vitro models of tissues and diseases, 3D bioprinting, and sensing applications. This symposium brings together the world experts in granular biomaterials to share their recent discoveries on this burgeoning biomaterial platform, while welcoming submissions from those conducting research on tissue engineering aspects of granular and particle-based biomaterials. This symposium covers a broad scope of research, spanning from granular biomaterial design strategies, chemistry, microfluidic approaches, in vitro models, and in vivo assessment to clinical studies. As a newly emerged area in "Biomaterials", it is expected that this symposium will attract a broad range of senior and junior researchers, and act as a hub to connect current granular biomaterial researchers to the future generation of scientists in this field, which will strengthen the mission of WBC2024 in Biomaterials for Tissue Engineering. Submission from researchers who are from groups traditionally underrepresented in Biomaterials are particularly encouraged in this symposium. 

Keywords : Granular Hydrogels, Tissue Engineering, Regenerative Medicine

  • Session TrackBiomaterials for tissue engineering
  • Session TitleAdvanced biofabrication for tissue engineering and disease modeling
  • Session CodeSP-T04-0134
  • Date & Time / RoomMay 29 (Wed) 13:40~15:10 / Room 314
Organizer

Junmin Lee (POSTECH, Korea, Republic of)

Chair

Kristopher A. Kilian (University of New South Wales (UNSW), Australia)

Junmin Lee (POSTECH, Korea, Republic of)

Keynote Speaker

13:40~14:05 : In situ cell condensation-based tissue engineering Eben Alsberg (University of Illinois Chicago, USA)

Invited Speaker

14:05~14:20 : Advanced micromaterials and modular bio-inks for multiscale tissue engineering Jeroen Leijten (University of Twente, Netherlands)

Oral Presenter

14:20~14:30 : Phenotypic DMD biomarker exhibited by hiPSC-derived myogenic cells on engineered biomaterials Wei Shen (University of Minnesota, USA)

14:30~14:40 : Biofabrication approaches for middle ear regeneration  Carlos Mota (Maastricht University, Netherlands)

14:40~14:50 : Intracellular delivery of nitric oxide enhances the therapeutic efficacy of mesenchymal stem cells for ischaemic diseases Qiang Zhao (Nankai University, China)

14:50~15:00 : Microfluidic electrospinning for neural tissue engineering Shivesh Anand (Aarhus University, Denmark)

15:00~15:10 : Fabrication of nanofibrillar microbundle scaffolds for enhanced myogenic induction in human adipose-derived stem cells Taufiq Ahmad (University of Würzburg, Germany)

Description

Tissue engineering aims to maintain, restore, and stimulate the normal function of organs/tissues using biomaterials and live cells by integrating concepts from bioengineering, materials science/chemical engineering, biological sciences, and medicine. Biofabrication aims at producing tissue-engineered constructs to restore or replace damaged/diseased tissues to be functional. In addition, biofabricated tissue/organ models with multifunctional and bioactive biomaterials could be employed for modeling various diseases and thus potentially for developing personalized therapy/medicine. This symposium will highlight recent trends in the advancement of biofabrication strategies for tissue engineering and disease modeling that play critical roles in tissue engineering and regenerative medicine. Moreover, the session will also feature cutting–edge bioengineering technologies including 3D bioprinting and microfluidics for the design of hydrogels-based complex extracellular microenvironments, and translational strategies for taking these approaches for personalized disease modeling and regenerative therapies. We anticipate that our interdisciplinary session including biofabrication, tissue engineering, biomaterials, and regenerative medicine will be of great significance to scientists and engineers working in biomedical engineering, life sciences, and clinical medicine.

Keywords : Biofabrication, Tissue Engineering, Biomaterials

  • Session TrackBiomaterials for tissue engineering
  • Session TitleFunctional nanomaterials for tissue engineering
  • Session CodeSP-T04-0146
  • Date & Time / RoomMay 29 (Wed) 9:30~11:00 / Room 314
Organizer

Anderson Oliveira Lobo (Federal University of Piauí, Brazil)

Chair

Thomas Jay Webster (Interstellar Therapeutics, USA)

Keynote Speaker

Y. Shrike Zhang (Harvard Medical School, USA)

Invited Speaker

9:55~10:10 : Introducing nanoporous metallic membranes for improved stem cell delivery and function: A collection of in vitro and in vivo studies Thomas Jay Webster (Interstellar Therapeutics, USA)

10:10~10:25 : Nanotechnology in Dentistry: SPIONs Coated Chitosan Hydrochloride for Improved Therapeutic Delivery Rodrigo França (University of Manitoba, Canada)

Oral Presenter

10:25~10:35 : Regulation of human mesenchymal stem cells by surface-carboxylated cellulose nanofiber scaffolds Mayumi Hatakeyama (Kyushu University, Japan)

10:35~10:45 : Liquid capsules: A versatile tool for tissue engineering strategies Sara Nadine (CICECO - Aveiro Institute of Materials, University of Aveiro, Portugal)

10:45~10:55 : Development of a Hybrid Acellular Biological and Electrospun Synthetic Vascular Conduit for Haemodialysis BESHAIR ALSAFFAR (UCL and KACST, United Kingdom)

Description

Advanced functional scaffolds for tissue engineering place high demands on materials to exceed the passive biocompatibility requirements previously considered acceptable for biomedical implants. Along with (bio)-degradability, the activation of specific cell–material interactions and a three-dimensional environment that mimics the extracellular matrix (ECM), numerous challenges and pre-requisites for the organization of living cells for functional tissues exist. Biomimetic materials which possess nanomaterials and nanoscale topographies potentially mimic many roles of the natural ECM in tissues. For example, biomimetic nano scaffolds can provide biological cues for cell–matrix interactions to promote tissue growth, limit infection, reduction inflammation, and can incorporate peptide sequences into materials making the materials degradable by specific protease enzymes. This symposium seeks abstracts focused on the design, evaluation, and characterization of novel nano materials that can mimic the ECM to improve cell-material interactions important for any medical application including but not limited to: orthopedic hard and soft tissue, cardiovascular, neurological, spinal, wound healing, skin, drug delivery, etc.



This topic is of high interest because the field of biomaterials has recently been focused on the design of more proactive materials. Toward this goal, materials have been developed that can provide specific bioactive signals to control the biological environment around them during the process of material integration and wound healing. Materials that mimic the nano features of the ECM have shown particular promise in tissue engineering.

 

Keywords : extra cellular matric (ECM), biomimetic, tissue engineering, nanotechnology

  • Session TrackBiomaterials for tissue engineering
  • Session TitleAdvanced biofabrication techniques for musculoskeletal tissue engineering
  • Session CodeSP-T04-0176
  • Date & Time / RoomMay 28 (Tue) 13:40~15:10 / Room 314
Organizer

Junmin Lee (POSTECH, Korea, Republic of)

Chair

Junmin Lee (POSTECH, Korea, Republic of)

Jeroen Leijten (University of Twente, Netherlands)

Keynote Speaker

Tim Woodfield (University of Otago, New Zealand)

Invited Speaker

14:05~14:20 : Multi-tissue type cell condensation for vascularized osteochondral tissue regeneration via individual cell bioprinting Oju Jeon (University of Illinois Chicago, USA)

14:20~14:35 : Designer micro/nano-crumpled MXene multilayer coatings accelerate osteogenesis and regulate macrophage polarization Jouha Min (University of Michigan Ann Arbor, USA)

Oral Presenter

14:35~14:45 : Exploring Chondrogenic Pathways: Unlocking SOX9 Regulation in Mesenchymal Stem Cells within Hydrogel Bioscaffolds for Cartilage In-Situ Tissue Engineering carmine onofrillo (The University of Melbourne, Australia)

14:45~14:55 : Tailoring Bioinks for Cultured Meat Engineering: Differentiating Bioprinted Spheroids into Myogenic and Adipogenic Phenotypes in Edible Gellan-Protein Blends Petra Kluger (Reutlingen University, Germany)

14:55~15:05 : Bioactive Magnesium Incorporated Scaffold for Challenging Bone Defects Repair Yuxiao LAI (Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, China)

Description

The musculoskeletal system includes various supportive tissues, such as muscle, bone, cartilage, tendon, ligament, and meniscus, which support the shape/structure of the body. Severe injuries due to various causes, including serious diseases or trauma, affecting the tissues of the musculoskeletal system do not entirely restore themselves due to a limited/insufficient ability of these tissues to repair themselves, resulting in permanent disability spontaneously. Among several clinical and pre-clinical options to address such problems, the musculoskeletal tissue engineering-based strategies combined with emerging biomedical engineering technologies and biomaterials can provide engineered tissue constructs to reproduce the native musculoskeletal tissue structures and original functions of patients by stimulating reparative processes in sites of injury. Althou! gh considerable progress has been made in developing and optimizing engineered tissue implants for the musculoskeletal system, none have been successfully translated into clinical use. This session will highlight recent and advanced trends in the development of functional biomaterials and various technologies that cover a range of musculoskeletal tissues, including, but not limited to, the biocompatibility of materials and interactions at the material-tissue interface, bioengineering technologies for building tissue organoids/spheroids, and molecular guidance to in vitro disease models. We believe this session will offer an overview of the most advanced techniques that could be employed as tools to enhance the healing/regeneration of musculoskeletal disorders in future translational approaches. We anticipate that our session including biomaterials, tissue engineering, biofabrication, and regenerative medicine will be of great significance to the biomedical engineering commu! nities, the materials science communities, the stem cell biolo! gy communities, and the regenerative medicine communities.

Keywords : musculoskeletal tissue engineering, biofabrication techniques

  • Session TrackBiomaterials for tissue engineering
  • Session TitleHydrogels for fibrocartilage regeneration
  • Session CodeSP-T04-0204
  • Date & Time / RoomMay 28 (Tue) 9:30~11:00 / Room 314
Organizer

Joana Silva-Correia (3B's Research Group, University of Minho, Portugal)

Chair

Joana Silva-Correia (3B's Research Group, University of Minho, Portugal)

Changyou Gao (Zhejiang University, China)

Keynote Speaker

9:30~9:55 : Natural-based biomaterials in the biofabrication of fibrocartilage tissues and personalised implants J. Miguel Oliveira (3B's Research Group - University of Minho, Portugal)

Invited Speaker

9:55~10:10 : Hydrogels with enhanced oxygen control, tissue integration and immunomodulatory properties for biofabrication of cartilage implants Gabriella Lindberg (University of Oregon, USA)

10:10~10:25 : Structure/property/processing relationships in hydrogel based materials Maurice N. Collins (School of Engineering, University of Limerick, Ireland)

Oral Presenter

10:25~10:35 : Broad spectrum antimicrobial hyperbranched poly-L-lysine and its applications in medicinal devices Changyou Gao (Zhejiang University, China)

10:35~10:45 : Encapsulation of mesenchymal stem cells in alginate does not impair their immunoregulatory potential Cécile Boyer (Nantes Université, France)

10:45~10:55 : Delivery of Biological Molecules from Hydrogels for Enhanced Cartilage Tissue Engineering Lilith M. Caballero Aguilar (Melbourne University, Australia)

Description

Complex fibrocartilaginous tissues, such as meniscus and intervertebral disc, have minimal vascularity, low cellularity and are subjected to large mechanical forces, which makes them difficult to repair endogenously. Advanced engineered hydrogels, which can be combined with biofabrication methods, bioreactor technologies, biologicals, gene therapies, and nanotechnologies, have the potential to reshape tissue engineering and regenerative medicine, particularly in disease areas where conventional approaches are inadequate, such as articular conditions affecting fibrocartilaginous tissues.

This symposium will target professionals from academia, industries and research institutes and foster their interaction and boost new synergies to uplift the area of fibrocartilage regeneration. It is planned to discuss the latest contributions to the design, synthesis, and functionalization of hydrogels and formulations for fibrocartilage regeneration (with emphasis on pre-clinical validation of advanced engineered hydrogels), aiming also to debate the problems with current hydrogels and the different perspectives to follow to significantly improve the clinical treatment of articular injuries and contribute to the overall quality of healthcare systems across the world. The symposium will be dedicated to several significant contributions concerning disruptive innovations deriving from new developments in hydrogels in convergence with emergent techniques such as biofabrication, bioreactors, and gene and nano therapies. In this way, the symposium is fully aligned with the main topic and objectives of WBC 2024.

Keywords : Hydrogels; Regenerative medicine; Fibrocartilage

  • Session TrackBiomaterials for tissue engineering
  • Session TitleBiomaterials and Modular Approaches in Tissue Engineering and Regenerative Medicine
  • Session CodeSP-T04-0249
  • Date & Time / RoomMay 27 (Mon) 13:00~14:30 / Room 314
Organizer

Jeroen Leijten (University Twente, Netherlands)

Chair

Aleksandr Ovsianikov (TU Wien, Austria)

Jeroen Leijten (University of Twente, Netherlands)

Keynote Speaker

Mark Skylar-Scott (Stanford University, USA)

Invited Speaker

13:25~13:40 : Smart Design of Biomaterials for Tissue Engineering Applications Junmin Lee (Postech, Korea, Republic of)

13:40~13:55 : Polyphenol-based Nano-Microparticles for Tissue Engineering Su-Hwan Kim (Dong-A University, Korea, Republic of)

Oral Presenter

13:55~14:05 : Anisotropic 3D hydrogels with spatial patterns in degradation guide hMSC differentiation Claudia Garrido (Charite, Germany)

14:05~14:15 : Emerging strategies in bone regeneration Mariana Ionita (National University of Science and Technology Politehnica Bucharest, Romania)

14:15~14:25 : 3D Printed Biodegradable Polyester Scaffolds that Address Wound Biofilms and Bacterial Colonization Abraham Joy (Northeastern University, USA)

Description

Designing functional living tissues to replace, repair, or regenerate damaged, diseased, or aged tissues requires exquisite control over the biomaterial’s biophysical and biochemical properties. However, emulating the complex structures that endow tissues with their specific function is an ongoing and unresolved challenge. Integrating of recent concepts from bioengineering, materials science/chemical engineering, biological sciences, and medicine in the form of innovative modular approaches is anticipated to address important aspects of this grand challenge. Modular tissue engineering holds the potential to integrate function-enabling design elements such as spatial patterning or multiscale hierarchies into living tissues in a controlled, facile, and scalable manner.

This symposium highlights recent and impactful trends in the advancement of bottom-up tissue engineering strategies and modular biomaterial and bio-ink designs. They are anticipated to play a pivotal role in future tissue engineering and regenerative medicine strategies. Furthermore, cutting-edge technologies including bioprinting, microfluidics, micromaterials, and advanced biomaterials are required for the design of modular strategies, and will be highlighted in this symposium. The innovations and associated discussions within this multidisciplinary, future-oriented, and solution-seeking symposium is anticipated to be of high interest for a wide range of investigators including material scientists, tissue engineers, applied stem cell biologist, biofabricators that work in the domain of biomaterials, biomedical engineering, implantology, drug screening, and regenerative medicine. Herewith, this symposium is highly relevant for the attendees of the WBC2024 and the declared congress theme “Convergence in Biomaterials: a vision for the future of healthcare”. Tissue Engineering and Regenerative Medicine International Society (TERMIS) endorses the Symposium’s goal of promoting collaboration between researchers active in TERMIS and biomaterials societies. This will help to attract further attendees to the symposium and the congress.

Keywords : Modular, Bottom-Up, Self-Assembly

  • Session TrackBiomaterials for tissue engineering
  • Session TitleBiomaterial models of the hierarchical tumor microenvironment
  • Session CodeSP-T04-0255
  • Date & Time / RoomMay 31 (Fri) 11:20~12:50 / Room 324-B
Organizer

Brendan Harley (University of Illinois at Urbana-Champaign, USA)

Chair

Brendan Harley (University of Illinois at Urbana-Champaign, USA)

Alireza Sohrabi (The University of Texas at Austin, USA)

Keynote Speaker

11:20~11:45 : Deconstructing a complex microenvironment through designer nano- and micro-engineered matrices
Kristopher A. Kilian (UNSW Sydney (Australia), Australia)

Invited Speaker

11:45~12:00 : Microenvironmental Stiffness Induces Metabolic Reprogramming in Glioblastoma Alireza Sohrabi (The University of Texas at Austin, USA)

Oral Presenter

12:00~12:10 : A PDA-Functionalized 3D Lung Scaffold Bioplatform to Construct Complicated Breast Tumor Microenvironment for Anticancer Drug Screening and Immunotherapy Yongtao Wang (The Sixth People's Hospital of Nantong, China)

12:10~12:20 : Engineering bioelectronic scaffolds for hosting and monitoring 3D tissue models Emma Sumner (University of Cambridge, United Kingdom)

12:20~12:30 : Liposome-loaded composite scaffolds for stepwise synergistic photothermal and chemotherapy of breast cancer Huajian Chen (National Institute for Materials Science, Japan)

12:30~12:40 : Remote stimuli-responsive nanomaterials in various morphologies for stem cell regulation and cancer therapy Hyunsik Hong (Korea University, Korea, Republic of)

Description

The cancer microenvironment is often hierarchical, graded, and heterogeneous over multiple length and time scales. Biomaterials provide an opportunity to mimic elements of the tumor structural, cellular, and biomolecular microenvironment. This symposia will hilight aspects of bioamaterial innovation to create tools to study multicellular crosstalk, methods to locally manipulate material microstructure and chemistry, and generative design principles and three-dimensional printing to create composite and granular biomaterials that the tumor microenvironment. The proposed program will feature world-leaders who will provide state of the art approaches to create multidimensional tissue engineering model of the tumor environment, including in depth study of the role of perivascular environment, stromal cell-mediated remodeling, and matrix (visco)elasticity on cancer invasion, stem cell proliferation, and therapeutic resistance. Cancer tissue engineering models described in this session will consider the convergence of synthetic biology, spatial-omics technologies, and patient-derived biospecimens to achieve precision medicine goals. Cancer tissue engineering represents an exciting area of growth for the world biomaterials community making the goals of this session in alignment with the WBC2024 conference.

 

Keywords : cancer, biomaterials, synthetic models

  • Session TrackBiomaterials for tissue engineering
  • Session TitleBiomaterials for 3D stem cell mechanotransduction and differentiation
  • Session CodeSP-T04-0104
  • Date & Time / RoomMay 29 (Wed) 16:30~18:00 / Room 314
Organizer

Yu Suk Choi (University of Western Australia, Australia)

Chair

Yu Suk Choi (University of Western Australia, Australia)

Jennifer Young (National University of Singapore / Mechanobiology Institute, Singapore)

Keynote Speaker

16:30~16:55 : Viscoelastic hydrogels and pluripotent stem cell morphogenesis Ovijit Chaudhuri (Stanford University, USA)

Invited Speaker

16:55~17:10 : Cell Dancing Enhances Stem Cell Differentiation in 3D Hydrogels via Nuclear Mechanotransduction Fan Yang (Stanford University, USA)

17:10~17:25 : Stem cell migration, mechanotransduction, and differentiation in confinement Andrew Holle (National University of Singapore / Mechanobiology Institute, Singapore)

Oral Presenter

17:25~17:35 :

Engineering Spatio-Temporal Biomaterials for Materiobiology
Koichiro Uto (National Institute for Materials Science, Japan)

17:35~17:45 : Advanced biomaterials mimicking the physicochemical properties of the human mesenchymal stem cell microenvironment to control cell behavior Bethany Almeida (Clarkson University, USA)

17:45~17:55 : Determing relationships between nanoscale curvature and stem cell fate to build predictive models for rational biomaterial design Elizabeth Byers (The Pennsylvania State University, USA)

Description

1) Objectives or purposes

Recent advances in biomaterials allowed better mimicry of the extracellular matrix (ECM) to study stem cell biology. The mechanical properties of ECM emerged as one of the main controlling factors for stem cell differentiation. One of the well-studied mechanical properties is elasticity also known as stiffness or rigidity that various studies showed tissue-specific stiffness-dependent stem cell lineage specification. Bone marrow-derived stem cells differentiated into neuro-, myo-, and osteogenic cells on substrates with the stiffness of brain, muscle and calcified bone tissues, respectively. More recently, this stiffness-dominated mechanotransduction-mediated stem cell differentiation has been challenged by other observations mainly in 2 categories; 1) 3D differentiation seemed to be independent or even opposite trend to 2D and 2) viscoelasticity showed varying degrees of differentiation marker expressions when stiffness was controlled same. More recently, cell volume, and how much materials allowed the expansion of stem cells in 3D, have been suggested as a better indicator / marker for 3D mechanotransduction and differentiation. A discussion on this topic will greatly benefit the overall Biomaterials field and Tissue Engineering and Regenerative Medicine.



2) Proposed program and intended audience

‘Biomaterials for 3D stem cell mechanotransduction and differentiation’ will invite experts in the field of mechanobiology, Ovijit Chaudhuri, Fan Yang, Andrew Holle and Jennifer Young, to generate a robust discussion on this emerging topic. It will target the broad Biomaterials field however, the focus area can be mechanobiology and cell-matrix interaction.



3) Expected outcomes and relevance to the main topic of WBC 2024

It is expected to generate more tractions in mechanobiological incorporation in the Biomaterials field, which will greatly help in designing better biomaterials for better treatments in the future.

Keywords : Mechanobiology, 3D, differentiation

  • Session TrackBiomaterials for tissue engineering
  • Session TitleBiomaterials for the Maternal-Fetal Interface
  • Session CodeSP-T04-0164
  • Date & Time / RoomMay 28 (Tue) 16:30~18:00 / Room 314
Organizer

Samantha Zambuto (Washington University in St. Louis, USA)

Chair

Samantha Zambuto (Washington University in St. Louis, USA)

Juan Gnecco (Tufts University, USA)

Keynote Speaker

Samantha Zambuto (Washington University in St. Louis, USA)

Oral Presenter

17:10~17:20 : Selection of a kidney cell line for organoid studies in collagen scaffolds Emrys Thursfield Thursfield (University of Cambridge / AstraZeneca, United Kingdom)

17:20~17:30 : Generation of low immunogenic stem cell by induced cardiomyocyte differentiation TzuCheng Sung (The Eye hospital of Wenzhou medical university, China)

17:30~17:40 : Forming and probing human neuromuscular junctions using iPSC-derived cell types within microfabricated devices Stephanie Michelena Tupiza (The University of Queensland, Australia)

17:40~17:50 : Microgranular endometrial orgnaoids to reconstruct endometrial injuries for infertility treatment Myeong Jae Baek (Kyungpook national university, Korea, Republic of)

17:50~18:00 : A CONTROLLABLE HUMAN SPINAL CORD MODEL WITH FULL DORSOVENTRAL PATTERNING Jeyoon Bok (University of Michigan, USA)

Description

Pregnancy involves a complex spatiotemporal cellular dialogue between trophoblast cells from the invading blastocyst and cells from the site of implantation in the endometrium. This dialogue dictates the extent of invasion of trophoblast into the uterus and can dictate the success of pregnancy. The maternal-fetal interface describes the location of uterine-blastocyst interfacing during implantation and the subsequent unique microenvironment of pregnancy once the blastocyst has implanted and continues to grow. The maternal-fetal interface is extremely challenging to study in humans and due to significant differences between animal and human pregnancies, animal models are not ideal. As experts in biomaterials, we have unique capabilities to harness advanced materials science and engineering skillsets to develop increasingly complex systems that can be applied to the maternal-fetal interface. From uterus to blastocyst to placenta, this symposium will highlight recent advances at the intersection of biomaterials and the maternal-fetal interface with the goal of providing a survey of engineering techniques to study this unique biological interface.



 

Keywords : Pregnancy, women’s health, interfaces

  • Session TrackBiomaterials for tissue engineering
  • Session TitleControlling degradation of bioresorbable materials to direct cell behavior
  • Session CodeSP-T04-0199
  • Date & Time / RoomMay 27 (Mon) 14:40~16:10 / Room 314
Organizer

Whitney Stoppel (University of Florida, USA)

Chair

Whitney Stoppel (University of Florida, USA)

Jonathan M. Grasman (New Jersey Institute of Technology, USA)

Keynote Speaker

14:40~15:05 : Enzyme-sensitive peptide-polymer conjugates for cell-mediated scaffold degradation Lesley Chow (Lehigh University, USA)

Invited Speaker

15:05~15:20 : Controlling scaffold architecture and structural properties to enhance tissue regeneration Jonathan M. Grasman (New Jersey Institute of Technology, USA)

15:20~15:35 : Silk fibroin lyophilized sponge degradation and mechanics: connecting silk fibroin crystalline domains to biological activity Whitney Stoppel (University of Florida, USA)

Oral Presenter

15:35~15:45 : Subcutaneous Injection of Tetra-Branched Poly(ethylene glycol) in Mice: A Study on Diffusion, Biodistribution, and Molecular Weight Influence Shohei Ishikawa (The university of Tokyo, Japan)

15:45~15:55 : 3D printable alginate-gelatin hydrogels with variable viscoelastic properties as sole differentiation factor of induced pluripotent stem cells for tissue engineering Lucas Lemarié (CNRS UMR 5305 - LBTI, France)

15:55~16:05 : Biomaterial tools for studying the early phase of osteoblast differentiation and building a 3D in vitro bone model Janne T. Koivisto (Tampere University, Finland)

Description

Degradation of bioresorbable materials can be controlled through various methods such as adjusting the composition and microstructure of the material, modifying the surface chemistry, and controlling the rate of degradation through crosslinking. Materials can be further optimized by incorporating enzymatic cleavage sites to directly control degradation and to facilitate release of bioactive factors to direct cellular and tissue functions over time. In this session, we will highlight how bioresorbable materials can be fabricated, and address how the degradation rate can be controlled by adjusting the composition of the material. For example, work that focuses on polymer level organization, surface chemistries, or rates of degradation will be chosen based on how these parameters influence cell behavior or in vivo performance. Alternatively, crosslinking methodologies can be employed to not only elicit further control of the polymer structure, but to also release bioactive molecules during degradation to further impact the in vivo performance. The overall session will highlight how controlling degradation of bioresorbable materials can direct cell behavior by providing the appropriate environment for cell growth and differentiation to direct regeneration and ultimately restore tissue function.

 

Keywords : biopolymers, controlled degradation

  • Session TrackBiomaterials for tissue engineering
  • Session TitleThe Macrophage as a target in biomaterial-based tissue regeneration strategies
  • Session CodeSP-T04-0217
  • Date & Time / RoomMay 27 (Mon) 16:30~18:00 / Room 314
Organizer

Jonathan Ian Dawson (University of Southampton, United Kingdom)

Chair

Yasuhiko Tabata (Kyoto University, Japan)

Jonathan Ian Dawson (University of Southampton, United Kingdom)

Keynote Speaker

16:30~16:55 : Macrophages as the gatekeepers of tissue repair and regeneration Mikael Martino (Monash University, Australia)

Invited Speaker

16:55~17:10 : Developing biomaterial technologies to modify macrophages polarization for tissue regeneration Yasuhiko Tabata (Kyoto University, Japan)

17:10~17:25 : The Role of Phagocytosis in Nanoclay Particle Induced Macrophage Polarisation Yanghee Kim (University of Southampton, United Kingdom)

Oral Presenter

17:25~17:35 : Neutrophil targeting platform reduces neutrophil extracellular traps for improved traumatic brain injury and stroke theranostics Longguang Tang (Zhejiang University, China)

17:35~17:45 : Mechanoregulation of MSC spheroid immunomodulation Sabrina Mierswa (University of California Davis, USA)

17:45~17:55 : Influence of secreted signals from macrophages on osteocyte maturation Paula Giraldo (University of Gothenburg, Sweden)

Description

The past decade has seen a growing appreciation for the role of the innate immune response in mediating repair. Such insights have moved the field of biomaterial design on considerably from the long-held view of the host immune/inflammatory response to foreign objects as an obstacle limiting stem and progenitor cell activity, to a fresh appreciation of the role of the macrophage as a pivotal orchestrator of the repair process. It is increasingly clear that future success in biomaterial guided regeneration will depend on engagement with the complex but powerful inter-relationship and functions of pro-inflammatory and anti-inflammatory states and their respective contributions to launching the stem cell regenerative response.



This symposium will consider critical aspects of immunomodulatory materials, focusing on modification of biomaterials’ mechanical properties, surface chemistry, topography, size, composition - as well as drug release strategies - and their ability to modulate macrophage phenotype/behaviour/function. Understanding and modulating the macrophage-biomaterial interaction and the intersecting influences of material science, immunology and stem cell biology is critical to effectively harnessing biomaterials in tissue repair. By highlighting the exciting possibilities of immunomodulatory biomaterials this symposium hopes to open up new vistas of exploration in biomaterial design to facilitate tissue regeneration and improve the quality of life in an increasing aging population.

Keywords : Immunomodulation, Macrophage, Tissue regeneration

  • Session TrackBiomaterials for tissue engineering
  • Session TitleMusculoskeletal tissue engineering
  • Session CodeSP-T04-0288
  • Date & Time / RoomMay 28 (Tue) 13:40~15:10 / Room 324-B
Organizer

Hyuk-Soo Han (Seoul National University College of Medicine, Korea, Republic of)

Chair

Hyuk-Soo Han (Seoul National University College of Medicine, Korea, Republic of)

Su Chin Heo (University of Pennsylvania, USA)

Keynote Speaker

13:40~14:05 : Tailored Decellularized Extracellular Matrix-based Hydrogel Systems for Zone-Specific Meniscus Repair Su Chin Heo (University of Pennsylvania, USA)

Invited Speaker

14:05~14:20 : In vivo Validation of a Continuous Gradient Porous Scaffold for Osteochondral Defect Repair in a Rabbit Model Riccardo Gottardi (Children’s Hospital of Philadelphia/University of Pennsylvania, USA)

14:20~14:35 : Guiding cartilage repair microenvironments to prevent contraction and fibrosis Jay Patel (Emory University, USA)

Oral Presenter

14:35~14:45 : Tribological properties of bare and gel-infiltrated fibrous materials Elisa Bissacco (ETHZ, Switzerland)

14:45~14:55 : Selective mineralization of nanofibers for enthesis repair Gabrielle Hamner (The Pennsylvania State University, USA)

14:55~15:05 : Periosteal topology creates a unique micro-environment for skeletal progenitor cells maintenance Hao Chen (Yangzhou University, China)

Description

The objectives of this symposium is to discuss recent biomaterial approaches for musculoskeletal tissue repair and regeneration, and to establish scientific collaboration networks in the research fields. In this symposium, Dr. Heo will present his recent study about developing tunable decellularized extracellular (dECM) matrix-based systems for meniscus and tendon repairs. In this talk, he will introduce novel bovine Achilles tendon dECM based multiphasic nanofibrous scaffold systems for rotator cuff repair and tunable age dependent bovine meniscus dECM based hydrogel systems for meniscus repair. Dr. Gottardi will introduce his recent approaches for hyaline cartilage repair using decellularized cartilage and auricular progenitor cells to engineer a cartilage implant populated with patients’ cells to circumvent the limitations of pediatric autologous cartilage. Dr. Petal will present his recent study about guiding cell microenvironments for cartilage repair and reservation. The first half of his presentation will cover a cartilage-penetrating hydrogel system that fortifies the microenvironment around chondrocytes, reduces the catabolic activity of these cells, and protects the tissue matrix from degeneration. The second half will then explore the marrow stimulation microenvironment following cartilage repair (e.g., microfracture), whereby control of the initial structure, remodeling rate, and cellular perception of these environments are tailored to optimize cartilage regeneration.

 

 

 

Keywords : Musculoskeletal tissues, Decellularized extracellular matrix, Hydrogel

  • Session TrackBiomaterials for tissue engineering
  • Session TitleBone biomaterials for the elderly patients
  • Session CodeSP-T04-0304
  • Date & Time / RoomMay 30 (Thu) 9:30~11:00 / Room 324-B
Organizer

Shengmin Zhang (Advanced Biomaterials and Tissue Engineering Center, Huazhong University of Science and Technology, China)

Chair

Shengmin Zhang (Advanced Biomaterials and Tissue Engineering Center, Huazhong University of Science and Technology, China)

Keynote Speaker

Yin Xiao (School of Medicine and Dentistry, Menzies Health Institute Queensland, Griffith University, Australia)

Invited Speaker

9:55~10:10 :

Upregulated Cell-Cell Communication via Gene Delivery Coating Accelerates Ischemic Tibia Fracture Healing
David Kohn (University of Michigan, USA)

10:10~10:25 : Effects of extracellular matrix of MSC on osteogenesis

Young-Kwon Seo (Dongguk University, Korea, Republic of)

10:25~10:40 : Bioactive Polyamide Composite for 3D Printer Feedstock Dasmawati Mohamad (Universiti Sains Malaysia, Malaysia)

Oral Presenter

10:40~10:50 : Nano biomaterials for hard tissue regeneration and multimodal tracing Xiyu Li (Sichuan University, China)

10:50~11:00 : Nanoparticle hybrid hydrogel induced mild photothermal therapy for bone tissue regeneration Jinfeng Liao (Sichuan University, China)

Description

Current therapeutic strategies are yet to resolve the challenge of impaired bone regeneration in the elderly. Compromised bone regeneration in older patients is mainly due to the dysregulated microenvironment resulting from immunosenescence, a research area currently being ignored in therapeutic strategies that focus on how to induce osteogenesis (e.g., via BMP-2 delivery). This symposium proposes a Biomaterials development concept to induce bone regeneration in the elderly by correcting this dysregulated microenvironment, after which bone regeneration can be induced. This symposium will focus on the discussion of the elderly wound healing environment, biomaterials development strategies, cell and biomaterials interactions in the regulation of local bone regeneration. The outcome of this symposium will form a discussion paper and guidelines in biomaterials development for the challenged healing environment of elderly patients.

Keywords : Bone biomaterials, aging, regeneration

  • Session TrackBiomaterials for tissue engineering
  • Session TitleNovel strategy for bone tissue engineering in oro-maxillofacial region
  • Session CodeSP-T04-0313
  • Date & Time / RoomMay 29 (Wed) 13:40~15:10 / Room 324-B
Organizer

Takuya Matsumoto (Okayama University, Japan)

Chair

Takuya Matsumoto (Okayama University, Japan)

Kent Leach (University of California Davis, USA)

Keynote Speaker

13:40~14:05 : Cell-derived biomaterial strategy for potentiating progenitor osteogenic differentiation and bone regeneration Kent Leach (University of California Davis, USA)

Invited Speaker

14:05~14:20 : Deciphering Osteogenic Induction Pathways of Decellularized Extracellular Matrix Derived from Dental Stem Cells Thanaphum (Noom) Osathanon (Chulalongkorn University, Thailand)

14:20~14:35 : Stem cell/nanotechnology-based strategies in dental tissue regeneration Hiroshi Egusa (Tohoku University, Japan)

14:35~14:50 : Histological and Clinical evidence of Demineralized Dentin Matrix as Osteoinductive Bone Substitutes Jeong-Kui Ku (Jeonbuk National University, Korea, Republic of)

Oral Presenter

14:50~15:00 : Natural polymers-based scaffolds for cartilage and bone regeneration Luis García-Fernández (Centro de Investigaciones Biomédicas en Red (CIBER-BBN), Spain)

15:00~15:10 : Next generation 3-Dimensional porous scaffolds for craniofacial bone regeneration - A study in cellular dynamics and mechanical integrity 
 
Hafsah Akhtar (Interdisciplinary research center in biomedical materials, COMSATS University Islamabad, Lahore Campus, Pakistan, Pakistan)

Description

1) Purposes or objectives

Oral and maxillofacial bone regeneration has been one of the important research targets since the beginning of tissue engineering research. Therefore, in recent years, the regeneration of small alveolar bone defects has been achieved at a high level. On the other hand, more advanced bone regeneration, such as regeneration of large bone defects and rapid bone regeneration, is an important future goal. This symposium will discuss recent new strategies for bone tissue engineering in the oral and maxillofacial region.



2) Proposed program and target audience

This symposium will focus on immunoregulation, cell-derived materials, and stem cell regulation, and discuss recent new strategies, especially bone regeneration research in the oral and maxillofacial region. The audience is bone tissue engineers, dental clinicians, and basic dental researchers.



3) Expected results and relevance to his main topic at WBC 2024

Bone regeneration is one of the important topics with a large researcher population. This symposium will include many contents of approaches that are significantly different from previous bone regeneration research. It indicates the major direction of future bone regeneration research.

 

Keywords : Oral and maxillofacial tissue, tissue manipulation, immunomodulation

  • Session TrackBiomaterials for tissue engineering
  • Session TitleGlass for bone repair: From bioglass to glass-polymer hybrids
  • Session CodeSP-T04-0081
  • Date & Time / RoomMay 30 (Thu) 13:40~15:10 / Room 321-A
Organizer

Justin Chung (Seoul National University Hospital, Korea, Republic of)

Chair

Justin Chung (Seoul National University Hospital, Korea, Republic of)

Gowsihan Poologasundarampillai (University of Birmingham, United Kingdom)

Keynote Speaker

13:40~14:05 : 3D printed Bouncy Bioglass for osteochondral regeneration Julian Jones (Imperial College London, United Kingdom)

Invited Speaker

14:05~14:20 : Cotton-wool-like sol-gel bioactive glasses with controlled ion releasability Akiko Obata (Nagoya Institute of Technology, Japan)

Oral Presenter

14:20~14:30 : Bone regeneration with Bioglass: a clinical and regulatory perspective Céline Saint Olive (NORAKER, France)

14:30~14:40 : Additive Manufacturing of “Bouncy Bioglass” for bone regeneration Haffsah Iqbal (Imperial college london, United Kingdom)

14:40~14:50 : Microstructural and mechanical evaluation of 3D-printed hybrid bone scaffolds using X-ray micro-computed tomography imaging and finite element analysis Jingwen Liu (University College London, United Kingdom)

14:50~15:00 : In-vitro study on the effect of magnesium-doped bioactive glass on the senescence and osteogenic differentiation ability of hDPSCs Sui Mai (Sun Yat-sen University, China)

Description

50 years ago, Larry Hench developed 45S5 Bioglass which was the first artificial material that formed chemical bond with bone. This discovery launched the field of bioactive ceramics for bone regeneration. Since then, it has been extensively studied by researchers to understand the effects of glass composition on bioactivity, and develop glass fabrication techniques for producing porous bone scaffolds. An ideal scaffold for bone regeneration must withstand mechanical loads with bone. However, bioglass is brittle for bone defects that are exposed to cyclic loads. To overcome this, Class II hybrids are being developed that have the potential to be tough and flexible. Hybrids have glass and polymer phases which form co-networks through covalent bonds. This molecular level interaction allows hybrids to have congruent degradation, and homogenous material interface. This symposium will cover recent progress and future directions of biomedical glasses for bone regeneration. It will be of great interest to audience who are part of the regenerative medicine, biomaterials, and translational medicine research fields. The symposium organizer believes that this session will attract large participants and audience from both academia and industry. This session will be a great fit for Track 4: Biomaterials for tissue engineering.

Keywords : Bioglass, Hybrids, Bone regeneration

  • Session TrackBiomaterials for tissue engineering
  • Session TitleNew Biomaterials for Cardiovascular Tissue Engineering
  • Session CodeSP-T04-0268
  • Date & Time / RoomMay 31 (Fri) 9:30~11:00 / Room 324-B
Organizer

Ngan Huang (Stanford University, USA)

Chair

Ngan Huang (Stanford University, USA)

Yi Hong (University of Texas at Arlington, USA)

Keynote Speaker

9:30~9:55 : Materials-driven in-situ cardiovascular tissue engineering Carlijn Bouten (Eindoven University of Technology, Netherlands)

Invited Speaker

9:55~10:10 : A new vascularization strategy to enhance the construction of islet organoids and their functionality Deling Kong (Nankai University, China)

10:10~10:25 : Stiffness relaxing hydrogels modulate endothelial cell angiogenic function Ngan Huang (Stanford University, USA)

10:25~10:40 : Highly Efficient Direct Reprogramming of Adult Fibroblasts to Endothelial Cells by ETV2 and SOX17 Guohao Dai (Northeastern University, USA)

Oral Presenter

10:40~10:50 : Comb-like copolymer with enhanced ROS scavenging improves border zone contractility and reduces myocardial remodeling after MI in sheep Kevin E. Healy (Department of Bioengineering, University of California-Berkeley, USA)

10:50~11:00 : Biomimetic collagen-based materials obtained by ice templating and topotactic fibrillogenesis for vascular repair Francisco Fernandes (Sorbonne University, France)

Description

Cardiovascular diseases remain high morbidity and mortality. Tissue engineering strategies have provided new opportunities and methodologies to simulate, manage, and treat various cardiovascular diseases. As a key element in the tissue engineering, the biomaterials provide significant roles as cell matrix, device materials, and implants, and so one. Recently, many new biomaterials have been designed and developed to study fundamental cardiovascular cell behaviors, treat heart diseases, replace blood vessels, generate organoids, and to deliver molecules.  Our proposed symposium will cover recently fantastic biofunctional materials and clinic trial biomaterials for cardiovascular disease treatment, and new applications in organoids, organ-on-chip, and 3D printing for heart and blood vessel use.  The symposium will be open to all audience with different backgrounds, and these new biomaterial strategies and translational research will also offer new inspiration for the audience without background in cardiovascular biomaterials.  Our symposium is well aligned with the WBC tracks and topics, including “Biomaterials Design”, “Biomaterials for tissue engineering”, and “Biomaterials for preclinical and clinical translation).

 

Keywords : cardiovascular, organoids, tissue engineering

  • Session TrackBiomaterials for tissue engineering
  • Session TitleSoft tissue regeneration
  • Session CodeSP-T04-0290
  • Date & Time / RoomMay 29 (Wed) 9:30~11:00 / Room 324-B
Organizer

Ji-Ung Park (Seoul National University College of Medicine, Korea, Republic of)

Chair

Ji-Ung Park (Seoul National University College of Medicine, Korea, Republic of)

Su Ryon Shin (Harvard Medical School, USA)

Keynote Speaker

9:30~9:55 : Engineering nano-biomaterials for tissue fabrication and regenerative medicine Su Ryon Shin (Harvard Medical School, USA)

Invited Speaker

9:55~10:10 : Deciphering the Complexity of Tissue Repair: 3D Models, Fibrosis, and Beyond Jiranuwat Sapudom (New York University Abu Dhabi, United Arab Emirates)

Oral Presenter

10:10~10:20 : Light-activated adipose tissue grafts for soft tissue reconstruction Khoon Lim (University of Sydney, Australia)

10:20~10:30 : Establishment of a clinical application technique for breast reconstruction using in vitro vascularized 3D adipose tissue:injectable prevascularized adipose tissues (iPAT) Yoshihiro Sowa (Jichi Medical University, Japan)

10:30~10:40 : Spider silk as potential biomaterial for a biological annular closure device after disc herniation Janin Reifenrath (Hannover Medical School, Germany)

10:40~10:50 : Reproducible preparation of transplantable hepatic tissue sheets using thermoresponsive surfaces Jun Kobayashi (Tokyo Women's Medical University, Japan)

10:50~11:00 : Sequential intervention of anti-inflammatory and osteogenesis with silk fibroin coated polyethylene terephthalate artificial ligaments for anterior cruciate ligament reconstruction Jun Chen (Huashan Hospital, Fudan University, China)

Description

In order to repair damaged soft tissue, it is important to maintain balance and homeostasis. However, the incidence of difficult-to-heal soft tissue defect including chronic wounds due to diabetic foot, arteriovenous ulcer, burn, pressure sore, etc. is rapidly increasing worldwide. Recently, various biomaterials and technologies including nano-complex material, natural and synthetic biomaterials, electrical stimulation and so on have been developed to regenerate these problematic soft tissue defect. In addition, hypertrophic scars or keloids appearing after wound healing is another important issue which can arise serious clinical deformity. Studies for overcoming these scars and achieving scarless wound regeneration are being actively conducted. Although various biomaterials have been used for soft tissue regeneration, short and long-term safety and efficacy are still controversial. This session will focus on recent researches in the various fields of advanced biomaterials for soft tissue regeneration including natural product, polymers and bioengineered tissues.

 

Keywords : Soft tissue regeneration, biomaterials, bioenginnering

  • Session TrackBiomaterials for tissue engineering
  • Session TitleNeuronal tissue engineering
  • Session CodeSP-T04-0291
  • Date & Time / RoomMay 27 (Mon) 14:40~16:10 / Room 324-B
Organizer

In Bo Han (CHA Univ. School of Medicine, Korea, Republic of)

Chair

In Bo Han (CHA Univ. School of Medicine, Korea, Republic of)

Xiang Zeng (Sun-Yat-Sen University, China)

Keynote Speaker

Xiang Zeng (Sun-Yat-Sen University, China)

Invited Speaker

15:05~15:20 : SMART 3D Assembly of Nanomedicine and Stem Cells for Spine and Spinal Cord Regeneration Letao Yang (Tongji University, China)

Oral Presenter

15:20~15:30 : Microfiber topography drives neural and specifically oligodendroglial differentiation and extracellular matrix deposition in 3D hydrogels Kyle Lampe (University of Virginia, USA)

15:30~15:40 : A Recombinant Elastin-Like Protein-based Hydrogel Enhances Neuroprotection in a Neonatal Rat Model of Arterial Ischaemic Stroke Maria Martinez-Vega (Hospital Clinico San Carlos/Universidad Cmplutense, Spain)

15:40~15:50 : Let’s talk about neuroprotection! Exploring biodegradable dendrimers as delivery vectors in stroke Marília Torrado (i3S - Institute for Research and Innovation in Health, Portugal)

15:50~16:00 : Rolipram loaded PgP nanoparticles via intrathecal administration reduces secondary injury and improves motor function after spinal cord injury Jeoung Soo Lee (Clemson University, USA)

16:00~16:40 : Microvascular endothelial cells derived from spinal cord promote spinal cord injury repair He Shen (Chinese Academy of Sciences, China)

Description

Damage to the central nervous system causes very fatal neurological disorders. There is no effective treatment yet, and new treatment technologies such as tissue engineering are needed. Therefore, the purpose of this symposium is to find out the latest knowledge and technology related to nerve regeneration using tissue engineering after central nervous system injury. We have prepared a program for central nervous system regeneration using the latest tissue engineering technology using stem cells and biomaterials, and it will be of great help to researchers studying central nervous system regeneration. Through this symposium, it will be a forum to check the latest tissue engineering technology for regeneration of central nervous system damage and to cooperate with each other.

 

Keywords : CNS injury, Tissue engineering, Regeneration

  • Session TrackBiomaterials for tissue engineering
  • Session TitleInteroception mediated musculoskeletal tissue regeneration
  • Session CodeSP-T04-0049
  • Date & Time / RoomMay 30 (Thu) 16:30~18:00 / Room 314
Organizer

Kelvin Yeung (The University of Hong Kong, Hong Kong SAR, China)

Chair

Soo-Hong Lee (Dongguk University, Korea, Republic of)

Wei Qiao (The University of Hong Kong, Hong Kong SAR, China)

Keynote Speaker

Kelvin Yeung (The University of Hong Kong, Hong Kong SAR, China)

Invited Speaker

16:55~17:10 : Biomaterials-based mass production of mesenchymal stem cells and extracellular vesicles for personalized bone tissue regeneration Soo-Hong Lee (Dongguk University, Korea, Republic of)

Oral Presenter

17:10~17:20 : Age-associated functional healing of musculoskeletal trauma through regenerative engineering and rehabilitation Karina Nakayama (Oregon Health & Science University, USA)

17:20~17:30 : Role of macro-pore structure and parameters on compressive properties of porous tantalum scaffolds additively manufactured by laser powder bed fusion Xia Jin (Qingdao University of Technology, China)

17:30~17:40 : 3D-Printed Bone Tissue-Engineered Scaffolds Using Bioactive Methacrylated Gellan Gum LUIGI AMBROSIO (National Research Council of Italy, Italy)

17:40~17:50 : Engineering functional 3D skeletal muscle tissue with acoustic patterning for neuromuscular regeneration EUNSEON JEONG (YONSEI UNIV., Korea, Republic of)

Description

1) Objectives or purposes: Central nervous system (CNS) has been found to play an important role in bone homeostasis. Indeed, the CNS receives signals from many physiological systems inside the body as interoception. It consists of ascending neural pathways that transmit the internal body signals to the brain, the CNS where the input interoceptive information is processed, and the descending neural pathways through which the interoceptive signals are circled back to regulate peripheral organs. Hence, this symposium aims to explore how biomaterials trigger or mediate the musculoskeletal tissue regeneration undergoing this specific pathway.  



2) Proposed program and intended audience: The propsoed sympoisum will approximately include 1 keynote talk, 1 invited talk and 3-4 free papers. The academia and company representatives from musculoskeletal and neuroscience fields; the clinicians from orthopaedics and neurology and the research students from the relevant fields.



3) Expected outcomes and relevance to the main topic of WBC 2024: We expect that the symposium can help advocate how musculoskeletal tissue regeneration can be achieved by the CNS-skeletal circuit. Hence, researchers in the field can then design a series of novel biomaterials that may harness the power of this specific pathway.

Keywords : CNS-skeletal axis, bone regeneration, bone homeostasis

  • Session TrackBiomaterials for tissue engineering
  • Session TitleTissue-specific Strategies for Soft Connective Tissue Regeneration
  • Session CodeSP-T04-0305
  • Date & Time / RoomMay 29 (Wed) 16:30~18:00 / Room 324-B
Organizer

Lauren Flynn (Western University, Canada)

Chair

Lauren Flynn (Western University, Canada)

Brian Amsden (Queen's University, Canada)

Keynote Speaker

16:30~16:55 : Learnings from COVID: Biomaterial Scaffolds for the Delivery of Gene Therapeutics for Enhanced Tissue Repair Fergal O'Brien (RCSI, Ireland)

Invited Speaker

16:55~17:10 : Chondroinductive and chondroprotective biomaterials for cartilage engineering Julie Liu (Purdue University, USA)

Oral Presenter

17:10~17:20 : In situ forming, mechanically resilient hydrogels for nucleus pulposus cell delivery Brian Amsden (Queen's University, Canada)

17:20~17:30 : Co-delivery of adipose-derived stromal cells and endothelial colony-forming cells in novel cell-assembled scaffolds as a pro-angiogenic cell therapy platform Lauren Flynn (Western University, Canada)

17:30~17:40 : Biomimetic proteoglycan-dexamethasone conjugate for rescue of cartilage degradation – a novel therapeutic Annika Bergstrom (Villanova University, USA)

17:40~17:50 : Using acoustic cell patterning to engineer vascularized human skin equivalents Dhananjay Deshmukh (ETH Zürich, Switzerland)

17:50~18:00 : Multi-functional hydrogels with bioinspired mechanical properties and biodegradability for vascularized skeletal muscle regeneration Huan Zhou (Hebei University of Technology, China)

Description

Injury to, and degeneration of, soft connective tissues, including cartilage, muscle, ligament, intervertebral disc, skin, and adipose tissue, represent significant and growing problems that can dramatically impact the quality of life of those afflicted. The treatment of these tissues is technically challenging as they have a low inherent healing capacity. The limited efficacy and high costs associated with current clinical therapies have motivated the investigation of a wide range of strategies integrating biomaterials to stimulate the in situ regeneration of these damaged tissues. Realization of the potential of this approach requires the rational design of tissue-specific platforms that possess the appropriate structural, biological, and biomechanical properties to help guide the response of seeded and/or infiltrating host cells to enable long-term functional tissue regeneration. While biomaterial scaffolds on their own may be sufficient for some applications, therapies integrating pro-regenerative cell populations may be necessary to augment or expedite regeneration, particularly in individuals whose capacity for healing may be restricted by age or pathological conditions. For example, the delivery of mesenchymal stromal cell (MSC) populations may be an effective strategy to modulate the host response to implanted biomaterials to establish an environment conducive for regeneration. This symposium will bring together experts in biomaterials and stem cell biology to highlight exciting recent advancements in the development and application of tissue-specific strategies to induce effective soft connective tissue regeneration, with a focus on the design and pre-clinical testing of innovative cell-instructive biomaterials towards future clinical translation.

Keywords : Soft connective tissue regeneration, cell-instructive biomaterials, tissue engineering.

  • Session TrackBiomaterials for tissue engineering
  • Session TitleBiomaterials for Women’s Reproductive Health
  • Session CodeSP-T04-0051
  • Date & Time / RoomMay 31 (Fri) 9:30~11:00 / Room 314
Organizer

Shelly Peyton (University of Massachusetts Amherst, USA)

Chair

Shelly Peyton (University of Massachusetts Amherst, USA)

Michelle Oyen (Washington University in St. Louis, USA)

Keynote Speaker

9:30~9:55 : Bridging the Gap: 3D High Throughput Screening Models for Gynecological Disease Kaitlin Fogg (Oregon State University, USA)

Invited Speaker

Tina Chowdhury (Queen Mary University of London, United Kingdom)

10:10~10:25 : Matrix glycation regulates neurodegeneration in the aged neurovascular-on-a-chip Minjeong Jang (Korea Institute of Radiological Medical Sciences, Korea, Republic of)

Oral Presenter

10:25~10:35 : Development of a bioabsorbable implant capable of regenerating adipose tissue for breast reconstruction Shuichi Ogino (Shiga University of Medical Science, Japan)

10:35~10:45 : Mimicking extracellular matrix based scaffolds as functional biomaterials for supporting surgical application in disease tissue removal Jirut Meesane (Prince of Songkla University, Thailand)

10:45~10:55 : Revolutionizing Bone-on-a-Chip: Novel approaches in three-dimensional tissue engineering through protein-based 3D scaffolds Christoph Naderer (University of Applied Sciences Upper Austria, Austria)

Description

Women's reproductive health is an important and understudied area of research. While there is a long history of engineers working with medical practitioners, particularly in the orthopaedic and cardiovascular fields, the field of biomedical engineering has a potential role to create solutions specific to women's health issues. This proposed Symposium aims to address these recent developments in women’s reproductive health, including normal physiology, pathology, and pregnancy.  This includes topics such as women's cancers like ovarian, cervical, and breast (predominantly), diseases that affect women at higher rates like osteoporosis, and hormone related disorders associated with puberty and menopause; and pregnancy, the uterus and placenta, post-pregnancy pelvic floor disorders, and breast feeding. The need for biomaterials approaches in this broad area will be discussed and special opportunities for collaborations presented. Research presented will include a variety of experimental and computational approaches, including biomechanics, tissue engineering, and imaging, to highlight the growth and continuing interest in this emerging field.  This perspective will encourage and inspire future researchers, while engaging current researchers to think about redirecting their skills to problems in women's reproductive health.

 

Keywords : breast cancer models, ovarian cancer models, tissue engineering in women's health

  • Session TrackBiomaterials for tissue engineering
  • Session TitleReproducing Reproductive Organs/Tissues via Tissue Engineering
  • Session CodeSP-T04-0316
  • Date & Time / RoomMay 27 (Mon) 16:30~18:00 / Room 324-B
Organizer

Min Wang (Department of Mechanical Engineering, The University of Hong Kong, Hong Kong SAR, China)

Chair

Min Wang (Department of Mechanical Engineering, The University of Hong Kong, Hong Kong SAR, China)

Bin Duan (University of Nebraska Medical Center, University of Nebraska, USA)

Keynote Speaker

16:30~16:55 : Tissue Engineering: Current Perspectives in the Reproductive Field James J. Yoo (Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, USA)

Invited Speaker

16:55~17:10 : Tissue engineering for difficult infertility cases Seung-Yup Ku (Seoul University, Korea, Republic of)

Oral Presenter

17:10~17:20 : Design and biosynthesis of recombinant humanized collagen toward application: strategies and practices Hai Lin (Sichuan University, China)

17:20~17:30 : Design of hydrogel scaffolds for stable and consistent in vitro complex human skin reconstruction Kun Liang (A*STAR Skin Research Labs, Singapore)

17:30~17:40 : Construction of multifunctional protein consisting of Elastin-like polypeptides for tissue engineering Mutawakil Al Muqadasi (Tokyo Institute of Technology, Japan)

17:40~17:50 : Culture systems matter: Comparing the longevity, regenerative capabilities, and secretome production of mesenchymal stem cells in different systems Jacob Hodge (Ronawk Inc., USA)

17:50~18:00 : Enhancing male infertility treatment through tissue-engineered sperm Production Rakesh Bhaskar (Yeungnam University, Korea, Republic of)

Description

Reproduction is one the most important functions of human bodies and giving birth to healthy babies by females is essential for modern society’s development. However, millions of women suffer from infertility, which deprive women in reproductive age of the rights and joy of having their own biological children. Around the world, about 14% of couples in reproductive age cannot conceive or carry a viable fetus to term due to infertility. A female’s internal reproductive organs are the vagina, uterus, fallopian tubes, and ovaries. The male reproductive system includes the penis, urethra, vas deferens, testes, etc.. Congenital anomaly, serious injury or cancer can cause reproductive organ failure for women and men. Restoring and maintaining the normal functions of reproductive organs such as vagina, uterus, ovaries and penis using the tissue engineering approach have been pursued worldwide. However, owing to their anatomical and functional complexities, reconstructing or regenerating reproductive organs/tissues presents unique challenges and hence the progress in this area has been slow in comparison with tissue engineering advances for skin, bone, cartilage, etc.. It is therefore important and necessary to review the progress, assess the status and look into the future of tissue engineering for reproductive organs/tissues at WBC2024, the world’s premier conference on biomaterials, which has the focus on the convergence in biomaterials that shapes the future of healthcare. This symposium will provide a forum for exchanges and interactions for people, both experienced workers and newcomers, involved in tissue engineering of reproductive organs/tissues. These people are biomaterials scientists and engineers, tissue engineers, biological scientists, clinicians and industrialists, and they will gather to discuss designs, materials (synthetic or natural, e.g., decellularized extracellular matrix), cells (e.g., stem cells), scaffolds, advanced biofabrication technologies (e.g., 3D bioprinting), assessments (in vitro and in vivo), clinical applications and future developments for reproducing/regenerating reproductive organs/tissues.

Keywords : reproductive, reproducing, tissue engineering

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WBC 2024 SECRETARIAT

Address
6F, 11-13, Hwarang-ro 8-gil, suseong-gu, Daegu, Republic of Korea (42038)
E-MAIL
(Congress)info.wbc2024@gmail.com
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PHONE+82-53-740-0424, 0405

FAX+82-53-742-9007

REGISTRATION NO.138-82-76927

REPRESENTATIVEKi Dong Park

THE KOREAN SOCIETY FOR BIOMATERIALS

Address
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REGISTRATION NO.209-82-61032

REPRESENTATIVEKun Na

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FAX+82-02-554-9978

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