Scientific Program

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  • Session TrackBiomaterials for theranostics
  • Session TitleEngineering of biomaterials for drug delivery
  • Session CodeSP-T03-0343
  • Date & Time / RoomMay 28 (Tue) 9:30~11:00 / Room 324-A
Organizer

Yoon Shin Park (Chungbuk National University, Korea, Republic of)

Chair

Yongzhuo Huang (Shanghai Institute of Materia Medica, China)

Jinhwan Kim (UC Davis, USA)

Keynote Speaker

9:30~9:55 : Engineering the nanomaterials for the image-guided drug delivery and controlled release Stanislav Emelianov (Georgia Tech, USA)

Invited Speaker

Allan E. David (Auburn University, USA)

10:10~10:25 : Targeting tumor metabolism using advanced drug delivery systems for treatment enhancement Yongzhuo Huang (Shanghai Institute of Materia Medica, China)

Aharon (Roni) Azagury (Ariel University, Israel)

10:40~10:55 : Natural-Based Liposomes for Versatile Drug Delivery Applications Dai Hai Nguyễn (Institute of Chemical Technology - Vietnam Academy of Science and Technology, Vietnam)

Description

The symposium session for Engineering of Biomaterials for Drug Delivery will bring together leading experts and researchers in the field to discuss the latest advancements in the engineering of biomaterials for drug delivery. The session will explore the design, synthesis, and characterization of advanced biomaterials for drug delivery applications, with a focus on their performance, safety, and efficiency.



The session will cover various topics, including the design of nanoscale and micron-scale biomaterials for drug delivery, the synthesis of biocompatible polymers and hydrogels for drug delivery, and the use of novel materials and fabrication techniques for the development of advanced drug delivery systems. Additionally, the session will focus on the engineering of new materials with unique properties that can be utilized for drug delivery, such as high stability, biocompatibility, and high drug-loading capacities.

The symposium will also provide an opportunity for attendees to learn about the current challenges in the field of engineering biomaterials for drug delivery, including the development of effective drug release profiles, the optimization of drug efficacy, and the safety and toxicity of biomaterials. In addition, attendees will have the opportunity to discuss exchange ideas with other researchers and experts in the field, and to learn about the latest innovations and developments in the field.



This symposium session is ideal for researchers, scientists, engineers, and medical professionals working in the fields of biomaterials, drug delivery, and pharmaceutical science. The session will provide a platform for attendees to learn about the latest advancements in the field, exchange ideas, and network with other professionals in the field.

Keywords : Nanomaterials, Smart materials, Drug delivery system

  • Session TrackBiomaterials for theranostics
  • Session TitleNanomedicine for Immunotherapeutics
  • Session CodeSP-T03-0351
  • Date & Time / RoomMay 27 (Mon) 14:40~16:10 / Room 324-A
Organizer

In-Kyu Park (Chonnam National University, Korea, Republic of)

Co-organizer

Won Jong Kim (Pohang University of Science and Technology (POSTECH), Korea, Republic of)

Chair

In-Kyu Park (Chonnam National University, Korea, Republic of)

Chien-Wen Jeff Chang (National Tsing Hua University, Chinese Taipei)

Keynote Speaker

14:40~15:05 : Control of Nitric Oxide for the Treatment of Inflammatory Disease Won Jong Kim (Pohang University of Science and Technology (POSTECH), Korea, Republic of)

Invited Speaker

15:05~15:20 : Nano-Sensor-Based Isolation and Characterization of Multidrug-Resistant Human Cancer Cells Chien-Wen Jeff Chang (National Tsing Hua University, Chinese Taipei)

15:20~15:35 : mRNA Vaccine Delivery using Polymeric Platforms for Global Health Equity Jooli Han (Massachusetts Institute of Technology (MIT), USA)

15:35~15:50 : Modification of antigenicity of cancer cells by conjugate consisting of hyaluronic acid and foreign antigen Shinichi Mochizuki (The University of Kitakyushu, Japan)

Oral Presenter

15:50~16:00 : Biomedical Application of Emerging NanoAlum Beyond Drug Delivery System Lingxiao Zhang (Aarhus University, Denmark)

16:00~16:10 : Immunomodulatory, highly respirable yeast beta-glucan microparticles prepared by pressurized gas expanded liquid (PGX) technology to treat idiopathic pulmonary fibrosis Nate Dowdall (McMaster University, Canada)

Description

Nanomedicine is an emerging technology in the healthcare division to treat verities of diseases. Engineered nanomedicines have been designed to interact with biological systems and fundamentally improve the current therapeutic procedures. Recently, immunotherapy has gained tremendous attention and the role of nanomedicine escalated the efficacy of immunotherapies. Delivery of immunomodulatory agents by using nanotechnology effectively targets the immune microenvironment to promote specific immune responses. Immunomodulation with nanomedicine has emerged as a promising approach for treating and preventing various diseases like cancer, inflammatory disease, infectious diseases, autoimmune diseases, and wound healing. Nanomedicine-based immunotherapies can overcome the limitation of conventional approaches, such as inadequate immune activation, nontarget delivery, and degradation of immunomodulatory agents during circulation. The role of nanomedicine in vaccine delivery has been approved clinically for the treatment and many of them are under clinical preclinical trials. Targeted delivery of nanovaccine stimulates the immune response and amplifies the therapeutic efficacy. In addition, the combination of immunotherapy with other therapeutic procedures by using nanomedicine is an emerging field that needs to be explored more.

Keywords : Nano-immunotherapies, nanovaccine, immunoengineering

  • Session TrackBiomaterials for theranostics
  • Session TitleFerroptosis-mediated cancer target therapy (Sponsored by Methods, an Elsevier's interdisciplinary journal in life and medical sciences)
  • Session CodeSP-T03-0100
  • Date & Time / RoomMay 29 (Wed) 16:30~18:00 / Room 324-A
Organizer

Su-Geun Yang (Inha University, Korea, Republic of)

Chair

Zheyu Shen (Southern Medical University, China)

Su-Geun Yang (Inha University, Korea, Republic of)

Keynote Speaker

16:30~16:55 : Magnetic Resonance Imaging Contrast Agents and Their Applications for Tumor Ferroptosis Therapy Zheyu Shen (Southern Medical University, China)

Invited Speaker

16:55~17:10 : Photocatalytic nanoparticles for combination therapy of KRAS mutant colorectal cancer via controlled enzymatic pathway of ferroptosis Su-Geun Yang (Inha University, Korea, Republic of)

17:10~17:25 : DNA/Drug nanocomplexes for efficient and safe cancer therapy: Facile, efficient, scalable, and safe for clinical translation Young Jik Kwon (University of California, Irvine, USA)

Oral Presenter

17:25~17:35 : Iron-Based Nanomaterials for Tumor Theranostics: Applications and Challenge Yanglong Hou (Sun Yat-Sen University, China)

17:35~17:45 : pH-sensitive Single-Atom Catalyst with Natural Immunoadjuvant for Precising Catalytic Therapy and Amplifying Immunity of Ferroptosi Hung-Wei Cheng (National Yang Ming Chiao Tung University, Chinese Taipei)

17:45~17:55 : Targeted sonodynamic therapy mediated by ultrasound-controlled release platelets induces cancer cell ferroptosis and macrophage repolarization in glioblastom Xiao Chen (Wuhan University, CHINA, China)

Description

1) Objectives or purposes

Ferroptosis is a new type of cell death that was discovered in recent years and is usually accompanied by a large amount of iron accumulation and lipid peroxidation during the cell death process; the occurrence of ferroptosis is iron-dependent. Ferroptosis-inducing factors can directly or indirectly affect glutathione peroxidase through different pathways, resulting in a decrease in antioxidant capacity and accumulation of lipid reactive oxygen species (ROS) in cells, ultimately leading to oxidative cell death. This symposia presents the latest progress in ferroptosis research.



2) Proposed program and intended audience

- Now two scientists agreed to attend the WBC2024  and  present a talk about ferroptosis and related science.  

- And other presenting scientists will be filed very soon. 



3) Expected outcomes and relevance to the main topic of WBC 2024

Ferroptosis is now really growing science in area of cancer-therapeutic nanomaterials.  A total of 1,285 publications on ferroptosis research were identified. The literature on ferroptosis had been continuously growing since 2012, and the expansion might continue at a rapid pace in the following years. China contributed the greatest proportion (43.74%) of ferroptosis publications, and the United States ranked first in the number of citation frequency (20,980 times) and H-index (70).



So handing this topic in WBC 2024 will get great interests from scientists in this area.

Keywords : Ferroptosis; Targeted cancer therapy; Nanoparticles

  • Session TrackBiomaterials for theranostics
  • Session TitleStimuli-Responsive Macromolecular Assembly for Theranostics
  • Session CodeSP-T03-0101
  • Date & Time / RoomMay 31 (Fri) 11:20~12:50 / Room 324-A
Organizer

Beom Jin Kim (University of Ulsan, Korea, Republic of)

Chair

Beom Jin Kim (University of Ulsan, Korea, Republic of)

Ja-Hyoung Ryu (UNIST, Korea, Republic of)

Keynote Speaker

11:20~11:50 : Enzyme-Instructed Intracellular Peptide Assemblies Bing Xu (Brandeis University, USA)

Invited Speaker

11:50~12:05 : Selective death of cancer cells induced by the self-assembly of a peptide amphiphile that is responsive to an overexpressed kinase Tatsuo Maruyama (Kobe University, Japan)

12:05~12:20 : New strategies based on self-assembly for Theranostics Gaolin Liang (Southeast University, China)

12:20~12:35 : Enzyme assisted peptide folding and self-assembly Zhimou Yang (Nankai University, China)

12:35~12:50 : Proton-Catalyzed Self-Assembly to Control Intracellular Assemblies Formation of Peptide Huaimin Wang (Westlake University, China)

Description

Macromolecular self-assembly is ubiquitous in living system, leading to the formation of innumerable biological complexes. Since each of biological complexes formed plays the key role in a living system according to ever-changing cellular environment, living cells adopt cellular signaling mechanism to spatiotemporally control the self-assembly or disassembly process. Inspiring by cellular signaling, the research is recently progressed to artificially induce the macromolecular self-assembly or disassembly by using the stimuli (like cellular signals) within living cells. Based on the in-depth understand of stimuli-responsive assembly, tremendous efforts have been focused on development of the advanced strategy for spatiotemporally controlled macromolecular assemblies. More importantly, the macromolecular assemblies formed via stimuli provided the cellular selectivity according to the specific environment in which the cells are exposed, promising the potential applications to theranostics. However, there is still room for improvement for the stimuli-responsive macromolecular assemblies for theranostics, which would require the synergistic convergence of biomaterials science, biomedical engineering, biochemistry, and other disciplines. In this symposium, current topics and new directions of stimuli-responsive macromolecular assemblies for theranostics, including novel synthetic design, multi-functional biomaterials for theranostics, as well as peptide assembly/disassembly in a specific cellular milieu, will be presented and discussed. Since the fields as well as the presenters’ geography are diverse, we anticipate that this symposium will provide a great opportunity for inter-national and inter-continental networks and possible generation of new research ideas and perhaps even research fields.

Keywords : Stimuli-responsive self-assembly, Theranostics, Macromolecular biomaterials

  • Session TrackBiomaterials for theranostics
  • Session TitleBiomaterials for theranostics
  • Session CodeSP-T03-0133
  • Date & Time / RoomMay 30 (Thu) 13:40~15:10 / Room 324-A
Organizer

Sei Kwang Hahn (POSTECH, Korea, Republic of)

Chair

Guosong Hong (Stanford University, USA)

Hyunjoo Jenny Lee (KAIST, Korea, Republic of)

Keynote Speaker

13:40~14:05 : Smart Wearable Materials and Devices for Theranostic Healthcare Applications Sei Kwang Hahn (POSTECH, Korea, Republic of)

Invited Speaker

Guosong Hong (Stanford University, USA)

14:20~14:35 : Ultrasound-Mediated Neuromodulation Hyunjoo Jenny Lee (KAIST, Korea, Republic of)

14:35~14:50 : Atomically precise molecular materials of noble metal for Real-Time Monitoring and Therapeutic Management of Alzheimer's Diseas Jayasree R S (Sree Chitra Tirunal Institute for Medicla Sciences and Technology, India)

Oral Presenter

14:50~15:00 : Biomimetic targeting nanoplatform for atherosclerosis theranostics via photoacoustic diagnosis and “hand-in-hand” immunoregulation Boxuan Ma (Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, China)

15:00~15:10 : Glycogen nanoparticles as next generation biomaterials in nanomedicine Quinn Besford (Leibniz Institute for Polymer Research, Germany)

Description

With the remarkable progress in convergence technology, biomaterials with various biological, optical and mechanical functionalities offer promising approaches to diagnostic, therapeutic, and theranostic applications. Recently, there have been a rapid expansion of new ideas on healthcare devices including wearable devices, nanomotors, and photonic and ultrasound-mediated nanomedicines. This innovation is enabled by the development of multifunctional biomaterials. Among various wearable devices, smart contact lenses are especially noticeable for healthcare applications, because they can be used as an excellent interface between the human body and electronic devices. In addition, multi-functional biomaterials have enabled the development of micro and nanomotors for active healthcare applications. Furthermore, biophotonic and ultrasound-mediated photonic materials have attracted great attention for theranostic applications. The theranostic applications are based on fluorescence imaging, plasmon resonance sensing and imaging, photoacoustic imaging, photothermal therapy, photodynamic therapy, and optogenetic therapy. Reasonable endeavors have begun to translate some of promising wearable healthcare devices, nanomotors, and photo and sonomedicines to the clinics. In this symposium, the co-chairs of Prof. Samuel Sánchez at Institute for Bioengineering of Catalonia, Spain and Prof. Guosong Hong at Stanford University will host a keynote speaker, Prof. Sei Kwang Hahn at POSTECH. This proposed program is intended to attract diverse audiences in the fields of biomaterials for theranostic applications based on biosensing, bioimaging and drug delivery. Prof. Hahn will give a keynote talk on biomaterials for theranostic wearable devices, Prof. Sánchez will give an invited talk on healthcare nanomotors, and Prof. Hong will give an invited talk on photonic and ultrasound-mediated nanomedicines for theranostic applications. These talks are well matched with the main topic of biomaterials for theranostics in WBC2024. With the previous organizing experiences in several academic symposiums including WBC2020, we will present and discuss the current state-of-the-art research and clinical feasibility of emerging biomaterials for various theranostic applications.

Keywords : Wearable device, Nanomotor, Nanomedicine

  • Session TrackBiomaterials for theranostics
  • Session TitleBiomaterials for Drug Delivery and Tissue Regeneration
  • Session CodeSP-T03-0138
  • Date & Time / RoomMay 30 (Thu) 9:30~11:00 / Room 324-A
Organizer

Yunching Chen (National Tsing Hua University, Chinese Taipei)

Chair

Yunching Chen (National Tsing Hua University, Chinese Taipei)

Che-Ming Jack Hu (Academia Sinica, Chinese Taipei)

Keynote Speaker

Samir Mitragotri (Harvard University, USA)

Invited Speaker

Shyh-Dar Li (University of British Columbia, Canada)

10:10~10:25 : Wireless charging-mediated angiogenesis and nerve repairby adaptable microporous hydrogels Shang-Hsiu Hu (National Tsing Hua University, Chinese Taipei)

10:25~10:40 : Organ and cell selective delivery using synthetic lipid nanoparticle for mRNA delivery Qiaobing Xu (Tufts University, USA)

10:40~10:50 : Pseudovirus-like particles for RNA self-packaging and delivery Yu-Chen Hu (National Tsing Hua University, Chinese Taipei)

Description

Biomaterials have been explored to fabricate drug delivery systems or tissue regeneration platforms. Many researchers have attempted to develop more effective biomaterials used in drug delivery and tissue regeneration to improve the treatment efficiency and to reduce the risk of side effects. Various biomaterials such as naturally occurring or synthetic lipids, biodegradable stimuli-responsive polymers, conductive hydrogels can be designed for targeted delivery and controlled release of therapeutic cargoes and other biologically active agents in the disease sites for more promising efficacy and acceptable safety. The symposium discusses various novel biomaterials in drug delivery and tissue regeneration including lipid nanoparticle technologies, polymer technologies, adaptable conductive hydrogels for their applications on child-friendly oral formulation, cancer immunotherapy, chronic hepatitis B and traumatic brain injury, etc.



1) Objectives or purposes

To provide various applications of biomaterials in drug delivery and tissue regeneration including lipid nanoparticle technologies, polymer technologies, adaptable conductive hydrogels for treatment of cancer, chronic hepatitis B and traumatic brain injury, etc and discuss challenges and future directions for clinical applications of biomaterials in drug delivery and tissue regeneration.



2) Proposed program and intended audience

intended audience: research scientists, clinicians, pharmaceutical industry specialists, post-graduate students, graduate students



3) Expected outcomes and relevance to the main topic of WBC 2024

closely and highly related to the main theme of WBC2024 - Convergence in Biomaterials: a vision for the future of healthcare

Keywords : Lipid nanoparticle, cancer immunotherapy, Polymeric Backpacks

  • Session TrackBiomaterials for theranostics
  • Session TitleBiomaterials for Image-guided Therapy
  • Session CodeSP-T03-0153
  • Date & Time / RoomMay 29 (Wed) 13:40~15:10 / Room 324-A
Organizer

Wooram Park (Sungkyunkwan University, Korea, Republic of)

Chair

Wooram Park (Sungkyunkwan University, Korea, Republic of)

Chun Gwon Park (Sungkyunkwan University, Korea, Republic of)

Keynote Speaker

13:40~14:05 : Theranostic carriers for image guided nano-immuno cancer therapy Dong-Hyun Kim (Northwestern University, USA)

14:05~14:30 : Dynamic Nano-Assemblies for Biological Sensing, Imaging and Regulation Daishun Ling (Shanghai Jiao Tong University, China)

Invited Speaker

14:30~14:45 : Ion-responsive Nano-probe Fang Yuan Li (Zhejiang University, China)

14:45~15:00 : In situ Cancer Immunization Utilizing a Synergistic Approach of Irreversible Electroporation and Immunostimulatory Nanoparticles

Wooram Park (Sungkyunkwan University, Korea, Republic of)

Description

Through the convergence of new functional biomaterial-based nanoparticles and bioimaging technology, image-guided therapy for targeting and treating a disease location has rapidly evolved in recent years. This session will focus on the most recent research trends and prospects in image-guided therapy with functional nanoparticles. This session will be of broad interest to researchers working in biomaterials, nanoparticles, and biomedical imaging. Specifically, the theme of functional nanomaterials with imaging and therapeutic applications is perfectly compatible with the main topic of WBC2024.

Keywords : Image-guided therapy, Nanoparticle, Bioimaging

  • Session TrackBiomaterials for theranostics
  • Session TitleBiomaterials for Biomedical Imaging: Applications and Challenges
  • Session CodeSP-T03-0173
  • Date & Time / RoomMay 29 (Wed) 9:30~11:00 / Room 324-A
Organizer

Hua Ai (West China Hospital, Sichuan University, China)

Chair

Yanglong Hou (College of Engineering, Peking University, China)

Brent Weinberg (Emory University School of Medicine, USA)

Keynote Speaker

Ning Gu (Southeast University, China)

Invited Speaker

9:55~10:10 : Ultrasound Contrast Nanoparticles and Their Diagnosis and Treatment in Chronic Diseases Aiguo Wu (Ningbo Institute of Materials Technology & Engineering, Chinese Academy of Sciences, China)

10:10~10:25 : Strategies to Promote Cancer Nanomedicine Clinical Translation Twan Lammers (RWTH Aachen University Clinic, Germany)

10:25~10:40 : Challenges and opportunities in MRI contrast agents Brent Weinberg (Emory University School of Medicine, USA)

10:40~10:55 : MRI nanoprobes: design considerations and biological responses Hua Ai (West China Hospital, Sichuan University, China)

Description

Biomedical imaging has shown promising applications in disease early diagnosis, therapeutic efficacy evaluation and pathological pathway discovery. Sensitive and specific imaging probes are key factors deciding the outcomes of imaging quality and accuracy. This symposium will showcase the most recent advances in imaging probes, with emphasis on the unique materials' properties and nanofabrication for intended biomedical applications. Topics of interest include, but are not limited to imaging probes, imaging methods, multimodality imaging and cell/drug/gene delivery using biomaterials. The applications of such probes may include but not limited to: early diagnosis, cell therapy monitoring, drug delivery evaluation, understanding of certain pathology, etc. The symposium will also discuss challenges of imaging probes during their applications, especially for in vivo studies and clinical translations. Researchers from both basic science research and clinical practice are encouraged to submit their work to this topic. We have organized symposia with similar topics during the last three World Biomaterials Congress meetings.

Keywords : biomaterials; biomedical imaging; imaging probes

  • Session TrackBiomaterials for theranostics
  • Session TitleExtracellular vesicles-based nanomedicine for theranostics
  • Session CodeSP-T03-0358
  • Date & Time / RoomMay 27 (Mon) 13:00~14:30 / Room 324-A
Organizer

Kyung Min Park (Incheon National University, Korea, Republic of)

Chair

Michael Davis (Emory University, USA)

Han Young Kim (The Catholic University of Korea, Korea, Republic of)

Keynote Speaker

Michael Davis (Emory University, USA)

Invited Speaker

13:25~13:40 : Versatility of Exosomes for Cancer Therapy Donovan (Dong In) Kim (University of Oklahoma, USA)

Han Young Kim (The Catholic University of Korea, Korea, Republic of)

13:55~14:10 : Cellular function recovery through rejuvenation effect of exosome-mimicking nanovesicles extracted from stem cells Suk Ho Bhang (School of Chemical Engineering / Sungkyunkwan University, Korea, Republic of)

Oral Presenter

14:10~14:20 : Exploring exosome potential for bone healing with ceramic scaffolds Ekaterina Maevskaia (University of Zurich, Switzerland)

Description

Biomaterials have attracted substantial attention for a broad range of nanomedicine applications, including clinical diagnostics and therapeutics, due to their tunable properties and biocompatibility. Recently, theranostic (combined therapy and diagnostic) biomaterials have been widely utilized to provide monitoring and treatment capabilities and advance the field toward personalized technologies. Among these theranostic biomaterials, extracellular vesicles (EVs), such as exosomes, show promising potential in translational medicine and provide new avenues for creating effective clinical diagnostics and therapeutic strategies.

The EVs are common membrane-bound nanovesicles that contain diverse biomolecules, such as lipids, proteins, and nucleic acids. These cell-derived biomaterials have a natural ability to carry functional biomolecules, such as small RNAs, DNAs, and proteins, in their lumen structure. This unique property makes them attractive for drug delivery and molecular diagnosis. Moreover, EVs can be utilized for high-precision imaging. Based on their unique properties, EVs have recently been harnessed as theranostics for advanced personalized medicine.

This session will focus on emerging trends in cell-derived nanovesicles as theranostic biomaterials for nanomedicine applications. Specifically, the session will cover topics ranging from designing EVs, their characterizations and purification, disease treatments and monitoring, etc. Cutting-edge extracellular vesicle-based nanomedicine for theranostics will be included.

Keywords : Extracellular vesicles, nanomedicine, theranostics

  • Session TrackBiomaterials for theranostics
  • Session TitleBiomaterial-assisted gene therapy to treat musculoskeletal disorders
  • Session CodeSP-T03-0353
  • Date & Time / RoomMay 28 (Tue) 13:40~15:10 / Room 324-A
Organizer

Nicholas Dunne (Dublin City University, Ireland)

Chair

Nicholas Dunne (Dublin City University, Ireland)

Ahmed Elkashif (Queen's University Belfast, United Kingdom)

Keynote Speaker

13:40~14:05 : Peptide-microRNA nanoparticles delivered via a thermoresponsive hydrogel for enhanced bone regeneration Helen McCarthy (Queen's University Belfast, United Kingdom)

Invited Speaker

14:05~14:20 : Nanoparticle-mediated non-viral gene editing for in utero treatment of Duchenne muscular dystrophy Aijun Wang (University of California, Davis, USA)

Oral Presenter

14:20~14:30 : Delivery of microRNA loaded nanoparticles via a 3D printed PEG-chitosan-PCL wound dressing Ahmed Elkashif (Queen's University Belfast, United Kingdom)

14:30~14:40 : Urinary Extracellular Vesicles as Therapy in Genetic Kidney Disease Eunji Chung (University of Southern California, USA)

14:40~14:50 : Plasmid DNA Mono-Ion Complexes with Mono-cationic PEGs for Muscular Gene Delivery Shoichiro Asayama (Tokyo Metropolitan University, Japan)

14:50~15:00 : Targeting ROS-induced osteoblast senescence and RANKL production by Prussian blue nanozyme based gene editing platform to reverse osteoporosis Huihui Wang (Yangzhou University, China)

15:00~15:10 : Bone-targeted nanoparticle-mediated osteoimmunomodulation for enhanced fracture healing Danielle Benoit (University of Oregon, USA)

Description

Although there are a plethora of clinical options currently available to treat disorders of the musculoskeletal system for millions of patients globally; to date there are no options capable of consistently repairing and regenerating sites of tissue damage in terms of their native structure and mechanical functionality.



Gene therapy is a highly disruptive technology that can enable the sustained delivery and production of therapeutic candidate gene sequences in musculoskeletal injuries over a relatively long period compared to the application of recombinant gene products displaying relatively short pharmacological half-lives. A recent technological development is to augment human musculoskeletal gene therapy approaches in vivo by providing gene-based treatments via biomaterial-assisted procedures. Biomaterial-assisted gene therapy is an example of such a procedure, which is based on the delivery of gene carriers using biocompatible, integrative, biodegradable, and mimicking materials used in tissue engineering approaches as a platform to support biological cues and provide the endogenous reparative processes in damaged musculoskeletal tissues by offering a cell-supporting scaffold in injury sites. Such technologies may offer off-the-shelf compounds that support non-invasive, patient-independent direct treatments in clinical settings compared with a more complicated, less expedient administration of genetically modified cells that requires repeated patient management.



The proposed symposium is currently a hot research topic within the Biomaterials community that will attract significant interest from researchers, industry and clinicians working in the areas gene therapy, nanomedicine, biomaterials science, biomedical engineering and clinical translation. Within this symposium, we will focus on showcasing research that unwraps the principles of biomaterial-assisted gene therapy and providing a snapshot of the global research directed towards the opportunities and challenges associated with its translational application for the musculoskeletal disorder treatment in relevant models in vivo.

Keywords : Musculoskeletal diseases, Nanomedicine, Gene therapy

  • Session TrackBiomaterials for theranostics
  • Session TitlePlatform technology for theranostics
  • Session CodeSP-T03-0344
  • Date & Time / RoomMay 27 (Mon) 16:30~18:00 / Room 324-A
Organizer

Yong Kyu Lee (KNUT, Korea, Republic of)

Chair

Youngwook Won (University of North Texas, USA)

Hwan Kim (KNUT, Korea, Republic of)

Keynote Speaker

16:30~16:55 : Protein-based cell engineering for targeted cancer therapy Youngwook Won (University of North Texas, USA)

Invited Speaker

16:55~17:10 : A theranostic approach to high tissue parenchymal accumulation of nanoparticles Jayoung Kim (University of North Texas Health Science Center, USA)

Md. Nurunnabi (School of Pharmacy at the University of Texas at El Paso, USA)

17:25~17:40 : Theranostic Applications of Polymersomes with Dual Agent Loading in Computed Tomography and Magnetic Resonance Imaging Jessica Larsen (Clemson University, USA)

17:40~17:55 : Nano-adaptor for Antibody Delivery Jun Wang (South University of Science and Technology, China)

Description

The symposium on biocompatible biomaterials combined with therapeutic agents containing theranostics ions are welcome. The symposium on synthesizing methods of theranostics biomaterials with different methods, including (I) dry methods (solid-state and mechanochemical routes); (II) wet methods (chemical precipitation, hydrolysis, sol-gel, hydrothermal, emulsion, and sonochemical routes); (III) high-temperature processes (combustion, pyrolysis methods); (IV) approaches based on biogenic sources (biogenic wastes); and (V) combination procedures are welcome. The application of these biomaterials for cancer therapy, including drug delivery, photothermal/photodynamic therapy, imaging, etc.The present symposium topic aims to provide an invaluable collection of contributions and a platform for a scientific discussion focused on the role of different types of biocompatible biomaterials.

Keywords : therapeutic agents, theranostics biomaterials, platform

  • Session TrackBiomaterials for theranostics
  • Session TitleSelf-assembled and stimuli responsive nanobiomaterials for delivery and targeting of biological drugs
  • Session CodeSP-T03-0109
  • Date & Time / RoomMay 31 (Fri) 9:30~11:00 / Room 324-A
Organizer

Alejandro Sosnik (Technion Israel Institute of Technology Technion Research and Development Foundation Ltd, Israel)

Chair

HyunJin Kim (Inha University, Korea, Republic of)

Keynote Speaker

9:30~9:55 : Self-assembling nanobiomaterials for the safe and efficient delivery of complex nucleic acid payloads: heteroatomic tuning and supramolecular insights Omar F. Khan (University of Toronto, Canada)

Invited Speaker

9:55~10:10 : Overcoming the barrier - Topical gene therapy of skin and lung Sarah Hedtrich (Berlin Institute of Health - Charite, Germany)

Oral Presenter

10:10~10:20 : H2O2-activatable and self-immolative prodrug nanoassemblies as novel nanomedicine with cooperative therapeutic actions Dongwon Lee (Jeonbuk National University, Korea, Republic of)

10:20~10:30 : Stimuli-responsive polymersomes-enabled activatable therapeutic nanoreactors for tumor-specific cancer therapy Junjie Li (Kyushu University, Japan)

10:30~10:40 : PEGylated Carbon Nanohorn-Based Nanocarrier for Targeted Delivery to Enhance Phototherapy Efficacy in Cancer Treatment Fitriani Jati Rahmania (National Taiwan University of Science and Technology, Chinese Taipei)

10:40~10:50 : Mimicking amelogenesis to remineralize enamel through co-assembly of PTL fibrils and CMC/ACP Yangyang Ye (Tianjin Medical University, China)

Description

Objectives: Self-assembled polymeric nanoparticles represent one of the most promising nanotechnology platforms for the encapsulation, delivery, and targeting of small-molecule drugs (e.g., chemotherapy) and biologics (e.g., silencing RNA). Their promise stems from the great versatility and modularity to tailor features such as size, shape, spatial organization, and the encapsulated cargo's nature. The emergence of the COVID-19 pandemic paved the way for the clinical research of messenger RNA vaccines and opened new horizons in therapeutics. At the same time, the timeous and spatial delivery required to achieve efficacy relies on their integration with advanced delivery technologies. This symposium will gather experts in the field of self-assembled and stimuli-responsive nanomaterials for the delivery of biological drugs, including nucleic acids and proteins, and serve as a forum for the discussion of the most recent advances in the field with a focus on the delivery of nucleic acids and proteins and with a fully translational vision and the major challenges faced in the future to realize these strategies in the clinic.

Proposed program: The program will include a keynote lecture by Prof. Omar F. Khan, an expert in nucleic acid therapeutics, one invited lecture by Prof. Sarah Hedtrich who is an expert in gene/protein delivery to the skin, and 3 oral presentations that will be selected among the submitted abstracts. The audience of this symposium is broad and includes researchers in fields such as polymers, nanotechnology, colloidal sciences, gene and protein delivery, cancer, and immune system diseases.  

Expected outcomes and relevance to the main topic of WBC 2024: The meeting motto is "Convergence in Biomaterials: a vision for the future of healthcare". The proposed topic is in line with this motto as it requires the convergence of disciplines to design the optimal delivery platform that maximizes the efficacy of these advanced biological therapies.  

Keywords : Self-assembled nanoparticles; nucleic acid delivery; vaccines

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WBC 2024 SECRETARIAT

Address
6F, 11-13, Hwarang-ro 8-gil, suseong-gu, Daegu, Republic of Korea (42038)
E-MAIL
(Congress)info.wbc2024@gmail.com
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PHONE+82-53-740-0424, 0405

FAX+82-53-742-9007

REGISTRATION NO.138-82-76927

REPRESENTATIVEKi Dong Park

THE KOREAN SOCIETY FOR BIOMATERIALS

Address
502, 22, Teheran-ro 7-gil, Gangnam-gu, Seoul, Republic of Korea (06130)

REGISTRATION NO.209-82-61032

REPRESENTATIVEKun Na

PHONE+82-02-554-9977

FAX+82-02-554-9978

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