Scientific Program

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  • Session TrackBiomaterials for pre-clinical and clinical translation
  • Session TitleTranslation of bioactive ceramics from bench to bedside and emerging technologies for patient specific approaches
  • Session CodeSP-T08-0259
  • Date & Time / RoomMay 29 (Wed) 13:40~15:10 / Room 320-A
Organizer

Christine Knabe (Philipps University Marburg, Germany)

Chair

Ahmed El-Ghannam (University of North Carolina at Charlotte, USA)

Min Wang (Department of Mechanical Engineering, The University of Hong Kong, Hong Kong SAR, China)

Keynote Speaker

13:40~14:05 : Bioactive calcium alkali phosphate bone grafts enhance osteogenesis and facilitate bone repair in vivo – Translational research in oral implantology Christine Knabe (Philipps University Marburg, Germany)

Oral Presenter

14:05~14:15 : Long term stability and functionality of regenerated bone induced by SCPC resorbable bioactive graft Ahmed El-Ghannam (University of North Carolina at Charlotte, USA)

14:15~14:25 : In vivo analysis of Porous Bioactive Silicon Carbide Scaffold for Craniofacial Bone Augmentation RANDA ALFOTAWI (King Saud University, Saudi Arabia)

14:25~14:35 : Nanoscale 3D Printing of Bioceramics Iman Roohani (University of Sydney, Australia)

14:35~14:45 : Effect of interfacial energy on the mechanical properties of ZrO2-SiO2 glass-ceramics Huasi Zhou (Uppsala University, Sweden)

Description

Translation of bioactive ceramics from bench to bedside and emerging technologies for patient specific approaches



Session Scope: Over the last three decades, considerable progress has been made with regards to exploring the fundamental molecular and cellular events at the bone bioactive ceramic interface, which underlie the stimulatory effect of these materials on cell function and bone tissue formation, and with utilizing the knowledge gained to take bioactive ceramic bone grafting materials to the clinical arena in an evidence-based fashion. This has resulted in considerable contributions to improving patient care. It furthermore has prompted emerging patient-specific tissue engineering strategies, soft tissue augmentation approaches, concepts for continuous drug release, enhancement of angiogenesis etc. and has led to an array of approved products. Moreover, due to the inherent bioactive properties of these biomaterials achieving regulatory approval is less demanding than with biomaterials/devices which contain biologics such as growth factors, peptides and others.



The objective of this interdisciplinary symposium is to highlight how the fundamental research that helped to decipher the molecular events that underlie the stimulatory effect of bioactive ceramics on bone tissue formation and how recent advanced in additive manufacturing technologies and drug  release concepts led to translation of these materials to the clinic and contributed to the design of patient specific therapeutic concepts.



The program will highlight the evidence-based translation of different bioactive ceramics for various clinical applications. The intended audience will be material scientists, bioengineers, orthopedic surgeons and oral and maxillofacial surgeons.



The expected outcome is to heighten the awareness regarding the impact of this important class of biomaterials on health care in a globally ageing population and to foster interdisciplinary research worldwide.

Keywords : bioactive ceramics, bone regeneration, tissue engineering

  • Session TrackBiomaterials for pre-clinical and clinical translation
  • Session TitleBiomaterials Interventions in Aging Around the World
  • Session CodeSP-T08-0264
  • Date & Time / RoomMay 27 (Mon) 16:30~18:00 / Room 320-A
Organizer

Liisa Kuhn (University of Connecticut Health Center, USA)

Chair

Liisa Kuhn (University of Connecticut Health Center, USA)

Keynote Speaker

16:30~16:55 : Biomaterial interventions in aging of the musculoskeletal system Stuart Goodman (Stanford University, USA)

Invited Speaker

16:55~17:10 : From 3D bioengineered Models to Therapeutic Solutions: Senescence in Musculoskeletal Disease Okhee Jeon (Korea University, Korea, Republic of)

Oral Presenter

17:10~17:20 : Local delivery of ruxolitinib modulates aged macrophage phenotype transitions and promotes aged bone healing Liisa Kuhn (University of Connecticut Health Center, USA)

17:20~17:30 : Microvesicles-hydrogel breaks the cycle of cellular senescence by improving mitochondrial function Senrui Liu (The first affiliation of Chongqing medical university, China)

17:30~17:40 : Optimization towards the tipping point of senescence induction: a method for a passageable, induced-senescent osteoprogenitor cell line for biomaterials research Travis Wallace (University of Connecticut Health Center (UConn Health), USA)

17:40~17:50 : Cell-Free Osteoarthritis Treatment with Sustained-Release of Chondrocyte-Targeting Exosomes from Umbilical Cord-Derived Mesenchymal Stem Cells to rejuvenate ageing chondrocytes Hongfu Cao (Sichuan university, China)

Description

Introductory abstract of a maximum of 300 words that addresses the symposium’s

1) objectives or purposes;

2) Proposed program and intended audience

3) expected outcomes and relevance to the main topic of WBC 2024.



Recent research has identified anti-aging strategies that extend a healthy life span. This international symposium will feature biomaterials research from around the world that is focused on overcoming age-related diseases.The resolution of overactive inflammatory processes is one key strategy to overcome inflammaging related aging. Nanosystems that promote neuroprotection and neuroregeneration to address nervous system problems in older patients is an approach that will be featured. Eliminating or modifying the accumulation of senescent cells in the elderly is another new strategy that will be discussed.   Drug delivery, tissue engineering or immune modulation approaches with applications to the nervous system, or musculoskeletal or inflammatory diseases are sought. These include neural targeted nanoparticles, bioactive hydrogels, and aged neural tissue testing platforms as well as localized delivery of anti-aging drugs evaluated in aging animal models that down-regulate inflammaging.  This symposium has a goal of accelerating international scientific exchange and stimulating international collaboration in the area of aging which connects many preclinical research areas. In this symposium participants will have the opportunity to acquire knowledge about biomaterials with the most promise to address aging-related health concerns. 

 

Keywords : aging, inflammation, senescence

  • Session TrackBiomaterials for pre-clinical and clinical translation
  • Session TitleClinical and Pre-clinical Application of Biomaterials toward Next-Generation Medicine
  • Session CodeSP-T08-0053
  • Date & Time / RoomMay 31 (Fri) 9:30~11:00 / Room 315
Organizer

Atsushi Mahara (Department of Biomedical Engineering, National Cerebral and Cardiovascular Center Research Institute, Japan)

Chair

Atsushi Mahara (Department of Biomedical Engineering, National Cerebral and Cardiovascular Center Research Institute, Japan)

Yuji Teramura (Cellular and Molecular Biotechnology Research Institute (CMB), National Institute of Advanced Industrial Science and Technology, Japan)

Keynote Speaker

9:30~9:55 : Enhancing kidney transplantation: Addressing ischemia-reperfusion injury through ex vivo cell surface engineering with a novel amphiphilic polymer Alireza Biglarnia (Lund University, Sweden)

Invited Speaker

9:55~10:10 : Development of a high-hydrostatic pressure device for nevus tissue inactivation and dermal regeneration for the treatment of giant melanocytic nevus Naoki Morimoto (Department of Plastic and Reconstructive Surgery, Graduate School of Medicine and Faculty of Medicine, Kyoto University, Japan)

10:10~10:25 : Cell surface engineerinf for transplantation therapy Yuji Teramura (Cellular and Molecular Biotechnology Research Institute (CMB), National Institute of Advanced Industrial Science and Technology, Japan)

Oral Presenter

10:25~10:35 : Hydrogel-delivery of stem cell-derived neurons to repair the injured adult cervical spine Vanessa Doulames (Stanford University, USA)

10:35~10:45 : Pre-clinical evaluation of a new class III biodegradable stent for the treatment of urethral stricture Yurena Polo Arroyabe (Polimerbio SL, Spain)

10:45~10:55 : Development and clinical application of biodegradable silk protein bone screw Yafei Feng (Xijing Hospital, China)

Description

In this session, we will focus on pre-clinical and clinical research mainly and invite worldwide top-level clinical surgeons and basic scientists to discuss the requirements and possibilities of biomaterials for next-generation medicine. In accordance with the WBC's symposia policy, we have invited Prof. Bo Nilsson from Uppsala University, Sweden as a keynote lecturer, Prof. Sarah Heilshorn, from Stanford University, USA, and Prof. Naoki Morimoto, from Kyoto University, Japan as an invited speaker for our symposium proposal who are extremely diverse in terms of gender, geographic location, and clinical and research expertise. This session will be very attractive to all audiences not only academic researchers but also students and industrial and clinical researchers.

[Detail description] Although clinical transplantation of cells, organs, and decellularized tissues has been successful, the availability is still quite limited due to the poor biocompatibility with the host’s immune systems. Therefore, we have worked on the improvement of graft survival with help of biomaterials. To address this issue, we have developed various microencapsulation techniques using biomaterials, and some of them made it possible to improve graft survival. This approach is in the middle of clinical trials, but there are promising clinical outcomes. In addition, biomaterials have been used for the transplantation of organs and decellularized tissues, and some of them are studied in preclinical and clinical trials. By the use of biomaterials, the blood compatibility and vascularization of the graft have been improved. This innovation also opened-up the use of xenograft for human recipients. We would like to invite world-leading researchers working on these issues to discuss the current situation and new prospects for next-generation medicine.

Keywords : Transplantation, Clinical trials, Proof of concept

  • Session TrackBiomaterials for pre-clinical and clinical translation
  • Session TitleRegulatory science for the translation of biomaterials products
  • Session CodeSP-T08-0311
  • Date & Time / RoomMay 28 (Tue) 16:30~18:00 / Room 320-A
Organizer

Kai Zhang (Sichuan University, China)

Chair

Kai Zhang (Sichuan University, China)

Arthur J. Coury (Northeastern University, USA)

Keynote Speaker

Kai Zhang (Sichuan University, China)

Invited Speaker

16:55~17:10 : Regulatory Science for Medical Devices Suping Lyu (Medtronic Inc., USA)

Oral Presenter

17:10~17:20 : A safe-by-design approach for medical implants Anniek Gielen (National institute of public health, Netherlands)

17:20~17:30 : Immunogenicity assessment for swim bladder-derived biomaterials Jing Liu (Institute of Biomedical Engineering, Peking Union Medical College, Chinese Academy of Medical Sciences, China)

17:30~17:40 : The research on key technology for evaluation of soft tissue wound repair materials LI NA (Si chuan university, China)

17:40~17:50 : A low-cost and open-source bio-multimaterial multinozzle 3D printer (BioMM3D) Jonathan Weiss (Stanford University, USA)

17:50~18:00 : Research Status of Nanomaterial Medical Devices and Discussion on Biological Evaluation SUN Lingxiao (Shandong Institute of Medical Device and Pharmaceutical Packaging Inspection, China)

Description

Introductory abstract of a maximum of 300 words that addresses the symposium’s

1) objectives or purposes;

2) Proposed program and intended audience

3) expected outcomes and relevance to the main topic of WBC 2024.



Regulatory science is “the science of developing new tools, standards, and approaches to assess a product’s safety, efficacy, quality, and performance of regulated products”. The process from innovative basic research to successful clinical translation of biomaterials products needs the strong involvement of regulatory science. Innovative biomaterials-based medical products (i.e., “the products”) need to be designated and classified. Whether they are medical devices, combination devices, or drugs need to be appropriately and clearly identified. This classification will determine the future regulatory paths for the products. Preclinical research and evaluations of such products may need to develop new tools, standards and approaches. The design and understanding of the novel tools and methods and the establishment of new standards and guidance documents can strongly impact the regulatory and commercialization processes of the products. Current good manufacturing practice (cGMP) under a robust quality systems regulation (QSR) is required for manufacturing the products. How should the unique characteristics and risk management of the products be regulated under QSR and cGMP? In order to make the clinical translation of the products, clinical evaluations need to be conducted with the appropriate selections of indications, control and primary endpoints. Post-market surveillance along with real-world research of the products would also request strong scientific understanding after successful regulatory approval and market commercialization processes. Presentations with case studies will demonstrate how regulatory science can help the research, development and translation of biomaterials. Special attention should also be paid to the collaboration between regulatory science and biomaterials during the process from their basic research to clinical translation.

Keywords : Regulatory science, biomaterials translation, safety and efficacy

  • Session TrackBiomaterials for pre-clinical and clinical translation
  • Session TitleBiomaterials for cardiovascular disease models and therapeutics
  • Session CodeSP-T08-0071
  • Date & Time / RoomMay 28 (Tue) 9:30~11:00 / Room 320-A
Organizer

Ho-Wook Jun (University of Alabama at Birmingham, USA)

Chair

Ho-Wook Jun (University of Alabama at Birmingham, USA)

Hun-Jun Park (The Catholic University of Korea, Seoul St. Mary Hospital, Korea, Republic of)

Keynote Speaker

9:30~9:55 : Investigating heart development and disease using cardiac organoids Do-Sun Lim (Korea University, Anam Hospital, Korea, Republic of)

Invited Speaker

9:55~10:10 : Pro-healing Nanomatrix Coated Stent Analysis in an In Vitro Vascular Double-Layer System and in a Rabbit Model Ho-Wook Jun (University of Alabama at Birmingham, USA)

10:10~10:25 : Therapeutic potential of 3D cardiac spheroids derived from human pluripotent stem cells for cardiac regeneration Hun-Jun Park (The Catholic University of Korea, Seoul St. Mary Hospital, Korea, Republic of)

10:25~10:40 : Bioengineering human vascular networks for therapeutic applications Juan Melero-Martin (Boston Children's Hospital, USA)

Oral Presenter

10:40~10:50 : Preclinical Evaluation of Cell-Assembled Extracellular Matrix Sheets for Surgical Fallot’s Tetralogy Repair Fabien Kawecki (University of Bordeaux, Inserm BioTis U 1026, France)

10:50~11:00 : Development and characterization of a geometrically-tunable blood shunt for pediatric heart reconstruction Akari Seiner (Drexel University, USA)

Description

This symposium will highlight development and applications of biomaterials for cardiovascular disease models and therapeutics. Preclinical in vitro models are commonly used to evaluate the efficacy and safety of novel therapeutics and cardiovascular devices prior to initiating complicated in vivo and clinical studies. Topics include biomaterials based engineering cardiac tissues, scaffolds, organoids, or organs-on-a-chip for atherosclerosis or any cardiovascular disease models. Therapeutics will include biomaterials based drug delivery, biofabrication, cell therapy, cardiac devices for heart tissue regeneration, vascular grafts, valves, pacemaker, and cardiovascular disease treatments. Audiences will include academics, industry leaders, clinicians, and regulation representatives. It will also provide the networking opportunity among the leaders, emerging leaders, and trainees to spur further collaborations that would benefit members of biomaterials societies. Outcomes will provide new insights on various biomaterials for cardiovascular disease models and therapeutics to better understand and improve human health via different approaches in multi-disciplines.

 

Keywords : cardiovascular disease; cardiovascular devices; heart tissue

  • Session TrackBiomaterials for pre-clinical and clinical translation
  • Session TitleUnderstanding the role of the immune system in tissue generation, repair, and wound healing
  • Session CodeSP-T08-0074
  • Date & Time / RoomMay 30 (Thu) 16:30~18:00 / Room 315
Organizer

Erika Moore (University of Maryland, USA)

Chair

Erika Moore (University of Maryland, USA)

Keynote Speaker

Evan Scott (Northwestern University, USA)

Invited Speaker

16:55~17:10 : Silicate nanoplatelet-based shear-thinning hydrogel for immunotherapeutic agent delivery Hanjun Kim (Korea University, Korea, Republic of)

Oral Presenter

17:10~17:20 : Micro-computed tomographic imaging of foreign body giant cells in tissue engineering scaffold Lucia Baixauli-Marin (University of Oulu, Finland)

17:20~17:30 : Anatomical location and alloy composition-specific immune responses observed from metallic medical implants Jessica Stelzel (Johns Hopkins University, USA)

17:30~17:40 : Immunomodulation of fibroblast and keratinocyte cytokine response on transepithelial implants with peptide nanocoatings Daniel Moreno (International University of Catalonia, Spain)

17:40~17:50 : Anti-inflammatory function-enhancing engineered small extracellular vesicles promote temporomandibular joint regeneration Zhiling Zhang (Nankai University, China)

17:50~18:00 : Incorporating bone-derived extracellular matrix into macroporous microribbon scaffolds for bone regeneration Cassandra Villicana (Stanford University, USA)

Description



The objective of this symposium is to investigate the intersection of biomaterials and immunology in determining tissue regeneration and leverage our expertise to design informed materials for desired immune outcomes. Particular emphasis will be on materials tunable for individualized therapy, biomaterials for studying immunity, and those with strong potential for clinical translation all for various regenerative medicine applications.

The proposed program will encompass 1 invited keynote speaker (25 min), 1 invited speaker (15 min talk), and 3 podium presentations selected from submitted abstracts (15 min each). The program is designed for researchers working on modulating immunity using biomaterials with clinically translational potential. 

Our program encompasses the convergence of different scales of biomaterials from molecular protein engineering to larger-scale biomaterial scaffold development. The primary focus will be on materials that are translatable to the clinic for modulating immunity for tissue regeneration, fitting with the theme of WBC 2024.

Keywords : immunoengineering, tissue regeneration, translational medicine

  • Session TrackBiomaterials for pre-clinical and clinical translation
  • Session TitleClinical Translation of Biodegradable Materials
  • Session CodeSP-T08-0385
  • Date & Time / RoomMay 28 (Tue) 13:40~15:10 / Room 320-A
Organizer

Huinan Liu (University of California, Riverside, USA)

Chair

Huinan Liu (University of California, Riverside, USA)

Yufeng Zheng (Peking University, China)

Keynote Speaker

13:40~14:05 : Technology Development and Translation of Citrate-Based Biomaterials Jian Yang (Westlake University, China)

Invited Speaker

14:05~14:20 : Elastic biodegradable hydrogels for tissue repair Yi Hong (University of Texas at Arlington, USA)

14:20~14:35 : Magnesium Oxide and Magnesium Hydroxide Nanoparticles Disrupted Pseudomonas aeruginosa, Staphylococcus epidermidis, and Staphylococcus aureus Biofilms in vitro Patricia Holt-Torres (University of California, Riverside, USA)

14:35~14:50 : Preparation and biological evaluation of high strength and toughness degradable zinc alloys Lijing Yang (Ningbo Institute of Materials Technology & Engineering, Chinese Academy of Sciences, China)

Oral Presenter

14:50~15:00 : Engineering Bioresorbable Implants and Composites for Medical Applications Huinan Liu (University of California, Riverside, USA)

15:00~15:10 : Biodegradable polymer stents for the treatment of Eustachian tube dysfunction Kerstin Lebahn (Rostock University Medical Center, Germany)

Description

The objective of this 90-minute symposium is to discuss recent progress on preclinical and clinical translation of biodegradable materials, including polymers, metals, ceramics, and composites, for tissue repair, drug delivery, cell therapies, and medical devices and implants.

The 90-minute program will include one keynote speaker and two invited speakers to cover the topics of biodegradable polymers, biodegradable metals, biodegradable composites and devices, and their recent progress toward clinical translation, in the first hour. Rest of the speakers (15 minutes including questions and transition) will be selected from the unsolicited abstract submissions. The target audience will include researchers and development engineers from academia and industry.

The expected outcomes include (1) training of researchers who are interested in clinical translation of biodegradable materials, (2) understanding of the promise, challenges, and key assessment methods for clinical translation of biodegradable materials, and (3) sharing experience, success stories, and wisdom in developing clinical translation pathways in different countries.

Keywords : Biodegradable polymers, metals, and composites

  • Session TrackBiomaterials for pre-clinical and clinical translation
  • Session TitleGelatin and collagen based biomaterials: advances towards pharmaceutical and clinical translation of tissue biofabrication
  • Session CodeSP-T08-0171
  • Date & Time / RoomMay 31 (Fri) 9:30~11:00 / Room 320-A
Organizer

Jos Olijve (Rousselot Biomedical, Netherlands)

Chair

Riccardo Levato (University Utrecht, Department of Biofabrication and Regenerative Medicine, Netherlands)

Jos Olijve (Rousselot Biomedical, Netherlands)

Keynote Speaker

9:30~9:55 : Gelatin methacryloyl (GelMA): A versatile material for tissue engineering and regenerative medicine applications Ali Khademhosseini (Terasaki Institute, USA)

Invited Speaker

9:55~10:10 : Enhancing performance as a corneal adhesive restorative material: Development of photocurable cornea-derived decellularized extracellular matrix hydrogels with gelatin methacryloy Juyoung Park (BioBricks, Korea, Republic of)

10:10~10:25 : Gelatin advances and clinical translation of tissue biofabrication, the endotoxin story. Jos Olijve (Rousselot Biomedical, Netherlands)

Kyung Min Park (Incheon National University, Korea, Republic of)

Hee-Gyeong Yi (Dept. of Convergence Biosystems Engineering/Chonnam National University, Korea, Republic of)

Oral Presenter

10:55~11:05 : Lyophilized platelet concentrate collagen composite scaffold for hard tissue regeneration NURUL AIDA NGAH (Universiti Teknologi MARA, Malaysia)

11:05~11:15 : Advantages of photo-curable collagen-based cell-laden bioinks compared to methacrylated gelatin (GelMA) in digital light processing (DLP) and extrusion bioprinting Huimin Shi (Zhejiang University, China)

Description

The symposium will constitute a forum to highlight and discussing the role of gelatin and collagen requirements; tunability and degree of purity, as key aspects towards reproducible and effective research and translational opportunities of biomaterial based devices for current and future healthcare applications.

The exponential growth in the biofabrication field, involving (cell-laden) biomaterials design in combination with automated bioassembly and bioprinting technologies, is creating new opportunities for patient specific regenerative implants and diagnostic tools such as organ-on-chip technologies.

Commercially available pharmaceutical and clinical grade biomaterials are essential for the clinical translation of these technologies and so the future of healthcare.

Biomaterials extracted from the extracellular matrix (ECM), such as gelatins and collagens are favorable biomaterials due to their biocompatibility, biodegradability, tunability, cell-interactivity and longstanding use in pharmaceutics. It has been demonstrated that the ECM steer cell and tissue function in relation to mechanical properties and 3D architecture. Gelatins and collagens can be tuned based on molecular weight and chemical modification to create tissue like constructs which are important for (pre)clinical and pharmaceutical translations like drug testing or disease modelling. Additionally purity requirements for such biomaterials are paramount, both in effective research, and in the translation towards clinical and pharmaceutical use.

The symposium will be of interest for biomaterial chemists, engineers, bioprinting researchers, pharmaceutical industry specialists and physicians, and will be opened by a keynote lecture from Prof. Ali Khademhosseini (Terasaki Institute, USA), who contributed to the development and commercialization of several gelatin-based devices for healthcare. Invited talks will cover key aspects of innovation in collagenous materials, from material sourcing, modification, biofabrication, purity requirements, as well as applications in disease modelling and organ-on-chip models. The program will be complemented by podium presentations from selected abstracts submitted.

Keywords : gelatin, clinical-translation, biofabrication

  • Session TrackBiomaterials for pre-clinical and clinical translation
  • Session TitleClinical application of biomaterials in Orthopaedic field
  • Session CodeSP-T08-0198
  • Date & Time / RoomMay 29 (Wed) 9:30~11:00 / Room 320-A
Organizer

Ji-Hoon Bae (Department of Orthopaedic Surgery, Korea University Guro Hospital, Korea, Republic of)

Chair

Hyung Bin Park (Gyeongsang National University, Korea, Republic of)

Hongsik Cho (1) Dept. of Orthopaedic Surgery, UTHSC-Campbell Clinic 2) VA Medical Center, USA)

Keynote Speaker

Hongsik Cho (1) Dept. of Orthopaedic Surgery, UTHSC-Campbell Clinic 2) VA Medical Center, USA)

Invited Speaker

9:55~10:10 : Development of Scaffold-free Three-dimensional Tendon Construct Using Mouse Tendon Cells Kyu Sang Joeng (McKay Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, USA)

10:10~10:25 : Clinical Application of Polydeoxyribonucleotide for Shoulder and Elbow Diseases Jung-Taek Hwang (Department of Orthopedic Surgery, Cuncheon Sacred Heart Hospital, Hallym University Medical College, Korea, Republic of)

Oral Presenter

10:25~10:35 : Mechanical properties and bone regeneration ability of additively manufactured trabecular porous tantalum scaffolds Jiaxiang Wang (Qingdao University of Technology, China)

10:35~10:45 : In vivo studies of an innovative 3D printed device for articular cartilage regeneration Xinyu Li (Imperial College London, United Kingdom)

10:45~10:55 : Internal fixation with biodegradable high purity magnesium screw in the treatment of ankle fracture tianwei Zhang (Dalian university,China, China)

Description

In this symposium, we will discuss about 'clinical application of biomaterials in Orthopaedic field' as follows.

1) The core of orthopaedic research lies at the intersection of fundamental biomedical science and clinical applications. In terms of theranostic target delivery, we focus on optimizing target nanosome systems using animal imaging techniques and developing animal models for posttraumatic osteoarthritis. Through collaboration with fellow researchers, I aim to apply my findings in the field of targeted drug therapy, fluorescent diagnostic methods, and stem cell-based implantation techniques. The re-discovery of theranostic nano-techniques for cartilage repair will open new avenues for improving existing tissue engineering technology and will create new strategies for developing treatment options in the field of orthopaedic research.

2) Three-dimentional tendon constructs are engineered tissue structures that mimic the structure and function of natural tendons. In our lab, we developed a scaffold-free, three-dimensional (3D) tendon culture system using mouse tendon cells and a differentially adherent growth channel. Our 3D tendon culture system is a reliable in vitro system to study underlying mechanisms that regulate cellular and matrix maturation in tendon. The application of this construct in clinical treatment will be the future direction of this study.

3) Polydeoxyribonucleotide (PDRN) is a tissue regeneration activator that is composed of a mixture of nucleotides and activates adenosine A2A receptors, stimulating vascular endothelial growth factor (VEGF) expression and the activity of fibroblast. We had performed two clinical trials to verify of the effect of PDRN on tendon healing of rotator cuff tear and lateral epicondylitis. The results suggest that PDRN might improve tendon healing and fatty degeneration in arthroscopic rotator cuff repair, and exercise with counter force brace (EX) combined with PDRN might exhibit a greater improvement than EX only or EX combined with extracorporeal shockwave therapy for lateral epicondylitis.

Keywords : Nanosomes, 3D tendon construct, Polydeoxyribonucleotide

  • Session TrackBiomaterials for pre-clinical and clinical translation
  • Session TitleTranslation of nanoplatforms for surgical applications
  • Session CodeSP-T08-0242
  • Date & Time / RoomMay 30 (Thu) 16:30~18:00 / Room 320-A
Organizer

Alicia El Haj (University of Birmingham, United Kingdom)

Chair

Alicia El Haj (University of Birmingham, United Kingdom)

Mohd Fauzi MH Busra (Universiti Kebangsaan Malaysia, Malaysia)

Keynote Speaker

16:30~16:55 : Using multidisciplinary science to drive healthcare innovations Molly Stevens (Imperial College London, United Kingdom)

Invited Speaker

Ken Dawson (University College Dublin, Ireland)

17:10~17:25 : Antibacterial-coated collagen biomatrix for future use in diabetic wound care Mohd Fauzi MH Busra (Universiti Kebangsaan Malaysia, Malaysia)

17:25~17:40 : Development of Durable and Facile Anti-Biofouling Coating: Lynk Coating for Biomedical Implants Jungmok Seo (Yonsei Univ. / Lynk Solutec Inc., Korea, Republic of)

Oral Presenter

17:40~17:50 : Silver/strontium co-incorporated mesoporous silica nanoparticles-loaded polylactic acid electrospun fibers for bone tissue engineering Zhang Yuhan (NWPU, China)

17:50~18:00 : Tumor ultrasound-switchable fluorescence imaging for pre-clinical applications Baohong Yuan (University of Texas at Arlington, USA)

18:00~18:10 : Nature-inspired nanoparticles for therapeutics and vaccine delivery Hao Song (Massachusettes Institute of Technology, USA)

Description

Nanoparticles have been developed in many formulations ranging from polymer to magnetic in nature. Recently these approaches have been used to create further complexity in cell delivery and tissue engineered scaffolds applications by creating hybrids which provide further benefits. The particle approaches can be for tagging and activation as well as release and structural ECM cues. In addition, the use of biomaterials integrated with nanoparticles can define additional properties such as antioxidant, angiogenic, and anti-inflammatory, to be used as implantable and injectable bioscaffolds.  These approaches can provide a permanent replacement for a tissue defect as well as deliver biological compounds into the repair site. However, a balance of safety and efficacy is an important consideration to allow for the translation of biomaterials to medical devices. Hence, rational design and development of nano and complex biomaterials requires further understanding before future preclinical and clinical applications can be delivered for improving patients’ health and life.  This workshop will present the’ state of the art’ for this field and consider how the route to the clinic can be improved and defined more clearly to facilitate the translation of more products. The topic will be relevant to academics and industry who are developing new nanoplatforms for the future.

 

Keywords : nanoparticle translation surgery

  • Session TrackBiomaterials for pre-clinical and clinical translation
  • Session TitleOsteonecrosis: The Biology and Treatment with Implants, Biologics, and Cells
  • Session CodeSP-T08-0248
  • Date & Time / RoomMay 30 (Thu) 13:40~15:10 / Room 320-A
Organizer

Lynne Jones (Johns Hopkins University School of Medicine, USA)

Chair

Shin-Yoon Kim (Kyungpook National University, Korea, Republic of)

Keynote Speaker

13:40~14:05 : Pathology, Diagnosis, and Clinical Aspects of Osteonecrosis: A Comprehensive Overview Nobuhiko Sugano (Osaka University Graduate School of Medicine, Japan)

Invited Speaker

Seung-Hoon Baek (Kyungpook National University, Korea, Republic of)

14:20~14:35 : The use of cells and biologics for treatment of early stage ONFH Stuart Goodman (Stanford University, USA)

Oral Presenter

14:35~14:45 : Composite elastin derivative-based hydrogel designed for promoting bone formation, vascularization, and innervation: In vivo evaluation in ectopic and heterotopic model Micaela ROQUE (Bioingénierie Tissulaire (BioTis), Université de Bordeaux - Inserm U1026, France)

14:45~14:55 : Engineering Bio-inspired Materials for Multicellular-Mediated Bone Regeneration Ching-Chang Ko (Ohio State University, USA)

14:55~15:05 : 3D printed synergistic graphene citrate composite scaffold for craniofacial bone reconstruction Mirae Kim (Northwestern University, USA)

Description

The goal of this symposium is to inform the audience about the past, present, and future treatment of osteonecrosis, a disorder of the major joints characterized by lesions of dead bone and interrupted blood circulation. This panel discussion features world renown experts in the field of osteonecrosis reviewing the clinical  aspects of the condition as well as important developments and outcomes of preclinical and translational studies for treatment, including scaffolds, cell therapy, and biologics. The symposium will be of interest to biomaterials scientists, bioengineers, biologists and clinicians. The audience will better understand the need for novel treatments for osteonecrosis and the vision for a biological approach.

 

Keywords : osteonecrosis, cell-based therapy, bone scaffold

  • Session TrackBiomaterials for pre-clinical and clinical translation
  • Session TitleCraniofacial tissues and implants
  • Session CodeSP-T08-0107
  • Date & Time / RoomMay 31 (Fri) 11:20~12:50 / Room 320-A
Organizer

Do-Gyoon Kim (Ohio State University, USA)

Chair

Do-Gyoon Kim (Ohio State University, USA)

Hiroshi Kamioka (Okayama University, Japan)

Keynote Speaker

11:20~11:45 : Dental Implants: from titanium to zirconia Jung Suk Han (Seoul National University, Korea, Republic of)

Invited Speaker

11:45~12:00 : Engineering Bio-inspired Materials for Multicellular-Mediated Bone Regeneration Ching-Chang Ko (The Ohio State University, USA)

12:00~12:15 : In vitro synthesis of artificial bone tissue that reproduces a three-dimensional hierarchical structure Takuya Matsumoto (Okayama University, Japan)

12:15~12:30 : Advances in mesenchymal stem cell spheroid research: Enhancing biological function and therapeutic potential in regenerative medicine Jun-Beom Park (The Catholic University of Korea, Korea, Republic of)

Oral Presenter

12:30~12:40 : Potential of neodymium-Iron-boron magnets in aligner therapy Toru Deguchi (University of Louisville, USA)

12:40~12:50 : Promoting craniofacial regeneration using biomaterials and epigenetics  Christine Hong (UCSF, USA)

Description

Biomaterials in dentistry include craniofacial tissues (bone, tooth, muscle, tendon, ligament, cartilage, and other soft tissues), metals and ceramics for dental implants, and polymers for scaffold. A primary role of the craniofacial tissues is to bear loads during mastication, control movement of the jaw, and maintain facial shape. Each component is composed at the multiple length scale of molecules (nanometers), cells (micrometers), and tissues (millimeters). Cells are responsible for providing molecules that are used for building blocks of tissues. At the organ scale, ligaments connect between bones or teeth and bones while tendon bridges bones to muscles. Cartilage lubricates and protect articulating surfaces of bones at a temporomandibular joint. Loads applied during daily activities transmit through these multiscale components of craniofacial system. However, mechanistic and biological links of these multiscale components has not been fully understood. Implantation is needed to treat tooth loss, orthodontic anchorage, or critical size defects in the craniofacial tissues. The dental implants including temporary anchorage devices and scaffolds are fabricated using foreign materials. As such, biocompatibility and stability at the interface between implanted materials and surrounding tissues are of importance in determining an immediate and long-term success following implantation. A pre-clinical animal model is necessary to validate an efficacy of the implantation for clinical translation. Knowledge accumulated through multiscale characterization of the craniofacial tissues can be directly applied to evaluate success of the implant system. A clinical evaluation provides practical information to improve the existing implant systems and develop a novel approach. Taken together, this symposium aims to provide up-to-date information on multiscale characterization of craniofacial tissues and implants in vitro, the pre-clinical models and clinic.

Keywords : Bone, Dental biology, Dental Implant

  • Session TrackBiomaterials for pre-clinical and clinical translation
  • Session TitleUp-to-date technology in periodontal tissue engineering
  • Session CodeSP-T08-0115
  • Date & Time / RoomMay 30 (Thu) 9:30~11:00 / Room 320-A
Organizer

Jeong-Ho Yun (College of Dentistry, Jeonbuk National University, Korea, Republic of)

Chair

Jeong-Ho Yun (College of Dentistry, Jeonbuk National University, Korea, Republic of)

Takanori Iwata (Tokyo Medical Dental University, Japan)

Keynote Speaker

9:30~9:55 : Various methods and effects of BMP application in tissue-engineered periodontal tissue and alveolar bone regeneration Jeong-Ho Yun (College of Dentistry, Jeonbuk National University, Korea, Republic of)

Invited Speaker

9:55~10:10 : Periodontal regeneration with periodontal ligament-derived mesenchymal stromal cell sheets Takanori Iwata (Tokyo Medical Dental University, Japan)

10:10~10:25 : Periodontal tissue regeneration by transplantation of autologous adipose tissue-derived multi-lineage progenitor cells Masahide Takedachi (Osaka University Dental Hospital, Japan)

10:25~10:40 : Multifunctional barrier membrane systems for periodontal tissue regeneration Josephine Wong (Collagen Solutions, United Kingdom)

Oral Presenter

10:40~10:50 : A hybrid 3D printed scaffold loaded with macrophages for immune-mediated periodontal regeneration Jinhui Huang (Kunming Medical University, China)

Description

Periodontitis is a chronic oral Inflammatory disease which accompanies the loss of periodontal tissues (alveolar bone, periodontal ligament, cementum) by oral causative bacteria. The reestablishment of damaged tooth-supporting complex should contain the intricate regenerations of unique tissues and functional regeneration of periodontal apparatus is one of the most important aims of research in current periodontal regenerative therapy.

To achieve an advanced reconstruction of lost periodontal tissue, various regenerative techniques have been evaluated: guided tissue regeneration (GTR) with barrier membranes and graft materials, cytokine therapy using growth factors, and cell therapy by various kinds of cells, etc. Nevertheless, current techniques have still challenging limitations for tooth-supporting structure neogenesis because the ideal periodontal regeneration, which means the formation of new cementum and the functional insertion of periodontal ligament fibers into it, has not been achieved with satisfaction until now. In an effort to overcome these limitations, new approaches using additional signaling molecules and cells have been introduced and are recently underway.

The purpose of this international joint symposium is to develop the novel therapeutic strategy for periodontal tissue regeneration using various tissue engineering techniques with clinical/pre-clinical scenarios.

This symposium can critically propose the next therapeutic milestone in periodontal tissue engineering and regenerative medicine for better life qualities of dental patients. Through this symposium, we are able to establish strong network with world-renowned research groups to create advanced therapeutic technologies and exchanging/sharing translational knowledges. Moreover, it is possible to create new opportunities for possible international cooperative/collaborative research projects.

Keywords : Dentistry, Periodontal regeneration, Tissue engineering

  • Session TrackBiomaterials for pre-clinical and clinical translation
  • Session TitleClinically relevant dental biomaterials
  • Session CodeSP-T08-0116
  • Date & Time / RoomMay 27 (Mon) 14:40~16:10 / Room 320-A
Organizer

Jae-Sung Kwon (Yonsei University College of Dentistry, Korea, Republic of)

Chair

Jae-Sung Kwon (Yonsei University College of Dentistry, Korea, Republic of)

James Tsoi (Hong Kong University, Hong Kong SAR, China)

Keynote Speaker

14:40~15:05 : Titania Nanotube Applications in Dentistry: Innovations and Perspective Seung Han Oh (Wonkwang University, Korea, Republic of)

Invited Speaker

15:05~15:20 : Colourization of zirconia using photons James Tsoi (Hong Kong University, Hong Kong SAR, China)

15:20~15:35 : Developing symbiotic bio-interaction with dental materials for oral health improvement Utkarsh Mangal (Yonsei University College of Dentistry, Korea, Republic of)

Oral Presenter

15:35~15:45 : Urchin-like fluorohydroxyapatite coating on sulfonated PEEK implants with antimicrobial activity and osseointegration properties Ning Huang (College of Stomatology, Shanghai Jiao Tong University; Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, China, China)

15:45~15:55 : Particle release from dental implants and the potential of bioactive glass in implant dentistry Siwei Li (VSS Academy Training and Education Ltd, Imperial College London, United Kingdom)

15:55~16:05 : Enhancing osteogenesis and bacteriostatic properties through a strontium-doped coating inspired by mussel byssus cuticle Jinsong Liu (Wenzhou Medical University, China)

16:05~16:15 : Self-Assembling Antimicrobial Titanium Implant Coatings for Enhanced Osseointegration Zhou Ye (The University of Hong Kong, Hong Kong SAR, China)

Description

Due to aging population and advancement of technologies in digital dentistry such as 3D printing and CAD/CAM, translational research of dental biomaterials from pre-clinical studies to clinical application has been rapidly evolving. The objective of this symposium is to consider dental biomaterials research that are relevant in clinical fields.

 Proposed program will consist of chairs and speakers who are dental clinician, medical doctor, and basic scientist. With audience who would be interested in both pre-clinical and clinical science to dental biomaterials and biomaterials, the program will discuss current and prospective development of clinically relevant biomaterials such as bioactive, antibacterial and biofouling biomaterials for the dental medical devices.

 The symposium will provide opportunity to share state of the art knowledge and research outcomes from such dental biomaterials while allowing buildup of networks between researchers working on pre-clinical studies to clinical studies. Finally, the symposium will allow convergence of many different aspects of dental biomaterials such as conventional dental materials, 3D printing, esthetic materials etc., for provision of improved dental healthcare in the future, which will be in line with the main theme of WBC 2024.

Keywords : Dentistry, Dental Materials, Translational Research

  • Session TrackBiomaterials for pre-clinical and clinical translation
  • Session TitleBiomaterials in Stomatology Application and Clinical Translation
  • Session CodeSP-T08-0243
  • Date & Time / RoomMay 29 (Wed) 16:30~18:00 / Room 320-A
Organizer

Xinquan Jiang (College of Stomatology, Shanghai Jiao Tong University, China)

Chair

Xinquan Jiang (College of Stomatology, Shanghai Jiao Tong University, China)

Hala Zreiqat (Biomaterials and Tissue Engineering Research Unit, School of Biomedical Engineering, Faculty of Engineering University of Sydney, Australia)

Keynote Speaker

16:30~16:55 : New strategies for oral and maxillofacial tissue regeneration and it’s translation application Xinquan Jiang (College of Stomatology, Shanghai Jiao Tong University, China)

Invited Speaker

16:55~17:10 : Revolutionizing Bone Tissue Regeneration: Innovations in Nanostructured 3D-Printed Biomaterials for Personalized Healing and Anti-Senescence Strategies Hala Zreiqat (Biomaterials and Tissue Engineering Research Unit, School of Biomedical Engineering, Faculty of Engineering University of Sydney, Australia)

17:10~17:25 : Design and fabrication of silk fibroin biomaterials for dental medicine Shengjie Ling (Shanghaitech University, China)

Oral Presenter

17:25~17:35 : Hybrid dental biomaterials comprise hDPSC potential for dental pulp regeneration Azam Ali (University, New Zealand)

17:35~17:45 : Development of a multifunctional chitosan-catechol-based hydrogel for in situ dental applications Maud Viallon (Laval University, Canada)

17:45~17:55 : Concept, synthesis, and bio-evaluation of biostable and clinically-translatable dental restoratives Zach Gouveia (University of Toronto, Canada)

Description

With the theme of "Opportunities and challenges coexist, Characteristics and innovation advance together", this topic will focus on the basic research and translational application of biomaterials in stomatology (dentistry). Well-known experts and scholars in the field will be invited and a large number of distinguished young scientists, entrepreneurs and people of insight will be gathered to discuss the characteristics and future trends of this special field. This topic aims to build a communication platform for "New ideas, New technologies and New progress", and actively boost the rapid development of advanced biomaterials in stomatology. 

Keywords : Biomaterials; Stomatology; Clinical translation

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