Scientific Program

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  • Session TrackBioactive materials
  • Session TitleSmart biomaterials for the modulation of inflammation and coagulation process
  • Session CodeSP-T12-0266
  • Date & Time / RoomMay 28 (Tue) 16:30~18:00 / Room 322
Organizer

Wendong Gao (Queensland University of Technology, Australia)

Chair

Yingying Du (Huazhong University of Science and Technology, China)

Keynote Speaker

Yin Xiao (Griffith University, Australia)

Invited Speaker

16:55~17:10 : Immunomodulation Based Strategy for Improving Metal Implant-Soft Tissue Integration Zetao Chen (Sun Yat-sen University, China)

17:10~17:25 : Multifunctional magnetic nanovesicles for treating severe bacteremia Joo Hun Kang (Ulsan National Institute of Science & Technology, Korea, Republic of)

Oral Presenter

17:25~17:35 : Rendering antimicrobial hernia meshes without an adverse immune reaction Cynthia Calligaro (SPARTHA Medical, France)

17:35~17:45 : Superhydrophilic poly(ε-caprolactone)/Tween-20 electrospun fiber coated with chitosan/heparin - A promising material for developing cardiac patches Roberta Maia Sabino (University of Wyoming, USA)

17:45~17:55 : An off-the-shelf artificial blood clot hydrogel neutralizing multiple proinflammatory mediators for pro-regenerative periodontitis treatment Yini Huangfu (Tianjin University, China)

Description

Traditional biomaterials for tissue regeneration rely on the modulation of the inflammation phase and regeneration phase. Recent studies have revealed that blood clot formation plays an essential role in regulating inflammation and following tissue regeneration. In this regard, it is of great potential to develop novel strategies that modulate the coagulation process to achieve ideal clot-immune interplay. Inspired by the innate regeneration process, the state-of-the-art synthetic biomaterials can precisely control biophysical and biochemical cues to direct the polymerization of the fibrin network thus modulating the clot structure and the inflammation response. Therefore, we want to focus this symposium on novel strategies involving the design and evaluation of smart biomaterials aiming at stimulating the optimal blood clot formation and immunomodulation to achieve tissue regeneration. Strategies for applying defined physical properties (viscoelasticity, stiffness, architecture, degradation, and surface properties) and biochemical characteristics (cytokines, growth factors, reprogramming factors, ions) to regulate hematocytes and immunocytes are especially interesting. The symposium will cover a range of issues and target a large variety of researchers and clinicians in the field of tissue engineering and regenerative medicine.

Keywords : inflammation, coagulation, smart biomaterials

  • Session TrackBioactive materials
  • Session TitleSmart biomaterials for the modulation of inflammation
  • Session CodeSP-T12-0269
  • Date & Time / RoomMay 27 (Mon) 13:00~14:30 / Room 322
Organizer

Lan Xiao (Queensland University of Technology, Australia)

Chair

Lan Xiao (Queensland University of Technology, Australia)

Yulin Li (East China University of Science and Technology, China)

Keynote Speaker

13:00~13:25 : Dynamic immune modulation empowered by designer biomaterials Yong Taik Lim (Sungkyunkwan University, Korea, Republic of)

Invited Speaker

13:25~13:40 : Heparin loading microsphere conjugated pancreatic islets transplantation for prevention of IBMIR Jee-Heon Jeong (Sungkyunkwan University, Korea, Republic of)

13:40~13:55 : Synthetic nano-engineered antimicrobial polymers (SNAPs) Sebastien Perrier (University of Warwick, United Kingdom)

Oral Presenter

13:55~14:05 : Nanozymes-armed Microbes for Alleviating Intestinal Inflammation and Microbiota Dysbiosis Zhengwei Mao (Zhejiang University, China)

14:05~14:15 : Effects of shape and surface property of thermoresponsive core-corona type particles on phagocytic behavior of macrophages Akihiko Kikuchi (Tokyo University of Science, Japan)

14:15~14:25 : Gas therapy and nanomedicine Xiaojun Cai (Wenzhou Medical University, China)

Description

Inflammation control is one of the most fundamental parts of biomaterial-based tissue engineering. This is due to the nature of biomaterials as alien objects when recognized by the host immune system and inevitably trigger inflammation. An inflammatory microenvironment around the biomaterial is detrimental to tissue regeneration by hindering tissue cell differentiation and maturation. Ideally, a tissue engineering biomaterial is expected to modulate the local immune environment into one beneficial for tissue regeneration. This can be achieved by using drug delivery systems to release anti-inflammatory chemicals/biomolecules, however, due to the difference between individuals (e.g., age, gender, and disease conditions such as obesity, diabetes, cancer, immune deficiency, etc.), the basal level of inflammation/immune cell activation varies among individuals, which making it difficult to optimize the drug-loading amount and release timing for each patient. To solve this problem to achieve personalized immune modulation, recent advances in nanotechnology have endowed drug delivery systems with the capacity for environmental-responsive drug release. Such a “smart material” can sense the levels of inflammatory factors/changes (e.g., pH value, reactive oxidative species, cytokines, surface markers, etc.) and release a certain amount of anti-inflammatory factors in response to different inflammatory levels, therefore ensuring a personalized immune modulation to optimize the local environment for tissue regeneration. Hence, this proposed symposium aims to summarize the cutting-edge technologies in smart biomaterial design/development for personalized immunomodulation and inflammation control. The program will include 1-2 keynote speakers and 3-4 speakers to discuss the latest advances in this area, which is expected to attract audiences such as scholars in the fields of tissue engineering, regenerative medicine, immunology, material science, clinical practitioners, and biomedical industry partners. It will provide an excellent platform to discuss future strategies for tissue engineering biomaterial development and translation, which is relevant to the conference's main topic (biomaterials for the future of healthcare).    

 

Keywords : Tissue engineering, Immunomodulation, Smart materials

  • Session TrackBioactive materials
  • Session TitleDirecting cell fate & tissue regeneration by extracellular matrix signalling
  • Session CodeSP-T12-0286
  • Date & Time / RoomMay 28 (Tue) 13:40~15:10 / Room 322
Organizer

Catherine Le Visage (Nantes University, France)

Chair

Catherine Le Visage (Nantes University, France)

Evelyn Yim (University of Waterloo, Canada)

Keynote Speaker

13:40~14:05 : Directing cell fate & tissue regeneration by biomimetic scaffolds Sing Yian Chew (Nanyang Technological University, Singapore)

Invited Speaker

14:05~14:20 : Applications of Transplantable and Biodegradable Nanoarchitecture Scaffolds for Tissue Engineering Hee Seok Yang (Dankook University, Korea, Republic of)

14:20~14:35 : Overcoming Challenges in Islet Encapsulation for Bioartificial Pancreas Applications Kisuk Yang (Incheon National University, Korea, Republic of)

Oral Presenter

14:35~14:45 : Tissue Tuning with Liminal Spaces and Signal Density: Reimagining the signalling landscape via Self Assembled Regenerative Hydrogels Richard Williams (Deakin University, Australia)

14:45~14:55 : Tissue-engineered highly biomimetic and anisotropic vascularized cardiac patch Feng Zhao (Texas A&M University, USA)

14:55~15:05 : High-throughput screening of physicochemical material properties to prevent biomaterial-associated fibrosis of implants Lisa Tromp (University Medical Center Groningen, Netherlands)

Description

Signals from the extracellular microenvironment play significant roles in dictating cell behavior. In particular, biophysical signals like matrix topography and compliance affect cellular response. In combination with biochemical signals, such as surface chemistry of biomaterials, controlled delivery of drugs, growth factors and nucleic acids, synergistic effects are often seen.

This symposium gathers the recent advancements in bio-functional scaffold designs that focus on imparting synergistic physical and biochemical cues to support cell transplantation, direct cell differentiation and in vivo host-implant integration as well as tissue regrowth for regenerative medicine. 

 

Keywords : Stem cell differentiation; cell transplantation, matrix compliance, matrix topography, controlled release, tissue regeneration in vivo

  • Session TrackBioactive materials
  • Session TitleMarine biomaterials towards tissue engineering
  • Session CodeSP-T12-0295
  • Date & Time / RoomMay 29 (Wed) 9:30~11:00 / Room 322
Organizer

Hyung Joon Cha (Pohang University of Science and Technology, Korea, Republic of)

Chair

Hyung Joon Cha (Pohang University of Science and Technology, Korea, Republic of)

Tiago H. Silva (University of Minho, Portugal)

Keynote Speaker

9:30~9:55 : Innovative marine adhesive platform biomaterial for effective tissue regeneration Hyung Joon Cha (Pohang University of Science and Technology, Korea, Republic of)

Invited Speaker

9:55~10:10 : Marine Inspired Biomaterials as enabling tools for different Advanced Therapies Tiago H. Silva (University of Minho, Portugal)

10:10~10:25 : Sutureless Bioelectronics Integrated with Tissue-adhesive Hydrogel Biointerfaces Inspired by Marine Mussels Mikyung Shin (Sungkyunkwan University, Korea, Republic of)

Oral Presenter

10:25~10:35 : Marine Shells Biomaterials Jingdi Chen (Shandong University, China)

10:35~10:45 : From the Depths of the Sea to The Skin: Advancing Wound Healing through a Tough and Print-Friendly Marine Hydrogel Hafez Jafari (Polymer Chemistry and Biomaterials Group, Department of Organic and Macromolecular Chemistry, CMAC - Centre of Macromolecular Chemistry, Ghent University, Krijgslaan 281, 9000 Ghent, Belgium, Belgium)

10:45~10:55 : Cationic complexes of chelated nanohydroxyapatite modulate alveolar bone regeneratio Peilei Wang (Sichuan univercity, China)

Description

Marine organisms are gaining growing attention within the biomedical community, not only as an untapped source of chemical compounds with vast biological activity, but also as inspiration for the development of novel applications based on striking phenomena or architectural features found in marine organisms.



In particular, scientists, engineering and clinicians working on tissue engineering and regenerative medicine are looking to marine environment for new compounds with anti-tumor, anti-inflammatory or immunomodulatory effects, support materials for the development of scaffolds, as the well-established chitosan and alginate but also the arising marine collagens and seaweed-derived polysaccharides. Additionally, astonishing features are being explored and mimicked, as the mutable collagenous tissues exhibited by echinoderms (sea cucumbers, sea urchins, etc.), the hierarchical morphologies exhibited by marine sponges, but more deeply the wet adhesive properties observed in mussels, with biomimetic biomaterials derived from the mussel foot proteins being proposed, some of which already in clinical trial in Korea.



The proposed symposium aims to set a forum for discussion of this crosstalk between the blue and red biotechnologies, being important to address not only the sustainable production of marine origin materials needed to feed the development of new biomaterials and medical devices, but also their biological performance, namely in vivo and in clinical experimental procedures, together with the ethical and regulatory constraints that currently govern this field.

Keywords : Marine Biomaterials, Marine Biomemetics, Tissue Engineering

  • Session TrackBioactive materials
  • Session TitleBiomaterials Functionalization with Tethered Growth Factors and Proteins for Tissue Engineering Applications
  • Session CodeSP-T12-0299
  • Date & Time / RoomMay 27 (Mon) 14:40~16:10 / Room 322
Organizer

Oh Hyeong Kwon (Kumoh National Institute of Technology, Korea, Republic of)

Chair

Oh Hyeong Kwon (Kumoh National Institute of Technology, Korea, Republic of)

Naoki Kawazoe (National Institute for Materials Science, Japan)

Keynote Speaker

14:40~15:05 : Mussel-inspired adhesive growth factors for biosignalling materials. Yoshihiro Ito (RIKEN, Japan)

Invited Speaker

15:05~15:20 : High-performance hydrogel bioadhesives and dressings for wounds healing Hongli Mao (Nanjing Tech University, China)

Oral Presenter

15:20~15:30 : Cysteine mastery: transforming platelet lysate proteins into advanced microparticles Maria Clara Gomes (University of Aveiro, Portugal)

15:30~15:40 : Suspension sprayed calcium phosphate (CaP) coatings with antibacterial properties Maria Carolina Lanzino (University of Stuttgart, Germany)

15:40~15:50 : Polymer-based self-assembled coacervates Pengchao Zhao (South China University of Technology, China)

15:50~16:00 : Surface functionalization by micropatterning for investigation of stem cell differentiation in the viscous microenvironment Naoki Kawazoe (National Institute for Materials Science, Japan)

Description

The extracellular matrix, an assembly of multiple types of molecules that surround cells in vivo, plays an important role in regulating cell functions and tissue regeneration. Highly bioactive biomaterials have been designed and developed to mimic the functions of extracellular matrices. So far, immobilization of cell growth factors and proteins, hybridization of organic/polymer compounds and inorganic compounds, and incorporation of functional nanoparticles and bioactive molecules have been performed. In particular, growth factors have been tethered to biomaterials surfaces and tissue engineering scaffolds by a variety of physicochemical, genetic and biological approaches. In this symposium, these approaches and functionalized biomaterials will be highlighted and discussed for their applications in stem cell research and tissue engineering.

Keywords : Functionalization, surface modification, tissue engineering

  • Session TrackBioactive materials
  • Session TitleBioactive Materials and Structures for Tissue Interface Engineering
  • Session CodeSP-T12-0323
  • Date & Time / RoomMay 28 (Tue) 9:30~11:00 / Room 322
Organizer

Eben Alsberg (University of Illinois Chicago, USA)

Chair

Sangamesh Kumbar (University of Connecticut Health, USA)

Melissa Krebs (Colorado School of Mines, USA)

Keynote Speaker

9:30~9:55 : Osteochondral Interface Engineering: The role of Biomaterials Syam Nukavarapu (University of Connecticut, USA)

Invited Speaker

9:55~10:10 : Unconventional Biomaterials for Tissue Engineering and Regenerative Medicine Gulden Camci-Unal (UMASS Lowell, USA)

Kyobum Kim (Dongguk University, Korea, Republic of)

Oral Presenter

10:25~10:35 : Innovative biphasic 3D scaffold based on bioglass or bone inorganic matrix and biodegradable polymer honeycomb membrane for bone tissue engineering Emmanuel PAUTHE (CY Cergy Paris Université, France)

10:35~10:45 : SILICATE and Silicate-Based Bioactive Glasses as Potential Therapies for Medication-Related Osteonecrosis of the Jaw (MRONJ) Maria Florez Martin (University College London (UCL), United Kingdom)

10:45~10:55 : Biological performance in mini pigs of 3D Ti6Al4V–beta Calcium phosphate composite scaffolds Jiaping Li (Kuros Biosciences, Netherlands)

Description

Successful tissue regeneration strategies utilize biomaterials and structures with a variety of cues to modulate cell behavior and healing. Tissue engineering has made significant progress in developing strategies for simple tissues such as skin, bone, and cartilage. However, there are outstanding challenges in approaching complex tissues such as tissue-tissue interfaces. Efforts towards complex tissue engineering need to develop advanced biomaterials and biomedical structures that both can facilitate individual tissue formation along with a seamless interface development. In order to acheive this, researchers have developed various new biomaterial platforms that are bioactive and can selectively promote the needed tissue formation. In addition, there are numerous efforts to design and develop complex grafts through advanced scaffolding fabrictaion methods including biofabrication. This session will highlight the recent developments in complex tissue engineering and identify the areas for collaboration to address some of the key challenges in this area.

A large body of work has been carried out with the focus of developing musculoskeletal tissue interface development. It is expected that this symposium will attract a number of participants from US and worldwide from various disciplines including chemistry, polymers, materials science and engineering, drug delivery and biomanufacturing. This symposium will also facilitate the needed collaborations between the basic scientists, engineers, industry folks and clinicians, which will lead to the devlopment of future materials and strategies for complex tissue engineering.

Keywords : Bioactive materials, Complex structures, Tissue Interfaces

  • Session TrackBioactive materials
  • Session TitleElectroactive Biomaterials for Tissue Engineering and of Regenerative Medicine Applications
  • Session CodeSP-T12-0202
  • Date & Time / RoomMay 30 (Thu) 13:40~15:10 / Room 322
Organizer

Vitor Correlo (3B’s Research Group I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics of University of Minho, Portugal)

Chair

Vitor Correlo (3Bs Research Group, I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics of University of Minho, Portugal)

Il Keun Kwon (Department of Dental Materials, School of Dentistry, Kyung Hee University,, Korea, Republic of)

Keynote Speaker

13:40~14:05 : Conductive Biomaterials for Tissue Engineering- Application of Conductive Polymers and 2D Nanomaterial Michael Monaghan (Trinity College Dublin, Ireland)

Invited Speaker

14:05~14:20 : Graphene-incorporated conductive hydrogels as new functional biomaterial Jae Young Lee (Gwangju Institute of Science and Technology, Korea, Republic of)

Oral Presenter

14:20~14:30 : Electrical and Chemical Stimulation Using Ionically Conductive Polymeric Implants for Soft Tissue and Wound Healing Sama Abdulmalik (University of Connecticut Health Center, USA)

14:30~14:40 : Electroactive biomaterials based on ion-doped piezoelectric barium titanate nanofibers for improved bone regeneration Tianyi Zheng (SINOPEC (Beijing) Research Institute of Chemical Industry Co., Ltd., China)

14:40~14:50 : Orally ingestible piezoelectric particulate stimulators for noninvasive vagus nerve stimulation in treating obesity and sepsis Cam Hoa Mac (National Tsing Hua University, Chinese Taipei)

14:50~15:00 : Redox-active and electroactive hydrogel for post-infarct myocardial repair enabled by a core-shell conductive polymer coating @MOF nanozyme Shuyi He (Sichuan University, China)

15:00~15:10 : Flexible, hydrophilic conductive elastomers for soft bioelectronic applications Estelle Cuttaz (Imperial College London, United Kingdom)

Description

Design of biodegradable biomaterials that can provide multiple cell-instructive cues to direct or modulate cell behavior is a fundamental pursued goal of tissue engineering and regenerative medicine. Cell fate depends on intrinsic biomaterial properties as they can provide mechanical, electrical, and biochemical cues, actively participating in tissue repair and regeneration. In different tissues, such as neural, cardiac and skeletal muscle tissues, cells require conductive features for signal transmission and alignment. Nevertheless, developing multifunctional matrices that synergistically guide cell behavior is underlined when cell polarity and organization are required. The possibility of tailoring cell behavior using electrical stimulus by using conductive materials is vast, though it has been difficult to take advantage of these effects to trigger tissue regeneration, due to the lack of suitable conducting, biocompatible biomaterials that can be easily adapted for targeting different tissues. In this context, a symposium discussing the state-of-art of the most recent methods to prepare electroactive biomaterials, the behavior of electrophysiological active cells cultured on electroactive hydrogels it is of the utmost importance.

Researchers working on different areas of biomaterials and tissue engineering applications, will get an opportunity to know about the current methodologies and technologies for the development and uses of a large plethora of biocompatible electroactive hydrogel-based matrices, mainly for Tissue Engineering and Regenerative Medicine applications.

Graduate and postgraduate students, and experienced researchers in biotechnology, biomedical engineering working in the fields of natural or synthetic biomaterials, emerging technologies, tissue engineering and regenerative medicine, comprise the audience of this symposium. Moreover, the use of electroactive biomaterials for tissue engineering strategies is increasingly popular among our community scientists. Therefore, the topic proposed is expected to interest to the WBC audience at large.

 

Keywords : Electroactive biomaterials, electrical stimulus, neural, cardiac, skeletal muscle

  • Session TrackBioactive materials
  • Session TitleExtracellular matrix for mechanobiology and therapeutics
  • Session CodeSP-T12-0211
  • Date & Time / RoomMay 30 (Thu) 9:30~11:00 / Room 322
Organizer

Kwideok Park (Korea Institute of Science and Technology, Korea, Republic of)

Chair

Kwideok Park (Korea Institute of Science and Technology, Korea, Republic of)

Jennifer H. Shin (Korea Advanced Institute of Science and Technology, Korea, Republic of)

Keynote Speaker

9:30~9:55 : BLOOD AS DRIVER OF REGENERATIVE PROCESSES Viola Vogel (ETH Zürich, Switzerland)

Invited Speaker

9:55~10:10 : Engineering Extracellular Matrix: Components, Mechanics, and Architecture Pilnam Kim (Korea Advanced Institute of Science and Technology, Korea, Republic of)

10:10~10:25 : Hybrid hydrogel-extracellular matrix scaffolds identify distinct roles of matrix in cardiac aging Jennifer Young (National University of Singapore, Singapore)

10:25~10:40 : Molecular tension-dependent integrin-ligand binding regulates mechanosensitive cell adhesion and migration Dong-Hwee Kim (Korea University, Korea, Republic of)

Oral Presenter

10:40~10:50 : Norbornene-modified decellularized small intestine submucosa as a versatile photo-crosslinkable biomaterial Chien-Chi Lin (Purdue University, USA)

10:50~11:00 : Engineering modular tissues with multiscale hierarchy using mass produced living microbuilding blocks Castro Johnbosco (University of Twente, Netherlands)

Description

Extracellular matrix (ECM), a highly organized complex of macromolecules and signaling factors, directly influences a wide range of cellular responses, such as cell adhesion, proliferation, migration, and differentiation. Cell-ECM interactions are crucial in deciphering cell behaviors but still poorly understood. In particular, ECM stiffness is one of the key factors in regulating cell responses. Stem cells are sensitive enough to recognize their substrate stiffness and subsequently adapt themselves in directing their fate. On the other hand, ECM is also crucial in maintaining tissue homeostasis and tissue regeneration. Uncontrolled ECM biosynthesis is a major source of many pathological diseases, including cancer, fibrotic diseases, and myocardial infarction. ECM is also a very useful biological material in regenerating damaged tissues and organs. In this symposium, we aim to share recent progress of ECM mechanobiology and ECM-based therapeutics. In particular interest, this symposium deals with the reciprocal relationship between ECM mechanics and biology, which hold important implications for mechanotransduction and clinical applications.

Keywords : Extracellular matrix; Mechanobiology; Regeneration

  • Session TrackBioactive materials
  • Session TitleBioenergetic-active Materials for Regenerative Engineering
  • Session CodeSP-T12-0213
  • Date & Time / RoomMay 29 (Wed) 16:30~18:00 / Room 322
Organizer

Jian Yang (Westlake University, China)

Chair

Jian Yang (Westlake University, China)

Vivek Kumar (New Jersey Institute of Technology, USA)

Keynote Speaker

Bioenergetic-active materials in regenerative engineering Shengmin Zhang (Huazhong University of Science and Technology, China)

Invited Speaker

Bioactive Polymeric Micro-Nano Structures for Tissue Repair and Regeneration Sangamesh Kumbar (University of Connecticut, USA)

Modulation of cellular microenvironment for enhanced bioactivities and tissue regeneration Jung Seung Lee (Sungkyunkwan University, Korea, Republic of)

Oral Presenter

: Hierarchically designed 3D printed scaffold for repairing osteochondral interface tissue Yingying Du (Huazhong University of Science and Technology, China)

: Mito-engine equipped with coolant: a bioenergetic hybrid hydrogel for propelling intervertebral disc repair Zhe Wang (West China Hospital of Sichuan University, China)

: A customizable bioenergetic-active scaffold for multi-tissue regeneration Xin Zhang (Huazhong University of Science and Technology, China)

Description

Recent advances in cell metabolism studies have deepened the appreciation of the role of metabolic regulation in influencing cell behavior during differentiation, angiogenesis, and immune response in the regenerative engineering scenarios. Bioenergetic-active material is an emerging class of bioactive materials that present metabolic cues to deliberately guide cell metabolism and subsequent cell behaviors for enhanced regenerative engineering outcomes. Increasing evidence has suggested that engineering the modulation of oxidative metabolism to increase cellular ATP levels could help to address high energetic requirements associated with enhanced anabolic biosynthesis, mitosis, and migration involved in tissue regeneration. Biomaterials that could reprogram cellular bioenergetics through the delivery of metabolic factors, biochemical cues, and biophysical cues to promote tissue remodeling represent the forefront of biomaterials science and regenerative engineering. This symposium will highlight the recent exciting progress in bioenergetic-active biomaterials and their applications in regenerative engineering and will encourage cross-disciplinary collaborations for the development of the next generation of metabolic-regulating biomaterials to address the challenges in tissue repair and regeneration.



Given the nature of the topic, it is expected the symposium will attract a significant number of international participants from various disciplines ranging from chemistry, biology, materials science, medicine, and engineering. This symposium is a platform for promoting the burgeoning new frontiers in biomaterials science and engineering and provides an inclusive networking opportunity to nurture friendship and collaborations for faculty, trainees, and thought leaders from various background.

 

Keywords : cell metabolism, regenerative engineering, biomaterials

  • Session TrackBioactive materials
  • Session TitlePrecision Medicine in Biomaterials Application for Regeneration
  • Session CodeSP-T12-0222
  • Date & Time / RoomMay 29 (Wed) 13:40~15:10 / Room 322
Organizer

Lia Rimondini (Università del Piemonte Orientale, Italy)

Chair

Lia Rimondini (University of Eastern Piedmont, Italy)

Dagnija Loca (Riga Technical University, Latvia)

Keynote Speaker

13:40~14:05 : Dynamic Strategies for Host-Responsive Biomaterials: Functionalization, Integration, and Therapeutic Potential Abhay Pandit (CURAM SFI Research Centre for Medical Devices; University of Galway, Ireland)

Invited Speaker

14:05~14:20 : Deciphering the Intricate Interplay between Peripheral Innervation and Bone Tissue in Health and Disease Meriem Lamghari (Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Portugal)

14:20~14:35 : Multifunctional biomaterials and advanced in vitro bioreactors-based platforms: combining strategies and technologies towards precision medicine Andrea Cochis (University of Eastern Piedmont, Italy)

Oral Presenter

14:35~14:45 : Revolutionizing drug screening: harnessing human protein-based materials for ethical and accelerated in vitro testing Catarina Custódio (Metatissue, Portugal)

14:45~14:55 : Non-alcoholic steatohepatitis modeling with human liver microenvironment-incorporated organoids Su Kyeom Kim (Yonsei University, Korea, Republic of)

Description

Objectives or purposes

Biomaterials are no longer considered innate structures and using functionalisation and biofabrication strategies to modulate the desired response, whether it is a host or implant, is currently an important focus in current research paradigms. Fundamentally, a thorough understanding of the host response will enable us to design appropriate strategies. The input from the host response needs to be weighed in depending on the underlying pathology at a local and systemic level. The first objective of the proposed symposium is to shed light onto the criteria and technologies for the precise selection of the biomaterials for musculoskeletal regeneration according to the patient signature.



In addition, biomaterials themselves provide immense therapeutic benefits, which need to be accounted for in the design paradigm and therefore the symposium aims to present the structural and the functionalisation strategies for the development of scaffolds facing with the innumerable biological processes.



Proposed program and intended audience

The programme includes presentations of: 1) glyco-proteomics and transcriptomics based tools to predict the patient response to biomaterials for  regeneration technologies; 2) glycobiology approach for understanding and engineering supramolecular protein and sugar assemblies in biomaterials functionalization; 3) advanced 3D in-vitro tissue models for pre-clinical or evaluation of biomaterials or their precise application 4) in silico simulation of  biomaterials/biological environment interaction. The intended audience includes material scientists, biologists, clinicians, manufactures.



Expected outcomes and relevance to the main topic of WBC 2024

The symposium will contribute to increase the knowledge on the translational approach in biomaterials development and to arise the discussion about the precision medicine strategies for the development of the next generation scaffolds. The symposium is relevant for WBC main topic No 4,5,6 and 8.

 

Keywords : musculoskeletal regeneration, precision medicine, omics

  • Session TrackBioactive materials
  • Session TitleElastin-based biomaterials
  • Session CodeSP-T12-0237
  • Date & Time / RoomMay 27 (Mon) 16:30~18:00 / Room 322
Organizer

Jose Carlos Rodríguez-Cabello (University of Valladolid, Spain)

Chair

Jose Carlos Rodríguez-Cabello (University of Valladolid, Spain)

Giselle Yeo (University of Sydney, Australia)

Keynote Speaker

16:30~16:55 : Tropoelastin-based biomaterials Anthony Weiss (University of Sydney, Australia)

Invited Speaker

Giselle Yeo (University of Sydney, Australia)

Alvaro Mata (University of Nottingham, United Kingdom)

Oral Presenter

17:25~17:35 : Keratin-mediated Mechanotransduction and its Application to Cell and Tissue Regeneration HyeonJeong Kang (KyungHee University, Korea, Republic of)

17:35~17:45 : Utilizing Recombinant Humanized Collagen Proteins in Advancing Regenerative Medicine Yafang Chen (Sichuan university, China)

17:45~17:55 : In-vitro laboratory models to study pathological calcification Marta Cerruti (McGill University, Canada)

Description

1. Objectives and purposes

The Symposium draws on a blend of established and early-mid career researchers to broadcast the power and application of elastin biomaterials. Elastin is essential for the extension and elasticity of human tissue and is critical for the proper function of arteries, skin, heart and lung. Resident cells interact with dominant elastin component, tropoelastin, through surface integrins, and it is becoming increasingly apparent that this interaction elicits a broad range of pro-repair outcomes. The symposium will educate, interact with, and encourage interactions in this versatile field.



2. Proposed program and intended audience

The audience is primarily researchers working on elastic and/or soft materials. The program comprises a keynote speaker (Weiss), 2 invited speakers (Yeo and Mata), and one or more speakers chosen from submitted abstracts. Speakers are selected with appreciation of a diversity of age, gender, background and science.



3. Expected outcomes and relevance to the main topic of WBC 2024

Expected outcomes are an improved knowledge, utilisation and encouarged collaboration on tropoelastin, elastin- based materials, and peptides based on elastin sequences. These present the opportunity for versatile elastic biomaterials with specific mechanical properties. This will build on recent findings on the mechanisms of promoted repair by tropoelastin reveal a remarkable plethora of MSC, fibroblast, SMC and EC interactions (and more) that utilise sequential intercellular communication. These extraordinary, yet under-appreciated, developments will be expanded in this exciting and very current Symposium.

 

Keywords : Elastin, tropoelastin, elastin-mimics

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WBC 2024 SECRETARIAT

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