Scientific Program

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  • Session TrackBiomaterials for pre-clinical and clinical translation
  • Session TitleClinical and Pre-clinical Application of Biomaterials toward Next-Generation Medicine
  • Session CodeSP-T08-0053
  • Date & Time / RoomMay 31 (Fri) 9:30~11:00 / Room 315
Organizer

Atsushi Mahara (Department of Biomedical Engineering, National Cerebral and Cardiovascular Center Research Institute, Japan)

Chair

Atsushi Mahara (Department of Biomedical Engineering, National Cerebral and Cardiovascular Center Research Institute, Japan)

Yuji Teramura (Cellular and Molecular Biotechnology Research Institute (CMB), National Institute of Advanced Industrial Science and Technology, Japan)

Keynote Speaker

9:30~9:55 : Enhancing kidney transplantation: Addressing ischemia-reperfusion injury through ex vivo cell surface engineering with a novel amphiphilic polymer Alireza Biglarnia (Lund University, Sweden)

Invited Speaker

9:55~10:10 : Development of a high-hydrostatic pressure device for nevus tissue inactivation and dermal regeneration for the treatment of giant melanocytic nevus Naoki Morimoto (Department of Plastic and Reconstructive Surgery, Graduate School of Medicine and Faculty of Medicine, Kyoto University, Japan)

10:10~10:25 : Cell surface engineerinf for transplantation therapy Yuji Teramura (Cellular and Molecular Biotechnology Research Institute (CMB), National Institute of Advanced Industrial Science and Technology, Japan)

Oral Presenter

10:25~10:35 : Hydrogel-delivery of stem cell-derived neurons to repair the injured adult cervical spine Vanessa Doulames (Stanford University, USA)

10:35~10:45 : Pre-clinical evaluation of a new class III biodegradable stent for the treatment of urethral stricture Yurena Polo Arroyabe (Polimerbio SL, Spain)

10:45~10:55 : Development and clinical application of biodegradable silk protein bone screw Yafei Feng (Xijing Hospital, China)

Description

In this session, we will focus on pre-clinical and clinical research mainly and invite worldwide top-level clinical surgeons and basic scientists to discuss the requirements and possibilities of biomaterials for next-generation medicine. In accordance with the WBC's symposia policy, we have invited Prof. Bo Nilsson from Uppsala University, Sweden as a keynote lecturer, Prof. Sarah Heilshorn, from Stanford University, USA, and Prof. Naoki Morimoto, from Kyoto University, Japan as an invited speaker for our symposium proposal who are extremely diverse in terms of gender, geographic location, and clinical and research expertise. This session will be very attractive to all audiences not only academic researchers but also students and industrial and clinical researchers.

[Detail description] Although clinical transplantation of cells, organs, and decellularized tissues has been successful, the availability is still quite limited due to the poor biocompatibility with the host’s immune systems. Therefore, we have worked on the improvement of graft survival with help of biomaterials. To address this issue, we have developed various microencapsulation techniques using biomaterials, and some of them made it possible to improve graft survival. This approach is in the middle of clinical trials, but there are promising clinical outcomes. In addition, biomaterials have been used for the transplantation of organs and decellularized tissues, and some of them are studied in preclinical and clinical trials. By the use of biomaterials, the blood compatibility and vascularization of the graft have been improved. This innovation also opened-up the use of xenograft for human recipients. We would like to invite world-leading researchers working on these issues to discuss the current situation and new prospects for next-generation medicine.

Keywords : Transplantation, Clinical trials, Proof of concept

  • Session TrackBiomaterials for pre-clinical and clinical translation
  • Session TitleRegulatory science for the translation of biomaterials products
  • Session CodeSP-T08-0311
  • Date & Time / RoomMay 28 (Tue) 16:30~18:00 / Room 320-A
Organizer

Kai Zhang (Sichuan University, China)

Chair

Kai Zhang (Sichuan University, China)

Arthur J. Coury (Northeastern University, USA)

Keynote Speaker

Kai Zhang (Sichuan University, China)

Invited Speaker

16:55~17:10 : Regulatory Science for Medical Devices Suping Lyu (Medtronic Inc., USA)

Oral Presenter

17:10~17:20 : A safe-by-design approach for medical implants Anniek Gielen (National institute of public health, Netherlands)

17:20~17:30 : Immunogenicity assessment for swim bladder-derived biomaterials Jing Liu (Institute of Biomedical Engineering, Peking Union Medical College, Chinese Academy of Medical Sciences, China)

17:30~17:40 : The research on key technology for evaluation of soft tissue wound repair materials LI NA (Si chuan university, China)

17:40~17:50 : A low-cost and open-source bio-multimaterial multinozzle 3D printer (BioMM3D) Jonathan Weiss (Stanford University, USA)

17:50~18:00 : Research Status of Nanomaterial Medical Devices and Discussion on Biological Evaluation SUN Lingxiao (Shandong Institute of Medical Device and Pharmaceutical Packaging Inspection, China)

Description

Introductory abstract of a maximum of 300 words that addresses the symposium’s

1) objectives or purposes;

2) Proposed program and intended audience

3) expected outcomes and relevance to the main topic of WBC 2024.



Regulatory science is “the science of developing new tools, standards, and approaches to assess a product’s safety, efficacy, quality, and performance of regulated products”. The process from innovative basic research to successful clinical translation of biomaterials products needs the strong involvement of regulatory science. Innovative biomaterials-based medical products (i.e., “the products”) need to be designated and classified. Whether they are medical devices, combination devices, or drugs need to be appropriately and clearly identified. This classification will determine the future regulatory paths for the products. Preclinical research and evaluations of such products may need to develop new tools, standards and approaches. The design and understanding of the novel tools and methods and the establishment of new standards and guidance documents can strongly impact the regulatory and commercialization processes of the products. Current good manufacturing practice (cGMP) under a robust quality systems regulation (QSR) is required for manufacturing the products. How should the unique characteristics and risk management of the products be regulated under QSR and cGMP? In order to make the clinical translation of the products, clinical evaluations need to be conducted with the appropriate selections of indications, control and primary endpoints. Post-market surveillance along with real-world research of the products would also request strong scientific understanding after successful regulatory approval and market commercialization processes. Presentations with case studies will demonstrate how regulatory science can help the research, development and translation of biomaterials. Special attention should also be paid to the collaboration between regulatory science and biomaterials during the process from their basic research to clinical translation.

Keywords : Regulatory science, biomaterials translation, safety and efficacy

  • Session TrackBiomaterials for pre-clinical and clinical translation
  • Session TitleBiomaterials for cardiovascular disease models and therapeutics
  • Session CodeSP-T08-0071
  • Date & Time / RoomMay 28 (Tue) 9:30~11:00 / Room 320-A
Organizer

Ho-Wook Jun (University of Alabama at Birmingham, USA)

Chair

Ho-Wook Jun (University of Alabama at Birmingham, USA)

Hun-Jun Park (The Catholic University of Korea, Seoul St. Mary Hospital, Korea, Republic of)

Keynote Speaker

9:30~9:55 : Investigating heart development and disease using cardiac organoids Do-Sun Lim (Korea University, Anam Hospital, Korea, Republic of)

Invited Speaker

9:55~10:10 : Pro-healing Nanomatrix Coated Stent Analysis in an In Vitro Vascular Double-Layer System and in a Rabbit Model Ho-Wook Jun (University of Alabama at Birmingham, USA)

10:10~10:25 : Therapeutic potential of 3D cardiac spheroids derived from human pluripotent stem cells for cardiac regeneration Hun-Jun Park (The Catholic University of Korea, Seoul St. Mary Hospital, Korea, Republic of)

10:25~10:40 : Bioengineering human vascular networks for therapeutic applications Juan Melero-Martin (Boston Children's Hospital, USA)

Oral Presenter

10:40~10:50 : Preclinical Evaluation of Cell-Assembled Extracellular Matrix Sheets for Surgical Fallot’s Tetralogy Repair Fabien Kawecki (University of Bordeaux, Inserm BioTis U 1026, France)

10:50~11:00 : Development and characterization of a geometrically-tunable blood shunt for pediatric heart reconstruction Akari Seiner (Drexel University, USA)

Description

This symposium will highlight development and applications of biomaterials for cardiovascular disease models and therapeutics. Preclinical in vitro models are commonly used to evaluate the efficacy and safety of novel therapeutics and cardiovascular devices prior to initiating complicated in vivo and clinical studies. Topics include biomaterials based engineering cardiac tissues, scaffolds, organoids, or organs-on-a-chip for atherosclerosis or any cardiovascular disease models. Therapeutics will include biomaterials based drug delivery, biofabrication, cell therapy, cardiac devices for heart tissue regeneration, vascular grafts, valves, pacemaker, and cardiovascular disease treatments. Audiences will include academics, industry leaders, clinicians, and regulation representatives. It will also provide the networking opportunity among the leaders, emerging leaders, and trainees to spur further collaborations that would benefit members of biomaterials societies. Outcomes will provide new insights on various biomaterials for cardiovascular disease models and therapeutics to better understand and improve human health via different approaches in multi-disciplines.

 

Keywords : cardiovascular disease; cardiovascular devices; heart tissue

  • Session TrackBiomaterials for pre-clinical and clinical translation
  • Session TitleUnderstanding the role of the immune system in tissue generation, repair, and wound healing
  • Session CodeSP-T08-0074
  • Date & Time / RoomMay 30 (Thu) 16:30~18:00 / Room 315
Organizer

Erika Moore (University of Maryland, USA)

Chair

Erika Moore (University of Maryland, USA)

Keynote Speaker

Evan Scott (Northwestern University, USA)

Invited Speaker

16:55~17:10 : Silicate nanoplatelet-based shear-thinning hydrogel for immunotherapeutic agent delivery Hanjun Kim (Korea University, Korea, Republic of)

Oral Presenter

17:10~17:20 : Micro-computed tomographic imaging of foreign body giant cells in tissue engineering scaffold Lucia Baixauli-Marin (University of Oulu, Finland)

17:20~17:30 : Anatomical location and alloy composition-specific immune responses observed from metallic medical implants Jessica Stelzel (Johns Hopkins University, USA)

17:30~17:40 : Immunomodulation of fibroblast and keratinocyte cytokine response on transepithelial implants with peptide nanocoatings Daniel Moreno (International University of Catalonia, Spain)

17:40~17:50 : Anti-inflammatory function-enhancing engineered small extracellular vesicles promote temporomandibular joint regeneration Zhiling Zhang (Nankai University, China)

17:50~18:00 : Incorporating bone-derived extracellular matrix into macroporous microribbon scaffolds for bone regeneration Cassandra Villicana (Stanford University, USA)

Description



The objective of this symposium is to investigate the intersection of biomaterials and immunology in determining tissue regeneration and leverage our expertise to design informed materials for desired immune outcomes. Particular emphasis will be on materials tunable for individualized therapy, biomaterials for studying immunity, and those with strong potential for clinical translation all for various regenerative medicine applications.

The proposed program will encompass 1 invited keynote speaker (25 min), 1 invited speaker (15 min talk), and 3 podium presentations selected from submitted abstracts (15 min each). The program is designed for researchers working on modulating immunity using biomaterials with clinically translational potential. 

Our program encompasses the convergence of different scales of biomaterials from molecular protein engineering to larger-scale biomaterial scaffold development. The primary focus will be on materials that are translatable to the clinic for modulating immunity for tissue regeneration, fitting with the theme of WBC 2024.

Keywords : immunoengineering, tissue regeneration, translational medicine

  • Session TrackBiomaterials for pre-clinical and clinical translation
  • Session TitleClinical Translation of Biodegradable Materials
  • Session CodeSP-T08-0385
  • Date & Time / RoomMay 28 (Tue) 13:40~15:10 / Room 320-A
Organizer

Huinan Liu (University of California, Riverside, USA)

Chair

Huinan Liu (University of California, Riverside, USA)

Yufeng Zheng (Peking University, China)

Keynote Speaker

13:40~14:05 : Technology Development and Translation of Citrate-Based Biomaterials Jian Yang (Westlake University, China)

Invited Speaker

14:05~14:20 : Elastic biodegradable hydrogels for tissue repair Yi Hong (University of Texas at Arlington, USA)

14:20~14:35 : Magnesium Oxide and Magnesium Hydroxide Nanoparticles Disrupted Pseudomonas aeruginosa, Staphylococcus epidermidis, and Staphylococcus aureus Biofilms in vitro Patricia Holt-Torres (University of California, Riverside, USA)

14:35~14:50 : Preparation and biological evaluation of high strength and toughness degradable zinc alloys Lijing Yang (Ningbo Institute of Materials Technology & Engineering, Chinese Academy of Sciences, China)

Oral Presenter

14:50~15:00 : Engineering Bioresorbable Implants and Composites for Medical Applications Huinan Liu (University of California, Riverside, USA)

15:00~15:10 : Biodegradable polymer stents for the treatment of Eustachian tube dysfunction Kerstin Lebahn (Rostock University Medical Center, Germany)

Description

The objective of this 90-minute symposium is to discuss recent progress on preclinical and clinical translation of biodegradable materials, including polymers, metals, ceramics, and composites, for tissue repair, drug delivery, cell therapies, and medical devices and implants.

The 90-minute program will include one keynote speaker and two invited speakers to cover the topics of biodegradable polymers, biodegradable metals, biodegradable composites and devices, and their recent progress toward clinical translation, in the first hour. Rest of the speakers (15 minutes including questions and transition) will be selected from the unsolicited abstract submissions. The target audience will include researchers and development engineers from academia and industry.

The expected outcomes include (1) training of researchers who are interested in clinical translation of biodegradable materials, (2) understanding of the promise, challenges, and key assessment methods for clinical translation of biodegradable materials, and (3) sharing experience, success stories, and wisdom in developing clinical translation pathways in different countries.

Keywords : Biodegradable polymers, metals, and composites

  • Session TrackBiomaterials for pre-clinical and clinical translation
  • Session TitleGelatin and collagen based biomaterials: advances towards pharmaceutical and clinical translation of tissue biofabrication
  • Session CodeSP-T08-0171
  • Date & Time / RoomMay 31 (Fri) 9:30~11:00 / Room 320-A
Organizer

Jos Olijve (Rousselot Biomedical, Netherlands)

Chair

Riccardo Levato (University Utrecht, Department of Biofabrication and Regenerative Medicine, Netherlands)

Jos Olijve (Rousselot Biomedical, Netherlands)

Keynote Speaker

9:30~9:55 : Gelatin methacryloyl (GelMA): A versatile material for tissue engineering and regenerative medicine applications Ali Khademhosseini (Terasaki Institute, USA)

Invited Speaker

9:55~10:10 : Enhancing performance as a corneal adhesive restorative material: Development of photocurable cornea-derived decellularized extracellular matrix hydrogels with gelatin methacryloy Juyoung Park (BioBricks, Korea, Republic of)

10:10~10:25 : Gelatin advances and clinical translation of tissue biofabrication, the endotoxin story. Jos Olijve (Rousselot Biomedical, Netherlands)

10:40~10:55 : Oxygen-generating Tissue Adhesives for Wound Management Kyung Min Park (Incheon National University, Korea, Republic of)

Hee-Gyeong Yi (Dept. of Convergence Biosystems Engineering/Chonnam National University, Korea, Republic of)

Oral Presenter

10:55~11:05 : Lyophilized platelet concentrate collagen composite scaffold for hard tissue regeneration NURUL AIDA NGAH (Universiti Teknologi MARA, Malaysia)

11:05~11:15 : Advantages of photo-curable collagen-based cell-laden bioinks compared to methacrylated gelatin (GelMA) in digital light processing (DLP) and extrusion bioprinting Huimin Shi (Zhejiang University, China)

Description

The symposium will constitute a forum to highlight and discussing the role of gelatin and collagen requirements; tunability and degree of purity, as key aspects towards reproducible and effective research and translational opportunities of biomaterial based devices for current and future healthcare applications.

The exponential growth in the biofabrication field, involving (cell-laden) biomaterials design in combination with automated bioassembly and bioprinting technologies, is creating new opportunities for patient specific regenerative implants and diagnostic tools such as organ-on-chip technologies.

Commercially available pharmaceutical and clinical grade biomaterials are essential for the clinical translation of these technologies and so the future of healthcare.

Biomaterials extracted from the extracellular matrix (ECM), such as gelatins and collagens are favorable biomaterials due to their biocompatibility, biodegradability, tunability, cell-interactivity and longstanding use in pharmaceutics. It has been demonstrated that the ECM steer cell and tissue function in relation to mechanical properties and 3D architecture. Gelatins and collagens can be tuned based on molecular weight and chemical modification to create tissue like constructs which are important for (pre)clinical and pharmaceutical translations like drug testing or disease modelling. Additionally purity requirements for such biomaterials are paramount, both in effective research, and in the translation towards clinical and pharmaceutical use.

The symposium will be of interest for biomaterial chemists, engineers, bioprinting researchers, pharmaceutical industry specialists and physicians, and will be opened by a keynote lecture from Prof. Ali Khademhosseini (Terasaki Institute, USA), who contributed to the development and commercialization of several gelatin-based devices for healthcare. Invited talks will cover key aspects of innovation in collagenous materials, from material sourcing, modification, biofabrication, purity requirements, as well as applications in disease modelling and organ-on-chip models. The program will be complemented by podium presentations from selected abstracts submitted.

Keywords : gelatin, clinical-translation, biofabrication

  • Session TrackBiomaterials for pre-clinical and clinical translation
  • Session TitleClinical application of biomaterials in Orthopaedic field
  • Session CodeSP-T08-0198
  • Date & Time / RoomMay 29 (Wed) 9:30~11:00 / Room 320-A
Organizer

Ji-Hoon Bae (Department of Orthopaedic Surgery, Korea University Guro Hospital, Korea, Republic of)

Chair

Hyung Bin Park (Gyeongsang National University, Korea, Republic of)

Hongsik Cho (1) Dept. of Orthopaedic Surgery, UTHSC-Campbell Clinic 2) VA Medical Center, USA)

Keynote Speaker

Hongsik Cho (1) Dept. of Orthopaedic Surgery, UTHSC-Campbell Clinic 2) VA Medical Center, USA)

Invited Speaker

9:55~10:10 : Development of Scaffold-free Three-dimensional Tendon Construct Using Mouse Tendon Cells Kyu Sang Joeng (McKay Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, USA)

10:10~10:25 : Clinical Application of Polydeoxyribonucleotide for Shoulder and Elbow Diseases Jung-Taek Hwang (Department of Orthopedic Surgery, Cuncheon Sacred Heart Hospital, Hallym University Medical College, Korea, Republic of)

Oral Presenter

10:25~10:35 : Mechanical properties and bone regeneration ability of additively manufactured trabecular porous tantalum scaffolds Jiaxiang Wang (Qingdao University of Technology, China)

10:35~10:45 : In vivo studies of an innovative 3D printed device for articular cartilage regeneration Xinyu Li (Imperial College London, United Kingdom)

10:45~10:55 : Internal fixation with biodegradable high purity magnesium screw in the treatment of ankle fracture tianwei Zhang (Dalian university,China, China)

Description

In this symposium, we will discuss about 'clinical application of biomaterials in Orthopaedic field' as follows.

1) The core of orthopaedic research lies at the intersection of fundamental biomedical science and clinical applications. In terms of theranostic target delivery, we focus on optimizing target nanosome systems using animal imaging techniques and developing animal models for posttraumatic osteoarthritis. Through collaboration with fellow researchers, I aim to apply my findings in the field of targeted drug therapy, fluorescent diagnostic methods, and stem cell-based implantation techniques. The re-discovery of theranostic nano-techniques for cartilage repair will open new avenues for improving existing tissue engineering technology and will create new strategies for developing treatment options in the field of orthopaedic research.

2) Three-dimentional tendon constructs are engineered tissue structures that mimic the structure and function of natural tendons. In our lab, we developed a scaffold-free, three-dimensional (3D) tendon culture system using mouse tendon cells and a differentially adherent growth channel. Our 3D tendon culture system is a reliable in vitro system to study underlying mechanisms that regulate cellular and matrix maturation in tendon. The application of this construct in clinical treatment will be the future direction of this study.

3) Polydeoxyribonucleotide (PDRN) is a tissue regeneration activator that is composed of a mixture of nucleotides and activates adenosine A2A receptors, stimulating vascular endothelial growth factor (VEGF) expression and the activity of fibroblast. We had performed two clinical trials to verify of the effect of PDRN on tendon healing of rotator cuff tear and lateral epicondylitis. The results suggest that PDRN might improve tendon healing and fatty degeneration in arthroscopic rotator cuff repair, and exercise with counter force brace (EX) combined with PDRN might exhibit a greater improvement than EX only or EX combined with extracorporeal shockwave therapy for lateral epicondylitis.

Keywords : Nanosomes, 3D tendon construct, Polydeoxyribonucleotide

  • Session TrackBiomaterials for pre-clinical and clinical translation
  • Session TitleTranslation of nanoplatforms for surgical applications
  • Session CodeSP-T08-0242
  • Date & Time / RoomMay 30 (Thu) 16:30~18:00 / Room 320-A
Organizer

Alicia El Haj (University of Birmingham, United Kingdom)

Chair

Alicia El Haj (University of Birmingham, United Kingdom)

Mohd Fauzi MH Busra (Universiti Kebangsaan Malaysia, Malaysia)

Keynote Speaker

16:30~16:55 : Using multidisciplinary science to drive healthcare innovations Molly Stevens (Imperial College London, United Kingdom)

Invited Speaker

Ken Dawson (University College Dublin, Ireland)

17:10~17:25 : Antibacterial-coated collagen biomatrix for future use in diabetic wound care Mohd Fauzi MH Busra (Universiti Kebangsaan Malaysia, Malaysia)

17:25~17:40 : Development of Durable and Facile Anti-Biofouling Coating: Lynk Coating for Biomedical Implants Jungmok Seo (Yonsei Univ. / Lynk Solutec Inc., Korea, Republic of)

Oral Presenter

17:40~17:50 : Silver/strontium co-incorporated mesoporous silica nanoparticles-loaded polylactic acid electrospun fibers for bone tissue engineering Zhang Yuhan (NWPU, China)

17:50~18:00 : Tumor ultrasound-switchable fluorescence imaging for pre-clinical applications Baohong Yuan (University of Texas at Arlington, USA)

18:00~18:10 : Nature-inspired nanoparticles for therapeutics and vaccine delivery Hao Song (Massachusettes Institute of Technology, USA)

Description

Nanoparticles have been developed in many formulations ranging from polymer to magnetic in nature. Recently these approaches have been used to create further complexity in cell delivery and tissue engineered scaffolds applications by creating hybrids which provide further benefits. The particle approaches can be for tagging and activation as well as release and structural ECM cues. In addition, the use of biomaterials integrated with nanoparticles can define additional properties such as antioxidant, angiogenic, and anti-inflammatory, to be used as implantable and injectable bioscaffolds.  These approaches can provide a permanent replacement for a tissue defect as well as deliver biological compounds into the repair site. However, a balance of safety and efficacy is an important consideration to allow for the translation of biomaterials to medical devices. Hence, rational design and development of nano and complex biomaterials requires further understanding before future preclinical and clinical applications can be delivered for improving patients’ health and life.  This workshop will present the’ state of the art’ for this field and consider how the route to the clinic can be improved and defined more clearly to facilitate the translation of more products. The topic will be relevant to academics and industry who are developing new nanoplatforms for the future.

 

Keywords : nanoparticle translation surgery

  • Session TrackBiomaterials for pre-clinical and clinical translation
  • Session TitleOsteonecrosis: The Biology and Treatment with Implants, Biologics, and Cells
  • Session CodeSP-T08-0248
  • Date & Time / RoomMay 30 (Thu) 13:40~15:10 / Room 320-A
Organizer

Lynne Jones (Johns Hopkins University School of Medicine, USA)

Chair

Shin-Yoon Kim (Kyungpook National University, Korea, Republic of)

Keynote Speaker

13:40~14:05 : Pathology, Diagnosis, and Clinical Aspects of Osteonecrosis: A Comprehensive Overview Nobuhiko Sugano (Osaka University Graduate School of Medicine, Japan)

Invited Speaker

Seung-Hoon Baek (Kyungpook National University, Korea, Republic of)

14:20~14:35 : The use of cells and biologics for treatment of early stage ONFH Stuart Goodman (Stanford University, USA)

Oral Presenter

14:35~14:45 : Composite elastin derivative-based hydrogel designed for promoting bone formation, vascularization, and innervation: In vivo evaluation in ectopic and heterotopic model Micaela ROQUE (Bioingénierie Tissulaire (BioTis), Université de Bordeaux - Inserm U1026, France)

14:45~14:55 : Engineering Bio-inspired Materials for Multicellular-Mediated Bone Regeneration Ching-Chang Ko (Ohio State University, USA)

14:55~15:05 : 3D printed synergistic graphene citrate composite scaffold for craniofacial bone reconstruction Mirae Kim (Northwestern University, USA)

Description

The goal of this symposium is to inform the audience about the past, present, and future treatment of osteonecrosis, a disorder of the major joints characterized by lesions of dead bone and interrupted blood circulation. This panel discussion features world renown experts in the field of osteonecrosis reviewing the clinical  aspects of the condition as well as important developments and outcomes of preclinical and translational studies for treatment, including scaffolds, cell therapy, and biologics. The symposium will be of interest to biomaterials scientists, bioengineers, biologists and clinicians. The audience will better understand the need for novel treatments for osteonecrosis and the vision for a biological approach.

 

Keywords : osteonecrosis, cell-based therapy, bone scaffold

  • Session TrackBiomaterials for pre-clinical and clinical translation
  • Session TitleCraniofacial tissues and implants
  • Session CodeSP-T08-0107
  • Date & Time / RoomMay 31 (Fri) 11:20~12:50 / Room 320-A
Organizer

Do-Gyoon Kim (Ohio State University, USA)

Chair

Do-Gyoon Kim (Ohio State University, USA)

Hiroshi Kamioka (Okayama University, Japan)

Keynote Speaker

11:20~11:45 : Dental Implants: from titanium to zirconia Jung Suk Han (Seoul National University, Korea, Republic of)

Invited Speaker

11:45~12:00 : Engineering Bio-inspired Materials for Multicellular-Mediated Bone Regeneration Ching-Chang Ko (The Ohio State University, USA)

12:00~12:15 : In vitro synthesis of artificial bone tissue that reproduces a three-dimensional hierarchical structure Takuya Matsumoto (Okayama University, Japan)

12:15~12:30 : Advances in mesenchymal stem cell spheroid research: Enhancing biological function and therapeutic potential in regenerative medicine Jun-Beom Park (The Catholic University of Korea, Korea, Republic of)

Oral Presenter

12:30~12:40 : Potential of neodymium-Iron-boron magnets in aligner therapy Toru Deguchi (University of Louisville, USA)

12:40~12:50 : Promoting craniofacial regeneration using biomaterials and epigenetics  Christine Hong (UCSF, USA)

Description

Biomaterials in dentistry include craniofacial tissues (bone, tooth, muscle, tendon, ligament, cartilage, and other soft tissues), metals and ceramics for dental implants, and polymers for scaffold. A primary role of the craniofacial tissues is to bear loads during mastication, control movement of the jaw, and maintain facial shape. Each component is composed at the multiple length scale of molecules (nanometers), cells (micrometers), and tissues (millimeters). Cells are responsible for providing molecules that are used for building blocks of tissues. At the organ scale, ligaments connect between bones or teeth and bones while tendon bridges bones to muscles. Cartilage lubricates and protect articulating surfaces of bones at a temporomandibular joint. Loads applied during daily activities transmit through these multiscale components of craniofacial system. However, mechanistic and biological links of these multiscale components has not been fully understood. Implantation is needed to treat tooth loss, orthodontic anchorage, or critical size defects in the craniofacial tissues. The dental implants including temporary anchorage devices and scaffolds are fabricated using foreign materials. As such, biocompatibility and stability at the interface between implanted materials and surrounding tissues are of importance in determining an immediate and long-term success following implantation. A pre-clinical animal model is necessary to validate an efficacy of the implantation for clinical translation. Knowledge accumulated through multiscale characterization of the craniofacial tissues can be directly applied to evaluate success of the implant system. A clinical evaluation provides practical information to improve the existing implant systems and develop a novel approach. Taken together, this symposium aims to provide up-to-date information on multiscale characterization of craniofacial tissues and implants in vitro, the pre-clinical models and clinic.

Keywords : Bone, Dental biology, Dental Implant

  • Session TrackBiomaterials for pre-clinical and clinical translation
  • Session TitleUp-to-date technology in periodontal tissue engineering
  • Session CodeSP-T08-0115
  • Date & Time / RoomMay 30 (Thu) 9:30~11:00 / Room 320-A
Organizer

Jeong-Ho Yun (College of Dentistry, Jeonbuk National University, Korea, Republic of)

Chair

Jeong-Ho Yun (College of Dentistry, Jeonbuk National University, Korea, Republic of)

Takanori Iwata (Tokyo Medical Dental University, Japan)

Keynote Speaker

9:30~9:55 : Various methods and effects of BMP application in tissue-engineered periodontal tissue and alveolar bone regeneration Jeong-Ho Yun (College of Dentistry, Jeonbuk National University, Korea, Republic of)

Invited Speaker

9:55~10:10 : Periodontal regeneration with periodontal ligament-derived mesenchymal stromal cell sheets Takanori Iwata (Tokyo Medical Dental University, Japan)

10:10~10:25 : Periodontal tissue regeneration by transplantation of autologous adipose tissue-derived multi-lineage progenitor cells Masahide Takedachi (Osaka University Dental Hospital, Japan)

10:25~10:40 : Multifunctional barrier membrane systems for periodontal tissue regeneration Josephine Wong (Collagen Solutions, United Kingdom)

Oral Presenter

10:40~10:50 : A hybrid 3D printed scaffold loaded with macrophages for immune-mediated periodontal regeneration Jinhui Huang (Kunming Medical University, China)

Description

Periodontitis is a chronic oral Inflammatory disease which accompanies the loss of periodontal tissues (alveolar bone, periodontal ligament, cementum) by oral causative bacteria. The reestablishment of damaged tooth-supporting complex should contain the intricate regenerations of unique tissues and functional regeneration of periodontal apparatus is one of the most important aims of research in current periodontal regenerative therapy.

To achieve an advanced reconstruction of lost periodontal tissue, various regenerative techniques have been evaluated: guided tissue regeneration (GTR) with barrier membranes and graft materials, cytokine therapy using growth factors, and cell therapy by various kinds of cells, etc. Nevertheless, current techniques have still challenging limitations for tooth-supporting structure neogenesis because the ideal periodontal regeneration, which means the formation of new cementum and the functional insertion of periodontal ligament fibers into it, has not been achieved with satisfaction until now. In an effort to overcome these limitations, new approaches using additional signaling molecules and cells have been introduced and are recently underway.

The purpose of this international joint symposium is to develop the novel therapeutic strategy for periodontal tissue regeneration using various tissue engineering techniques with clinical/pre-clinical scenarios.

This symposium can critically propose the next therapeutic milestone in periodontal tissue engineering and regenerative medicine for better life qualities of dental patients. Through this symposium, we are able to establish strong network with world-renowned research groups to create advanced therapeutic technologies and exchanging/sharing translational knowledges. Moreover, it is possible to create new opportunities for possible international cooperative/collaborative research projects.

Keywords : Dentistry, Periodontal regeneration, Tissue engineering

  • Session TrackBiomaterials for pre-clinical and clinical translation
  • Session TitleClinically relevant dental biomaterials
  • Session CodeSP-T08-0116
  • Date & Time / RoomMay 27 (Mon) 14:40~16:10 / Room 320-A
Organizer

Jae-Sung Kwon (Yonsei University College of Dentistry, Korea, Republic of)

Chair

Jae-Sung Kwon (Yonsei University College of Dentistry, Korea, Republic of)

James Tsoi (Hong Kong University, Hong Kong SAR, China)

Keynote Speaker

14:40~15:05 : Titania Nanotube Applications in Dentistry: Innovations and Perspective Seung Han Oh (Wonkwang University, Korea, Republic of)

Invited Speaker

15:05~15:20 : Colourization of zirconia using photons James Tsoi (Hong Kong University, Hong Kong SAR, China)

15:20~15:35 : Developing symbiotic bio-interaction with dental materials for oral health improvement Utkarsh Mangal (Yonsei University College of Dentistry, Korea, Republic of)

Oral Presenter

15:35~15:45 : Urchin-like fluorohydroxyapatite coating on sulfonated PEEK implants with antimicrobial activity and osseointegration properties Ning Huang (College of Stomatology, Shanghai Jiao Tong University; Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, China, China)

15:45~15:55 : Particle release from dental implants and the potential of bioactive glass in implant dentistry Siwei Li (VSS Academy Training and Education Ltd, Imperial College London, United Kingdom)

15:55~16:05 : Enhancing osteogenesis and bacteriostatic properties through a strontium-doped coating inspired by mussel byssus cuticle Jinsong Liu (Wenzhou Medical University, China)

16:05~16:15 : Self-Assembling Antimicrobial Titanium Implant Coatings for Enhanced Osseointegration Zhou Ye (The University of Hong Kong, Hong Kong SAR, China)

Description

Due to aging population and advancement of technologies in digital dentistry such as 3D printing and CAD/CAM, translational research of dental biomaterials from pre-clinical studies to clinical application has been rapidly evolving. The objective of this symposium is to consider dental biomaterials research that are relevant in clinical fields.

 Proposed program will consist of chairs and speakers who are dental clinician, medical doctor, and basic scientist. With audience who would be interested in both pre-clinical and clinical science to dental biomaterials and biomaterials, the program will discuss current and prospective development of clinically relevant biomaterials such as bioactive, antibacterial and biofouling biomaterials for the dental medical devices.

 The symposium will provide opportunity to share state of the art knowledge and research outcomes from such dental biomaterials while allowing buildup of networks between researchers working on pre-clinical studies to clinical studies. Finally, the symposium will allow convergence of many different aspects of dental biomaterials such as conventional dental materials, 3D printing, esthetic materials etc., for provision of improved dental healthcare in the future, which will be in line with the main theme of WBC 2024.

Keywords : Dentistry, Dental Materials, Translational Research

  • Session TrackBiomaterials for pre-clinical and clinical translation
  • Session TitleBiomaterials in Stomatology Application and Clinical Translation
  • Session CodeSP-T08-0243
  • Date & Time / RoomMay 29 (Wed) 16:30~18:00 / Room 320-A
Organizer

Xinquan Jiang (College of Stomatology, Shanghai Jiao Tong University, China)

Chair

Xinquan Jiang (College of Stomatology, Shanghai Jiao Tong University, China)

Hala Zreiqat (Biomaterials and Tissue Engineering Research Unit, School of Biomedical Engineering, Faculty of Engineering University of Sydney, Australia)

Keynote Speaker

16:30~16:55 : New strategies for oral and maxillofacial tissue regeneration and it’s translation application Xinquan Jiang (College of Stomatology, Shanghai Jiao Tong University, China)

Invited Speaker

16:55~17:10 : Revolutionizing Bone Tissue Regeneration: Innovations in Nanostructured 3D-Printed Biomaterials for Personalized Healing and Anti-Senescence Strategies Hala Zreiqat (Biomaterials and Tissue Engineering Research Unit, School of Biomedical Engineering, Faculty of Engineering University of Sydney, Australia)

17:10~17:25 : Design and fabrication of silk fibroin biomaterials for dental medicine Shengjie Ling (Shanghaitech University, China)

Oral Presenter

17:25~17:35 : Hybrid dental biomaterials comprise hDPSC potential for dental pulp regeneration Azam Ali (University, New Zealand)

17:35~17:45 : Development of a multifunctional chitosan-catechol-based hydrogel for in situ dental applications Maud Viallon (Laval University, Canada)

17:45~17:55 : Concept, synthesis, and bio-evaluation of biostable and clinically-translatable dental restoratives Zach Gouveia (University of Toronto, Canada)

Description

With the theme of "Opportunities and challenges coexist, Characteristics and innovation advance together", this topic will focus on the basic research and translational application of biomaterials in stomatology (dentistry). Well-known experts and scholars in the field will be invited and a large number of distinguished young scientists, entrepreneurs and people of insight will be gathered to discuss the characteristics and future trends of this special field. This topic aims to build a communication platform for "New ideas, New technologies and New progress", and actively boost the rapid development of advanced biomaterials in stomatology. 

Keywords : Biomaterials; Stomatology; Clinical translation

  • Session TrackBiomaterials for industrial applications
  • Session TitleBiomaterials' challenges: From academia to industry
  • Session CodeSP-T09-0320
  • Date & Time / RoomMay 28 (Tue) 16:30~18:00 / Room 320-B
Organizer

Sandra Van Vlierberghe (Ghent University, Belgium)

Chair

Sandra Van Vlierberghe (Ghent University, Belgium)

Insup Noh (Seoul National University of Science and Technology, Korea, Republic of)

Keynote Speaker

16:30~16:55 : From BIO INK to BIO INCorporation: the launch of BIO INX Jasper Van Hoorick (BIO INX, Belgium)

Invited Speaker

16:55~17:10 : Taking exosome therapeutics from academia to industry Yong Woo Cho (Hanyang University, Korea, Republic of)

17:10~17:25 : Academia, Start-Ups, CDMOs, CROs and Strategics: The challenge of translating innovative biomaterials to the clinic Chris Wattengel (Collagen Solutions, United Kingdom)

Oral Presenter

17:25~17:35 : Evaluating Global Participation in Biomaterials Science: Addressing Disparities in Authorship and Editorial Boards Ana Maria Porras (University of Florida, USA)

17:35~17:45 : Double network bioadhesives for tissue adhesion Terry Steele (Nanyang Technological University, Singapore)

17:45~17:55 : The Impact of Salt on the Skin Adhesion Properties of Cosmetic Acrylic Polymer Gels Jihoon Ha (Kolmar Korea, Korea, Republic of)

Description

In recent years, there have been tremendous advances in the fields of biomaterials’ design as well as 3D bioprinting and biofabrication. Nevertheless, a large part of conducted research output remains in academia and never makes it to the clinic. This is in part related to a lack of standardization and reproducibility of biomaterials and associated protocols. Many companies are focusing on the development of 3D-printing hardware which enables the creation of biomaterial-based patient-specific implants and medical devices. More recently, also industrial efforts have emerged regarding the  commercialization of available biomaterials and bio(material) ink formulations. Especially, when targeting high resolution, light-based technologies have gained increasing interest.

The keynote lecture will be focussing on the spin-off BIO INX. BIO INX was launched in April 2022 focusing on the commercialization of highly performing bioinks serving multiple printing technologies going from low to high resolution. In this respect, a lot of aspects had to be taken into consideration, which are typically overlooked when working in academia.

The proposed symposium will address all contributions involving industrial translation of academic findings. We aim to address both early career PhD students, post-doctoral researchers, but also clinicians, policy makers and industry to find out about the journey from academic researcher to entrepreneur, and getting insight in the needs for successful industrial translation to happen. We envision that our symposium will inspire academic researchers to become more active in translational efforts. In addition, the proposed symposium will form an excellent base for networking between scientists and industry which will give rise to the establishment of novel collaborations and at the same time, will ensure that biomaterials’ researchers will consider the need for industrial translation at all times throughout a developmental trajectory pursued in academia. The symposium thus seamlessly fits the overall theme of WBC featuring convergence in biomaterials.

 

Keywords : SME, industrial translation of biomaterials

  • Session TrackBiomaterials for industrial applications
  • Session TitleBiodegradable Metals for Medical Devices
  • Session CodeSP-T09-0157
  • Date & Time / RoomMay 29 (Wed) 9:30~11:00 / Room 320-B
Organizer

Diego Mantovani (Laval University, Canada)

Chair

Yufeng Zheng (Peking University, China)

Diego Mantovani (Laval University, Canada)

Keynote Speaker

9:30~9:55 : Biodegradable metals advance into clinical applications Frank Witte (Berlin Charite Research Center - Dental Schoool, Germany)

Invited Speaker

9:55~10:10 : Synthesis of Inorganic nanomaterials for Soft Bioelectronics SangIhn Han (Center for Biomaterials, Biomedical Research Division, Korea Institute of Science and Technology, Korea, Republic of)

10:10~10:25 : In vitro and in vivo assessment of biodegradable metals Regine Willumeit-Romer (Helmholtz-Zentrum Hereon GmbH, Germany)

Oral Presenter

10:25~10:35 : Bio-integrative Fixation Implants: Post-Market Clinical Evaluation of 9,851 Cases Orahn Preiss-Bloom (OSSIO Ltd, Israel)

10:35~10:45 : HEALING OF BONE, AND ENHANCED JOINT FIXATION, WITH A NOVEL ADHESIVE, PHOSPHOSERINE CALCIUM PHOSPHATE, IN-VIVO & EX-VIVO Philip Procter (Uppsala University, France)

10:45~10:55 : In vivo studies of additive manufactured bioabsorbable magnesium/zinc scaffolds Donghui Zhu (Stony Brook University, USA)

Description

Context

Metallic biodegradable alloys constitute a new class of biomaterials for temporary support for reparative and regenerative medicine. They represent a paradigm shift in biomaterials science and engineering, mainly because the degradation of the alloy, under controlled mechanisms, constitutes the expected event after implantation, even stimulating the healing process. Mainly composed of Fe, Mg or Zn, their successful implantation involves their complete absorption and elimination by the surrounding tissue and the body. Mg-based alloys constitutes the most clinically translated bioabsorbable metal. A small dozen of clinical products are on the market available for clinicians in Europe, Asia and Latino-America while few others are today following the FDA regulatory process. 



Objectives

This Symposium will highlight the rationale behind the development of biodegradable and bioresorbable alloys, present the requirements for their use and implantation, and, finally, discuss outcomes and their clinical relevance.



Proposed program (90 min)

Introductive remarks (5min, co-chairs)

One keynote (30 min), Dr Frank Witte (Germany)

Two invited (20 min each - total 40 min), Dr Hyung-Seop Han (South Korea) and Dr Regina Willumeit-Romer (Germany)

One regular talk (10 min, from the submitted abstracts, for example Dr Julietta Rau, National Research Council if Italy or Dr Lily Tan, Metals Research Chinese Academy of Science)



Intended audience

Young and experienced biomaterialists, industrials, regulatory officers, clinicians and other scientists keen to rapidly acquire a broad and unbiased vision in the rapidly growing field of biodegradable metals.



Expected outcomes and relevance to the main topic of WBC 2024

The idea behind this symposium will be to provide a balanced analysis of the potential that this new family of biomaterials may, or may not, represent for the future of medical treatments. This symposium on biodegradable metals will complete and extend WBC2024 topics, adding value to the event.



 

Keywords : Bioresorbable metals, Magnesium alloys, Iron alloys

  • Session TrackBiomaterials for industrial applications
  • Session TitleBiomedical technology based on rheology
  • Session CodeSP-T09-0140
  • Date & Time / RoomMay 28 (Tue) 13:40~15:10 / Room 320-B
Organizer

Jun Dong Park (Sookmyung Women's University, Korea, Republic of)

Chair

Atsushi Matsumoto (University of Fukui, Japan)

Jun Dong Park (Sookmyung Women's University, Korea, Republic of)

Keynote Speaker

13:40~14:05 : Polymer Lung Surfactant: A Novel Synthetic Therapy for Respiratory Distress Syndrome You-Yeon Won (Purdue University, USA)

Invited Speaker

14:05~14:20 : Development of Human Skin Model: Evaluation of Antibiotic Treatment and Transdermal Absorption Jae Jung Kim (Hongik University, Korea, Republic of)

14:20~14:35 : Understanding rheological behavior of thixotropic fluids during swallowing Seon Yeop Jung (Dankook University, Korea, Republic of)

Oral Presenter

14:35~14:45 : New methodological insights into supply-agnostic control of collagen slurry rheology Emma Gough (University of Cambridge, United Kingdom)

14:45~14:55 : Rheology of entangled polyelectrolyte solutions in the semidilute regime studied by diffusing wave spectroscopy microrheometry Atsushi Matsumoto (University of Fukui, Japan)

Description

 The vast majority of biomaterials, both during the production process and when they are finally put to use, manufactured and applied in the forms of fluids and other kinds of soft matter. This symposium will cover a subject of the flow and deformation of various soft matter and fluids, including hydrogel, cosmetics, and biomedical materials, along with relavant physical and chemical aspects. In the keynote talk, topics including polymer lung surfactant for the treatment of acute respiratory syndrome and radioluminescent nanoparticles for enhancement of cancer radiotherapy are going to be covered. Invited talks will focus on the application of microfluidics for the identification of diseases as well as the treatment of dysphagia using rheological property of food, especially thixotropy. It is anticipated that participants who are interested in the control of manufacturing processes and the development of the performance of products thorugh the tuning of the rheological properties of biomaterials will benefit from attending this symposium.

Keywords : Soft material, Rheology, Cosmetic and biomedical applications

  • Session TrackBiomaterials for industrial applications
  • Session TitleMicro- and Nanotechnology for clinical diagnostics
  • Session CodeSP-T09-0367
  • Date & Time / RoomMay 27 (Mon) 13:00~14:30 / Room 320-B
Organizer

Jinmyoung Joo (Ulsan National Institute of Science and Technology, Korea, Republic of)

Chair

Joo Hun Kang (Ulsan National Institute of Science and Technology, Korea, Republic of)

Ester J. Kwon (University of California San Diego, USA)

Keynote Speaker

13:00~13:25 : Bioengineering Synthetic Biomarkers for Earlier Cancer Detection Gabe Kwong (Georgia Institute of Technology, USA)

Invited Speaker

13:25~13:40 : Activity-based nanosensors for calpain activity as biomarkers in traumatic brain injury Ester J. Kwon (University of California San Diego, USA)

Oral Presenter

13:40~13:50 : Nanomaterials enabled microfluidic chip for nucleic acid detection without pre-extraction  Yu Zhang (Shandong University, China)

13:50~14:00 : Lab-in-a-fiber (LiF) device for detection and capturing of cancer cells João Carlos Varela (KTH Royal Institute of Technology/Science for Life Laboratory, Sweden)

14:00~14:10 : Putrescine binding mechanism with Human Serum Albumin Vida Dehghan Niestanak (University of Alberta, Canada)

14:10~14:20 : Metal-Organic Framework-Based Nanozymes for Colorimetric Detection of Alzheimer's Disease Biomarker Qingqing Fan (University of New South Wales, Australia)

14:20~14:30 : A CRISPR/Cas fluorescence aptasensor for the rapid and sensitive detection of ampicillin Minhaz Uddin Ahmed (Universiti Brunei Darussalam, Brunei Darussalam)

Description

This session aims to provide leading scientists working in the fields of micro/nanotechnology for biomedical diagnostics with robust common platforms. This symposia will share and discuss the latest research and promote the advancement of micro/nanotechnology with functional diagnosis.

Keywords : biosensor, diagnostics, nano-biotechnology

  • Session TrackBiomaterials for industrial applications
  • Session TitleBiomaterials-based startups for tissue engineering
  • Session CodeSP-T09-0103
  • Date & Time / RoomMay 29 (Wed) 13:40~15:10 / Room 320-B
Organizer

Insup Noh (Seoul National University of Science and Technology, Korea, Republic of)

Chair

Insup Noh (Seoul National University of Science and Technology, Korea, Republic of)

Xiumei Wang (Tsingua University, China)

Sandra Van Vlierberghe (Ghent University, Belgium)

Keynote Speaker

13:40~14:05 : Control of in situ bioprinting for even cell distribution and mechanical properties of tissue engineering scaffold by 3D bioprinting pen Insup Noh (Seoul National University of Science and Technology, Korea, Republic of)

Invited Speaker

14:05~14:20 : Colon-targeted S100A8/A9-specific peptide systems ameliorate colitis and colitis-associated colorectal cancer in mouse models Chul-Su Yang (Hanyang University, Korea, Republic of)

Oral Presenter

14:20~14:30 : Multifunctional aligned nanofiber hydrogels deliver multimodal cell-regulatory signals for nerve regeneration Xiumei Wang (Tsinghua University, China)

14:30~14:40 : Microfluidic bioreactors for the sustainable development of local drug delivery systems William Oates (University of Manchester, United Kingdom)

14:40~14:50 : Flow-based downstream processing of in vitro transcribed mRNA and comparative assessment Vikas Sharma (Pohang University of Science and Technology, Korea, Republic of)

14:50~15:00 : PHAsT: revolutionizing medical devices Andrea Mele (University of Sheffield, United Kingdom)

15:00~15:10 : Has Determination of Biocompatibility Been Hijacked? Biomaterial Scientists Take Heed Elaine Duncan (Paladin Medical, Inc. & Adjunct Professor, F. Joseph Halcomb III, M.D. Department of Biomedical Engineering Pigman College of Engineering, University of Kentucky, USA)

Description

1) Objectives or purposes

Obhectives of this session is to introduce academic-based startup companies and their biomaterials technologies from the new companies with less than 3 years history after setups. 



2) Proposed program and intended audience

Proposed program:

- The program title is biomaterials-based startups.

- The company should be recently setup (e.g. within 3 years).

- presentation content is startup-related issues such as biomaterials, technlogies, applications, markets such as medical devices and tissue engineering and others, and other issues in approval from FDA, commericalization of biomaterials in market.



Intended audience: graduate students, businessmans and researchers from both academics and industrial companies.



3) Expected outcomes and relevance to the main topic of WBC 2024

- This session will make connections between startup companies and academic researches by showing how to setup and grow biomateirals-based new companies in worldwide. 

- Market trends and career development

Keywords : biomaterials, startup, technologies

  • Session TrackBiomaterials for industrial applications
  • Session TitleEmerging biomaterials: From bench to startup
  • Session CodeSP-T09-0366
  • Date & Time / RoomMay 27 (Mon) 14:40~16:10 / Room 320-B
Organizer

Jinmyoung Joo (Ulsan National Institute of Science and Technology, Korea, Republic of)

Chair

Jinmyoung Joo (Ulsan National Institute of Science and Technology, Korea, Republic of)

Keynote Speaker

Michael J. Sailor (University of California San Diego, USA)

Invited Speaker

15:05~15:20 : Soft Materials for Hard Problems in Healthcare: Hydrogels as Novel Medical Device Hyunwoo Yuk (SanaHeal, USA)

15:20~15:35 : Sustainable release of retinoic acid by porous silicon microparticles enhances the functional maturation of induced pluripotent stem cell-derived motor neurons Alec Smith (University of Washington, USA)

15:35~15:50 : Bridging Bench to Startup: Advancements in Emerging Biomaterials for Regenerative Medicine Eun Je Jeon (Cellartgen, Korea, Republic of)

Oral Presenter

15:50~16:00 : SymClot: synthetic platelets for improved hemorrhage control Seema Nandi (SelSym Biotech, Inc., USA)

16:00~16:10 : Confined migration drives stem cell epigenetics and differentiation Xu Gao (National University of Singapore, Singapore)

Description

1) Objectives or purposes: The aim of this symposium is to showcase the next generation of functional and emerging nanomaterials towards biomedical applications. 



2) Proposed program and intended audience: This session will target researchers working in material science and/or bioengineering fields interested in learning about opportunities to expand the reach and capabilities of their work. Topics of interest include bioelectronics, programmed biosynthesis of materials, artificial cells and organelles, biosensing and therapeutic materials, as well as tool development to produce and/or characterize biologically engineered materials.



3) Expected outcomes and relevance to the main topic of WBC 2024: This symposium will span from strategies for biomaterials for clinical translation, which wil also focus on tecnological transfer related with startup company. The symposium will also cover parametric and fundamental studies which showcase key biological, chemical, and physical phenomena observed during biomaterials and medical translation.

Keywords : translational medicine, startup company, responsive biomaterials

  • Session TrackBiomaterials for industrial applications
  • Session TitleDrop-based microfluidic technologies
  • Session CodeSP-T09-0218
  • Date & Time / RoomMay 27 (Mon) 16:30~18:00 / Room 320-B
Organizer

Hyomin Lee (POSTECH, Korea, Republic of)

Chair

To Ngai (Chinese University of Hong Kong, Hong Kong SAR, China)

Siyoung Choi (KAIST, Korea, Republic of)

Keynote Speaker

16:30~16:55 : Oil-eating bacteria lay down to stay fit Andrew S. Utada (University of Tsukuba, Japan)

Invited Speaker

16:55~17:10 : Designing hydrogel-shelled microcapsules through multiple-emulsion templating Shin-Hyun Kim (KAIST, Korea, Republic of)

17:10~17:25 : All-aqueuous interfacial materials Ho Cheung Anderson SHUM (Advanced Biomedical Instrumentation Centre, Hong Kong SAR, China)

Oral Presenter

17:25~17:35 : 3D microfluidic bioprinting of foams for hierarchical fabrication of skeletal substitutes Federico Serpe (La Sapienza University of Rome, Italy)

17:35~17:45 : Sustainable synthesis of calcium phosphate microparticles in 3D-printed droplet micro-reactors for precise morphological control    Konstantinos Tsachouridis (the University of Manchester, United Kingdom)

Description

Droplet microfluidics have significantly contributed to the recent biomaterials and biomedical research by serving as a disruptive toolbox to integrate newly developed biomaterials into innovative products for diverse applications in biotech, medical diagnostics, and pharmaceutical industry. The precise control of fluids on the pico- to nanoliter scale have allowed high-throughput production of monodisperse emulsions, vesicles, and microparticles with unprecedented structure and functionality. Topics spanning from fundamental droplet formation mechanisms to device design and emerging biological application in biomaterials industry will be presented, which would be of significant interest to broad range of audience from experts in microfluidic design to users of the next-generation droplet microfluidic platforms, both in academia and industry. The drop-based microfluidic technologies symposium will bring together top researchers, emerging research leaders, and industry participants on the relevant fields to stimulate scientific exchange and discussion with the biomaterials community.

Keywords : Droplet, Microfluidics, Emulsion

  • Session TrackBiomaterials for industrial applications
  • Session TitleNano- and microencapsulation technologies
  • Session CodeSP-T09-0149
  • Date & Time / RoomMay 28 (Tue) 9:30~11:00 / Room 320-B
Organizer

Jinwoong kim (Sungkyunkwan university/School of Chemical Engineering, Korea, Republic of)

Chair

Ho Cheung Anderson SHUM (Advanced Biomedical Instrumentation Centre, Hong Kong SAR, China)

Shin-Hyun Kim (KAIST, Korea, Republic of)

Keynote Speaker

9:30~9:55 : Stimuli-responsive smart microcapsules for controlled release Liang-Yin Chu (Sichuan University, China)

Invited Speaker

9:55~10:10 : Formation of Controllable Complex Emulsions: From Functional Particles to Encapsulation Chang-Soo Lee (Chungnam National University, Korea, Republic of)

10:10~10:25 : Light-Driven Spatiotemporal Pickering Emulsion Droplet Manipulation Enabled by Plasmonic Hybrid Microgels To Ngai (Chinese University of Hong Kong, Hong Kong SAR, China)

Oral Presenter

10:25~10:35 : Direct visualization of phase transformation between lamellae and bicontinuous cubic phase within microspheres Wenpeng Shan (Shanghai Institute of Ceramics, Chinese Academy of Sciences, China)

10:35~10:45 : Development of novel biomacromolecule microcapsules based on designed synthetic coacervates Akihiro Kishimura (Faculty of Engineering, Kyushu University, Japan)

10:45~10:55 : Redox-responsive disulfide polymer synthesized by the oxidation polymerization of a dithiol trehalose derivative for drug delivery applications Naozumi Teramoto (Chiba Institute of Technology, Japan)

Description

Biomaterials industry are of great interest in developing a robust means of fabricating smart nano- and microcapsules. They can be a form of vesicles, emulsions, foams, and solid shell materials. The key to this encapsulation technology is to provide them with associative interactions against target biological sites, creating a capsule system with controllable diffusivity as well as interactive surface properties. They are indeed advantageous for active drug delivery. Another advantage of using these types of capsule materials is that we cannot only engineer interactive drug carriers, but also impart unique rheological properties to the biofluids. These characteristics enable the development of novel smart biofluids that are truly useful for biomedical applications. From this point of view, this symposium will introduce the recent trend of smart capsule development and industrialization technology. In particular, high-performance, high-intelligence capsule technologies implemented in materials engineering, colloidal physics, and biomedical engineering will be covered.

Keywords : encapsulation, Drug delivery, Nanofluids

  • Session TrackBiomaterials enabling technologies
  • Session TitleExtracellular vesicles for biomedical applications
  • Session CodeSP-T10-0037
  • Date & Time / RoomMay 27 (Mon) 13:00~14:30 / Room 315
Organizer

Eunji Chung (University of Southern California, USA)

Chair

Eunji Chung (University of Southern California, USA)

Minh Le (National University of Singapore, Singapore)

Keynote Speaker

13:00~13:25 : Delivery of nucleic acid therapeutics using extracellular vesicles from red blood cells Minh Le (National University of Singapore, Singapore)

Invited Speaker

13:25~13:40 : Extracellular Vesicle (EV) And EV-mimetic Therapies For Joint Disorders Wei Seong Toh (National University of Singapore (NUS), Singapore)

13:40~13:55 : Digital detection of tumor-derived EVs in blood plasma Yoon-Kyoung Cho (UNIST, Korea, Republic of)

Oral Presenter

13:55~14:05 : Endogenous Protease Mediated Delivery of Engineered Immunomodulatory Extracellular Vesicles Kasey Leung (University of Illinois Chicago, USA)

14:05~14:15 : A biomimetic enriched microenvironment strategy based on exosomes-loaded hydrogel to promote poststroke recovery via endogenous neurogenesis Yifan Liang (Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, China)

14:15~14:25 : Endovesiclosis: A Novel Technology for Nanoparticle Labeling of Extracellular Vesicles Koushik Debnath (University of Illinois Chicago, USA)

Description

Extracellular vesicles (EVs) are natural nanoparticles that carry RNA, DNA, proteins, and lipids, and have been given much attention in recent years due to the growing knowledge of their role in driving disease and maintaining health. The objective of this session entitled " Extracellular Vesicles for Biomedical Applications" is to bring together investigators focusing on the characterization and biology of EVs, engineering of EVs, and their utility as diagnostic biomarkers and therapeutics. Example topics include EV nanomaterials science, the interaction of EVs with biological systems, EV biodistribution in vivo and pharmacology, and the utility of EVs for molecular targeting, imaging, diagnostics, tissue engineering, and drug delivery. This session will target scientists from a wide background (graduate students, postdoctoral fellows, academic professors, industry members, clinicians) who are developing EVs towards biomedical applications.

Keywords : extracellular vesicles, exosomes, drug delivery

  • Session TrackBiomaterials enabling technologies
  • Session TitleImmunoengineering Redefines Biocompatibility
  • Session CodeSP-T10-0052
  • Date & Time / RoomMay 28 (Tue) 13:40~15:10 / Room 315
Organizer

Buddy Ratner (University of Washington, USA)

Chair

Buddy Ratner (University of Washington, USA)

Yoon Sung Nam (Korea Advanced Institute of Science and Technology, Korea, Republic of)

Keynote Speaker

13:40~14:05 : Redefining Biocompatibility Buddy Ratner (University of Washington, USA)

Invited Speaker

14:05~14:20 : Immunological Cloaking of Lytic Bacteriophage for In vivo Anti-bacterial Therapy Yoon Sung Nam (Korea Advanced Institute of Science and Technology, Korea, Republic of)

Oral Presenter

14:20~14:30 : Establishing an Artificial Intelligence-Driven Definition of Biomaterial Biocompatibility Miguel Mateu Sanz (Universitat Politècnica de Catalunya, Spain)

14:30~14:40 : Cadmium ions removal by dissolution/precipitation of calcium phosphate Ahmad Bikharudin (Okayama University, Japan)

14:40~14:50 : AI-Based Macrophage Phenotype Discrimination Method Reveals Morphological and Migratory Differences between Cell Line Yurika Shibuya (Shibaura Institute of Technology, Japan)

14:50~15:00 : Supervised Machine Learning Tool for Precision Bioink Printing Parameter Prediction Yaxi Chen (University College London, United Kingdom)

15:00~15:10 : Polypept(o)ides: From functional materials based on endogenous amino acids to cancer immune therapies Matthias Barz (Leiden Academic Center for Drug Research, Leiden University, Netherlands)

Description

Biocompatibility is a central concept in understanding the special properties of biomaterials, leading to safe and effective use in humans. Biocompatibility today is defined by a definition formulated in 1986, a time when little was known about the biology of the macrophage, the innate immune system and the foreign body reaction. Advances in immunomodulatory biomaterials in the last 10 years have led to biomaterials that heal in a reconstructive, regenerative manner, without the foreign body reaction. This symposium reflects on the 1986 definition of biocompatibility and asks if it might be updated to the 21st century.

Keywords : biocompatibility, immunomodulation, healing

  • Session TrackBiomaterials enabling technologies
  • Session TitleBiomaterials and Fabrication for Multicellular Engineered Systems
  • Session CodeSP-T10-0085
  • Date & Time / RoomMay 29 (Wed) 13:40~15:10 / Room 315
Organizer

Hyunjoon Kong (University of Illinois at Urbana-Champaign, USA)

Chair

Hyunjoon Kong (University of Illinois at Urbana-Champaign, USA)

Ho Jeong Jeon (Korean Institute of Science and Technology, Korea, Republic of)

Keynote Speaker

13:40~14:05 : An emergent multicellular system through biological phase transition Taher Saif (University of Illinois at Urbana-Champaign, USA)

Invited Speaker

14:05~14:20 : Biomimetic hydrogel-based direct contact pressing culture for cell fate control Ho Jeong Jeon (Korean Institute of Science and Technology, Korea, Republic of)

14:20~14:35 : Discovery of Biomaterials for Salivary Gland Regeneration Inspired by Its Branching Morphogenesis Mechanisms Sang Woo Lee (Seoul National University, Korea, Republic of)

14:35~14:50 : High-throughput microfluidics for synthetic biology and microbial bioproduction Arum Han (TEXAS A&M University, USA)

Oral Presenter

14:50~15:00 : Advancing 3D Bioprinting: Automated Fidelity Assessment for Precision and Efficiency for Cartilage Tissue Engineering Applications halima boutouil (DCU, Ireland)

15:00~15:10 : Microvascular Oral Soft Tissue Engineering using Bioprinting and Melt Electro-Writing (MEW) Maedeh Rahimnejad (Postdoctoral Fellow at University of Michigan, USA)

Description



In biosystems, cells perform their intended functions collectively by forming three-dimensional structures to evolve over time. These structures are composed of cells that operate complex physiological activities throughout active or passive cell-cell and cell-matrix interactions. Extensive research has focused on individual cells' genotypic and phenotypic activities in controlled environments engineered with biomaterials and fabrication technologies. In contrast, little is known about the extent to which cellular adhesion to neighboring cells in the 3D clusters modulates the complex morphogenesis and physiological function of engineered tissue and organs and underlying fundamental process. Such a knowledge gap has been one of the challenges towards successful tissue and organ regeneration.



Therefore, we propose a symposium that can address this grand challenge of assembling, measuring, and regulating multi-cellular systems, including organoids and a biological machine that exhibits desired functionalities and prescribed tasks. These multicellular systems can perform sensing, information processing, actuation, protein secretion, and transport elements. We plan to invite leaders in this biophysics and fabrication field and learn how multiple cells interact to integrate their internal developmental program, determine their phenotypes, and build biosystems with physiological or pathophysiological activities. Throughout this symposium, the audience can advance a fundamental understanding of cell-cell interactions and their control by biochemical and mechanical cues; to predict and engineer physiologically functional tissues and organs. Therefore, this symposium will define the biological materials and design disciplines crucial for building new tissue and organs for various applications. Furthermore, we can construct complex systems to perform new tasks that have never been explored.



 

Keywords : Biologics, Microphysiological system, Bio-Bot

  • Session TrackBiomaterials enabling technologies
  • Session TitleBiomaterials for Cultured Meat Production
  • Session CodeSP-T10-0094
  • Date & Time / RoomMay 29 (Wed) 16:30~18:00 / Room 315
Organizer

Tatsuya Shimizu (Tokyo Women's Medical University, Japan)

Co-organizer

Jinkee Hong (Yonsei University, Korea, Republic of)

Chair

Michiya Matsusaki (Osaka University, Japan)

Deepak Choudhury (Bioprocessing Technology Institute, Singapore)

Hee Ho Park (Hanyang University, Korea, Republic of)

Keynote Speaker

16:30~16:50 : Cultured Meat Production Based on Circular Cell Culture System Using Microalgae. Tatsuya Shimizu (Tokyo Women's Medical University, Japan)

16:50~17:10 : Structure- and mechano-design of bioink for 3D-printed personalized cell-based Wagyu beef meat Michiya Matsusaki (Osaka University, Japan)

Invited Speaker

Katsuhisa Sakaguchi (Waseda University, Japan)

17:25~17:40 : Cell sheet-based engineering of structural and physiological biomimetic bovine muscle tissue for cultured meat production Hironobu Takahashi (Tokyo Women's Medical University, Japan)

Oral Presenter

17:40~17:50 : Plant-Based Decellularized Scaffolds for a Cultured Meat Prototype Deepak Choudhury (DR, Singapore)

Description

Nowadays food shortage has become serious problem in the world. Especially livestock breeding cause green housegas emission. Recently, research and development in the field called "cellular agriculture", which produces food from isolated cells, has become popular in the world.  In particular, cultured meat production has been focused and various types of biomaterials have been used in each process of the production. The basic technologies used in cultured meat production are common to regenerative medicine. The processes include cell sources, culture medium, cell expansion, and tissue engineering.  However new or modified biomaterials and technologies are needed in the several points of view. The research and development have focused on sustainability, cost reduction, nutritional value, improvement of texture as food are emphasized. In this symposium, recent advances of cultured meat production will be presented and discussed. We believe that the technological development of regenerative medicine and cellular agriculture will stimulate each other and develop together.

 

Keywords : cultured meat, tissue engineering, bioreactor

  • Session TrackBiomaterials enabling technologies
  • Session TitleNucleic acid nanotechnology-based therapeutics and diagnostics
  • Session CodeSP-T10-0363
  • Date & Time / RoomMay 28 (Tue) 9:30~11:00 / Room 315
Organizer

Maartje Bastings (EPFL, Switzerland)

Co-organizer

Young Hoon Roh (Yonsei University, Korea, Republic of)

Minseok Kwak (Pukyong National University, Korea, Republic of)

Chair

Young Hoon Roh (Yonsei University, Korea, Republic of)

Maartje Bastings (EPFL, Switzerland)

Minseok Kwak (Pukyong National University, Korea, Republic of)

Keynote Speaker

Dan Luo (Cornell University, USA)

Invited Speaker

9:55~10:10 : The impact of ligand spatial distribution on therapeutic outcomes using DNA origami: CpG spacing for cancer vaccine Ju Hee Ryu (KIST, Korea, Republic of)

10:10~10:25 : Intelligent Wearable Skins and Soft Probing Contractile Forces of Cardiac Organoids Wenlong Cheng (University of Sydney, Australia)

10:25~10:40 :

Reconfigurable multi-component assemblies built from DNA origami voxels
Shelley Wickham (The University of Sydney, Australia)

Oral Presenter

10:40~10:50 : (Super-) Selective biomaterials? A balancing act of rigidity and geometry at the nanoscale Maartje Bastings (EPFL, Switzerland)

10:50~11:00 : Plasmon-enhanced FRET between i-motif DNA encapsulated Silver Nanoclusters and Fluorescein amidites visualizes the redox state of live cells Seong Wook Yang (Yonsei University, Korea, Republic of)

Description

Embracing the innovative concept that DNA/RNA are not merely a biological macromolecule but also a genuine biopolymer, numerous scientists have dedicated several decades to engineering nucleic acids molecules as both genetic and generic material. Furthermore, nucleic acids stand out due to their biocompatibility, biodegradability and renewability. The aspiration is to facilitate the translation of knowledge from fundamental studies on DNA/RNA origami, therapeutic sequences, stimuli-responsive DNA/RNA nanostructures, and self-assembly chemistry into practical nanotechnology applications.



This session will cover how we have designed and engineered DNA/RNA-based materials on a large scale using various nanotechnologies for practical application in the biological and biomedical fields. Our endeavors span a wide spectrum and cross multiple disciplines, encompassing areas such as biosensing, theragnostics, controlled drug release, and life-mimicking soft robots. With the ongoing artificial intelligence (AI) revolution, we anticipate that DNA/RNA-based materials will serve as ideal materials interfacing with AI technologies. DNA/RNA-based materials will be soon gain recognition as versatile and intelligent biopolymers, providing sustainable solutions for a myriad of real-would challenges in the near future.

Keywords : DNA/RNA nanotechnology, Therapeutics, Diagnostics

  • Session TrackBiomaterials enabling technologies
  • Session TitleBiomineralization and biotemplating
  • Session CodeSP-T10-0364
  • Date & Time / RoomMay 27 (Mon) 14:40~16:10 / Room 315
Organizer

Jae-Byum Chang (Korea Advanced Institute of Science and Technology, Korea, Republic of)

Chair

Jae-Byum Chang (Korea Advanced Institute of Science and Technology, Korea, Republic of)

Keynote Speaker

14:40~15:05 : Osteocytic mechanisms of age-related bone fragility Tamara N. Alliston (Department of Orthopaedic Surgery, the University of California San Francisco, USA)

Invited Speaker

15:05~15:20 : Revolutionizing materials engineering and processing with microfluidic tools Josep Puigmartí-Luis (Department of Materials Science & Physical Chemistry, University of Barcelona, Spain)

Oral Presenter

15:20~15:30 : In-Situ TEM Studies of Biomineralization  Reza Shahbazian Yassar (University of Illinois Chicago, USA)

15:30~15:40 : Mussel-inspired Polydopamine-coated Mesoporous Bioactive Glass: An Exploration of Potential Metal Ion Loading Platform and Biomineralization Molecular Dynamics Mechanism BAIYAN SUI (Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, China)

15:40~15:50 : Metal-polyphenol complexes: unveiling photochemical routes to biomineralization Jeonga Kim (Korea Advanced Institute of Science and Technology (KAIST), Korea, Republic of)

15:50~16:00 : Biomineralization of functional cellulose nanocrystal-based hydrogel platforms with bone-healing potential: role of the surface chemistry in hydroxyapatite formation Jessica Borges Vilches (Aalto University, Finland)

16:00~16:10 : An advanced spheroid-based calcification model for small molecule drug screenings in the treatment of fibrodysplasia ossificans progressiva Steven Vermeulen (Maastricht University, Netherlands)

Description

The purpose of this symposium is to discuss recent research on the interface between biological and inorganic materials. It particularly focuses on two topics: biomineralization and bio-templating. Biomineralization is the process by which living organisms synthesize minerals and is widespread across all types of organisms, both uni- and multicellular. Examples of biomineralization include animal bones and teeth, insect exoskeletons, and silicates in diatoms. Minerals produced by biomineralization have different structures and properties than man-made and natural minerals. These distinctive features result from a highly controlled and organized synthesis process mediated by living organisms. Bio-templated materials are synthesized using biological structures—including bacteria, viruses, algae, proteins, and even entire organisms—as templates. The fundamental concept underlying bio-templating is the use of the highly ordered and hierarchical structures of biological systems to synthesize inorganic or metallic materials with similarly ordered and complex structures. The biomineralization and bio-templating processes may appear distinct and unrelated, but both occur at the interface of biological systems and inorganic materials. Recent studies on these two processes are discussed at this symposium. Internationally renowned researchers in these disciplines present their work and discuss the biomineralization mechanism and its application for developing bio-templated materials.

Keywords : Biomineralization, Bio-templated materials

  • Session TrackBiomaterials enabling technologies
  • Session TitlePhotothermal Biomaterials
  • Session CodeSP-T10-0365
  • Date & Time / RoomMay 30 (Thu) 13:40~15:10 / Room 315
Organizer

Ji Ho Park (KAIST, Korea, Republic of)

Chair

Ji Ho Park (KAIST, Korea, Republic of)

Gabe Kwong (Georgia Tech, USA)

Keynote Speaker

13:40~14:05 : Engineering photothermal neural interface using thermoplasmonics for neuromodulation Yoonkey Nam (KAIST, Korea, Republic of)

Invited Speaker

14:05~14:20 : Photothermal nanoparticles for biomedical applications Ji Ho Park (KAIST, Korea, Republic of)

Oral Presenter

14:20~14:30 : Cascade loop of ferroptosis induction and immunotherapy based on metal-phenolic networks for combined therapy of colorectal cancer BIN YANG (Guangzhou Medical University, China)

: New graphene-containing pharmaceutical formulations for infrared lamps-based phototherapy of skin cancer: in vitro validation and ex-vivo human skin permeation Artur Moreira Pinto (LEBABE - University of Porto, Portugal)

: Polydopamine nanoparticles-based combinational hyperthermal chemotherapy for the treatment of liver cancer Melis Emanet (Istituto Italiano di Tecnologia (IIT), Italy)

: 4D printing of shape memory polymer composites for bioresorbable and deployable medical devices Saswat Choudhury (Indian Institute of Science Bangalore, India)

: Amplify antimicrobial photo dynamic therapy efficacy with poly-beta-amino esters (PBAEs) Polina Prokopovich (Cardiff University, United Kingdom)

Description

Photothermal biomaterials are materials that have the property of strongly absorbing light at a specific wavelength and effectively converting it into heat for a wide range of applications in biological and medical fields. The past 20 years have witnessed significant progress in the preparation of various photothermal biomaterials, mainly based on metallic components. These photothermal nanomaterials can be hybridized with other components to achieve enhanced photothermal performance. In this symposium, we will discuss fundamental insights in photothermal biomaterials, including photothermal conversion mechanisms/characteristics as well as potential biomedical applications in various diseases. Furthermore, we will discuss fundamental challenges and prospects for the future development of photothermal biomaterials.

Keywords : Photothermal, Materials, Therapy

  • Session TrackBiomaterials enabling technologies
  • Session TitleBiomaterials for immunoisolation
  • Session CodeSP-T10-0124
  • Date & Time / RoomMay 29 (Wed) 9:30~11:00 / Room 315
Organizer

Nathaniel Hwang (Seoul National University, Korea, Republic of)

Chair

Nathaniel Hwang (Seoul National University, Korea, Republic of)

Minglin Ma (Cornell University, USA)

Keynote Speaker

9:30~9:55 : Delivering insulin-producing cells without immunosuppression Minglin Ma (Cornell University, USA)

Invited Speaker

Nathaniel Hwang (Seoul National University, Korea, Republic of)

Oral Presenter

10:10~10:20 : MRI contrast-enhanced alginate formulation for efficient surgical explantation of beta cell-containing islets in diabetes therapy Marc-Andre Fortin (CR-CHU de Québec - Université Laval, Canada)

10:20~10:30 : Human stem cell-derived β-cells delivered with vasculogenic hydrogels reverse hyperglycemia in diabetic immunodeficient mice Sophia Kioulaphides (Georgia Institute of Technology, USA)

10:30~10:40 : Porous Microwell Scaffolds for 3D Culture of Pancreatic Beta Cells to Promote Cell Aggregation and Insulin Secretion Tianjiao Zeng (National Institute for Materials Science, Japan)

10:40~10:50 : Photo-responsive 3D hydrogel platform promotes vascularization for islet transplantation Martha Fowler (Rice University, USA)

10:50~11:00 : Dynamic 3D perfusable cell culture systems for organ-on-chip studies Durante Pioche-Lee (Univ. of Michigan, USA)

Description

Immunoisolation devices can be used to transplant cells for treating a variety of human diseases without the need for immunosuppressive drugs. In recent years, pre-clinical applications utilizing xenogenic cell transplantation have been widely investigated. Transplanted cells are enclosed within a material that provides protection from the immune system while allowing adequate transport of nutrients, oxygen, waste products, and therapeutic products. In this symposium, we intend to invite world experts who have developed novel immunoisolation strategies in single cell level.  In particular, we would like to focus on microfluidic device for single cell encapsulation and layer-by-layer strategies to encapsulate single cell for allogenic/xenogeneic cell transplantation. Even though immunobarrier devices such as intravascular, extravascular macrocapsules, and microcapsules have been investigated, we hypothesized that single cell level encapsulation and protection strategies would provide novel insight into the stem cell or cell-based therapy applications.

Keywords : immunoisolation, hydrogel, single cell, microfluidics

  • Session TrackBiomaterials enabling technologies
  • Session TitleDNA or RNA Nanotechnologies
  • Session CodeSP-T10-0390
  • Date & Time / RoomMay 27 (Mon) 16:30~18:00 / Room 315
Organizer

Maartje Bastings (EPFL, Switzerland)

Co-organizer

Minseok Kwak (Pukyong National University, Korea, Republic of)

Young Hoon Roh (Yonsei University, Korea, Republic of)

Chair

Maartje Bastings (EPFL, Switzerland)

Minseok Kwak (Pukyong National University, Korea, Republic of)

Young Hoon Roh (Yonsei University, Korea, Republic of)

Keynote Speaker

William M. Shih (Harvard University, USA)

Invited Speaker

16:55~17:10 : Ultrasound-responsive and autonomously acting nucleic acid materials Andreas Herrmann (RWTH Aachen University, Germany)

17:10~17:25 : Rapid Nucleic Acid Detection using CLASSIC Youngeun Kim (Seoul National University, Korea, Republic of)

Oral Presenter

17:25~17:35 : DNA origami for photonics and phononics Seungwoo Lee (Korea University, Korea, Republic of)

17:35~17:45 : Toward real-time analysis and design of DNA origami nanostructures using AI Do-Nyun Kim (Seoul National University, Korea, Republic of)

Description

DNA or RNA nanotechnology is an interdisciplinary field that combines the principles of biochemistry, physics, and engineering to design and fabricate nanoscale structures and devices using nucleic acid molecules. The ability of such molecules to self-assemble into defined structures based on specific base-pairing rules is leveraged to create nanoscale objects with well-defined shapes and functions. For instance, the unique properties of DNA/RNA, such as its biocompatibility and programmability, make it a versatile building block for the development of new technologies in areas such as nanomedicine, molecular electronics, and materials science. The ultimate goal of nucleic acid nanotechnology is to use this versatile molecule as a tool to manipulate matter on the nanoscale and advance our understanding of the molecular world.



DNA or RNA nanotechnology is related to biomaterials in that it uses biological materials to create new materials with specific properties and functions. The use of DNA and other biological materials in the development of new materials has the potential to lead to the creation of more biocompatible and biodegradable materials for various applications.

Keywords : Nucleic Acids, Nanobiomaterials, Bioploymers

  • Session TrackBiomaterials enabling technologies
  • Session TitleEmerging Nanobiomaterials and Nanofabrication
  • Session CodeSP-T10-0185
  • Date & Time / RoomMay 28 (Tue) 16:30~18:00 / Room 315
Organizer

Bingyun Li (West Virginia University School of Medicine, USA)

Chair

Bingyun Li (West Virginia University School of Medicine, USA)

Malcolm Xing (University of Manitoba and Children's Hospital Research Institute of Manitoba, Canada)

Keynote Speaker

16:30~16:55 : Proteomic-driven discovery of developmental peptides for guiding iPSC pancreatic lineage specification and maturation Kaiming Ye (Binghamton University, State University of New York, USA)

Invited Speaker

16:55~17:10 : Near-atomic-scale tribocorrosion testing of metallic biomaterial surfaces and e-beam formed carbon overlayers Jeremy L. Gilbert (Clemson University, USA)

17:10~17:25 : Engineered nanoparticles for treating ischemic cardiovascular diseases Jianjun Guan (Washington University in St. Louis, USA)

Oral Presenter

17:25~17:35 : Unique Antimicrobial Peptide Presents Low in vitro Toxicity toward Mammalian Cells Bingyun Li (West Virginia University School of Medicine, USA)

17:35~17:45 : Nitrogen-Enriched Carbon Quantum Dots Immobilized in Hydrogels for Long-Term Continuous Glucose Monitorin Ranjit De (Pohang University of Science and Technology (POSTECH), Korea, Republic of)

17:45~17:55 : Biomimetic synthesis of Fe3O4 nanoparticles with different mineralization regulators Haiyan Zhang (Southeast University, China)

Description

Nanobiomaterials have found numerous applications in the fields of medicine, energy, environment, and electronics, to name a few. Meanwhile, diseases like COVID, hepatitis, and HIV/AIDS are a major burden to the global medical community. Nanomaterials have emerged as innovative approaches to treat such challenging diseases and nanotechnology has played a major role in the development of Moderna and Pfizer COVID vaccines. In this symposium, the emerging and advancement of new nanobiomaterials and the importance and regulation of nanofabrication will be presented, and perspectives for future research and development of nanobiomaterials and nanofabrication will be offered.

Keywords : Nanobiomaterial, nanofabrication, regulation

  • Session TrackBiomaterials enabling technologies
  • Session TitleAdvanced biofunctional and bioinspired materials/devices for healthcare and tissue engineering
  • Session CodeSP-T10-0196
  • Date & Time / RoomMay 30 (Thu) 9:30~11:00 / Room 315
Organizer

Emilio S. Hara (Okayama University, Japan)

Chair

Emilio S. Hara (Okayama University, Japan)

Takahiro Nomoto (University of Tokyo, Japan)

Keynote Speaker

9:30~9:55 : Innovations in Tissue Repair: Interdisciplinary Strategies for Biomaterial-Assisted Targeted Delivery and Scalable Synthesis Nicholas Dunne (Dublin City University, Ireland)

Invited Speaker

9:55~10:10 : Bioinspired cell-free therapeutic using cell membranes for bone tissue repair Emilio S. Hara (Okayama University, Japan)

10:10~10:25 : Design of biomaterials constituting drug delivery systems for boron neutron capture therapy Takahiro Nomoto (University of Tokyo, Japan)

Oral Presenter

10:25~10:35 : Tunable Triboelectric Nanogenerator for Precise Acceleration of Wound healing with varying Fluorinated Polymer Cholong Choi (Ulsan National Institute of Science and Technology, Korea, Republic of)

10:35~10:45 : Is iHuman a future reality or just science fiction? Andreia T. Pereira (i3S - Instituto de Investigação e Inovação em Saúde, Portugal)

10:45~10:55 : Development and optimization of a non-invasive electrode based on immobilization of glucose oxidase in Nafion-carbon nanotubes nanocomposites for diabetes management Shivam Gupta (National Tsing Hua University, Chinese Taipei)

Description

 The objective of this symposium is to present the state-of-the-art technologies in the field of bioinspired and biofunctional materials for diverse applications in healthcare and tissue engineering; and discuss future directions in the field.



  The program will bring together prominent young and middle-career scientists with diverse backgrounds and expertise showcasing their original and groundbreaking technologies. Prof. Nicholas Dunne (Dublin City University, Ireland), Executive Director of Biodesign Europe, is world widely recognized for his innovations in the field of biomaterial applied for tissue repair and cancer therapeutics. Prof. Nicholas Dunne focuses on the development of stratified approaches for the design, manufacture and characterization of drug-biomaterial combination medical devices for efficacious hard and soft tissue repair and regeneration (e.g., Acta Biomaterials 2023, 2022; Biomaterials 2003). The following 2 Japanese researchers have been recently awarded the prestigious JST-FOREST grant for young scientists. Associate Prof. Takahiro Nomoto (Tokyo University, Japan) is a young scientist developing cutting edge drug delivery technologies (e.g., Sci Adv 2020, Nat Nanotech 2016; Nat Commun 2019, 2014). Research Associate Prof. Emilio S. Hara (Okayama University, Japan) is a young scientist with a biology background focused on the development of biohybrid materials using, for instance, cell-derived membrane fragments as material for biodevices and tissue engineering (e.g., Adv Mater 2022, Adv Mater Technol, 2023; J Mater Chem B, 2023, 2018).



  A broad audience from early-career to senior scientists are mostly welcomed to join the symposium and discuss future perspectives in the field. This symposium is also expected to allow the interaction of scientists from diverse fields, and be a forum for the establishment of novel connections to create unique and unprecedented technologies for tissue engineering and future healthcare.

 

Keywords : bioactive materials, biohybrid materials, next-generation drug delivery systems

  • Session TrackSpecial Lectures
  • Session Title100 Years of Biomaterials Design Contributions of Edward Merrill (1923-2020)
  • Session CodeSP-T11-0265
  • Date & Time / RoomMay 29 (Wed) 16:30~18:00 / Room 325-AB
Organizer

Nicholas Peppas (Department of Biomedical Engineering and Dell Medical School, The University of Texas at Austin, USA)

Chair

Nicholas Peppas (Department of Biomedical Engineering and Dell Medical School, The University of Texas at Austin, USA)

Paula T. Hammond (Chemical Engineering, Massachusetts Institute of Technology, USA)

Keynote Speaker

16:30~17:00 : Cellular Backpacks: A Discrete Biomaterial for Drug and Cell Therapy Samir Mitragotri (Harvard University, USA)

Invited Speaker

17:00~17:30 : Think like a polymer Michael Sefton (University of Toronto, Canada)

17:30~17:55 : Injectable hydrogels for tissue engineering Antonios Mikos (Rice University, USA)

Description

The purpose of this symposium is to celebrate 100 years of the main international biomaterials scientnist Edeard W, Merrill of MIT, Cambridge, MA, USA by featuring leading biomaterials scientists who will address important problems in the design of new biomateials using a combination of molecular design and computatioal methods. The speakers will present rent results and future directions in their fields. The chais will stress the convergence and continuity of the subject covered will show how the pioneering work of EW Merrill ans his more that 4,000 disciples have changed the field/

Keywords : immunoengineering genome tissue-engineering

  • Session TrackSpecial Lectures
  • Session TitleSFB Awards Ceremony and Plenary Presentations 1
  • Session CodeSP-T11-0046
  • Date & Time / RoomMay 29 (Wed) 13:40~15:10 / Room 306-A
Organizer

Dan Lemyre (Society For Biomaterials (US), USA)

Chair

Shelly Sakiyama-Elbert (University of Washington, USA)

William Wagner (University of Pittsburgh, USA)

Invited Speaker

Natalie Artzi (BWH, USA)

Tatiana Segura (Duke University, USA)

14:40~15:10 : 3D Printing with Molecular Weight Polymer Blends to Decouple Scaffold Property Effects on Mesenchymal Stromal Cell Fate Lesley Chow (Lehigh University, USA)

Description

The US Society For Biomaterials would like to request TWO plenary sessions to be comprised of the 2024 SFB Award Recipients.  The 2024 Awards will include the Founders Award, the Technology Innovation & Development Award, the (3) Clemson Awards (Basic Research, Applied Research, Contributions to the Literature), the Mid Career Award, and the Young Investigator Award.  The award receipients will not be decided upon until the November 2023, but will be thought leaders in the field.

Keywords : SFB Awards Plenary

  • Session TrackSpecial Lectures
  • Session TitleESB International Award 2024 Symposium
  • Session CodeSP-T11-0348
  • Date & Time / RoomMay 30 (Thu) 16:30~18:00 / Room 306-A
Organizer

Ana Paula Pego (i3S / INEB, Portugal)

Chair

Ana Paula Pego (European Society for Biomaterials, Portugal)

Maria Grazia Raucci (National Research Council of Italy, Italy)

Invited Speaker

16:30~17:15 : Engineering Hydrogel Microstructures for Use in Biomedical Applications Jason Burdick (University of Colorado Boulder, USA)

Pamela Habibovic (Maastricht University, Netherlands)

Luis García-Fernández (Centro de Investigaciones Biomédicas en Red (CIBER-BBN), Spain)

Description

The International Award is a prestigious recognition by the European Society for Biomaterials (ESB) of scientists who have generally spent their career outside Europe, who have been internationally recognised, have a high scientific profile, and have made major contributions to the field of biomaterials. Strong evidence of collaborations with members of our scientific community in Europe throughout their career is expected.



In this symposium the 2024 Awardee of this pretigious acclaim will present their plenary talk. In addition, eminent speakers from the field of Biomaterials will be invited to share their view on the most recent developments of our field, with special emphasis on researchers that have been engaged in fruitfull international collaborations in the framework of the Biomaterials Community.

 

Round Table - “Looking at the future of biomaterials by standing on the shoulders of our giants Julio San Roman and Klaas de Groot”



Honouring the legacy of our deSavear colleagues and friends Julio San Roman and Klaas de Groot, whom we recently lost, we will discuss the future of biomaterials. Learning from their impressive careers and lives, we will discuss the current and the future scientific challenges of our field, as well equally important topics of mentorship, differentiating career paths and work-life balance.

Keywords : biomaterials development, biomaterials application

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