Scientific Program

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  • Session TrackBiomaterials for specific medical applications
  • Session TitleBiomaterials for environment sensitive drug release
  • Session CodeSP-T06-0278
  • Date & Time / RoomMay 27 (Mon) 13:00~14:30 / Room 323
Organizer

Won Jong Kim (Pohang University of Science and Technology, Korea, Republic of)

Chair

Jihoon Kim (Chung-Ang University, Korea, Republic of)

Zhen Gu (Zhejiang University, China)

Keynote Speaker

13:00~13:25 : Bioresponsive Drug Delivery Zhen Gu (Zhejiang University, China)

Invited Speaker

13:25~13:40 : Lipid based nanovesicles for targeted delivery of immune stimulating molecules Hyejung Mok (Konkuk University, Korea, Republic of)

Oral Presenter

13:40~13:50 : Sustained delivery of acetic acid to combat burn wound infection Thomas Robinson (University of Birmingham, United Kingdom)

13:50~14:00 : Infection-Triggered Adhesive Nanoparticles Capable of On-Demand Releasing Antibiotics for Self-Defensive Antibacterial Therapy Ji Won Choi (Kyungpook National University, Korea, Republic of)

14:00~14:10 : Antimicrobial solutions based on the controlled release of nitric oxide Xuewei Wang (Virginia Commonwealth University, USA)

Description

Environment-sensitive drug release systems are designed to respond to specific environmental cues or changes in physiological conditions to release drugs in a controlled and targeted manner. These biomaterials take advantage of various environmental factors, such as pH, temperature, enzymes, or specific biomolecules, to trigger drug release at the desired site. Here we cover some examples of biomaterials used for environment-sensitive drug release.

Keywords : TBD

  • Session TrackBiomaterials for specific medical applications
  • Session TitleBiomaterials for inflammatory bowel disease therapy
  • Session CodeSP-T06-0023
  • Date & Time / RoomMay 31 (Fri) 9:30~11:00 / Room 321-B
Organizer

Dong Yun Lee (Hanyang University, Korea, Republic of)

Chair

Joonseok Lee (Hanyang University, Korea, Republic of)

Jung Seung Lee (Sung Kyun Kwan University, Korea, Republic of)

Keynote Speaker

9:30~9:55 : Regulatory mechanism of the gut epithelial barrier function in inflammatory bowel diseases Sang H. Rhee (Oakland University, USA)

Invited Speaker

9:55~10:10 : Oral TNF-α siRNA delivery via milk-derived exosomes for effective treatment of inflammatory bowel disease Yoosoo Yang (Korea Institute of Science and Technology, Korea, Republic of)

10:10~10:25 : Mesalamine prodrug nanoassemblies for the treatment of inflammatory bowel disease Sun Hwa Kim (Korea Institute of Science and Technology, Korea, Republic of)

Oral Presenter

10:25~10:35 : Uniform gold nanostructure formation via weakly adsorbed gold films and thermal annealing for reliable localized surface plasmon resonance-based DNase-I detection Joon-Ha Park (Chung-Ang University, Korea, Republic of)

10:35~10:45 : Submucosal hydrogel for spring-mediated intestinal lengthening Narelli de Paiva Narciso (Stanford University, Brazil)

10:45~10:55 : Leveraging polymer-derived drug delivery systems to combat inflamamtory bowel disease Yuji Pu (Sichuan University, China)

Description

Inflammatory bowel disease (IBD) is a chronic disease associated with increased morbidity and disability. It is estimated that IBD affects more than 10 million people globally in 2022. Currently, there are salicylates and steroids traditionally used for the treatment of IBD. Despite significant advances in medical approaches, many critical side effects and insufficient efficiency still remain. Therefore, it is of great importance and demand to develop therapeutic biomaterials and discover new strategies for IBD treatment. Recently, researchers are interested in scavenging reactive oxygen species (ROS) or inhibition of extracellular release of damage-associated molecular pattern (DAMP) for the treatment of inflammatory diseases. Nanozymes such as Au, Mn3O4, and CeO2 has been designed as efficient scavengers of ROS. Receptors such as aptamer and repebody with high affinity and stability are promising candidates as inhibitors for target molecules. The symposium will focus on the new and recent developments in the field of therapeutic biomaterials and simultaneously enable researchers to receive a more in-depth perception of this field

Keywords : inflammatory bowel disease ; nanomedicine; nanozyme, IBD

  • Session TrackBiomaterials for specific medical applications
  • Session TitleSex as a biological variable in biomaterials research
  • Session CodeSP-T06-0042
  • Date & Time / RoomMay 30 (Thu) 16:30~18:00 / Room 322
Organizer

Brian Aguado (University of California San Diego, USA)

Chair

Brian Aguado (University of California San Diego, USA)

Shelly Peyton (University of Massachusetts Amherst, USA)

Keynote Speaker

16:30~16:55 : Matrix-dependent regulation of endothelial-mesenchymal transition in Turner Syndrome: relevance to bicuspid aortic valves Jane Grande-Allen (Rice University, USA)

Invited Speaker

16:55~17:10 : Biomaterial Tools to Interrogate Sex Differences in Knee Connective Tissue Regeneration Jenny Robinson (University of Washington, USA)

17:10~17:25 : Dissecting Cell-Matrix Interactions in Endometrial Disorders using Tissue Engineered Models Juan Gnecco (Tufts University, USA)

Oral Presenter

17:25~17:35 : Biomimicking trilayer scaffolds with high stretchability and sustained estradiol release for uterine tissue regeneration Min Wang (Department of Mechanical Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong, Hong Kong SAR, China)

17:35~17:45 : Sex-based differences in human mesenchymal stem cell osteogenic response on mineralized collagen scaffolds Vasiliki Kolliopoulos (Rice University, USA)

17:45~17:55 : Y-chromosome linked genes modulate sex-specific valvular myofibroblast methylation on hydrogels Rayyan Gorashi (University of California, San Diego, USA)

Description

Introductory abstract of a maximum of 300 words that addresses the symposium’s

1) objectives or purposes;

2) Proposed program and intended audience

3) expected outcomes and relevance to the main topic of WBC 2024.



Sex differences exist in both health and disease, yet our mechanistic knowledge of the underlying sex-specific molecular and cellular mechanisms involved remain poorly characterized. In terms of biomaterials, the effects of sex on processes such as fibrosis, wound healing, tissue regeneration, and immune rejection, are only now beginning to be appreciated. In this session, we seek to highlight the latest research in biomaterials-based technologies that enable sex-specific understanding of biological mechanisms in health and disease. Topics in this session include (and are not limited to) using biomaterials to design sex-specific cellular microenvironments, understand sex-specific disease pathologies and immune responses, and and develop sex-specific drug delivery and tissue engineered approaches. Incorporating sex as a biological variable in biomaterials research may enable the improved understanding of sex differences in health and disease and provide a path toward sex-specific therapies to help benefit diverse patient populations. Our session will align with the overall vision of WBC 2024, since we seek to develop therapies that will work in both women and men to achieve equity in medical practice and address sex and gender disparties in our discipline. 

Keywords : Sex differences, in vitro models

  • Session TrackBiomaterials for specific medical applications
  • Session TitleChallenge to Microbiology Using Nanomaterials
  • Session CodeSP-T06-0057
  • Date & Time / RoomMay 28 (Tue) 9:30~11:00 / Room 323
Organizer

Hu-Lin Jiang (China Pharmaceutical University, China)

Chair

Chong-Su Cho (Seoul National University, Korea, Republic of)

Hu-Lin Jiang (China Pharmaceutical University, China)

Keynote Speaker

9:30~9:55 : Challenge to Microorganism by Polysaccharide Nanoparticles as an Intracellular Inducer Chong-Su Cho (Seoul National University, Korea, Republic of)

Invited Speaker

9:55~10:10 : Tissue Fibrosis Therapy Hu-Lin Jiang (China Pharmaceutical University, China)

Amit Bandyopadhyay (Washington State University, USA)

Oral Presenter

10:25~10:35 : Microbe-material biointerface design of polyelectrolyte nanocomplexes to treat bacterial infections Joel Finbloom (University of British Columbia, Canada)

10:35~10:45 : Combatting antimicrobial resistance with selenium nanoparticle-antimicrobial peptide conjugates Shaveen Sasanka Bogahapitiya Gamage (University of Melbourne, Australia)

10:45~10:55 : Au/Pt bimetallic nanoparticles-decorated nonwoven mat promotes wound healing: meng-yi bai (National Taiwan University of Science and Technology, Chinese Taipei)

Description

  Recently, nanomaterials have become a research hotspot for researchers in many fields. Among them, we aim to approach the therapy of bacterial infection using nanomaterials because the evolution of antimicrobial resistance has posed great challenges to the existing antibacterial treatment regimes and there is an urgent need to develop new approaches to overcome bacterial infections.



  We proposed new therapeutic strategies to solve bacterial resistance. The first presenter challenged microbiology using polysaccharide-based nanoparticles (PSNPs) as a new formulation of prebiotics because the internalization of PSNPs into probiotics showed higher antimicrobial activities against Gram-positive and Gram-negative pathogens. The second presenter challenged bacterial membrane vesicles (MVs) as nanocarriers against bacterial infections because the various MVs induced both humoral and cellular immunity to protect mice from bacterial infections, and MVs-coated nano-delivery systems acted as antibacterial agents. The third presenter challenged the mechanism of cellular uptake of metallic nanomaterials because the antibacterial properties of nanomaterials stem from biophysical interactions between nanoparticles and bacteria, and the cellular uptake is affected by size, shape, shell structure, surface chemistry, and protein corona formation of the metallic nanomaterials. The fourth presenter challenged the mechanism of how to regulate the pathological barriers of tissue fibrosis using biomaterials.

Researchers from academies, institutes, companies, and hospitals are the intended audience.



  The therapy of bacterial infection using nanomaterials will be expected to be a novel approach to solving antimicrobial resistance.

Keywords : Antimicrobial resistance, Nanomaterials, Pathological barriers

  • Session TrackBiomaterials for specific medical applications
  • Session TitleBiomaterials from Creation to the Present and Beyond
  • Session CodeSP-T06-0058
  • Date & Time / RoomMay 29 (Wed) 16:30~18:00 / Room 320-B
Organizer

Tzu-Wei Wang (National Tsing Hua University, Chinese Taipei)

Chair

Tzu-Wei Wang (Department of Materials Science and Engineering, National Tsing Hua University, Taiwan, Chinese Taipei)

James Lai (Department of Bioengineering, University of Washington, USA)

Keynote Speaker

16:30~16:55 : Metallo-elastomers as biomaterials: why, how and what Yadong Wang (School of Biomedical Engineering, Cornell University, USA)

Invited Speaker

16:55~17:10 : Keratin Based Gradient Hydrogels for Wound Healing and Beyond Kee Woei NG (School of Materials Science and Engineering, Nanyang Technological University, Singapore)

17:10~17:25 : Cell-adhesive self-healing hydrogel as a new platform to construct biomimetic environment Won-Gun Koh (Yonsei University, Korea, Republic of)

Oral Presenter

17:25~17:35 : MXene-Decorated Nanofibrous Membrane with Programmed Antibacterial and AntiInflammatory Effects via Steering NF-κB Pathway for Infectious Cutaneous Regeneration Shuai He (sichuan university, China)

17:35~17:45 : β-Chitin chemical extraction from squid pens using ammonium-based ionic liquid for β-chitosan production Susiana Melanie (Imperial College London, United Kingdom)

Description

  To provide cutting-edge idea and strategy for developing novel biomaterials and their potential applications in regenerative medicine, especially for cardiovascular system and wound healing.



  Intended audience: research scientists, clinicians, pharmaceutical industry specialists, post-graduate students, graduate students



  Closely and highly related to the main theme of WBC2024 -Convergence in Biomaterials: a vision for the future of healthcare



  Biomaterials are natural, synthetic, or hybrid materials engineered to interact with biological systems for replacing damaged tissues or restoring natural functions.  They have been used tremendously in medical science with a variety of forms such as hydrogels, fibers, sponges, sheets and membranes to build medical devices or serve as implant/prosthesis for tissue engineering and regenerative medicine. Since the demand for polymers in medical applications has been significantly increasing, more advanced research on exploring new biomaterials and developing multifunctional biomimetic biomaterials is particularly important. The symposium discusses various applications of biomaterials in the medical and biological industry including metallo-elastomer as vascular conduit, self-powered multifunctional dressing, keratin-based gradient hydrogel for wound healing, etc.

Keywords : metallo-elastomer, self-powered dressing, gradient hydrogel

  • Session TrackBiomaterials for specific medical applications
  • Session TitleHarnessing Biomaterials Strategies to Model Lung Disease, Repair Damaged Tissue, and Deliver Drugs for Treatment
  • Session CodeSP-T06-0314
  • Date & Time / RoomMay 31 (Fri) 9:30~11:00 / Room 320-B
Organizer

Chelsea Magin (University of Colorado, Denver | Anschutz, USA)

Chair

Chelsea Magin (University of Colorado, Denver | Anschutz, USA)

Riccardo Gottardi (University of Groningen, Netherlands)

Keynote Speaker

9:30~9:55 : Enhancing Therapeutic Efficacy in Lung Diseases: Tailoring Drug Carriers for Better Results Jaehong Key (Yonsei University Mirae Campus, Korea, Republic of)

Invited Speaker

9:55~10:10 : Advances in biomaterials for modeling in vivo microenvironments in human lung disease Janette Burgess (University of Groningen, Netherlands)

10:10~10:25 : Engineering 3D Lung Tissue Models to Improve Drug Discovery and Validation Chelsea Magin (University of Colorado, Denver | Anschutz, USA)

Sungjune Jung (POSTECH, Korea, Republic of)

Oral Presenter

10:40~10:50 : Development of 3D-shaped cell delivering patch for skin regeneration Gunjae Jeong (The Catholic University of Korea, Korea, Republic of)

Description

Millions of people worldwide suffer from life-altering respiratory conditions. As SARS-CoV-2 infections continue, this number is expected to increase. Therefore, the need to engineer models for studying these conditions, treatments to repair lung damage, and/or targeted drug delivery is at an all-time high. Biomaterials are a promising tool to study and repair the lungs. Natural materials, such as human lung decellularized extracellular matrix, are scaffolds for tissue engineering, biomaterial-based lung sealants are treating injuries, nanoparticles are effective for drug delivery, and click-chemistry mechanisms are enabling temporal alterations in the cellular microenvironment. These technologies emphasize the role of biomaterials in a new vision for the future of pulmonary healthcare. This symposium will focus on using biomaterials to engineer the lung microenvironment, enhance therapeutic drug delivery, repair damaged tissue, and how these advances impact pulmonary medicine.



We propose one Keynote Speaker, two Invited Speakers, and talks selected from unsolicited abstract submissions. Keynote and Invited Speakers have confirmed their participation if this session is accepted. The Keynote Speaker, Dr. Key, from Yonsei University Mirae Campus, Republic of Korea, will open the session with a presentation on biomaterials for targeted drug delivery to the lungs. Dr. Westergren-Thorsson, Lund University, Sweden, will present on biomaterials for lung tissue engineering. Dr. Burgess, University of Groningen, will discuss biomaterials for modeling lung disease. The convergence of these topics closely relates to the conference theme because the future of healthcare must address the millions of patients suffering from chronic respiratory diseases.



Our intended audience is engineers, scientists, clinicians, students, postdocs, and other researchers interested in harnessing biomaterials to study or repair lung tissues. We expect that this session, which includes speakers from diverse regions, will catalyze new international collaborations across the globe to craft a new vision for the future of pulmonary healthcare.

Keywords : Lung, Drug Delivery, Tissue Engineering

  • Session TrackBiomaterials for specific medical applications
  • Session TitleAnti-pathogen surface technologies for medical devices
  • Session CodeSP-T06-0332
  • Date & Time / RoomMay 30 (Thu) 16:30~18:00 / Room 321-B
Organizer

Helmut Thissen (CSIRO, Australia)

Chair

Helmut Thissen (CSIRO, Australia)

Wei-Bor Tsai (National Taiwan University, Chinese Taipei)

Keynote Speaker

16:30~16:55 : Serum proteins adsorption on the nanostructured surfaces: does it compromise the mechano-bactericidal efficacy and immunomodulation of titanium surfaces? Elena Ivanova (RMIT University, Australia)

Oral Presenter

16:55~17:05 : Near-infrared irradiated graphene oxide films disrupt Staphylococcus epidermidis biofilms Inês Gonçalves (i3S - Institute for Research and Innovation in Health, Portugal)

17:05~17:15 : Derivatization of NO-Releasing Graphene Oxide Nanosheets for Antibacterial Biomaterial Hitesh Handa (University of Georgia, USA)

17:15~17:25 : Combination of antibiotic and antibacterial implant-a new strategy to reduce the clinical usage of antibiotics Ke Yang (Institute of metal research, Chinese academy of sciences, China)

17:25~17:35 : Activity and long-term stability of surface immobilized antimicrobial peptides (AMPs) using thiol-mediated coupling strategies. Andrew Boden (Swinburne University Technology, Australia)

17:35~17:45 : Induced pluripotent stem cells for repairing lens zonule using a biomimetic electrospinning scaffold combined with a directional differentiation strateg Tianhui Chen (Fudan University in Eye & ENT Hospital, China)

17:45~17:55 : Antimicrobial Biomaterials and Wearable Devices for Combating Drug-resistant Bacterial Infections Peng Li (Northwestern Polytechnical University, China)

Description

All medical devices suffer from associated infection rates. While infection rates over the lifetime of devices varies significantly, some devices clearly stand out due to unacceptably high rates of infection, which presents an enormous burden for healthcare systems around the world to this day. By addressing this problem through the development of effective antimicrobial technologies, and more broadly anti-pathogen technologies, the global biomaterials community can achieve outstanding impact. Moreover, these technologies can play an important role in the increasingly important fight against antimicrobial resistance. Here, the symposium will provide a snapshot of research and development activities around the globe that are focused specifically on effective surface technologies that can be applied to a broad range of biomedical materials and devices. The symposium will put a particular emphasis on exploring recent discoveries related to fundamental aspects that determine the fate of infected medical devices, and on investigating aspects that are relevant for the industrial translation of these technologies.

 

Keywords : Antimicrobial, Pathogen, Surface Technology

  • Session TrackBiomaterials for specific medical applications
  • Session TitleBiomaterials for Wearable and Implantable Medical Devices, Sensors, and Electronics
  • Session CodeSP-T06-0077
  • Date & Time / RoomMay 30 (Thu) 16:30~18:00 / Room 323
Organizer

Youngjae Chun (University of Pittsburgh, USA)

Chair

Youngjae Chun (University of Pittsburgh, USA)

Jae-Woong Jeong (KAIST, Korea, Republic of)

Keynote Speaker

16:30~16:55 : Soft Implantable Bioelectronic System for Wireless Continuous Monitoring of Restenosis Woon-Hong Yeo (Georgia Institute of Technology, USA)

Invited Speaker

16:55~17:10 : Advanced minmially invasive medical devices for treating cerebral, cardiac, and aortic diseases and injuries Youngjae Chun (University of Pittsburgh, USA)

Steve Park (KAIST, Korea, Republic of)

Oral Presenter

17:25~17:35 : A novel self-gripping long-term PLLA/TMC resorbable mesh providing temporary support for open primary ventral and incisional hernia YVES BAYON (Medtronic, France)

17:35~17:45 : Mechanisms identified in total hip arthroplasty corrode modular junctions in the knee Michael Kurtz (Drexel University, USA)

Description

Wearable and implantable medical devices, sensors and electronics have demonstrated great potential for a wide range of personalized health monitoring and therapeutic applications over the past several decades. These devices designed to interface with biology are an important class of biomaterials. Representative devices include: (1) wearable or patch sensors for various health monitoring, (2) implantable medical devices or bioelectronics that can monitor physiological conditions effectively, and (3) sensors and electronics for in vitro disease diagnostics or for electrical stimulation in tissue engineering. This symposium will highlight a broad range of recent technologies and trends in wearable and implantable medical devices that utilizes various forms of biomaterials. Presentations will also cover biocompatibility, fabrication technologies, and commercialization potential.



Potential audiences will be biomaterial engineers, electrical/mechanical engineers, basic biologists, clinicians who are from diverse fields.



The theme of WBC 2024 is “Convergence in Biomaterials: a vision for the future of healthcare”. Therefore, biomaterials driven cutting edge medical device research on wearable and implantable bioelectronics will gain a significant interest from the audience who attends the meeting.

 

Keywords : wearable, implantable, medical devices

  • Session TrackBiomaterials for specific medical applications
  • Session TitleAdvanced Biomaterials and Nanomaterials for Implantable Devices
  • Session CodeSP-T06-0339
  • Date & Time / RoomMay 30 (Thu) 9:30~11:00 / Room 323
Organizer

Tolou Shokuhfar (University of Illinois at Chicago, USA)

Chair

Amber Jennings (The University of Memphis, USA)

Reza Shahbazian (University of Illinois at Chicago, USA)

Keynote Speaker

Guillermo Ameer (Northwestern University, USA)

Invited Speaker

9:55~10:10 : Biodegradable photonic crystals for adhesive sensor of wound healing Jinmyoung Joo (Ulsan National Institute of Science and Technology(UNIST), Korea, Republic of)

10:10~10:25 : Evaluation of slow-degraded hydroxypropyl methylcellulose hydrogel with anti-inflammatory agent loading applied as vitreous substitutes Ching-Li Tseng (Taipei Medical University, Chinese Taipei)

Oral Presenter

10:25~10:35 : A New Perspective on Biomineralization in Healthy and Dysfunctional Ferritins Tolou Shokuhfar (University of Illinois at Chicago, USA)

10:35~10:45 : Dynamic nano-assemblies for biological sensing, imaging and regulation Daishun Ling (Shanghai Jiao Tong University, China)

10:45~10:55 : A novel TAVR device with fish swim bladder as valve leaflets Zhihong Wang (Institute of Transplant Medicine, Nankai University School of Medicine, China)

Description

The objective of this symposium is to cover advances in new research directions for biomaterials, nanomaterials and therapeutics for biomedical implants. It attracts researchers and clinicians audiences for pushing the envelope in tissue regeneration as well as disease prevention, detection, and treatment. It covers more traditional areas such as hip, craniofacial, and spinal implants but also pushes us in new directions such as nanomedicine, nanotheraputics and implantable nanomaterials  and covers biomaterials used for regaining functions in different organs in the body. It covers biomaterials  that can potentially determine changes in tissue health and then respond to those changes to ensure healthy tissues and organs. It also emphasizes novel solutions to traditionally difficult to treat diseases. 

Most importantly, highlights the dynamic field of nanomedicine and nanobiomaterials as it introduces new chemistries to tissue regeneration, drug delivery, and vaccine development. 

Keywords : Biomaterials, nanomedicine, implants

  • Session TrackBiomaterials for specific medical applications
  • Session TitleBiomaterials for immune tolerance against autoimmune diseases
  • Session CodeSP-T06-0089
  • Date & Time / RoomMay 30 (Thu) 13:40~15:10 / Room 321-B
Organizer

James Moon (University of Michigan, Ann Arbor, USA)

Chair

James Moon (University of Michigan, Ann Arbor, USA)

Jaeyun Kim (Sungkyunkwan University, Korea, Republic of)

Keynote Speaker

13:40~14:05 : Harnessing biomaterials to study and direct immune function Chris Jewell (University of Maryland, USA)

Invited Speaker

14:05~14:20 : Nanoparticle-based tolerogenic vaccines to treat multiple sclerosis via re-establishing immune tolerance Jaeyun Kim (Sungkyunkwan University, Korea, Republic of)

14:20~14:35 : Nanoparticle platform for immune tolerance against autoimmunity James Moon (University of Michigan, Ann Arbor, USA)

Oral Presenter

14:35~14:45 : Localized Immune Cell Homing Platform for Cellular Immunotherapy Corrine Ying Xuan Chua (Houston Methodist Research Institute, USA)

14:45~14:55 : An injectable, macroporous and immunoactive T cells-loaded scaffold for local cancer immunotherapy treatment Baptiste Marin (École de Technologie supérieure, Canada)

14:55~15:05 : Tracing immune cells around biomaterials with spatial anchors during large-scale wound regeneration Yang Yang (Sichuan University, China)

Description

The Symposium on Biomaterials for Immunotherapy against Autoimmune Diseases aims to bring together leading researchers and practitioners in the field to discuss the latest advances in the development and use of biomaterials for the treatment of autoimmune diseases. The symposium will cover a wide range of topics, including the design and synthesis of biomaterials, their mechanisms of action in the immune system, and clinical applications in autoimmune diseases, such as multiple sclerosis and type I diabetes. The symposium will feature keynote lectures from leading experts in the field, as well as oral presentations from attendees. There will also be opportunities for networking and discussion, including panel discussions and breakout sessions. The intended audience for this symposium includes researchers, clinicians, and other professionals working in the fields of biomaterials, immunology, and autoimmune diseases. We welcome attendees from academia, industry, and government agencies, as well as students and other interested parties. The expected outcomes of the symposium include the identification of new research directions and opportunities in the field of biomaterials for immunotherapy against autoimmune diseases, the establishment of collaborations and partnerships between attendees, and the dissemination of new research findings and clinical insights. We hope that the symposium will foster the exchange of ideas and knowledge and contribute to the advancement of this important and rapidly growing area of research and clinical practice.

Keywords : Biomaterials, autoimmune, tolerance

  • Session TrackBiomaterials for specific medical applications
  • Session TitleAdvanced Biomaterials with sensing properties to overcome the XXI century health challenges
  • Session CodeSP-T06-0346
  • Date & Time / RoomMay 31 (Fri) 11:20~12:50 / Room 322
Organizer

Maria Grazia Raucci (National Research Council of Italy, Italy)

Chair

Maria Grazia Raucci (ESB - Affiliated National Biomaterials Societies, Italy)

Ana Paula Pego (European Society for Biomaterials, Portugal)

Keynote Speaker

11:20~11:45 : FLIM and Raman spectroscopy-based analysis of cells and tissues Katja Schenke-Layland (Eberhard Karls University Tubingen, Germany)

Invited Speaker

11:45~12:00 : Peptide Aptamer-functionalised Biomaterials: a Novel and Industrially-sustainable Class of Biospecific Substrates for Diagnostic and Theranostic Devices. Matteo Santin (University of Brighton, United Kingdom)

12:00~12:15 : Novel approaches in biosensing and diagnostics for infectious diseases Hyun Jung Chung (Korea Advanced Institute of Science and Technology(KAIST), Korea, Republic of)

Oral Presenter

12:15~12:25 : Polydopamine nanoparticles as an organic biodegradable theranostic platform for the treatment of colorectal cancer matteo battaglini (Italian Institute of Technology Smart Bio-Interfaces, Italy)

12:25~12:35 : Rapid identification of therapeutic bacteriophages for personalized phage therapy using high throughput ATP bioluminescence assay Fereshteh Bayat (McMaster University, Canada)

Description

We have observed an evolution in the definition of biomaterial that is no longer limited to the materials used in medical devices. As per the last definitions conference in held in Chengdu in 2018, a biomaterial is “a material designed to take a form that can direct, through interactions with living systems, the course of any therapeutic or diagnostic procedure”. To handle with a high degree of complexity in terms of biological environment interactions we have seen in recent years several developments towards the design of materials with advanced therapeutic and biosensing properties. This has always required a multidisciplinary approach that has allowed the implementation of novel advanced biomaterials (e.g., responsive materials, multifunctional dendrimers, nanodiamonds, smart 2D substrates, etc.) to be used for the recognition of a specific cellular microenvironment, modulation of cellular response (eukaryotic and prokaryotic cells), diagnostic and therapy. The symposium, promoted by the ESB - Affiliated National Biomaterials Societies, aims to give an overview of these novel biomaterials with sensing and/or therapeutic properties with particular focus on those targeted to solve the health challenges of the XXI century: cancer treatment, overcoming bacterial resistance, wound healing, and neurodegenerative diseases management. Keynote and Invited Speakers are selected to give an overview of the scientific progress of biomaterials and their clinical applications in these areas.

 

Keywords : therapeutic, modulation, biosensors, diagnostic, theragnostic

  • Session TrackBiomaterials for specific medical applications
  • Session TitleInnovative biomaterials and devices for cardiovascular therapy
  • Session CodeSP-T06-0095
  • Date & Time / RoomMay 30 (Thu) 9:30~11:00 / Room 321-B
Organizer

Mikyung Shin (Sungkyunkwan University, Korea, Republic of)

Chair

Mikyung Shin (Sungkyunkwan University, Korea, Republic of)

Erika Moore (University of Maryland, USA)

Keynote Speaker

9:30~9:55 : Directed evolution enables sequential, affinity-controlled delivery of angiogenic growth factors for vascular network formation Marian Hettiaratchi (University of Oregon, USA)

Invited Speaker

9:55~10:10 : Leveraging biomaterial platforms and iPSC technology to study early-stage pathogenesis of inherited cardiomyopathies Nathaniel Huebsch (Washington University in St. Louis, USA)

10:10~10:25 : Engineered sEVs and miRNA modification for cardiac repair Hyun-Ji Park (Ajou University, Korea, Republic of)

Oral Presenter

10:25~10:35 : Smart surface constructing strategies for cardiovascular devices Xin Li (Third People’s Hospital of Chengdu Affiliated to Southwest Jiaotong University, China)

10:35~10:45 : Fabrication and evaluation of Mg microtubes for biodegradable cardiovascular stents Joung Sik Suh (Korea Institute of Materials Science, Korea, Republic of)

Description

Cardiovascular diseases are the leading cause of mortality worldwide. Thus, biomaterials for new therapeutic interventions with high efficacy are still required for the future healthcare. Up to date, versatile biomaterials in cardiovasuclar research have been developed for enhancing biocompatibility, functionally integrating with the myocardium, and as drug carrier and scaffold for tissue regeneration. This symposium will provide a forum for such advances of biomedical materials and devices regarding cardiovascular therapies, cardiovascular tissue engineering/repair and other translational research across this entire spectrum.

Keywords : Cardiovascular applications; Biomaterials and devices

  • Session TrackBiomaterials for specific medical applications
  • Session TitleBiomaterials for Antimicrobial and/or Antifouling coatings
  • Session CodeSP-T06-0128
  • Date & Time / RoomMay 29 (Wed) 13:40~15:10 / Room 323
Organizer

Xavier Banquy (Universite de Montreal, Canada)

Co-organizer

Dong Woog Lee (Ulsan National Institute of Science and Technology (UNIST), Korea, Republic of)

Chair

Xavier Banquy (Universite de Montreal, Canada)

Dong Woog Lee (Ulsan National Institute of Science and Technology (UNIST), Korea, Republic of)

Keynote Speaker

Byeong-Su Kim (Yonsei University, Korea, Republic of)

Invited Speaker

14:05~14:20 : Probing reversible noncovalent molecular interactions for advancing multifunctional soft Materials and surfaces Hongbo Zeng (University of Alberta, Canada)

14:20~14:35 : Bioinspired materials for marine antifouling coating Ronxin Su (Tianjin university, China)

Jing Yu (Nanyang Technological University, Singapore)

Oral Presenter

14:50~15:00 : Nanomechanics of Layer-by-layer nanofilms made of bottlebrush polymers Xavier Banquy (Universite de Montreal, Canada)

15:00~15:10 : Antifouling and antimicrobial bioresorbable coatings for protection of titanium-based implantable medical devices David Zermeno Perez (Ashland Specialties Ireland & University College Dublin, Ireland)

Description

  Biofouling of medical devices is characterized by the formation of a biofilm of highly proliferating bacteria. During the biofilm formation process, the bacteria produce exopolysaccharides acting as a scaffold bringing mechanical and chemical resistance to the biofilm. Bacteria within a biofilm are far more resistant to antimicrobials and less susceptible to the host immune systems. The rise of the demand of personal protection medical device, the increase of bacterial resistance and the ever-increasing number of bacterial infections involving biofilms urge scientist to design innovative, biomaterial-based, anti-infective technologies possessing both antibiofilm and antimicrobial activity for the effective control of biofouling in clinical settings.

 

  This symposium will feature talks on recent advances in biomaterials strategies to control protein adsorption, cellular and microbial adhesion, proliferation, and dispersion. Topics will include sustainable biomaterials approach to control fouling, new approaches in biomaterial and surface chemistry, new drug delivery strategies, and nanotopographical approaches to control cell and / or bacterial adhesion among others. The biomaterial can include, but not limited to, (i) polypeptides, polysaccharides, natural rubbers, and (ii) bio-mimetic polymers. The coatings may fulfill their antimicrobial/antifouling purpose by specific chemical moieties, structures, or any other factors. The application of coating materials includes, but not limited to, (i) biomedical devices, equipment, or implants, (ii) human organs, tissues, or blood vessels. Highlighted applications will include medical device contamination, including treatment and prevention of medical device-associated biofilms, and treatment and prevention of systemic microbial infections.



  This symposium fit well into the mission of WBC2024, to bring scientists with different expertise such as  biomaterials engineering, device manufacturing and biomedical engineering to address unmet medical needs.

Keywords : Antifouling; Antimicrobial; Antiadhesive

  • Session TrackBiomaterials for specific medical applications
  • Session TitleBiomaterials meets glia: biomaterials applications to study glia and gliopathologies
  • Session CodeSP-T06-0384
  • Date & Time / RoomMay 28 (Tue) 16:30~18:00 / Room 323
Organizer

Ana Paula Pego (i3S / INEB - University of Porto, Portugal)

Chair

Ana Paula Pego (i3S / INEB - University of Porto, Portugal)

Shelly Sakiyama-Elbert (University of Washington, USA)

Keynote Speaker

16:30~16:55 : Glial engineering and interfaces: multifunctional bio(nano)materials and devices to dialogue with glia Valentina Benfenati (Consiglio Nazionale delle Ricerche, Istituto per la Sintesi Organica e Fotoreattività, Italy)

Invited Speaker

16:55~17:10 : Unravelling glia mechanobiology in bioengineered models to tackle neural repair failure Ana Paula Pego (i3S / INEB - University of Porto, Portugal)

17:10~17:25 : Biomaterials scaffolds to modulate the role of astrocytes after spinal cord injury Shelly Sakiyama-Elbert (University of Washington, USA)

Oral Presenter

17:25~17:35 : Extracellular Matrix-based Biocompatible Adhesive Hydrogel for Neural-electrode Interface Yeonggwon Jo (Pohang University of Science and Technology, Korea, Republic of)

17:35~17:45 : Piezoelectric stimulation of microglia as an innovative approach for glioma immunotherapy Gianni Ciofani (Istituto Italiano di Tecnologia, Italy)

Description

So far, the neuroscience field has failed to grasp the full complexity of the brain and spinal cord. This has hampered our capacity to effectively treat the many diseases and conditions that afflict the central nervous system (CNS), which is vital for our survival.

While overlooked for centuries, the role of glial cells in health and disease is now undeniable and therapeutical strategies are now being oriented towards targeting these cells. Indeed, astrocytes synthesize and shape the extracellular matrix (ECM) throughout human lifespan. Furthermore, oligodendrocytes and microglia continuously crosstalk with the ECM in the so-called fourth-partite synapse. With the current lack of approaches for fully treat neurological disorders, there is a demand for the development of technologies that can not only allow the understanding of the glial cell microenvironment but also contribute to the design of efficient delivery systems of biomolecules, drugs, and/or cells to pathologic scenarios.

Tissue engineering strategies based on biomaterials are emerging as potential approaches for these purposes. Hydrogels have been produced to culture neural cells, allowing their study in a 3D environment, which constitutes an improved biologically relevant approach. Efforts have been made to produce an ideal ECM analogue that mimics, as far as possible, biochemical and biophysical properties of the nervous tissue. Along with hydrogels, other platforms have been proven to be efficient in guiding nervous tissue regeneration. Additionally, the regenerative engineering field is also proposing novel and efficient strategies for the delivery of therapeutic molecules, or cell populations, to the CNS to promote the restoration of the normal tissue function.

In this symposium we aim to introduce to the biomaterial’s community the specificities of these cells and the advantages of the exploration of biomaterials and tissue engineering strategies in the dissection of glial-related mysteries and in the treatment of gliopathologies.

Keywords : neurodegenerative diseases, in vitro models, sensors

  • Session TrackBiomaterials for specific medical applications
  • Session TitleAdvances in Antimicrobial and Antibiofilm Biomaterials
  • Session CodeSP-T06-0143
  • Date & Time / RoomMay 31 (Fri) 11:20~12:50 / Room 321-A
Organizer

Anita Shukla (Brown University, USA)

Chair

Anita Shukla (Brown University, USA)

Rachit Agarwal (Indian Institute of Science, India)

Keynote Speaker

11:20~11:45 : Antibacterial polymers and their applications as antibiotic replacements, antibiofilm agents, and for device applications Mary Chan-Park (Nanyang Technological University, Singapore)

Invited Speaker

11:45~12:00 : Strain-selectivity in nanomaterial-based antibacterial agent Mrinmoy De (Indian Institute of Science, India)

Oral Presenter

12:00~12:10 : Novel Platelet Storage Devices to Combat Bacterial Contamination and Growth Kai Yu (University of British Columbia, Canada)

12:10~12:20 : Antibacterial properties of multiple antigenic peptides (MAP) based on polyarginine: from experiments to molecular dynamic simulations Philippe Lavalle (Inserm / University of Strasbourg, France)

12:20~12:30 : Dynamic titanium surface adapts to multiple service stages by orchestrating responsive polymers and antimicrobial peptides Lin Wang (South China University of Technology, China)

12:30~12:40 : Properties of nano-magnesium oxide modified antibacterial light-curing adhesive resin Jing Fu (The Affiliated Hospital of Qingdao University, China)

Description

Microbial infections are among the leading causes of death worldwide. Drug resistance and the lack of new antimicrobial therapeutics have made it increasingly difficult to treat microbial infections. The World Health Organization has described antibiotic resistance as “one of the biggest threats to global health, food security, and development today.” Microbial biofilms can also severely complicate treatment and lead to chronic infections. These complex, three-dimensional microbial communities can form on a range of medical devices and biological surfaces and exhibit sophisticated defense mechanisms, evading traditional antimicrobial therapies. There is an immediate need to engineer advanced antimicrobial biomaterials, therapeutics, and delivery systems that can rapidly and effectively treat infections, while helping to control the spread of resistance and formation of biofilms. This session will focus on recent advances in developing materials for the prevention and treatment of bacterial, fungal, viral, biofilm, and polymicrobial infections.  The keynote and invited speakers will cover a broad range of biomaterials approaches to treating infection, ranging from new antimicrobial polymers to hydrogel drug delivery systems and 2D nanomaterials. Abstracts submitted may include topics from synthesis of new antimicrobial molecules and macromolecules to fabrication of antimicrobial surfaces, device coatings, nano- and micro-particle drug carriers, hydrogels, etc. Interdisciplinary biomaterials research including modulation of the immune system and host-microbiome interactions to influence antimicrobial activity will also be included. Research in the design, synthesis, characterization, testing, and translation of these antimicrobial materials will be discussed. The purpose of this session is to bring together various promising materials-based approaches to prevent and treat microbial infections and provide a discussion platform to researchers all across the world in synergizing their efforts.

Keywords : antimicrobial, antibiofilm, infection

  • Session TrackBiomaterials for specific medical applications
  • Session TitleMultifunctional biomaterials for blood contacting and cardiovascular applications
  • Session CodeSP-T06-0214
  • Date & Time / RoomMay 30 (Thu) 13:40~15:10 / Room 314
Organizer

Kyla Sask (McMaster University, Canada)

Chair

Kyla Sask (McMaster University, Canada)

Anna Waterhouse (The University of Sydney, Australia)

Keynote Speaker

13:40~14:05 : Strategies to improve the hemocompatibility and avoid infection in blood-contacting medical devices M. Cristina L. Martins (University of Porto, Portugal)

Invited Speaker

14:05~14:20 : HISTOPATHOLOGY EVALUATION OF MULTIFUNCTIONAL BIOMATERIALS FOR CARDIOVASCULAR APPLICATION Sabareeswaran A (Sree Chitra Tirunal Institute for Medical Sciences and Technology, India)

Oral Presenter

14:20~14:30 : Biomimetic approaches for cardiovascular medical device materials Anna Waterhouse (The University of Sydney, Australia)

14:30~14:40 : A thermo-responsive shape-memory polymer to enable the minimally invasive delivery of an implantable blood pressure measurement device Arjan Sall (Healthcare Technologies Institute, School of Chemical Engineering, University of Birmingham, United Kingdom)

14:40~14:50 : The well-designed nanobubbles for vascular inflammatory imaging Fang Yang (Southeast University, China)

14:50~15:00 : A novel total hip replacement design based on cylindrical joints: numerical simulation of stresses on a small-sized version Leonardo Fanton (University of Malta, Malta)

15:00~15:10 : A new class of hydrogel for soft and hard tisue repair. Fariba Dehghani (The University of Sydney, Australia)

Description

Despite progress in biomaterial design, cardiovascular and blood contacting devices are still limited by their susceptibility to thrombosis, inflammation, and infection. Researchers are investigating a variety of materials and modification methods to reduce these adverse responses and improve the outcomes of the devices. The biological interactions with these materials are complex and multifunctional strategies are needed to overcome the challenges with achieving blood compatibility. The purpose of this symposium is to share cutting edge research on multifunctional material design such as surface chemistry, bioactive modifications, micro- and nano-structured surfaces, and endothelialization approaches. Studies that highlight the importance of advanced techniques to evaluate blood-biomaterial interactions, thrombogenicity, inflammation, microbial adhesion, and biofilm formation on multifunctional materials will be included. This session is expected to bring together diverse perspectives from various areas of research and is relevant for numerous attendees including academics, clinicians, industry, and regulatory representatives.

Keywords : blood, multifunctional biomaterials, thromboinflammation

  • Session TrackBiomaterials for specific medical applications
  • Session TitleDiscovery, characterisation and applications of immune-instructive materials
  • Session CodeSP-T06-0247
  • Date & Time / RoomMay 29 (Wed) 16:30~18:00 / Room 321-A
Organizer

Amir Ghaemmaghami (University of Nottingham, United Kingdom)

Chair

Amir Ghaemmaghami (University of Nottingham, United Kingdom)

Nihal Engin Vrana (Sparha Medical, France)

Keynote Speaker

16:30~16:55 : Bioengineering Cell-Based Therapeutics Omid Veiseh (Rice University, USA)

Invited Speaker

16:55~17:10 : The Routes of Incorporation of Immunomodulatory Properties for Multifunction Supramolecular Biomaterial-based Systems Nihal Engin Vrana (Sparha Medical, France)

17:10~17:25 : Harnessing molecular nanoscale arrangement to modulate immunity Michelle Teplensky (Boston University, USA)

Oral Presenter

17:25~17:35 : Milk Exosome-immobilized Fibrous Matrix for Accelerated Wound Healing

 
Hoai-Thuong Duc Bui (Kangwon National University, Korea, Republic of)

17:35~17:45 : Mechano-activated cell therapy for accelerated diabetic wound healing Andy Tay (National University of Singapore, Singapore)

17:45~17:55 : Elucidating Interfacial Instabilities in Epithelial Tissue Gap Closure by Analyzing the Dynamic Features of Cells Jennifer Shin (KAIST, Korea, Republic of)

Description

Immune-instructive materials, are materials with the ability to modulate or mimic the function of immune cells. Such materials provide exciting opportunities for developing new therapies in many areas of unmet clinical need including medical devices, regenerative medicine/tissue engineering, chronic inflammation and cancer immunotherapy.  

In this symposium we discuss new material discovery techniques such as high throughput material screening methodologies and in silico predictive material/function models particularly using deep learning/machine learning techniques. The symposium will cover topics highlighting how key material properties such as topography, size, shape, and surface chemistry can be leveraged to develop immune-instructive materials, with focus on latest research involving material-based strategies for modulating the functional properties of the immune cells such as macrophages and dendritic cells. The symposium will also explore the potential application of such materials in cell-based therapeutics, new cancer vaccines, chronic wound healing, infection, fibrosis treatment and multi-functional bio-instructive coatings. The potential routes of exploitation and the barriers to commercialisation/industrialisation will be covered by industrial participants. 

This symposium will directly address ‘Biomaterials for specific medical applications' in the WBC's list of topics, and will be of interest to a broad range of researchers and clinicians with interest in developing new materials to mitigating foreign body response and infection associated with medical devices, materials based-cell therapies (e.g. for diabetes and cancer), materials for wound healing as well as material scientists who are interested in new material discovery and characterisation pipelines. We also believe the proposed topics on in-silico approaches in material design and pathways to market will be of great interest to researchers and entrepreneurs  with interest in machine learning and commercialisation.  

 

Keywords : immune-instructive materials, wound healing, cell therapies

  • Session TrackBiomaterials for specific medical applications
  • Session TitleBiomaterials for women’s health engineering
  • Session CodeSP-T06-0254
  • Date & Time / RoomMay 30 (Thu) 13:40~15:10 / Room 323
Organizer

Brendan Harley (University of Illinois at Urbana-Champaign, USA)

Chair

Brendan Harley (University of Illinois at Urbana-Champaign, USA)

Elizabeth Cosgriff Hernandez (University of Texas at Austin, USA)

Keynote Speaker

13:40~14:05 : Biomimetic scaffolds for vaginal tissue engineering Samantha Zambuto (Washington University in St. Louis, USA)

Invited Speaker

14:05~14:20 : Physiomimetic models of endometrioma initiation Brendan Harley (University of Illinois at Urbana-Champaign, USA)

Oral Presenter

14:20~14:30 : Self-fitting vaginal stents based on shape memory foams Elizabeth Cosgriff-Hernandez (The University of Texas at Austin, USA)

14:30~14:40 : Antibacterial albumin-tannic acid coatings for scaffold-guided breast reconstruction Silvia Cometta (Queensland University of Technology, Australia)

14:40~14:50 : In vitro accelerated ageing and infrared microscpectroscopy method study of silicone breast implant Credson Langueh (CY Cergy Paris University, France)

14:50~15:00 : 3D printing for engineering gynecological tissues John Fisher (University of Maryland, USA)

Description

Women have historically been excluded at all levels of biomedical research and medical device innovation which has led to a gaping hole in the healthcare landscape to meet even the most basic needs in women’s health.  To address this critical need, we need innovative biomaterial solutions to expand health technologies available to clinicians to treat women. This session will highlight advances in biomaterial approaches to address the myriad of clinical needs in women's health. Topics include disorders in reproductive tissues (e.g. endometriosis, cancer, premature ovarian insufficiency, infertility, preterm birth), multicellular tissue-level interactions and mechanics in reproductive health, extracellular matrix dynamics and sex-related differences in chronic diseases and device design, gynecological device design, and breast cancer and reconstruction.     

 

Keywords : biomaterials, women’s health, disease

  • Session TrackBiomaterials for specific medical applications
  • Session TitleInnovative biomaterials for neural applications
  • Session CodeSP-T06-0256
  • Date & Time / RoomMay 31 (Fri) 11:20~12:50 / Room 323
Organizer

Sarah Stabenfeldt (Arizona State University, USA)

Chair

Sarah Stabenfeldt (Arizona State University, USA)

Abhay Pandit (University of Galway, Ireland)

Keynote Speaker

11:20~11:45 : 3D printing complex human neural tissues Stephanie Willerth (University of Victoria, Canada)

Invited Speaker

David Nisbet (University of Melbourne, Australia)

12:00~12:15 : Biomaterial and drug-delivery based approach for spinal cord injury and for neuropathic pain Seil Sohn (Cha university, Korea, Republic of)

Oral Presenter

12:15~12:25 : Highly piezoelectric, biodegradable and flexible amino acid nanofibers for medical applications Thanh Nguyen (University of Connecticut, USA)

12:25~12:35 : Porous poly(glycerol sebacate)-methacrylate nerve guidance conduits for peripheral nerve regeneration Louis Johnson (University of Sheffield, United Kingdom)

12:35~12:45 : Transient and minimally invasive electronics platform for brain interfaces Jae-Young Bae (Seoul National University, Korea, Republic of)

Description

Engineered biomaterials are uniquely positioned for use in creating, testing, and regenerating neural tissue with applications like in vitro models of injury and disease, tissue engineering, therapeutic treatments, understanding neural development, and mapping the brain. This session will focus on cutting edge research in neural biomaterials including fundamental material development through pre-clinical and clinical studies.  These include big questions surrounding understanding and treating diseases and injuries of the peripheral and central nervous systems spanning cell types including stem and progenitor cells, neurons, astrocytes, oligodendrocytes, microglia, and Schwann cells. The target auidence is biomaterialist, clinicians, and biologists.

Keywords : central nervous system, peripheral nerve, neural tissue engineering

  • Session TrackBiomaterials for specific medical applications
  • Session TitleBiomaterials in regeneration applications and drug delivery
  • Session CodeSP-T06-0275
  • Date & Time / RoomMay 28 (Tue) 13:40~15:10 / Room 323
Organizer

Hyuk Sang Yoo (Kangwon National University, Korea, Republic of)

Chair

Hyuk Sang Yoo (Kangwon National University, Korea, Republic of)

Yu Han Lee (Harvard University, USA)

Keynote Speaker

13:40~14:05 : Noninvasive Gut-to-Brain Oral Delivery Systems Hsing Wen Sung (National Tsing Hua University, Chinese Taipei)

Invited Speaker

Yu Han Lee (Harvard University, USA)

14:20~14:35 : Cell Membrane-cloaked Scaffolds for Biomedical Applications Hye Sung Kim (Dankook University, Korea, Republic of)

Oral Presenter

14:35~14:45 : Surface-cellular interaction and protein adsorption on polymer coatings for implantable medical device application Bruna Cambraia Garms (Monash University, Australia)

14:45~14:55 : Hybrid collagen-based biomaterials for tissue Regeneration applications Yujiang Fan (Sichuan University, China)

Description

Biomaterials play a crucial role in a wide range of biomedical applications, particularly in the fields of tissue regeneration and drug delivery. These materials are designed to interact with biological systems and are used to augment or replace natural tissues, deliver therapeutic agents, and facilitate the healing process. In this session, we explore their applications in regeneration and drug delivery.

Keywords : regeneration, drug delivery

  • Session TrackBiomaterials for specific medical applications
  • Session TitleRegenerative Approaches for ENT Field
  • Session CodeSP-T06-0360
  • Date & Time / RoomMay 31 (Fri) 9:30~11:00 / Room 322
Organizer

Seong Keun Kwon (Seoul National University Hospital, Korea, Republic of)

Chair

Seong Keun Kwon (Seoul National University Hospital, Korea, Republic of)

Tsung-Lin Yang (National Taiwan University, Chinese Taipei)

Keynote Speaker

9:30~9:55 : Strategies and considerations in regenerative medicine of the larynx Nathan Welham (University of Wisconsin-Madison, USA)

Invited Speaker

Tsung-Lin Yang (National Taiwan University, Chinese Taipei)

10:10~10:25 : Tracheal reconstruction using an artificial trachea Yo Kishimoto (Kyoto University, Japan)

Oral Presenter

10:25~10:35 : 3D printed trabecular porous tantalum spine fusion device: mechanical behavior and in vivo osteointegration Jingzhou Yang (Tsinghua University, China)

10:35~10:45 : Mesenchymal Stem Cell Spheroids for Inducing Angiogenesis JI SUK CHOI (Seoul National University Hospital, Korea, Republic of)

Description

As in other medical fields, there are huge demands for the regeneration of the cells and tissues in the head and neck area. Vocal fold aging, defect of bone and cartilage in the facial or cranial region after ablative surgery, salivary gland hypofunction after radiotherapy of malignant head and neck tumors, severe oral mucositis or mucosal defect after chemotherapy, airway stenosis or tracheal defect after ablative surgery, idiopathic parathyroid hormone deficiency after thyroidectomy, and aspiration inducing vocal fold paralysis are some representative targets in tissue engineering in ENT field. However, tissue engineering approach in ENT field is considered more difficult compared with other sites of the body due to 1) limited vascular supply by distal location from the heart 2) constant exposure to septic environment 3) complex shape and composite tissue required for the regeneration. 

This symposium will discuss the current status and recent advances for regeneration of various organs in ENT field, such as vocal fold, salivary gland, and trachea.

 

Keywords : regeneration, head and neck

  • Session TrackBiomaterials for specific medical applications
  • Session TitleBioadhesive technologies for tissue repair and regeneration
  • Session CodeSP-T06-0166
  • Date & Time / RoomMay 31 (Fri) 9:30~11:00 / Room 321-A
Organizer

Jianyu Li (McGill University, Canada)

Chair

Yu Han Lee (Harvard Medical School, USA)

Keynote Speaker

9:30~9:55 : Integrating adhesion and hemostasis for tissue repair Malcolm Xing (University of Manitoba, Canada)

Invited Speaker

Jingda Tang (Xi'an Jiaotong University, China)

Oral Presenter

10:10~10:20 : Engineering highly cellularized materials with click clotting strategy Tianqin Ning (McGill University, Canada)

10:20~10:30 : Development and characterization of a bioresorbable bone adhesive using calcium phosphate cement, phosphoserine, and polydopamine nanoparticles Feng CHAI (Univ Lille, France)

10:30~10:40 : Bioinspired Adhesives: Unlocking the Potential of Phosphoserine-Modified Calcium Phosphates for Effective Bone Repair and Regeneration Antzela Tzagiollari (Dublin Citu University, Ireland)

10:40~10:50 : Adhesive muscle extracellular matrix hydrogels for functional regeneration in skeletal muscle atrophy

 
Mi Jeong Lee (Yonsei University, Korea, Republic of)

Description

Bioadhesive technologies enable appreciable adhesion between biological tissues and biomedical devices. They have found increasing use in a variety of medical settings, ranging from wound management, tissue repair to regenerative medicine. Their significant applications are further fueled by recent advances of the development and translation of new bioadhesives achieving superior mechanical, biological and therapeutic properties. Notable examples include bioinspired tough adhesives capable of forming strong bioadhesion on various tissues, electrical bioadhesives for cardiac interface, bioadhesive patch for sutureless repair of gastrointestinal defects. Major advances seen in the research area include the development of new experimental and computational tools to study bioadhesion, as well as new understanding of bioadhesive-tissue interactions.



Objectives: The exciting advances will be presented in the proposed symposiums by leading researchers from top institutions worldwide, who have key publications in high-impact journals and strived for clinical translation and commercialization of the new bioadhesive technologies.



Expected outcomes: This proposed symposium will effectively consolidate and disseminate new understanding and technological advances in the area of bioadhesives. This opportunity would not only enable the exchange between researchers working in this area, but also attract other researchers from other areas. As such, new design and applications of bioadhesives could emerge. The bioadhesive technology is an enabling platform for many branches of biomaterials research such as regenerative medicine, wearable and implantable devices, tissue repair and wound management.

Keywords : Bioadhesives, Surgical glues, Tissue repair

  • Session TrackBiomaterials for specific medical applications
  • Session TitleBiomaterial Systems and Devices for Hemostasis, Resuscitation, and Wound Care
  • Session CodeSP-T06-0183
  • Date & Time / RoomMay 30 (Thu) 16:30~18:00 / Room 321-A
Organizer

Ashley Brown (North Carolina State University and University of North Carolina at Chapel Hill, USA)

Chair

Anirban Sen Gupta (Case Western Reserve University, USA)

Ildoo Chung (Pusan National University, Korea, Republic of)

Keynote Speaker

16:30~16:55 : Storable and ready-to-use artificial red cells (hemoglobin vesicles) as a resuscitative fluid for emergency medicine Hiromi Sakai (Nara Medical University, Japan)

Invited Speaker

16:55~17:10 : Functional Effects of Platelet Manufacturing and Storage Susan Shea (University of Pittsburgh, USA)

17:10~17:25 : Ultrasoft colloidal hydrogels in confined environments Andrew Lyon (Chapman University, USA)

Oral Presenter

17:25~17:35 : Well-defined porous biodegradable and thermoresponsive micro/nanospheres ILDOO CHUNG (Pusan National University, Korea, Republic of)

17:35~17:45 : Impact of the drying approach on the properties of hydrogel/textile biohybrid vascular implants Dominic Pascal Andre (RWTH Aachen University, Germany)

17:45~17:55 : Chemically modified silk proteins and their applications Chengchen Guo (Westlake University, China)

Description

Stopping bleeding (hemostasis) and providing short and long-term wound care via passive and/or bioactive mechanisms is an important area of biomaterials-based technologies and includes external, intracavitary and intravascular hemostats, dressings, powders, foams, fibers and gels. The goal of this session is to highlight recent advances in biomaterials and biosystems/microdevices that focus on hemostasis, thrombosis, and/or wound healing.  The proposed session will invite presentations from researchers in this field that discuss biomaterials design, structure-property-function relationships, microdevice design, and achieved/ongoing/future visions of technology translation pathways. Presentations focused on material considerations for microdevices for investigating hemostatic pathways are also of interest for this session.



This session is aligned with the following WBC topics: Biomaterials design, Biomaterials for specific medical applications, and Biomaterials for preclinical and clinical translation. The expected outcomes of this session are 1) informing the audience of state-of-the art biomaterial technologies for hemostasis and wound healing and 2) facilitating international discussions and collaborations to further development of technologies in this field.

Keywords : Hemostasis, wound healing, blood contacting materialsstasis

  • Session TrackBiomaterials for specific medical applications
  • Session TitleBiomaterials and devices for cardiovascular applications
  • Session CodeSP-T06-0216
  • Date & Time / RoomMay 30 (Thu) 9:30~11:00 / Room 325-CD
Organizer

Yunbing Wang (Sichuan University, China)

Chair

Yunbing Wang (Sichuan University, China)

Song Li (University of California, Los Angeles, USA)

Keynote Speaker

9:30~9:55 : Biohybrid supports for heart failure: Integrating extracellular matrix digest into microfibrous, elastic composite materials to redirect tissue remodeling William Wagner (University of Pittsburgh, USA)

Invited Speaker

9:55~10:10 : Biomaterial research: from bioinspired to data driven approach Jian Ji (Zhejiang University, China)

10:10~10:25 : Nano-theranostics for atherosclerosis Gaocan Li (Sichuan University, China)

10:25~10:40 : Ostrich Carotid Artery-derived Acellular Blood Vessel with 2mm ID for Limb Salvage Tetsuji Yamaoka (National Cerebral and Cardiovascular Research Institute, Japan)

Oral Presenter

10:40~10:50 : Modulating matrix stiffness to reverse age-related cardiac dysfunction Ranmadusha Hengst (Mechanobiology Institute/National University of Singapore., Singapore)

10:50~11:00 : Selective NLRP3 inflammasome inhibitor MCC950 suppresses inflammation and facilitates healing in vascular materials Steven Wise (The University of Sydney, Australia)

Description

Innovative biomaterials and medical devices have become the most effective means in the treatment of cardiovascular diseases. This general session will focus on the recent advances in the development of biomaterials and devices for cardiovascular applications. There are several topics that will be presented during this symposium including biomaterials with anti-coagulation, anti-calcification, inflammation regulation and promoted tissue healing properties for the repair and replacement of cardiovascular tissues; medical devices including vascular stents, heart valves, drug-eluting balloons, cardiac occluders, artificial grafts, injectable hydrogels against heart failure, and left ventricular assist device (LVAD) for the treatment of diverse cardiovascular disease with innovative biomaterials and techniques; design strategy, synthesis, characterization, processing and fabrication of functional cardiovascular materials in terms of bulk materials, coatings, drug delivery system and composites; investigations on material/tissue and material/blood interactions and mechanism behind. Methods to evaluate cardiovascular materials from concept to clinical trial and product development for commercialization are also highlighted. The session will invite renowned experts and scholars to discuss and share the latest achievements and important progress in the field of cardiovascular materials and medical devices, and provide guidance and insights for the future development directions.

Keywords : cardiovascular biomaterials, medical devices, cardiovascular disease

  • Session TrackBiomaterials for in vitro (extracorporeal) analysis
  • Session TitleEx vivo model systems for cancer immunotherapy
  • Session CodeSP-T07-0063
  • Date & Time / RoomMay 27 (Mon) 13:00~14:30 / Room 321-B
Organizer

Junsang Doh (Seoul National University, Korea, Republic of)

Chair

Junsang Doh (Seoul National University, Korea, Republic of)

Kyobum Kim (Dongguk Univ, Korea, Republic of)

Keynote Speaker

Susan Thomas (Georgia Tech, USA)

Invited Speaker

Junsang Doh (Seoul National University, Korea, Republic of)

Oral Presenter

13:40~13:50 : 3D in vitro models of sinonasal cancers as a personalized platform to study new drugs Serena Danti (University of Pisa, Italy)

13:50~14:00 : Cell derived extracellular matrices for tumor models for in vitro testing Elisabeth Engel (Universitat Politecnica de Catalunya, Spain)

14:00~14:10 : Hydrolytically Degradable, Micro-organoids for Spatial Patterning of Human Lymph Node Tissue Chips Valeria Juarez (Georgia Institute of Technology, USA)

14:10~14:20 : IN VITRO HYDROGEL-BASED MODELS TO OBSERVE GLIOBLASTOMA SPHEROID GROWTH, INVASION AND THERAPY RESPONSIVENESS AT MATRIX INTERFACES Eya Ferchichi (Saint Louis University, USA)

Description

Cancer immunotherapy is a novel cancer treatment approach that relies on our immune system's ability to recognize and eliminate cancer cells. Cancer immunotherapy has recently been successful in treating a variety of different types of cancer, but it is still only effective for a small percentage of cancer patients. One of the key challenges in the advancement of cancer immunotherapy is lack of preclinical models representing tumor-immune microenvironments of cancer patients. In this symposium, ex vivo engineered model systems based on organoid or organ-on-a-chip technologies recapitulating various aspects of complex and dynamic tumor-immune microenvironments will be presented.

Keywords : Cancer immunotherapy, ex vivo model system

  • Session TrackBiomaterials for in vitro (extracorporeal) analysis
  • Session TitleIn vitro microphysiological systems for studying tumor microenvironment
  • Session CodeSP-T07-0064
  • Date & Time / RoomMay 27 (Mon) 16:30~18:00 / Room 321-B
Organizer

Joo Hun Kang (UNIST, Korea, Republic of)

Chair

Joo Hun Kang (UNIST, Korea, Republic of)

Junsang Doh (Seoul National University, Korea, Republic of)

Keynote Speaker

16:30~16:55 : Microengineered Biomimicry of Human Physiological Systems Dan Dongeun Huh (University of Pennsylvania, USA)

Invited Speaker

16:55~17:10 : Engineering patient-derived microphysiological systems to reconstruct the tumor microenvironments Jihoon Ko (Gachon University, Korea, Republic of)

17:10~17:25 : Reverse Engineering of Tumor Microenvironment Using Microfluidics and 3D Printing Sungsu Park (Sungkyunkwan University, Korea, Republic of)

Oral Presenter

17:25~17:35 : Intratumoral mapping of local 3D tissue viscoelasticity at cellular clength scales during breast cancer progression Christopher Moraes (McGill University, Canada)

17:35~17:45 : Comparative analysis of 3D-printed β-TCP and freeze-dried alginate-bioactive glass scaffolds as bone-like microenvironments for osteosarcoma in vitro modelling Ksenia Menshikh (Università del Piemonte Orientale, Italy)

Description

The development of in vitro microphysiological systems have spurred the exploration of the intricate dynamics of the tumor microenvironment. This symposium aims to converge researchers on a platform designed to share insights into the latest breakthroughs in the field. 



This symposium is to provide a comprehensive overview of the current state-of-the-art in in vitro microphysiological systems utilized for investigating the tumor microenvironment. It seeks to encourage the exchange of knowledge between researchers working at the interface of biology, engineering, and medicine. Through this collaboration, participants will not only deepen their understanding of these advanced models but also explore novel approaches and technologies that enable a more accurate representation of tumor dynamics in the microenvironment. 



The symposium's program comprises a keynote presentation (Prof. Dan Dongeun Huh, Penn), an eminent researcher in the field. Diverse perspectives will be highlighted, encompassing most-advanced techniques and clinical applications. The intended audience includes researchers and practitioners across the fields of oncology, tissue engineering, biomaterials, and drug development. 



Anticipated outcomes include an enriched understanding of how in vitro microphysiological systems can replicate the intricacies of the tumor microenvironment. Insights from this symposium will drive the development of more physiologically relevant tumor in vitro models, leading to enhanced predictive capabilities for drug testing and personalized treatment. Moreover, discussions around challenges and opportunities in this field will guide future research directions, accelerating the translation of findings from bench to bedside.

Keywords : organ on a chip, tumor microenvironment, in vitro microphysiological systems

  • Session TrackBiomaterials for in vitro (extracorporeal) analysis
  • Session TitleMicrophysiological systems for modeling pathologies of central nervous system
  • Session CodeSP-T07-0065
  • Date & Time / RoomMay 28 (Tue) 9:30~11:00 / Room 321-B
Organizer

Hong Nam Kim (Korea Institute of Science and Technology, Korea, Republic of)

Chair

Hong Nam Kim (Korea Institute of Science and Technology, Korea, Republic of)

Seokyoung Bang (Dongguk University, Korea, Republic of)

Keynote Speaker

Ki Bum Lee (Rutgers University, USA)

Invited Speaker

9:55~10:10 : Refining Cultivation Techniques for Human Neural Systems with Tailored Extracellular Matrix and Microfluidic Integration Yoonhee Jin (Yonsei University College of Medicine, Korea, Republic of)

10:10~10:25 : Human spinal cord organoids exhibiting neural tube morphogenesis for a quantifiable drug screening system of neural tube defects Ju-Hyun Lee (Korea Institute of Science and Technology, Korea, Republic of)

Oral Presenter

10:25~10:35 : A 3D in vitro cortical tissue model For Studying effects of ionizing radiation on human neuronal network function Chiara E Ghezzi (University of Massachusetts Lowell, USA)

10:35~10:45 : Acoustic Stimulation in BBB-on-a-Chip: Advancing Blood-Brain Barrier Research Melanie Stamp (University of Melbourne, Australia)

Description

In this symposium, we discuss the emerging microphysiological system-based central nervous system (CNS) models and their application in CNS disease modeling. By using the engineered human CNS models, the pathophysiological features of human CNS diseases can be recapitulated and the efficacy of therapeutic approaches can be evaluated. Especially, the CNS organoid and CNS organ-on-a-chip will be presented with their merits in mimicking the CNS ultrastructure and microenvironment. This symposium may be potentially useful for those who are working on biomaterials-based tissue modeling, next-generation pharmaceutics, and innovative nano-bio technologies. This symposium is believed to widen the knowledge in biomaterials with a particular focus on microphysiological system-based human CNS disease modeling.

Keywords : Microphysiological system, central nervous system, pathology modeling

  • Session TrackBiomaterials for in vitro (extracorporeal) analysis
  • Session TitleOptical biosensors for fast and accurate diagnosis
  • Session CodeSP-T07-0070
  • Date & Time / RoomMay 29 (Wed) 9:30~11:00 / Room 321-B
Organizer

Heebeom Koo (The Catholic University of Korea, Korea, Republic of)

Chair

Heebeom Koo (The Catholic University of Korea, Korea, Republic of)

Joonhyuck Park (The Catholic University of Korea, Korea, Republic of)

Keynote Speaker

Niko Hildebrandt (Université de Rouen Normandie, France)

Invited Speaker

9:55~10:10 : Engineering cells with nanomaterials for augmenting and tracking cell-based therapies Jinhwan Kim (UC Davis, USA)

Oral Presenter

10:10~10:20 : Nanomaterial based ultrasensitive bioimaging and biosensor platforms Joonhyuck Park (The Catholic University of Korea, Korea, Republic of)

10:20~10:30 : In vitro tissue-equivalent models for studying foreign body reaction Liliana Agresti (University Medical Center Groningen (UMCG), Netherlands)

10:30~10:40 : Hydrogel-Based 3D In Vitro Model of Liver Toxicity with Simulated Human Immune System for Predicting Hepatotoxicity and Immune Hyperactivity Yu Bin Lee (Korea Institute of Toxicology, Korea, Republic of)

10:40~10:50 : Ultrasensitive Paper-based Surface-Enhanced Raman Spectroscopy for Clinical Applications DEHUI WAN (National Tsing Hua University, Chinese Taipei)

Description

Highly sensitive detection of biomolecules is of paramount importance to understanding biological functions at the single-cell level and for various medical diagnoses. Various nanoparticles (NPs) including quantum dots, upconversion NPs, gold NPs, and graphene/carbon nanotubes are useful and have been used for this purpose. Cutting-edge technologies have been developed based on the rational combination of these nano-materials, and could achieve fast and efficient sensing of many biomolecules with low concentrations.

Keywords : sensor, optical imaging, nanoparticle

  • Session TrackBiomaterials for in vitro (extracorporeal) analysis
  • Session TitleImaging and spectroscopic analysis of biomaterials and biological systems
  • Session CodeSP-T07-0075
  • Date & Time / RoomMay 28 (Tue) 13:40~15:10 / Room 321-B
Organizer

Sung Sik Lee (ETH Zurich, Switzerland)

Chair

Sung Sik Lee (ETH Zurich, Switzerland)

Jong-Chan Lee (DGIST, Korea, Republic of)

Keynote Speaker

Yong Keun Park (KAIST, Korea, Republic of)

Invited Speaker

Byung Mook Weon (Sungkyunkwan University, Korea, Republic of)

14:20~14:35 : Tackling background noise problem in STED optical nanoscopy Jong-Chan Lee (DGIST, Korea, Republic of)

14:35~14:50 : Microfluidic platform for single live sperm analysis Jae Bem You (Kyungpook National University, Korea, Republic of)

Oral Presenter

14:50~15:00 : Comprehensive Analysis of Collagen Hydrogel Response to Physiological pH Fluctuations: Structure, Viscoelasticity, and Permeability Orit Bronner Shtrauchler (Ben-Gurion University of the Negev, Israel)

Description

Imaging and spectroscopy have been used to characterize biomaterials and biological systems. The goal of this symposium is to discuss current developing imaging and spectroscopy methods and applications that could be used with in vitro (extracorporeal) analysis (e.g. lab-on-a chip, organ models, 3D culture, Healthcare devices). X-ray imaging, quantitative phase imaging, Raman spectroscopy and imaging (SERS, CARS, SRS), super-resolution imaging, label-free imaging, single molecule detection, multi-photon imaging, light-sheet imaging and advanced imaging/spectroscopy for biomaterials and biological systems (e.g. organoid, soft matter, phase separation) are among the topics covered at the symposium. In addition, the symposium could cover biocompatible imaging/spectroscopy probes, visualization and spectroscopic quantification of biomaterials in in-vitro devices as well as biological systems.    

 

Keywords : Imaging, Spectroscopy, biocompatible probe for in-vitro device

  • Session TrackBiomaterials for in vitro (extracorporeal) analysis
  • Session TitleLiquid biopsy for cancer diagnosis and prognosis
  • Session CodeSP-T07-0349
  • Date & Time / RoomMay 28 (Tue) 16:30~18:00 / Room 321-B
Organizer

Seungpyo Hong (University of Wisconsin-Madison, USA)

Chair

Seungpyo Hong (University of Wisconsin-Madison, USA)

Tian Zhang (University of Texas Southwestern Medical Center, USA)

Keynote Speaker

Andrew Wang (University of Texas Southwestern Medical Center, USA)

Invited Speaker

16:55~17:10 : Liquid Biopsy for Cancer Immunotherapy Jiyoon Bu (Inha University, Korea, Republic of)

Yong-Sang Ryu (Korea University, Korea, Republic of)

Oral Presenter

17:25~17:35 : Investigation of extrachromosomal DNA (ecDNA) activities in extracellular matrix component-based environmen SeoYul Jo (Sungkyunkwan University, Korea, Republic of)

17:35~17:45 : Living single-cell secreted multiple biomarker profiling using microfluidic chip and machine learning for tumor cell classification Yu Zhang (Shandong University, China)

17:45~17:55 : An efficient strategy for circulating tumor cell detection: surface-enhanced Raman spectroscopy Jie Lin (Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, China)

Description

Liquid biopsies are emering, given their advantages over conventional tissue biopsy and imaging, such as minimially invasiveness

Keywords : Liquid biopsy; nanotechnology; in vitro diagnsostics

  • Session TrackBiomaterials for in vitro (extracorporeal) analysis
  • Session Title3D-Tissue Models for Infection and Immunological Assays
  • Session CodeSP-T07-0122
  • Date & Time / RoomMay 29 (Wed) 13:40~15:10 / Room 321-B
Organizer

Michiya Matsusaki (Osaka University, Japan)

Chair

Michiya Matsusaki (Osaka University, Japan)

Wei Li (Texas Tech University, USA)

Keynote Speaker

Juergen Groll (University of Wuerzburg, Germany)

Invited Speaker

Kendra Rumbaugh (Texas Tech University, USA)

14:20~14:35 : Treatment of Wound Infections with Bacteria-Responsive Hydrogel-Based Drug Delivery Anita Shukla (Brown University, USA)

Oral Presenter

14:35~14:45 : Study for Changes of IL-1α and IL-8 of RhE Model in vitro skin irritation test for medical devices Liu Jia (Shan Dong Institute of Medical Device and Pharmaceutical Packaging Inspection, China)

14:45~14:55 : Brain organoid-on-a-chip platform to spatiotemporally model virus infection via neuronal crosstalk Ann-Na Cho (University of Sydney, Australia)

Description

1) Objective of this symposium is to discuss the possibility and future direction of static and dinamic 3D-tissue models for the assessment of in vivo infection and immunological reactions.

2) This symposium invites one keynote and three invited speakers who are the world leading researcher in the fields of biofabrication, tissue engineering, biomaterials, microfluidic systems, and nanomaterials for infection and immunology.

3) Expected outcomes and relevance to the main topic of WBC 2024 is the participating experts can gather and share the latest information and knowledge in the recent hot and important areas of biomaterials research for infection and immunology.

Keywords : 3D-tissue models, infection assay, immunological assay

  • Session TrackBiomaterials for in vitro (extracorporeal) analysis
  • Session TitleBiomaterial-based platforms for tumor tissue engineering
  • Session CodeSP-T07-0174
  • Date & Time / RoomMay 29 (Wed) 16:30~18:00 / Room 321-B
Organizer

Daniela Loessner (Monash University, Australia)

Chair

Daniela Loessner (Monash University, Australia)

Carsten Werner (Leibniz Institute for Polymer Research, Germany)

Keynote Speaker

16:30~16:55 : Modelling complex interactions in the tumour microenvironment Claus Jorgensen (The University of Manchester, United Kingdom)

Invited Speaker

16:55~17:10 : Mineralized cryogels to recapitulate early events of breast cancer bone metastasis in vitro Carsten Werner (Leibniz Institute for Polymer Research, Germany)

Oral Presenter

17:10~17:20 : Construction of vascularized gastric cancer organoid-on-chip model via combining elastin-based hydrogels and 3D printing Leping Yan (The Seventh Affiliated Hospital, Sun Yat-sen University, China)

17:20~17:30 : Tumor-mimetic gradients in collagen fiber alignment enhance endothelial and cancer cell migration directionality and persistance Vinay Abhyankar (Rochester Institute of Technology, USA)

17:30~17:40 : AI Augmented 4D Bio-printed High-performance Invitro Disease Model of Oral Submucous Fibrosis. KANIKA SINGROHA (All India Institute of Medical Sciences Jodhpur- Indian Institute of TechnologyJodhpur, India)

17:40~17:50 : Spatially controlled construction of assembloids for modeling glioma infiltration Michelle Huang (Stanford University, USA)

Description

Tissue engineering technologies have produced innovative tools for cancer research. 3D cancer models based on molecularly designed biomaterials aim to harness the dimensionality, biomechanical and biochemical properties of tumor tissues. However, to date, in spite of the critical role that the extracellular matrix plays in cancer, only the minority of 3D cancer models is built on biomaterial-based matrices. Major reasons for avoiding this critical design feature are the difficulty to recreate the inherent complexity of the tumor microenvironment and the limited availability of practical analytical and validation techniques. Recent advances emerging at the interface of supramolecular chemistry, materials science and tumor biology are generating new approaches to overcome these boundaries and enable the design of physiologically relevant 3D models. In this symposium, we discuss how these 3D systems are applied to deconstruct and engineer the tumor microenvironment, opening opportunities to model primary tumors, metastasis and responses to anti-cancer treatment.



Objectives: The main goal of our symposium is to inform the audience about the emerging discipline of tumor tissue engineering. Therefore, we have several objectives: i) introduce the concept of tumor tissue engineering, ii) describe key parameters in tumor biology and iii) tools for rebuilding the tumor microenvironment, and iv) present novel applications of tumor-engineered models to investigate primary tumors, metastasis and anti-cancer treatment.



Audience: Our symposium targets an interdisciplinary audience that includes materials and polymer scientists, engineers, as well as biologists and life scientists.



Relevance to the main topic of WBC 2024: Our symposium is strategically aligned with the topic of WBC 2024. Biology can help to design materials and approaches for tumor tissue engineering. Biomaterials are a requisite for modeling cancer to rebuild tissue organisation, composition and function. In our symposium, we present bioengineering strategies that recreate the pathophysiology of cancer to address questions in cancer research and healthcare.

Keywords : tissue engineering, biomaterials, tumor biology, 3D cancer models, tumor microenvironment, extracellular matrix

  • Session TrackBiomaterials for in vitro (extracorporeal) analysis
  • Session TitleBiomaterials for Organoids
  • Session CodeSP-T07-0208
  • Date & Time / RoomMay 27 (Mon) 14:40~16:10 / Room 321-B
Organizer

Qun Wang (Iowa State University, USA)

Chair

Qun Wang (Iowa State University, USA)

Ying Mei (Clemson University, USA)

Keynote Speaker

14:40~15:05 : Biomaterial toolkits for advanced organoid engineering Seung-Woo Cho (Yonsei University, Korea, Republic of)

Invited Speaker

15:05~15:20 : Engineering a simple and robust organoid on chip to recapitulate full NASH function Hanry Yu (National University of Singapore, Singapore)

Tae-Eun Park (UNIST, Korea, Republic of)

Oral Presenter

15:35~15:45 : Rational design of oral drugs targeting mucosa delivery with gut organoid platforms Qun Wang (Iowa State University, USA)

15:45~15:55 : Multiscale control of nanofiber-composite hydrogel for complex 3D cell culture Chaenyung Cha (Ulsan National Institute of Science and Technology, Korea, Republic of)

15:55~16:05 : In vitro 3D bone organoids based on demineralized bone paper Jungwoo Lee (University of Massachusetts-Amherst, USA)

Description

An organoid is a self-organized 3D tissue typically derived from stem cells (pluripotent, fetal or adult) and mimics an organ's critical functional, structural and biological complexity. Three-dimensional ex vivo organoid cultures using biomaterial-based assembly and self-assembly have been shown to resemble and recapitulate most of the functionality of diverse multicellular tissues and organs, such as the gut, brain, liver, kidney, and lung. They can be dissected and interrogated for fundamental mechanistic studies on human tissue development, regeneration and repair. They can also be used in diagnostics, disease modeling, drug discovery and personalized medicine. Thus, organoids bridge a gap in existing model systems by providing a more stable system amenable to extended cultivation and manipulation while more representative of in vivo physiology. Organoids are typically seeded into biologically derived matrices such as Matrigel, a natural extracellular matrix (ECM) such as collagen, or synthetic hydrogels. However, the defined composition of the biologically derived matrix and the desired control over the biochemical and biophysical spatiotemporal cues are essential for improving organoid culture. This symposium will cover the most recent advancements in biomaterials-mediated organoid and tissue chip technologies in regenerative medicine, cancer therapy, drug testing, environmental control, monitoring, adaptive sensing, and translational applications. This topic was well-received in other scientific meetings and is an exciting emerging research area, such as Society For Biomaterials. This symposium will be helpful for graduate students and postdoctoral fellows to have an overview of the role of organoids in life science and medicine. It also helps engineering and medical professionals increase their awareness of biomimetic strategies in new biomaterials. The symposium will offer presentation and poster opportunities to enhance the workforce's diversity by recruiting students and post-doctorates from underrepresented groups in organoid-related research. In 2024, we will promote translational research to the commercial viability of biomaterials-mediated organoid projects.

 

Keywords : Organoids; Regenerative Medicine; Microenvironments

  • Session TrackBiomaterials for pre-clinical and clinical translation
  • Session TitleTranslation of bioactive ceramics from bench to bedside and emerging technologies for patient specific approaches
  • Session CodeSP-T08-0259
  • Date & Time / RoomMay 29 (Wed) 13:40~15:10 / Room 320-A
Organizer

Christine Knabe (Philipps University Marburg, Germany)

Chair

Ahmed El-Ghannam (University of North Carolina at Charlotte, USA)

Min Wang (Department of Mechanical Engineering, The University of Hong Kong, Hong Kong SAR, China)

Keynote Speaker

13:40~14:05 : Bioactive calcium alkali phosphate bone grafts enhance osteogenesis and facilitate bone repair in vivo – Translational research in oral implantology Christine Knabe (Philipps University Marburg, Germany)

Oral Presenter

14:05~14:15 : Long term stability and functionality of regenerated bone induced by SCPC resorbable bioactive graft Ahmed El-Ghannam (University of North Carolina at Charlotte, USA)

14:15~14:25 : In vivo analysis of Porous Bioactive Silicon Carbide Scaffold for Craniofacial Bone Augmentation RANDA ALFOTAWI (King Saud University, Saudi Arabia)

14:25~14:35 : Nanoscale 3D Printing of Bioceramics Iman Roohani (University of Sydney, Australia)

14:35~14:45 : Effect of interfacial energy on the mechanical properties of ZrO2-SiO2 glass-ceramics Huasi Zhou (Uppsala University, Sweden)

Description

Translation of bioactive ceramics from bench to bedside and emerging technologies for patient specific approaches



Session Scope: Over the last three decades, considerable progress has been made with regards to exploring the fundamental molecular and cellular events at the bone bioactive ceramic interface, which underlie the stimulatory effect of these materials on cell function and bone tissue formation, and with utilizing the knowledge gained to take bioactive ceramic bone grafting materials to the clinical arena in an evidence-based fashion. This has resulted in considerable contributions to improving patient care. It furthermore has prompted emerging patient-specific tissue engineering strategies, soft tissue augmentation approaches, concepts for continuous drug release, enhancement of angiogenesis etc. and has led to an array of approved products. Moreover, due to the inherent bioactive properties of these biomaterials achieving regulatory approval is less demanding than with biomaterials/devices which contain biologics such as growth factors, peptides and others.



The objective of this interdisciplinary symposium is to highlight how the fundamental research that helped to decipher the molecular events that underlie the stimulatory effect of bioactive ceramics on bone tissue formation and how recent advanced in additive manufacturing technologies and drug  release concepts led to translation of these materials to the clinic and contributed to the design of patient specific therapeutic concepts.



The program will highlight the evidence-based translation of different bioactive ceramics for various clinical applications. The intended audience will be material scientists, bioengineers, orthopedic surgeons and oral and maxillofacial surgeons.



The expected outcome is to heighten the awareness regarding the impact of this important class of biomaterials on health care in a globally ageing population and to foster interdisciplinary research worldwide.

Keywords : bioactive ceramics, bone regeneration, tissue engineering

  • Session TrackBiomaterials for pre-clinical and clinical translation
  • Session TitleBiomaterials Interventions in Aging Around the World
  • Session CodeSP-T08-0264
  • Date & Time / RoomMay 27 (Mon) 16:30~18:00 / Room 320-A
Organizer

Liisa Kuhn (University of Connecticut Health Center, USA)

Chair

Liisa Kuhn (University of Connecticut Health Center, USA)

Keynote Speaker

16:30~16:55 : Biomaterial interventions in aging of the musculoskeletal system Stuart Goodman (Stanford University, USA)

Invited Speaker

16:55~17:10 : From 3D bioengineered Models to Therapeutic Solutions: Senescence in Musculoskeletal Disease Okhee Jeon (Korea University, Korea, Republic of)

Oral Presenter

17:10~17:20 : Local delivery of ruxolitinib modulates aged macrophage phenotype transitions and promotes aged bone healing Liisa Kuhn (University of Connecticut Health Center, USA)

17:20~17:30 : Microvesicles-hydrogel breaks the cycle of cellular senescence by improving mitochondrial function Senrui Liu (The first affiliation of Chongqing medical university, China)

17:30~17:40 : Optimization towards the tipping point of senescence induction: a method for a passageable, induced-senescent osteoprogenitor cell line for biomaterials research Travis Wallace (University of Connecticut Health Center (UConn Health), USA)

17:40~17:50 : Cell-Free Osteoarthritis Treatment with Sustained-Release of Chondrocyte-Targeting Exosomes from Umbilical Cord-Derived Mesenchymal Stem Cells to rejuvenate ageing chondrocytes Hongfu Cao (Sichuan university, China)

Description

Introductory abstract of a maximum of 300 words that addresses the symposium’s

1) objectives or purposes;

2) Proposed program and intended audience

3) expected outcomes and relevance to the main topic of WBC 2024.



Recent research has identified anti-aging strategies that extend a healthy life span. This international symposium will feature biomaterials research from around the world that is focused on overcoming age-related diseases.The resolution of overactive inflammatory processes is one key strategy to overcome inflammaging related aging. Nanosystems that promote neuroprotection and neuroregeneration to address nervous system problems in older patients is an approach that will be featured. Eliminating or modifying the accumulation of senescent cells in the elderly is another new strategy that will be discussed.   Drug delivery, tissue engineering or immune modulation approaches with applications to the nervous system, or musculoskeletal or inflammatory diseases are sought. These include neural targeted nanoparticles, bioactive hydrogels, and aged neural tissue testing platforms as well as localized delivery of anti-aging drugs evaluated in aging animal models that down-regulate inflammaging.  This symposium has a goal of accelerating international scientific exchange and stimulating international collaboration in the area of aging which connects many preclinical research areas. In this symposium participants will have the opportunity to acquire knowledge about biomaterials with the most promise to address aging-related health concerns. 

 

Keywords : aging, inflammation, senescence

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WBC 2024 SECRETARIAT

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REPRESENTATIVEKi Dong Park

THE KOREAN SOCIETY FOR BIOMATERIALS

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