Scientific Program

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  • Session TrackBiomaterials processing and biofabrication
  • Session TitleNovel and multiple fabrication processes
  • Session CodeSP-T02-0090
  • Date & Time / RoomMay 27 (Mon) 13:00~14:30 / Room 325-CD
Organizer

Hee-Gyeong Yi (Dept. of Convergence Biosystems Engineering/Chonnam National University, Korea, Republic of)

Chair

Michiya Matsusaki (Department of Applied Chemistry, Osaka University, Japan)

Hee-Gyeong Yi (Dept. of Convergence Biosystems Engineering, Chonnam National University, Korea, Republic of)

Keynote Speaker

Tan Lay Poh (School of Materials Science & Engineering, Nanyang Technological University (NTU), Singapore)

Invited Speaker

13:25~13:40 : Machine learning-assisted optimization of printability in extrusion-based bioprinting Seung Yun Nam (Pukyong National University, Korea, Republic of)

Oral Presenter

13:40~13:50 : 3D Bio-Screen Printing for the Industrial Production of Textured Cultivated Meat Precursors Robin Maatz (Technical University of Darmstadt, Germany)

13:50~14:00 : Formulation and bioprinting of xanthan gum/iron hydrogels with tunable stiffness for long-term carrying of unstable and low-viscosity proteins Monize Caiado Decarli (1- University of Maastricht and 2- University Medical Center Groningen, Netherlands)

14:00~14:10 : A hydrogel blend for immobilizing carrot callus with microextrusion bioprinting Susmita Ghosh (Chonnam National University, Korea, Republic of)

14:10~14:20 : Days- to weeks-long perfusion of human-scale artificial pancreatic tissues created using sacrificial embedded writing into alginate Brenden Moeun (McGill University, Canada)

14:20~14:30 : 3D printing of primary adipose tissue with silk scaffold for volumetric soft tissue reconstruction Wonwoo Jeong (Wake Forest Institute for Regenerative Medicine, USA)

Description


  1. Objectives: Additive manufacturing, biofabrication, multiple(hybrid) fabrication processes, bioassembly, and other novel processing techniques that apply various materials, such as biomaterials, polymers, hydrogels, metals, ceramics, and etc in order to break through the conventional additive manufacturing process, construct 2D/3D structures, and produce a novel performance meeting unmet needs of the current field of tissue engineering.

  2. Proposed program and intended audience




  • Keynote Speaker: Prof. Tan Lay Poh

    Proposed Topic: Engineering edible tissues with additive manufacturing and biofabrication approaches

  • Invited Speaker 1: Prof. Michiya Matsusaki

    Proposed Topic: Engineeirng large-volume tissues and organs with development of bioassembly and novel biofabrication technologies

  • Invited Speaker 2: Dr. Linna Zhou

    Proposed Topic: Engineering natural and synthetic tissues with a novel additive manufacturing technologies assembling artificial cells and natural cells

  • Intended audience: Audience who is interested in getting insights from advanced biofabrication technologies that enable construction of living or synthetic tissues for the future-oriented purposes such as cultured foods, human-scale organ engineering, artificial tissues for biological, chemical, medical uses.




  1. Expected outcomes:




  • Share of recent research outcomes of the speakers between the researchers who joins the symposia

  • In a wide view of scope, review of the novel and recent biofabrication technologies pursuing the future-oriented purposes such as cultured foods, human-scale organ engineering, and artificial tissues

  • Open discussion of the perspectives of the development of new biofabrication technologies and the applicable area.

Keywords : Cultured food, Large-volume tissue engineering, Artificial and synthetic tissue

  • Session TrackBiomaterials processing and biofabrication
  • Session TitleFrontiers in Biofabrication Technologies
  • Session CodeSP-T02-0123
  • Date & Time / RoomMay 28 (Tue) 16:30~18:00 / Room 325-CD
Organizer

Lorenzo Moroni (Maastricht University, Netherlands)

Chair

Lorenzo Moroni (Maastricht University, Netherlands)

Koichi Nakayama (Saga University, Japan)

Keynote Speaker

16:30~16:55 : Dynamic biomaterials to enable biofabrication of personalized tissue mimics Sarah Heilshorn (Stanford University, USA)

Invited Speaker

16:55~17:10 : Matryoshka-inspired Biological Constructs to mimic skeletal niche for osteochondral regeneration Lorenzo Moroni (Maastricht University, Netherlands)

17:10~17:25 : Inventing for scalability: creating a formulation library to bioprint any human tissue from one tuneable synthetic biomaterial foundation Martin Engel (Inventia Life Science, Australia)

17:25~17:40 : Tissue regenerative medicine research using 3D bioprinters and bioinks Dong Hyuk Lee (Gachon University, CleCell Co., Ltd., Korea, Republic of)

Oral Presenter

17:40~17:50 : Bioinspired scaffolds for the regeneration of the temporomandibular joint Joanna BABILOTTE (MERLN Institute, Netherlands)

Description

Biofabrication technologies and approaches are becoming a mainstay in strategies pursued by researchers around the world to regenerate tissues of our body and create 3D in vitro advanced human models that can be used to discover alternative treatments to currently incurable diseases. In this context, new biomaterials and methodologies to process them are central to achieve proper cell-material communication and mimic that biological complexity typical of cells microenvironments for a targeted tissue or organ.

In this proposal, we would like to highlight most recent advances in biofabrication technlogies, spanning from the formulation of new bio(active) materials and bioinks, to new technologies able to fabricate biological constructs that better mimick our tissues and organs biological complexity. 

The program of the symposium is organized with a keynote speaker and 2 invited speakers setting the stage on biomaterial chemistry and fomrulations, bioprinting, and additive manufacturing of instructive scaffolds. The symposium will be then completed with selected abstracts that are of particular biomaterial and technology advancement

The symposium is intended to attract a scientific audience at the cross road between the biomaterial and the biofabrication community, so to spur new collaborations among these 2 community, where often times there is need to better understanding processing technologies for new biomaterials and on the other side new biomaterial forumaltions are direly needed for biofabrication approaches.

The symposium fits very well the main theme of WBC2024, and in particular sub-theme 2 on biomaterials for biofabrication and processing technologies. As Biofabrication technologies are nowadays mature to step from the bench to the bedside, we also hope to attract clinical translation studies showing how these technologies can positively affect healthcare.

Keywords : Biofabrication; Bioinks; Instructive Scaffolds

  • Session TrackBiomaterials processing and biofabrication
  • Session TitleMulti-layer biomaterials: emerging applications
  • Session CodeSP-T02-0126
  • Date & Time / RoomMay 30 (Thu) 16:30~18:00 / Room 320-B
Organizer

Wei Li (Texas Tech University, USA)

Chair

Wei Li (Texas Tech University, USA)

Michiya Matsusaki (Osaka University, Japan)

Keynote Speaker

16:30~16:55 : Development of layer-by-layer films for regenerative medicine and cell signalling studies: application to bone tissue engineering Catherine Picart (French Alternative Energies and Atomic Energy Commission, France)

Invited Speaker

16:55~17:10 : Building Bioactivity into Slippery Liquid-Infused Porous Surfaces David Lynn (University of Wisconsin Madison, USA)

17:10~17:25 : Tissue-interfaced electronics with multi-layered structure Toshinori Fujie (Tokyo Institute of Technology, Japan)

Oral Presenter

17:25~17:35 : 4D printed scaffolds for tissue repair and regeneration Kaushik Chatterjee (Indian Institute of Science, India)

17:35~17:45 :

SURFACE FUNCTIONALIZATION OF TITANIUM IMPLANTS FOR BIOLOGICALLY ACTIVE SURFACES: ALTERNATING CURRENT ELECTROPHORETIC DEPOSITION AND ATMOSPHERIC PRESSURE PLASMA TECHNOLOGY
Merve Kübra Aktan (Katholieke Universiteit Leuven, Belgium)

17:45~17:55 : Development of the core, titanium based material and polymer coating for the needs of individualized regenerative medical applications Ewa Rzad (Lukasiewicz Research Network – Krakow Institute of Technology, Poland)

17:55~18:05 : 3D printing of diamond for an iImproved hard tissue bio-interface Kate Fox (RMIT, Australia)

Description

1) Objective of this symposium is to present recent exciting work on fundementals and new applications of multilayered biomaterials. Furture research topics will be inspired. 

2) This symposium invites one keynote and three invited speakers who are the world leading researcher in the fields of multilayered films, tissue engineering, biomaterials, microfluidic systems, and nanomaterials for a variety of applications in RNA delivery, gene therapy, cancer detection, infection and immunology.

3) Expected outcomes and relevance to the main topic of WBC 2024 is the participating experts can gather and share the latest information and knowledge in the recent emerging and important areas of multilayerd biomaterials for research for better health care. 

Keywords : layer-by-layer, multi-layer biomaterials, polymer films,

  • Session TrackBiomaterials processing and biofabrication
  • Session TitleBiofunctional material and this use in medical device application
  • Session CodeSP-T02-0389
  • Date & Time / RoomMay 27 (Mon) 14:40~16:10 / Room 325-CD
Organizer

Jayden Park (Evonik Korea Ltd., Korea, Republic of)

Chair

Hyuk Sang Yoo (Kangwon National University, Korea, Republic of)

Jake Cho (Evonik Korea Ltd., Korea, Republic of)

Keynote Speaker

14:40~15:05 : Innovating biomaterials for clinical use Andreas Karau (Evonik Operations GmbH, Germany)

Invited Speaker

15:05~15:20 : Advancements in 3D-printed bioresorbable medical devices, bio-surgical solutions, and 3D bioprinting Heidy Cruz (T&R Biofab, Korea, Republic of)

15:20~15:35 : Artificial Intelligence Convergence Hyper-personalized SKIN Regeneration 3D Bioprinting Technology Jeehee Kim (ROKIT Healthcare, Inc., Korea, Republic of)

15:35~15:50 : Biomimetic and biosynthetic building blocks as platform technology in 3D-bioprinting Andreas Blaeser (Technical University of Darmstadt, Institute for Biomedical printing technology, Germany)

Oral Presenter

15:50~16:00 : Minimalistic strategies for designing new biomaterial solutions: From thin platforms to living materials Tiago Correia (University of Aveiro, Portugal)

16:00~16:10 : Bioinspired alginate-based bioinks to fabricate chemomechanically relevant disease models of hepatic steatosis Giuseppe Guagliano (Polytechnic University of Milan, Italy)

Description

The development of new and innovative biomaterials is rapidly expanding market opportunities for drug delivery, medical devices, tissue engineering and regenerative medicine. Bioresorbable polymers are of particular interest as they can be completely metabolized by the body. They are thus often deployed as delivery devices or scaffolds which are then remodeled into natural tissue to complement the natural healing process.



Bioresorbable materials can be either animal- or plant-derived, or be produced with a well-defined synthesis processes. Naturally derived materials, such as those derived from animals, often show high lot-to-lot-variation as well as a lack of traceability. By comparison, recombinant and synthetic materials are highly well-defined, with low batch-to batch variability. For example, PLA- and PLGA-based polyesters exhibit excellent biocompatibility and bioresorbability, can be easily tuned to match desired mechanical properties, and feature degradation profiles that match the target application. Recombinant biopolymers such as collagen and nanocellulose, offer unmatched biocompatibility and enhance the wound healing response.



In order to achieve maximum versatility for use across a range of applications, biomaterial process technologies to reproducibly achieve specific dimensions (microparticles, fibers, meshes, etc) are critical. There is an increasing trend towards the development of patient-specific or personalized designs for implants and scaffolds. To recreate the unique tissue architecture or to manipulate the release kinetics, sophisticated biofabrication techniques such as electrospinning and bioprinting are increasingly deployed. The symposia will give an insight into emerging biofabrication techniques for synthetic and recombinant biomaterials and how these techniques are critical for new application development.

Keywords : Biomaterial, Application, Biofabrication

  • Session TrackBiomaterials processing and biofabrication
  • Session TitleBiofabrication strategies to engineer complex tissues
  • Session CodeSP-T02-0145
  • Date & Time / RoomMay 28 (Tue) 9:30~11:00 / Room 325-AB
Organizer

Lesley Chow (Lehigh University, USA)

Chair

Lesley Chow (Lehigh University, USA)

Liliang Ouyang (Tsinghua University, China)

Keynote Speaker

9:30~9:55 : Light-based Biofabrication of Mammary Tissue Marcy Zenobi-Wong (ETH Zurich, Switzerland)

Invited Speaker

9:55~10:10 : 3D bioprinting of transplantable tracheas Yong He (Zhejiang University, China)

10:10~10:25 : Recreating tendon structure and biomechanical environment using magnetic 3D Bioprinting Manuela Gomes (3B's Research Group, University of Minho, Portugal)

Oral Presenter

10:25~10:35 : 3D Bioprinting of Perfusable Networks Using an Interfacial Diffusant Strategy Betty Cai (Stanford University, USA)

10:45~10:55 : 3D-Printing of Scaffolds with Surface Micropatterns For Oriented Tissue Regeneration Yonghui Ding (Worcester Polytechnic Institute, USA)

Description

Native tissues contain distinct cell populations and extracellular matrix components that are spatially organized into complex architectures. This organization is tightly linked to tissue function and evolves during different stages of development, disease, and repair/regeneration. Advances in fabrication techniques and biomaterials design have enabled us to engineer 3D constructs that more closely resemble native tissues and properties. Next-generation biofabrication strategies will further improve our ability to replace damaged or diseased tissues for clinically relevant therapies. These technologies will also generate robust in vitro models for drug discovery and studying development and disease. This session will highlight novel biomaterials-based approaches to fabricate biomimetic and bioinspired tissue-like constructs with a particular focus on platforms that combine biomaterials and/or cells with advanced biofabrication techniques. This symposium topic aligns well with the congress theme by merging state-of-the-art biomaterials and fabrication to impact the future of healthcare and will attract interest from academia and industry

Keywords : biofabrication, tissue engineering, advanced manufacturing

  • Session TrackBiomaterials processing and biofabrication
  • Session TitleConverged Technologies towards Tissue Biofabrication
  • Session CodeSP-T02-0156
  • Date & Time / RoomMay 28 (Tue) 13:40~15:10 / Room 325-CD
Organizer

Y. Shrike Zhang (Harvard Medical School, USA)

Chair

Y. Shrike Zhang (Harvard Medical School, USA)

Jinah Jang (Pohang University of Science and Technology, Korea, Republic of)

Keynote Speaker

13:40~14:05 : Biointerface fiber technology from electrospinning to in situ fibre printing Yan Yan Shery Huang (University of Cambridge, United Kingdom)

Invited Speaker

14:05~14:20 : Enabling bioinks with tunable mechanical and topological cues for 3D cell culture and vascularization Liliang Ouyang (Tsinghua University, China)

14:20~14:35 : Convergence of Biofabrication Approaches for the Generation of Small Diameter Vascular Tissue Models Tomasz Jungst (University of Würzburg, Germany)

Oral Presenter

14:35~14:45 : Advanced materials and biofabrication technologies to design in vitro central nervous system models Chiara Tonda Turo (Politecnico di Torino, Italy)

14:45~14:55 : Mechanical Behavior of 3D Printed Continuous Carbon Fiber Reinforced PEKK Composites for Trauma Plate Applications Steven Kurtz (Drexel University, USA)

Description

Biofabrication has demonstrated essential for engineering functional tissues for applications towards in vitro and in vivo applications. There are a variety of biofabrication methods based off different working principles, each of which has their unique advantages in terms of resolution, speed, and specific structures that they allow to be generated, among others. Nevertheless, they also come with weaknesses and none of them alone, in most situations, will be able to meet the requirements for the fabrication of all tissue types. To this end, convergence of different biofabrication technologies has not only been conceptulized, but also illustrated in actions. For example, bioprinting has been combined with organ-on-a-chip platforms to enable incorporation of both dynamic cues such as fluid flows and mechanical actuations, as well as volumetric tissue structures. Additional examples include integration of multiple (bio)printing methods to combine their strengths while mimimizing drawbacks, to produce multiscale tissue constructs. Accordingly, this symposium intends to provide a collection of presentations that cover the different aspects of the convergence in biofabrication technologies including but not limited to bioassembly, bioprinting, tissue/tissue model engineering, as well as biomaterials designs, in an effort to attract a large audience attending the conference who are working closely or peripherally in one or more of these topic areas. In particular, the symposium features a keynote and two invited speakers of mid- and early-career stages to expand their research exposure to the broader audience. The symposium topics are highly relevant to the Track #2 Biomaterials Processing and Biofabrication, and many other tracks as well, at WBC 2024.

Keywords : biofabrication, convergence, multiscale

  • Session TrackBiomaterials processing and biofabrication
  • Session TitleFostering international multidisciplinary collaboration in biomaterials research: Australasia- Germany case study (sponsored by Maverick)
  • Session CodeSP-T02-0201
  • Date & Time / RoomMay 31 (Fri) 11:20~12:50 / Room 321-B
Organizer

Khoon Lim (University of Sydney, Australia)

Chair

Michael Gelinsky (Technische Universität Dresden, Germany)

Jelena Rnjak-Kovacina (University of New South Wales, Australia)

Keynote Speaker

Juergen Groll (University of Würzburg, Germany)

Invited Speaker

11:45~12:00 : Structure, stimulation, and close interactions: keys to enhancing outcomes from international and multidisciplinary tissue engineering research Andrea O'Connor (University of Melbourne, Australia)

12:00~12:15 : What are the factors that drive effective international collaborations? Helmut Thissen (Commonwealth Scientific and Industrial Research Organisation, Australia)

Oral Presenter

12:15~12:25 : Bioprinting Corneal Tissue Mimics In Situ using Visible-Light Photopolymerizable Bioinks Daniela Duarte Campos (Heidelberg University, Germany)

12:25~12:35 : Dual-stage crosslinking hyaluronic acid-based bioinks for bioprinting advanced cartilaginous tissues Joerg Tessmar (University of Würzburg, Germany)

12:35~12:45 : Multi-architectural scaffold design unlocking clinically relevant cardiac patch attachment  Johannes Braig (University Hospital of Wuerzburg, Germany)

Description

This symposium is jointly proposed by the Australasian Society for Biomaterials and Tissue Engineering (ASBTE) and Germany Society for Biomaterials (DGBM) to highlight the key role of international multidisciplinary research collaboration in driving knowledge, personnel and resources exchange across the globe.



The field of biomaterials encompasses multiple research disciplines (polymer chemistry, biofabrication, bioengineering, cell biology etc), where research collaboration is crucial to provide opportunities for investigators to collectively learn how approaches from complementary disciplines may be applied to existing problems, and lead to the development of innovative solutions. However, these benefits are solely associated with good collaborations, where a bad collaboration often causes huge damage to research progress, time consuming, wasting precious resources and mentally draining for involved parties.



In this symposium, we propose to highlight a several examples of positive collaborative research projects between two geographically distant countries (Australia and Germany), and discuss the strategies required to establish, support and maintain good collaborations, and the role local research societies play in this. The format will involve a keynote speaker (30 minutes), 2 invited speakers (15 minutes each), followed by a panel discussion (30 minutes). The panel discussion will cover strategies to launch formal and informal collaborations, examples of failed collaborations, what to do and not-do in a collaborative relationship, as well as the impact of COVID-19 on ongoing research collaboration. We believe that this symposium will highlight the importance of working together in the biomaterials field and will be of particularly significant interest to researchers who are in early stages of their career (students, postdocs, junior faculty/PI). 

Keywords : Collaboration, mentoring, biofabrication

  • Session TrackBiomaterials processing and biofabrication
  • Session TitleInjectable Hydrogels For Regenerative Medicine
  • Session CodeSP-T02-0250
  • Date & Time / RoomMay 31 (Fri) 9:30~11:00 / Room 325-CD
Organizer

Arghya Paul (The University of Western Ontario, Canada)

Chair

Arghya Paul (The University of Western Ontario, Canada)

Akhilesh Gaharwar (Texas A&M University, USA)

Keynote Speaker

9:30~9:55 : Bioinspired immunomodulatory materials for regenerative medicine Milica Radisic (University of Toronto, Canada)

Invited Speaker

9:55~10:10 : Dynamic covalently-crosslinked zwitterionic injectable hydrogels enabling functional muscle repair and bioprinting of tissue mimics Todd Hoare (McMaster University, Canada)

10:10~10:25 : Immediately injectable dental stem cells-laden chitosan/hyaluronic acid hydrogel for vascularized bone tissue regeneration Sang Jin Lee (The University of Hong Kong, Hong Kong SAR, China)

10:25~10:40 : 3D printed stretchable skin scaffold for human joint Jin Woo Lee (Gachon University, Korea, Republic of)

Oral Presenter

10:40~10:50 : Time dependent Alginate Dialdehyde-Gelatin bioinks for cardiac regeneration Elena Marcello (Politecnico di Torino, Italy)

10:50~11:00 : Photo-crosslinked Mucin Bioink for 3D Bioprinting and Soft Tissue Engineering Sruthi C S (Indian Institute of Science, India)

Description

Title: Injectable Hydrogels For Regenerative Medicine

Injectable hydrogels for regenerative medicine is a rapidly growing area of research that aims to develop new therapies to repair and regenerate damaged or diseased tissues. Injectable hydrogels can be used to deliver cells or biomolecules, such as in the case of tissue engineering, drug delivery or 3D printing/bioprinting. In this session, we will explore important aspects of injectable hydrogels for tissue regeneration and 3D tissue models. In tissue regeneration, hydrogels can be used as a scaffold to deliver cells to a specific location in the body, where they can promote tissue regeneration. In tissue models, hydrogels can be used to create 3D in vitro models that mimic the microenvironment of the native tissue, to study cell behavior and the effects of drugs. Overall, new advances in the field of injectable hydrogels will be highlighted in this session, including new biomaterial, crosslinking approaches, and biological functions.

Keywords : hydrogel, tissue engineering, regeneration therapy

  • Session TrackBiomaterials processing and biofabrication
  • Session TitleOpen-source and low-cost technologies for advanced biomaterials fabrication
  • Session CodeSP-T02-0359
  • Date & Time / RoomMay 30 (Thu) 9:30~11:00 / Room 321-A
Organizer

Adam Feinberg (Carnegie Mellon University, USA)

Chair

Adam Feinberg (Carnegie Mellon University, USA)

Mark Skylar-Scott (Stanford University, USA)

Keynote Speaker

9:30~9:55 : Tissue Assembloids via Low-Cost Biofabrication Setups Yan Yan Shery Huang (University of Cambridge, United Kingdom)

Invited Speaker

9:55~10:10 : Open-source low-cost 3D bioprinters for advanced biomanufacturing Daniel Shiwarski (University of Pittsburgh, USA)

10:10~10:25 : High-precision 3D cell spheroid printing technology to produce engineered tissue with enhanced functionality Hyun-Wook Kang (Ulsan National Institute of Science and Technology, Korea, Republic of)

Oral Presenter

10:25~10:35 : The MEWron: Open-source melt electrowriting Simon Luposchainsky (Kyoto Institute of Technology, Japan)

10:35~10:45 : Effects of Painting Parameters on Tribological Properties in 3D Printed Parts Okan Gul (kocaeli university, Türkiye)

Description

Over the past decade there has been a revolution in grassroots innovation and creativity due to the development of open-source and/or low-cost fabrication tools and software. From 3D printing, to laser-based cutting and polymerization, to microscope design/automation to image analysis, the biomaterials research community has embraced many of these technologies.  This is leading to major advances in biomaterials fabrication in terms of new materials and design strategies and redefining the manufacturing process.  The open-source licensing is important because it enables widespread access to these technologies with the ability to modify the software/hardware and then contribute improvements back to the community. Further, the low-cost of many of these technologies enables a wider range of scientists and engineers to leverage these capabilities in their own labs, even in resource limited and educational environments.  WBC 2024 is an ideal setting for this type of special symposium because the open-source movement is truly driven by an international and diverse community. This forum will provide a unique opportunity to share these high impact biofabrication approaches that cover much more than just 3D printing, providing a forum for open and inexpensive technologies of broad interest to the global biomaterials research community.

Keywords : 3D printing, open-source, biofabrication

  • Session TrackBiomaterials processing and biofabrication
  • Session TitleAdditive manufacturing of biomaterials
  • Session CodeSP-T02-0142
  • Date & Time / RoomMay 30 (Thu) 13:40~15:10 / Room 325-CD
Organizer

Masaya Yamamoto (Tohoku University, Japan)

Chair

Masaya Yamamoto (Tohoku University, Japan)

Miho Nakamura (University of Turku, Finland)

Keynote Speaker

13:40~14:05 : Development of novel spinal fusion spacer fabricated by metal additive manufacturing focusing on the orientation of bone tissue architecture Takayoshi Nakano (Osaka University, Japan)

Invited Speaker

14:05~14:20 : Novel Support-less Bioceramics Additive Manufacturing Process in a Hydrogel Bath Hui-suk Yun (Korea Institute of Materials Science, Korea, Republic of)

Artemis Stamboulis (University of Birmingham, United Kingdom)

Oral Presenter

14:35~14:45 : Bioactive Ceramic for Immunotherapy: Effect of ionic composition on macrophage anti-inflammatory phenotypic expression Miho Nakamura (University of Turku/Tokyo Medical and Dental University, Finland)

14:45~14:55 : Modulated stem cell differentiation by 3D sandwich cell culture using stiffness-tunable hydrogels Masaya Yamamoto (Tohoku University, Japan)

14:55~15:05 : 3D printed Bioglass scaffolds with gyroid architecture for bone regeneration using DLP Meryem Lamari (Imperial College London, United Kingdom)

Description

This symposium aims to discuss recent advances in additive manufacturing and 3D-printing technologies in biomaterials processing. Not only metallic materials but also polymers and ceramics, even cells and/or cell spheroids, have been investigated as materials for fabricating 3D biomaterials constructs with a well-controlled 3D function. Therefore, this symposium will feature keynote and invited talks on 3D-printing technologies for different materials, such as metals, inorganic materials, polymers, and cells. While there should be many applications for symposia on additive manufacturing and biofabrication, the significance of this symposium is that it will cover a wide range of materials used in additive manufacturing. The symposium will discuss the similarities and differences in the broad aspects of materials in additive manufacturing and provide the audience with an opportunity to exchange knowledge and discovery in material sciences related to additive manufacturing. It is also suggested that the keynote and invited speakers include experts from different continents and genders. From these viewpoints, this symposium is considered to meet the main topic of WBC 2024.

Keywords : additive manufacturing, 3D-printing

  • Session TrackBiomaterials processing and biofabrication
  • Session Title3D Printing and Biofabrication in TERM, on the way to translation
  • Session CodeSP-T02-0154
  • Date & Time / RoomMay 29 (Wed) 16:30~18:00 / Room 323
Organizer

Aleksandr Ovsianikov (TU Wien [Technische Universität Wien], Austria)

Chair

Aleksandr Ovsianikov (TU Wien [Technische Universitaet Wien], Austria)

Tim Woodfield (University of Otago, New Zealand)

Keynote Speaker

Scott Hollister (Georgia Institute of Technology and Emory University, USA)

Invited Speaker

Jinah Jang (Pohang University of Science and Technology, Korea, Republic of)

17:10~17:25 : Bioengineering an Ovarian Microenvironment Informed by the Human Ovary BioMolecular Atlas Monica Laronda (Northwestern University, USA)

Oral Presenter

17:25~17:35 : 3D Bio-printing for Tissue Engineering Application Binbin Sun (Donghua University, China)

17:35~17:45 : Alveolar bone repair of rhesus monkeys by using BMP-2 gene and MSCs loaded three-dimensional printed bioglass scaffold Weikang Xu (Institute of biological and Medical Engineering, Guangdong Acamedy of Sciences, China)

17:45~17:55 : Additive manufactured porous titanium with gradient structure balancing bone ingrowth and antibacterial activity: evaluation of in vitro antibacterial activity Seiji Yamaguchi (Chubu University, Japan)

Description

Additive manufacturing technologies have experienced rapid growth in the medical sector, including the development of customized implants, and tissue engineering and regenerative medicine (TERM). In addition, 3D biofabrication has provided further opportunities for automated production of tissue constructs already containing living cells and/or cell-instructive molecules. Development and validation of suitable biomaterials and advanced bioinks compatible with multiple biofabrication technologies is another important aspect on the way to translation of these technologies from bench-to-bedside. Despite these significant advances and promises of breakthroughs in the field, translation of TERM and 3D bioprinting strategies clinically remains underwhelming, and a raft of challenges with respect to clinical complexity, tissue functionality and maturation hurdles, process scalability and speed, as well as regulatory environment still remain prevalent or under-addressed.

This symposium is dedicated to the latest innovations in the fields of 3D printing and Biofabrication, focusing on the clinical aspects applied to TERM. It intends to provide a collection of presentations that cover the different examples and experiences in clinical translation pathways, including but not limited to describing clinical successes and improved patient outcomes and standard of care, in vitro models that lead to translation in vivo as well as highlighting deficiencies in existing biomaterials, bioinks, convergence technologies and expertise that still continue to prevent rapid clinical translation. Accordingly, we expect this symposium will attract a large audience attending the conference who are working closely or peripherally in translational TERM in clinical settings.

This symposium specifically features experts working in a diverse range of translational bench-to-bedside research topic areas (including pediatric and reproductive biology), with senior keynote and two invited speakers at mid-career stages expanding research exposure to the broader audience. The symposium topics are highly relevant to the Track #2 Biomaterials Processing and Biofabrication, and many other tracks at WBC 2024.

 

Keywords : Additive Manufacturing, 3D Printing, Biofabrication

  • Session TrackBiomaterials processing and biofabrication
  • Session TitleVolumetric tissue printing
  • Session CodeSP-T02-0267
  • Date & Time / RoomMay 27 (Mon) 16:30~18:00 / Room 325-CD
Organizer

Jinah Jang (Pohang University of Science and Technology, Korea, Republic of)

Chair

Riccardo Levato (University Medical Center Utrecht, Netherlands)

Jinah Jang (Pohang University of Science and Technology, Korea, Republic of)

Keynote Speaker

16:30~16:55 : Filamented Light (FLight) Biofabrication of Tendons and Muscle Marcy Zenobi-Wong (ETH Zurich, Switzerland)

Invited Speaker

16:55~17:10 : Volumetric bioprinting: from the first development to advanced imaging-guided and multi-technology biofabrication Riccardo Levato (University Medical Center Utrecht, Netherlands)

Oral Presenter

17:10~17:20 : Stable and Homogeneous SPION-infused Photo-Resins for 3D-Printing Magnetic Hydrogels Ali Mohammed (Royal College of Art, Imperial College London, United Kingdom)

17:20~17:30 : Melt electrowriting and its applications in biofabrication for the generation of synthetic tubular constructs with defined mechanical characteristics Michael Bartolf-Kopp (Universitätsklinikum Würzburg, Germany)

17:30~17:40 : Development of Efficient Photoinitiating Systems for 3D Printing Pu Xiao (Chinese Academy of Sciences, China)

17:40~17:50 : Visible Light-Induced 3D Co-axial Bioprinting of 3D Biomimetic Liver-like Tissue Module with Patterned Vascular Structures for Volumetric Tissue Reconstruction Daekeun Kim (Pohang University of Science and Technology, Korea, Republic of)

17:50~18:00 : Fibrillogenesis-inhibited collagen-based photoclick resins enable facile volumetric biofabrication of multi-cellular tissues Parth Chansoria (ETH Zurich, Switzerland)

Description

Introductory abstract of a maximum of 300 words that addresses the symposium’s

1) objectives or purposes;

2) Proposed program and intended audience

3) expected outcomes and relevance to the main topic of WBC 2024.



3D bioprinting enables the fabrication of clinically relevant sized and anatomically shaped constructs in a time frame ranging from seconds to tens of seconds (e.g., optical-tomography-inspired printing). This symposium aims to promote scientific exchange, closer networks, and collaborative ties among multidisciplinary researchers in volumetric tissue printing. To cover the cutting-edge research and future perspectives, we have invited one senior keynote and three mid-career distinguished speakers as pioneers of the volumetric tissue printing area. The symposium topic is highly relevant to Track 2. Biomaterials processing and Biofabrication.



 

Keywords : Bioprinting; volumetric tissues and organs; scalable biofabrication

  • Session TrackBiomaterials processing and biofabrication
  • Session TitleCreating 3D architectures to facilitate organ regeneration
  • Session CodeSP-T02-0076
  • Date & Time / RoomMay 31 (Fri) 11:20~12:50 / Room 320-B
Organizer

Qi Gu (Beijing Institute for Stem Cell and Regenerative Medicine, China)

Chair

Qi Gu (Beijing Institute for Stem Cell and Regenerative Medicine, China)

Keynote Speaker

TBD (, )

Invited Speaker

11:45~12:00 : Exploring controlled cell movement to create engineered organs with natural properties Qi Gu (Beijing Institute for Stem Cell and Regenerative Medicine, China)

12:00~12:15 : Developing Personalized Vein-Chips for Enhanced Cerebral Venous Sinus Thrombosis Diagnosis using a Movable Type Manufacturing Technique Arnold Lining Ju (University of Sydney, Australia)

Oral Presenter

12:15~12:25 : Designing gradient bioinks for the musculoskeletal interface Lesthuruge De Silva (Deakin University, Australia)

12:25~12:35 : Bioprinting-assisted Tissue Assembly for Studying Cardiac Pathophysiology Dong Gyu Hwang (POSTECH, Korea, Republic of)

12:35~12:45 : Gastric-cancer-on-a-chip for predicting precision anti-cancer therapy. Jisoo Kim (POSTECH, Korea, Republic of)

Description

Fabrication of 3D tissue utilising biomaterials and living cells judiciously chosen and prearranged is poised to revolutionize stem cell research and regenerative medicine.The creation of large tissue constructs is based on cell proliferation, differentiation, and migration  within the 3D constructs with subsequent tissue formation and integration with the host. The proposed sysmposium “Creating 3D architectures to facilitate tissue regeneration” will examine the fundamental principles that underpin control of cell state and how best to organize cells and biomaterials to form a native tissue like hierarchical structure from the micro to macro scale. The symposium aims to discuss the  core issues underpinning tissue  fabrication and will therefore be of interest to a broad audience with backgrounds including stem cells, biomaterials, bioprinting and 3D cell culture.The symposium matches perfectly with the topics nominated for  WBC2024 such as “Biomaterials processing and Biofabrication” and “Biomaterials for tissue engineering”. We believe the symposium will inspire and impress the audience and promote in-depth thinking and  closer interdisplinary cooperation.

Keywords : 3D architectures, Tissue regeneration, Biofabrication

  • Session TrackBiomaterials processing and biofabrication
  • Session TitleBiofabrication in Suspensions Media for Tissue Engineering and In Vitro Modeling
  • Session CodeSP-T02-0356
  • Date & Time / RoomMay 29 (Wed) 13:40~15:10 / Room 325-CD
Organizer

Manuela Gomes (3B's Research Group, University of Minho, Portugal)

Chair

Manuela Gomes (3B's Research Group, University of Minho, Portugal)

Andrew Daly (National University of Ireland Galway, Ireland)

Keynote Speaker

13:40~14:05 : Advances in suspension bath printing to control the organization of cells and materials Jason Burdick (University of Colorado Boulder, USA)

Invited Speaker

14:05~14:20 : Biomanufacturing in vitro tendon microenvironments in suspension Rui M. A. Domingues (3B's Research Group, University of Minho, Portugal)

14:20~14:35 : Bioprinting models of early organ morphogenesis using cell-responsive hydrogels Andrew Daly (National University of Ireland Galway, Ireland)

Oral Presenter

14:35~14:45 : Enhanced angiogenic response of bioprinted vessel-like structures enriched with platelet rich plasma Maria Chatzinikolaidou (Foundation for Research and Technology Hellas (FORTH) Institute of Electronic Structure and Laser 100, N. Plastira str. Vassilika Vouton GR-70013 Heraklion, Greece VAT 090101655., Greece)

14:45~14:55 : Support baths to float your boat: 3D printing of low-viscosity PEG/graphene oxide inks to engineer vascular grafts Helena Ferreira (i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Portugal)

14:55~15:10 : Hydrogel microfibers as a granular material and its application as an ink or support bath in bioprinting
 
Chris Highley (University of Virginia, USA)

Description

The concept of matrix-assisted 3D bioprinting has allowed the widespread expansion of extrusion-based biofabrication systems in recent years.  By largely decoupling the printability of layer-by-layer 3D structures from the ink rheological properties, this technology has not only brought to the field an unprecedented level of liberty for 3D free-form biofabrication of living constructs but it has also opened new conceptual horizons towards the fabrication of bioengineered systems and devices for a variety of biomedical applications. Significant progress has been made on the development of new suspension media that allows printing at higher resolutions and with greater shape fidelity. Moreover, the suspension media has progressively evolved from “passive” macromolecular or granular materials used as temporary supports for low-viscosity bioinks printed in arbitrary locations of the 3D space, to active components that can “lock” the embedded constructs within their own tailor-made environments.

This symposium intends to be a forum of discussion on all of the exciting breakthroughs and different research directions in which matrix-assisted 3D bioprinting is being leveraged in the biomedical engineering field. Contributions are welcome not only on aspects related to the application of this fabrication technology for biomedical devices and bioengineered systems for tissue and organ regeneration, but also for in vitro modeling. This also includes, among others, growing applications where concepts of matrix-assisted 3D bioprinting merge with spheroid, tumoroid and organoid technology and their use as living microscale building blocks that mature into organ-specific tissues at high cell density, as well as with the assembly of components into microfluidic devices.

Keywords : 3D bioprinting, Suspension bath, In Vitro Modeling

  • Session TrackBiomaterials processing and biofabrication
  • Session TitleBio-hybrid tissue printing
  • Session CodeSP-T02-0112
  • Date & Time / RoomMay 28 (Tue) 9:30~11:00 / Room 325-CD
Organizer

Hyun-Wook Kang (Ulsan National Institute of Science and Technology, Korea, Republic of)

Chair

Aleksandr Ovsianikov (Technische Universität Wien, Austria)

Hyun-Wook Kang (Ulsan National Institute of Science and Technology, Korea, Republic of)

Keynote Speaker

9:30~9:55 : Scaffold-free Bio-3D Printing for Solid organ fabrication Koichi Nakayama (Saga University, Japan)

Invited Speaker

9:55~10:10 : 3D Bioprinting Strategies for Building Human Body Parts Sang Jin Lee (Wake Forest School of Medicine, USA)

10:10~10:25 : Scaffolded Spheroids – A New Strategy for Cartilage and Bone Tissue Engineering Aleksandr Ovsianikov (Technische Universität Wien, Austria)

10:25~10:40 : Non-adjacent wireless electrotherapy for tissue repair by a bioresorbable fully soft triboelectric nanogenerator Zhengwei You (Donghua University, China)

Oral Presenter

10:40~10:50 : 3D bioprinting hydrogel of biomimetic ECM for engineered brain-like constructs fabrication Yu Song (Tsinghua University, China)

10:50~11:00 : Voxel-by-voxel multi-material 3D printing for creating biomimetic interfaces Mohammad J. Mirzaali (TU Delft, Netherlands)

Description

3D hybrid tissue printing: multi-material printing process with cell spheroids, bio-inks, conductive materials, and bioplastics enabling rapid prototyping of tissue engineered construct, and body-on-a-chip

Keywords : 3D hybrid tissue printing, multi-material printing process

  • Session TrackBiomaterials processing and biofabrication
  • Session TitleCell Encapsulation and 3D Digital Assembly for Basic and Applied Biomedicine
  • Session CodeSP-T02-0245
  • Date & Time / RoomMay 31 (Fri) 11:20~12:50 / Room 325-CD
Organizer

Liheng Cai (University of Virginia, USA)

Chair

Liheng Cai (University of Virginia, USA)

Jae-Won Shin (University of Illinois at Chicago, USA)

Keynote Speaker

David Weitz (Harvard University, USA)

Invited Speaker

11:45~12:00 : Scaling 3D Bioprinting for Whole Organ Engineering Mark Skylar-Scott (Stanford University, USA)

12:00~12:15 : Voxelated Bioprinting: Digital Assembly of Viscoelastic Bio-ink Droplets Liheng Cai (University of Virginia, USA)

Oral Presenter

12:15~12:25 : Programmable collective self-assembly of cells in heterogeneous space via magneto-Archimedes effect Tanchen Ren (Zhejiang University, China)

12:25~12:35 : Development of a Biohybrid 3D-Printed Muscular Tissue-Sensor Platform for Excitation–Contraction Coupling Monitoring Uijung Yong (Pohang University of Science and Technology, Korea, Republic of)

12:35~12:45 : Development of drug-eluting contact lenses via 3D bioprinting to support corneal healing Mario Milazzo (Università di Pisa, Italy)

Description

Biological tissues are not a random assembly of cells but a hierarchical and tightly controlled three-dimensional (3D) organization of various cell types. Encapsulating cells in biomaterials with microscale tunability emulates the microenvironment in vivo, providing a powerful approach to modulating cell behavior and function. Moreover, recent advances demonstrated that exploiting 3D bioprinting technologies enables the digital assembly of tissues with microgels and encapsulated cells as building blocks. This approach allows for unprecedented control over the cell location, type, and cell-cell interactions in 3D space, enabling highly functional tissue constructs for basic and applied biomedicine. This symposium will focus on this emerging direction of research at the interface of biomaterials, digital assembly, and biology. 



The target audience would be researchers in academia, clinic, and industry who are interested in the development of novel encapsulation technologies, biomaterials, or advanced manufacturing such as 3D bioprinting for creating highly functional tissue constructs for general or specific biomedical applications.



To this end, we have strategically selected a set of Keynote and Invited Speakers to share their pioneering work in cell encapsulation and digital assembly.



Prof. David Weitz – a pioneer in droplet-based microfluidics for cell encapsulation, delivery, and diagnosis.

Prof. Mark Skylar-Scott – a prominent researcher in 3D bioprinting with experience in both academia and industry.

Prof. Omid Veiseh – a prominent researcher in cell encapsulation and 3D bioprinting and their applications for the delivery of therapeutic cells.



All the invited speakers have confirmed that they will attend if the proposal is accepted.

Keywords : Digital assembly; cell encapsulation; 3D bioprinting; drug delivery

  • Session TrackBiomaterials processing and biofabrication
  • Session TitleExploring the Frontiers of Micro-Nano Surface Engineering of Biomaterials
  • Session CodeSP-T02-0284
  • Date & Time / RoomMay 30 (Thu) 16:30~18:00 / Room 325-CD
Organizer

Ketul Popat (Colorado State University, USA)

Chair

Ketul Popat (Colorado State University, USA)

Geetha Manivasagam (Vellore Institute of Technology, India)

Keynote Speaker

16:30~16:55 : Nanotextural engineering of calcium phosphate bone grafts: interaction with proteins, cells and tissues Maria-Pau Ginebra (Universitat Politècnica de Catalunya (UPC), Spain)

Invited Speaker

16:55~17:10 : Cold Atmospheric Plasma Patch‐Mediated Skin Anti‐Inflammatory Therapy Seunghun Lee (Korea Institute of Materials Science, Korea, Republic of)

17:10~17:25 : Nanofiber membranes for reconstruction of tissue barriers and generation of uniform organoids Dong Sung Kim (POSTECH, Korea, Republic of)

Oral Presenter

17:25~17:35 : Two-dimensional architectures-transformed drugless conformational nanoarchitectonics for light-augmented nanocatalytic chemodynamic therapy Ranjith Kumar Kankala (Huaqiao University, China)

17:35~17:45 : Laser surface patterning of stainless steel for improvement of blood compatibility Yang Liu (Loughborough University, United Kingdom)

17:45~17:55 : Development of 3D-printed antimicrobial Si3N4-PEEK cervical spine cages: phase I Ryan Bock (SINTX Technologies, Inc., USA)

Description

The field of biomaterials has made significant advances in recent years, with the development of new materials and techniques that have improved the performance of medical devices and therapies. However, one area that remains largely unexplored is the use of micro-nano surface engineering to improve the performance of biomaterials. This symposium aims to bring together experts in the field to discuss the latest research and developments in this area, with a focus on the potential applications and future directions of this technology.



Objectives: To provide a forum for researchers and practitioners to share their latest findings and developments in the field of micro-nano surface engineering of biomaterials, To identify key challenges and opportunities in the field, and to explore potential collaborations and solutions, To identify key areas for future research and development in the field.



Proposed Program: The symposium will consist of a series of talks and panel discussions featuring leading experts in the field of micro-nano surface engineering of biomaterials. Topics will include:Overview of micro-nano surface engineering techniques and their applications in biomaterials, The role of micro-nano surface engineering in improving the properties of biomaterials, Micro-nano surface engineering of biomaterials for medical devices and therapies, Challenges and opportunities in the field



Expected Outcomes: Participants will gain a deeper understanding of the latest research and developments in the field of micro-nano surface engineering of biomaterials, Participants will have the opportunity to discuss and exchange ideas with leading experts in the field, The symposium will help promote collaboration and cross-disciplinary research in the micro-nano surface engineering of biomaterials.



With the increasing importance of micro-nano surface engineering in biomaterials, this symposium will help promote further research and innovation in this important area.

 

Keywords : micro-nano surface, surface engineering, biomaterials

  • Session TrackBiomaterials processing and biofabrication
  • Session TitleMelt Electrowriting of Scaffolds
  • Session CodeSP-T02-0315
  • Date & Time / RoomMay 30 (Thu) 13:40~15:10 / Room 320-B
Organizer

Paul Dalton (University of Oregon, USA)

Chair

Paul Dalton (University of Oregon, USA)

Małgorzata Włodarczyk-Biegun (Silesian University of Technology, Poland)

Keynote Speaker

13:40~14:05 : MEW, Hydrogels, and BMP-2 Converge to Orchestrate Membrane Guided Bone Regeneration Dietmar Hutmacher (Max Planck Queensland Center, Queensland University of Technology, Australia)

Invited Speaker

Naomi Paxton (University of Oregon, USA)

14:20~14:35 : Melt Electrowriting to assist regeneration of injured gradient tissues Małgorzata Włodarczyk-Biegun (Silesian University of Technology, Poland)

Oral Presenter

14:35~14:45 : Development of smart nanofibers as a wearable blood purification filter Makoto Sasaki (National Institute for Materials Science, Japan)

14:45~14:55 : Piezoelectric nanoyarns to advance self-powered acoustic cochlear transducers Bahareh Azimi (University of Pisa, Italy)

14:55~15:05 : Ultrasonic levitated electrospinning Haoyu Wang (UCL, United Kingdom)

Description

1) objectives or purposes;

Electrohydrodynamic phenomenon underpin several important manufacturing technologies used to make tissue engineering scaffolds and their components, including electrospinning, electrospraying and electrowriting. Out of these, melt electrowriting (MEW) can most readily ainclude 3D printing principles, providing a dramatic increase in scaffold complexity results that allows better approximation of natural tissue ultrastructure. MEW has also been combined with other biofabrication techniques such as 3D bioprinting, volumetic bioprinting, extrusion 3D printing and solution electrospinning with the aim to create unique tissue constructs that are greater than either of these technologies can fabricate alone. The improved control of MEW means better resolved multi-material, multi-phasic scaffolds, which is especially relevant for interfaces such as tendon/bone, the basement membrane and the periodontal ligament, for example. By focusing on MEW, this proposed session emphasizes the importance of scaffold fabrication technologies that is inclusive and can be applied to many different tissue engineering, biofabrication and 3D cell culture paradigms.



2) Proposed program and intended audience

Researchers who perform electrospinning, melt electrowriting as well as 3D printing, 3D bioprinting and biofabrication will be attracted to this session. This session looks at a technology, and shows how this can be applied across several applications. Prof Dietmar Hutmacher is additionally known as a thought leader in the field of tissue engineering, with a proven record of translating to to the clinic. 



3) expected outcomes and relevance to the main topic of WBC 2024.

Melt electrowriting (MEW) is a highlight of emerging fabrication technologies and is especially suited for clinical translation, a major bottleneck in the existing biomaterial pipeline. As an emerging technology, MEW has been primarily developed in Australia/Europe and a session at WBC will provide the first session of this technology at a global conference. 











 

Keywords : scaffold; 3D printing;

  • Session TrackBiomaterials processing and biofabrication
  • Session TitleMicro/nano-patterning
  • Session CodeSP-T02-0135
  • Date & Time / RoomMay 29 (Wed) 9:30~11:00 / Room 325-CD
Organizer

Dong Sung Kim (POSTECH, Korea, Republic of)

Chair

Dong Sung Kim (POSTECH, Korea, Republic of)

Jennifer H. Shin (KAIST, Korea, Republic of)

Keynote Speaker

9:30~9:55 : Hair regenerative medicine using tissue engineering approaches Junji Fukuda (Yokohama National University (YNU), Japan)

Invited Speaker

9:55~10:10 : Role of ECM Microstructures in the Dynamics of the Tumor Microenvironment Jennifer H. Shin (KAIST, Korea, Republic of)

10:10~10:25 : Understanding matrix remodeling-directed lineage specification through microfluidic encapsulation of single stem cells Jae-Won Shin (University of Illinois at Chicago, USA)

Oral Presenter

10:25~10:35 : Shape-specific microcomposites induce osteogenic differentiation in bottom-up engineered microtissue Ke Song (Maastricht University, Netherlands)

10:35~10:45 : Vanillin-based functionalization strategy to construct multifunctional microspheres for treating inflammation and regenerating intervertebral disc zhuang zhu (Soochow University, China)

10:45~10:55 : In situ culture of the unculturable human gastrointestinal bacteria Sydney Wheatley (École de technologie supérieure, Canada)

Description

Using biomaterials, such as synthetic/natural polymers and hydrogels, micro- and/or nano-patterning has been extensively utilized in a broad range of application fields including biology, medicine, biomedical engineering and pharmaceutics. The micro- and/or nano-structures enable to control, stimulate and promote cell/tissue behaviors in cell culture platforms and tissue engineering through mimicking cellular microenvironment. The objective of this symposium is to foster and promote advanced research and development through sharing state-of-the-art of micro- and/or nano-patterning of biomaterials and applications, thereby supporting and accelerating collaborative researches in this multidisciplinary field.

This symposium covers wide aspects of micro- and nano-patterning researches, not only from micro- and nano-fabrication and manufacturing techniques, such as photolithography, soft lithography (microcontact printing, microtransfer printing, and replica molding), wet-, melt- and electro-spinning, and mass-producible techniques like nanoimprinting and injection molding, but also to micro- and/or nano-scale surface patterning as well as construction of precise self-standing micro/nano-structures of biomaterials. Discussions on controlling and enhancing both cellular and tissue/organ functions and behaviors in response to the micro- and/or nano-structures of biomaterials are also recommended through oral and poster presentations.

This multidisciplinary topic will be of great significance to the academic and industrial members in the fields of material, chemical and mechanical engineering, biology, chemistry and medicine.

Keywords : Biomaterials processing, Micro/nano fabrication and manufacturing, Cellular microenvironment

  • Session TrackBiomaterials for theranostics
  • Session TitleEngineering of biomaterials for drug delivery
  • Session CodeSP-T03-0343
  • Date & Time / RoomMay 28 (Tue) 9:30~11:00 / Room 324-A
Organizer

Yoon Shin Park (Chungbuk National University, Korea, Republic of)

Chair

Yongzhuo Huang (Shanghai Institute of Materia Medica, China)

Jinhwan Kim (UC Davis, USA)

Keynote Speaker

9:30~9:55 : Engineering the nanomaterials for the image-guided drug delivery and controlled release Stanislav Emelianov (Georgia Tech, USA)

Invited Speaker

Allan E. David (Auburn University, USA)

10:10~10:25 : Targeting tumor metabolism using advanced drug delivery systems for treatment enhancement Yongzhuo Huang (Shanghai Institute of Materia Medica, China)

Aharon (Roni) Azagury (Ariel University, Israel)

10:40~10:55 : Natural-Based Liposomes for Versatile Drug Delivery Applications Dai Hai Nguyễn (Institute of Chemical Technology - Vietnam Academy of Science and Technology, Vietnam)

Description

The symposium session for Engineering of Biomaterials for Drug Delivery will bring together leading experts and researchers in the field to discuss the latest advancements in the engineering of biomaterials for drug delivery. The session will explore the design, synthesis, and characterization of advanced biomaterials for drug delivery applications, with a focus on their performance, safety, and efficiency.



The session will cover various topics, including the design of nanoscale and micron-scale biomaterials for drug delivery, the synthesis of biocompatible polymers and hydrogels for drug delivery, and the use of novel materials and fabrication techniques for the development of advanced drug delivery systems. Additionally, the session will focus on the engineering of new materials with unique properties that can be utilized for drug delivery, such as high stability, biocompatibility, and high drug-loading capacities.

The symposium will also provide an opportunity for attendees to learn about the current challenges in the field of engineering biomaterials for drug delivery, including the development of effective drug release profiles, the optimization of drug efficacy, and the safety and toxicity of biomaterials. In addition, attendees will have the opportunity to discuss exchange ideas with other researchers and experts in the field, and to learn about the latest innovations and developments in the field.



This symposium session is ideal for researchers, scientists, engineers, and medical professionals working in the fields of biomaterials, drug delivery, and pharmaceutical science. The session will provide a platform for attendees to learn about the latest advancements in the field, exchange ideas, and network with other professionals in the field.

Keywords : Nanomaterials, Smart materials, Drug delivery system

  • Session TrackBiomaterials for theranostics
  • Session TitleNanomedicine for Immunotherapeutics
  • Session CodeSP-T03-0351
  • Date & Time / RoomMay 27 (Mon) 14:40~16:10 / Room 324-A
Organizer

In-Kyu Park (Chonnam National University, Korea, Republic of)

Co-organizer

Won Jong Kim (Pohang University of Science and Technology (POSTECH), Korea, Republic of)

Chair

In-Kyu Park (Chonnam National University, Korea, Republic of)

Chien-Wen Jeff Chang (National Tsing Hua University, Chinese Taipei)

Keynote Speaker

14:40~15:05 : Control of Nitric Oxide for the Treatment of Inflammatory Disease Won Jong Kim (Pohang University of Science and Technology (POSTECH), Korea, Republic of)

Invited Speaker

15:05~15:20 : Nano-Sensor-Based Isolation and Characterization of Multidrug-Resistant Human Cancer Cells Chien-Wen Jeff Chang (National Tsing Hua University, Chinese Taipei)

15:20~15:35 : mRNA Vaccine Delivery using Polymeric Platforms for Global Health Equity Jooli Han (Massachusetts Institute of Technology (MIT), USA)

15:35~15:50 : Modification of antigenicity of cancer cells by conjugate consisting of hyaluronic acid and foreign antigen Shinichi Mochizuki (The University of Kitakyushu, Japan)

Oral Presenter

15:50~16:00 : Biomedical Application of Emerging NanoAlum Beyond Drug Delivery System Lingxiao Zhang (Aarhus University, Denmark)

16:00~16:10 : Immunomodulatory, highly respirable yeast beta-glucan microparticles prepared by pressurized gas expanded liquid (PGX) technology to treat idiopathic pulmonary fibrosis Nate Dowdall (McMaster University, Canada)

Description

Nanomedicine is an emerging technology in the healthcare division to treat verities of diseases. Engineered nanomedicines have been designed to interact with biological systems and fundamentally improve the current therapeutic procedures. Recently, immunotherapy has gained tremendous attention and the role of nanomedicine escalated the efficacy of immunotherapies. Delivery of immunomodulatory agents by using nanotechnology effectively targets the immune microenvironment to promote specific immune responses. Immunomodulation with nanomedicine has emerged as a promising approach for treating and preventing various diseases like cancer, inflammatory disease, infectious diseases, autoimmune diseases, and wound healing. Nanomedicine-based immunotherapies can overcome the limitation of conventional approaches, such as inadequate immune activation, nontarget delivery, and degradation of immunomodulatory agents during circulation. The role of nanomedicine in vaccine delivery has been approved clinically for the treatment and many of them are under clinical preclinical trials. Targeted delivery of nanovaccine stimulates the immune response and amplifies the therapeutic efficacy. In addition, the combination of immunotherapy with other therapeutic procedures by using nanomedicine is an emerging field that needs to be explored more.

Keywords : Nano-immunotherapies, nanovaccine, immunoengineering

  • Session TrackBiomaterials for theranostics
  • Session TitleFerroptosis-mediated cancer target therapy (Sponsored by Methods, an Elsevier's interdisciplinary journal in life and medical sciences)
  • Session CodeSP-T03-0100
  • Date & Time / RoomMay 29 (Wed) 16:30~18:00 / Room 324-A
Organizer

Su-Geun Yang (Inha University, Korea, Republic of)

Chair

Zheyu Shen (Southern Medical University, China)

Su-Geun Yang (Inha University, Korea, Republic of)

Keynote Speaker

16:30~16:55 : Magnetic Resonance Imaging Contrast Agents and Their Applications for Tumor Ferroptosis Therapy Zheyu Shen (Southern Medical University, China)

Invited Speaker

16:55~17:10 : Photocatalytic nanoparticles for combination therapy of KRAS mutant colorectal cancer via controlled enzymatic pathway of ferroptosis Su-Geun Yang (Inha University, Korea, Republic of)

17:10~17:25 : DNA/Drug nanocomplexes for efficient and safe cancer therapy: Facile, efficient, scalable, and safe for clinical translation Young Jik Kwon (University of California, Irvine, USA)

Oral Presenter

17:25~17:35 : Iron-Based Nanomaterials for Tumor Theranostics: Applications and Challenge Yanglong Hou (Sun Yat-Sen University, China)

17:35~17:45 : pH-sensitive Single-Atom Catalyst with Natural Immunoadjuvant for Precising Catalytic Therapy and Amplifying Immunity of Ferroptosi Hung-Wei Cheng (National Yang Ming Chiao Tung University, Chinese Taipei)

17:45~17:55 : Targeted sonodynamic therapy mediated by ultrasound-controlled release platelets induces cancer cell ferroptosis and macrophage repolarization in glioblastom Xiao Chen (Wuhan University, CHINA, China)

Description

1) Objectives or purposes

Ferroptosis is a new type of cell death that was discovered in recent years and is usually accompanied by a large amount of iron accumulation and lipid peroxidation during the cell death process; the occurrence of ferroptosis is iron-dependent. Ferroptosis-inducing factors can directly or indirectly affect glutathione peroxidase through different pathways, resulting in a decrease in antioxidant capacity and accumulation of lipid reactive oxygen species (ROS) in cells, ultimately leading to oxidative cell death. This symposia presents the latest progress in ferroptosis research.



2) Proposed program and intended audience

- Now two scientists agreed to attend the WBC2024  and  present a talk about ferroptosis and related science.  

- And other presenting scientists will be filed very soon. 



3) Expected outcomes and relevance to the main topic of WBC 2024

Ferroptosis is now really growing science in area of cancer-therapeutic nanomaterials.  A total of 1,285 publications on ferroptosis research were identified. The literature on ferroptosis had been continuously growing since 2012, and the expansion might continue at a rapid pace in the following years. China contributed the greatest proportion (43.74%) of ferroptosis publications, and the United States ranked first in the number of citation frequency (20,980 times) and H-index (70).



So handing this topic in WBC 2024 will get great interests from scientists in this area.

Keywords : Ferroptosis; Targeted cancer therapy; Nanoparticles

  • Session TrackBiomaterials for theranostics
  • Session TitleStimuli-Responsive Macromolecular Assembly for Theranostics
  • Session CodeSP-T03-0101
  • Date & Time / RoomMay 31 (Fri) 11:20~12:50 / Room 324-A
Organizer

Beom Jin Kim (University of Ulsan, Korea, Republic of)

Chair

Beom Jin Kim (University of Ulsan, Korea, Republic of)

Ja-Hyoung Ryu (UNIST, Korea, Republic of)

Keynote Speaker

11:20~11:50 : Enzyme-Instructed Intracellular Peptide Assemblies Bing Xu (Brandeis University, USA)

Invited Speaker

11:50~12:05 : Selective death of cancer cells induced by the self-assembly of a peptide amphiphile that is responsive to an overexpressed kinase Tatsuo Maruyama (Kobe University, Japan)

12:05~12:20 : New strategies based on self-assembly for Theranostics Gaolin Liang (Southeast University, China)

12:20~12:35 : Enzyme assisted peptide folding and self-assembly Zhimou Yang (Nankai University, China)

12:35~12:50 : Proton-Catalyzed Self-Assembly to Control Intracellular Assemblies Formation of Peptide Huaimin Wang (Westlake University, China)

Description

Macromolecular self-assembly is ubiquitous in living system, leading to the formation of innumerable biological complexes. Since each of biological complexes formed plays the key role in a living system according to ever-changing cellular environment, living cells adopt cellular signaling mechanism to spatiotemporally control the self-assembly or disassembly process. Inspiring by cellular signaling, the research is recently progressed to artificially induce the macromolecular self-assembly or disassembly by using the stimuli (like cellular signals) within living cells. Based on the in-depth understand of stimuli-responsive assembly, tremendous efforts have been focused on development of the advanced strategy for spatiotemporally controlled macromolecular assemblies. More importantly, the macromolecular assemblies formed via stimuli provided the cellular selectivity according to the specific environment in which the cells are exposed, promising the potential applications to theranostics. However, there is still room for improvement for the stimuli-responsive macromolecular assemblies for theranostics, which would require the synergistic convergence of biomaterials science, biomedical engineering, biochemistry, and other disciplines. In this symposium, current topics and new directions of stimuli-responsive macromolecular assemblies for theranostics, including novel synthetic design, multi-functional biomaterials for theranostics, as well as peptide assembly/disassembly in a specific cellular milieu, will be presented and discussed. Since the fields as well as the presenters’ geography are diverse, we anticipate that this symposium will provide a great opportunity for inter-national and inter-continental networks and possible generation of new research ideas and perhaps even research fields.

Keywords : Stimuli-responsive self-assembly, Theranostics, Macromolecular biomaterials

  • Session TrackBiomaterials for theranostics
  • Session TitleBiomaterials for theranostics
  • Session CodeSP-T03-0133
  • Date & Time / RoomMay 30 (Thu) 13:40~15:10 / Room 324-A
Organizer

Sei Kwang Hahn (POSTECH, Korea, Republic of)

Chair

Guosong Hong (Stanford University, USA)

Hyunjoo Jenny Lee (KAIST, Korea, Republic of)

Keynote Speaker

13:40~14:05 : Smart Wearable Materials and Devices for Theranostic Healthcare Applications Sei Kwang Hahn (POSTECH, Korea, Republic of)

Invited Speaker

Guosong Hong (Stanford University, USA)

14:20~14:35 : Ultrasound-Mediated Neuromodulation Hyunjoo Jenny Lee (KAIST, Korea, Republic of)

14:35~14:50 : Atomically precise molecular materials of noble metal for Real-Time Monitoring and Therapeutic Management of Alzheimer's Diseas Jayasree R S (Sree Chitra Tirunal Institute for Medicla Sciences and Technology, India)

Oral Presenter

14:50~15:00 : Biomimetic targeting nanoplatform for atherosclerosis theranostics via photoacoustic diagnosis and “hand-in-hand” immunoregulation Boxuan Ma (Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, China)

15:00~15:10 : Glycogen nanoparticles as next generation biomaterials in nanomedicine Quinn Besford (Leibniz Institute for Polymer Research, Germany)

Description

With the remarkable progress in convergence technology, biomaterials with various biological, optical and mechanical functionalities offer promising approaches to diagnostic, therapeutic, and theranostic applications. Recently, there have been a rapid expansion of new ideas on healthcare devices including wearable devices, nanomotors, and photonic and ultrasound-mediated nanomedicines. This innovation is enabled by the development of multifunctional biomaterials. Among various wearable devices, smart contact lenses are especially noticeable for healthcare applications, because they can be used as an excellent interface between the human body and electronic devices. In addition, multi-functional biomaterials have enabled the development of micro and nanomotors for active healthcare applications. Furthermore, biophotonic and ultrasound-mediated photonic materials have attracted great attention for theranostic applications. The theranostic applications are based on fluorescence imaging, plasmon resonance sensing and imaging, photoacoustic imaging, photothermal therapy, photodynamic therapy, and optogenetic therapy. Reasonable endeavors have begun to translate some of promising wearable healthcare devices, nanomotors, and photo and sonomedicines to the clinics. In this symposium, the co-chairs of Prof. Samuel Sánchez at Institute for Bioengineering of Catalonia, Spain and Prof. Guosong Hong at Stanford University will host a keynote speaker, Prof. Sei Kwang Hahn at POSTECH. This proposed program is intended to attract diverse audiences in the fields of biomaterials for theranostic applications based on biosensing, bioimaging and drug delivery. Prof. Hahn will give a keynote talk on biomaterials for theranostic wearable devices, Prof. Sánchez will give an invited talk on healthcare nanomotors, and Prof. Hong will give an invited talk on photonic and ultrasound-mediated nanomedicines for theranostic applications. These talks are well matched with the main topic of biomaterials for theranostics in WBC2024. With the previous organizing experiences in several academic symposiums including WBC2020, we will present and discuss the current state-of-the-art research and clinical feasibility of emerging biomaterials for various theranostic applications.

Keywords : Wearable device, Nanomotor, Nanomedicine

  • Session TrackBiomaterials for theranostics
  • Session TitleBiomaterials for Drug Delivery and Tissue Regeneration
  • Session CodeSP-T03-0138
  • Date & Time / RoomMay 30 (Thu) 9:30~11:00 / Room 324-A
Organizer

Yunching Chen (National Tsing Hua University, Chinese Taipei)

Chair

Yunching Chen (National Tsing Hua University, Chinese Taipei)

Che-Ming Jack Hu (Academia Sinica, Chinese Taipei)

Keynote Speaker

Samir Mitragotri (Harvard University, USA)

Invited Speaker

Shyh-Dar Li (University of British Columbia, Canada)

10:10~10:25 : Wireless charging-mediated angiogenesis and nerve repairby adaptable microporous hydrogels Shang-Hsiu Hu (National Tsing Hua University, Chinese Taipei)

10:25~10:40 : Organ and cell selective delivery using synthetic lipid nanoparticle for mRNA delivery Qiaobing Xu (Tufts University, USA)

10:40~10:50 : Pseudovirus-like particles for RNA self-packaging and delivery Yu-Chen Hu (National Tsing Hua University, Chinese Taipei)

Description

Biomaterials have been explored to fabricate drug delivery systems or tissue regeneration platforms. Many researchers have attempted to develop more effective biomaterials used in drug delivery and tissue regeneration to improve the treatment efficiency and to reduce the risk of side effects. Various biomaterials such as naturally occurring or synthetic lipids, biodegradable stimuli-responsive polymers, conductive hydrogels can be designed for targeted delivery and controlled release of therapeutic cargoes and other biologically active agents in the disease sites for more promising efficacy and acceptable safety. The symposium discusses various novel biomaterials in drug delivery and tissue regeneration including lipid nanoparticle technologies, polymer technologies, adaptable conductive hydrogels for their applications on child-friendly oral formulation, cancer immunotherapy, chronic hepatitis B and traumatic brain injury, etc.



1) Objectives or purposes

To provide various applications of biomaterials in drug delivery and tissue regeneration including lipid nanoparticle technologies, polymer technologies, adaptable conductive hydrogels for treatment of cancer, chronic hepatitis B and traumatic brain injury, etc and discuss challenges and future directions for clinical applications of biomaterials in drug delivery and tissue regeneration.



2) Proposed program and intended audience

intended audience: research scientists, clinicians, pharmaceutical industry specialists, post-graduate students, graduate students



3) Expected outcomes and relevance to the main topic of WBC 2024

closely and highly related to the main theme of WBC2024 - Convergence in Biomaterials: a vision for the future of healthcare

Keywords : Lipid nanoparticle, cancer immunotherapy, Polymeric Backpacks

  • Session TrackBiomaterials for theranostics
  • Session TitleBiomaterials for Image-guided Therapy
  • Session CodeSP-T03-0153
  • Date & Time / RoomMay 29 (Wed) 13:40~15:10 / Room 324-A
Organizer

Wooram Park (Sungkyunkwan University, Korea, Republic of)

Chair

Wooram Park (Sungkyunkwan University, Korea, Republic of)

Chun Gwon Park (Sungkyunkwan University, Korea, Republic of)

Keynote Speaker

13:40~14:05 : Theranostic carriers for image guided nano-immuno cancer therapy Dong-Hyun Kim (Northwestern University, USA)

14:05~14:30 : Dynamic Nano-Assemblies for Biological Sensing, Imaging and Regulation Daishun Ling (Shanghai Jiao Tong University, China)

Invited Speaker

14:30~14:45 : Ion-responsive Nano-probe Fang Yuan Li (Zhejiang University, China)

14:45~15:00 : In situ Cancer Immunization Utilizing a Synergistic Approach of Irreversible Electroporation and Immunostimulatory Nanoparticles

Wooram Park (Sungkyunkwan University, Korea, Republic of)

Description

Through the convergence of new functional biomaterial-based nanoparticles and bioimaging technology, image-guided therapy for targeting and treating a disease location has rapidly evolved in recent years. This session will focus on the most recent research trends and prospects in image-guided therapy with functional nanoparticles. This session will be of broad interest to researchers working in biomaterials, nanoparticles, and biomedical imaging. Specifically, the theme of functional nanomaterials with imaging and therapeutic applications is perfectly compatible with the main topic of WBC2024.

Keywords : Image-guided therapy, Nanoparticle, Bioimaging

  • Session TrackBiomaterials for theranostics
  • Session TitleBiomaterials for Biomedical Imaging: Applications and Challenges
  • Session CodeSP-T03-0173
  • Date & Time / RoomMay 29 (Wed) 9:30~11:00 / Room 324-A
Organizer

Hua Ai (West China Hospital, Sichuan University, China)

Chair

Yanglong Hou (College of Engineering, Peking University, China)

Brent Weinberg (Emory University School of Medicine, USA)

Keynote Speaker

Ning Gu (Southeast University, China)

Invited Speaker

9:55~10:10 : Ultrasound Contrast Nanoparticles and Their Diagnosis and Treatment in Chronic Diseases Aiguo Wu (Ningbo Institute of Materials Technology & Engineering, Chinese Academy of Sciences, China)

10:10~10:25 : Strategies to Promote Cancer Nanomedicine Clinical Translation Twan Lammers (RWTH Aachen University Clinic, Germany)

10:25~10:40 : Challenges and opportunities in MRI contrast agents Brent Weinberg (Emory University School of Medicine, USA)

10:40~10:55 : MRI nanoprobes: design considerations and biological responses Hua Ai (West China Hospital, Sichuan University, China)

Description

Biomedical imaging has shown promising applications in disease early diagnosis, therapeutic efficacy evaluation and pathological pathway discovery. Sensitive and specific imaging probes are key factors deciding the outcomes of imaging quality and accuracy. This symposium will showcase the most recent advances in imaging probes, with emphasis on the unique materials' properties and nanofabrication for intended biomedical applications. Topics of interest include, but are not limited to imaging probes, imaging methods, multimodality imaging and cell/drug/gene delivery using biomaterials. The applications of such probes may include but not limited to: early diagnosis, cell therapy monitoring, drug delivery evaluation, understanding of certain pathology, etc. The symposium will also discuss challenges of imaging probes during their applications, especially for in vivo studies and clinical translations. Researchers from both basic science research and clinical practice are encouraged to submit their work to this topic. We have organized symposia with similar topics during the last three World Biomaterials Congress meetings.

Keywords : biomaterials; biomedical imaging; imaging probes

  • Session TrackBiomaterials for theranostics
  • Session TitleExtracellular vesicles-based nanomedicine for theranostics
  • Session CodeSP-T03-0358
  • Date & Time / RoomMay 27 (Mon) 13:00~14:30 / Room 324-A
Organizer

Kyung Min Park (Incheon National University, Korea, Republic of)

Chair

Michael Davis (Emory University, USA)

Han Young Kim (The Catholic University of Korea, Korea, Republic of)

Keynote Speaker

Michael Davis (Emory University, USA)

Invited Speaker

13:25~13:40 : Versatility of Exosomes for Cancer Therapy Donovan (Dong In) Kim (University of Oklahoma, USA)

Han Young Kim (The Catholic University of Korea, Korea, Republic of)

13:55~14:10 : Cellular function recovery through rejuvenation effect of exosome-mimicking nanovesicles extracted from stem cells Suk Ho Bhang (School of Chemical Engineering / Sungkyunkwan University, Korea, Republic of)

Oral Presenter

14:10~14:20 : Exploring exosome potential for bone healing with ceramic scaffolds Ekaterina Maevskaia (University of Zurich, Switzerland)

Description

Biomaterials have attracted substantial attention for a broad range of nanomedicine applications, including clinical diagnostics and therapeutics, due to their tunable properties and biocompatibility. Recently, theranostic (combined therapy and diagnostic) biomaterials have been widely utilized to provide monitoring and treatment capabilities and advance the field toward personalized technologies. Among these theranostic biomaterials, extracellular vesicles (EVs), such as exosomes, show promising potential in translational medicine and provide new avenues for creating effective clinical diagnostics and therapeutic strategies.

The EVs are common membrane-bound nanovesicles that contain diverse biomolecules, such as lipids, proteins, and nucleic acids. These cell-derived biomaterials have a natural ability to carry functional biomolecules, such as small RNAs, DNAs, and proteins, in their lumen structure. This unique property makes them attractive for drug delivery and molecular diagnosis. Moreover, EVs can be utilized for high-precision imaging. Based on their unique properties, EVs have recently been harnessed as theranostics for advanced personalized medicine.

This session will focus on emerging trends in cell-derived nanovesicles as theranostic biomaterials for nanomedicine applications. Specifically, the session will cover topics ranging from designing EVs, their characterizations and purification, disease treatments and monitoring, etc. Cutting-edge extracellular vesicle-based nanomedicine for theranostics will be included.

Keywords : Extracellular vesicles, nanomedicine, theranostics

  • Session TrackBiomaterials for theranostics
  • Session TitleBiomaterial-assisted gene therapy to treat musculoskeletal disorders
  • Session CodeSP-T03-0353
  • Date & Time / RoomMay 28 (Tue) 13:40~15:10 / Room 324-A
Organizer

Nicholas Dunne (Dublin City University, Ireland)

Chair

Nicholas Dunne (Dublin City University, Ireland)

Ahmed Elkashif (Queen's University Belfast, United Kingdom)

Keynote Speaker

13:40~14:05 : Peptide-microRNA nanoparticles delivered via a thermoresponsive hydrogel for enhanced bone regeneration Helen McCarthy (Queen's University Belfast, United Kingdom)

Invited Speaker

14:05~14:20 : Nanoparticle-mediated non-viral gene editing for in utero treatment of Duchenne muscular dystrophy Aijun Wang (University of California, Davis, USA)

Oral Presenter

14:20~14:30 : Delivery of microRNA loaded nanoparticles via a 3D printed PEG-chitosan-PCL wound dressing Ahmed Elkashif (Queen's University Belfast, United Kingdom)

14:30~14:40 : Urinary Extracellular Vesicles as Therapy in Genetic Kidney Disease Eunji Chung (University of Southern California, USA)

14:40~14:50 : Plasmid DNA Mono-Ion Complexes with Mono-cationic PEGs for Muscular Gene Delivery Shoichiro Asayama (Tokyo Metropolitan University, Japan)

14:50~15:00 : Targeting ROS-induced osteoblast senescence and RANKL production by Prussian blue nanozyme based gene editing platform to reverse osteoporosis Huihui Wang (Yangzhou University, China)

15:00~15:10 : Bone-targeted nanoparticle-mediated osteoimmunomodulation for enhanced fracture healing Danielle Benoit (University of Oregon, USA)

Description

Although there are a plethora of clinical options currently available to treat disorders of the musculoskeletal system for millions of patients globally; to date there are no options capable of consistently repairing and regenerating sites of tissue damage in terms of their native structure and mechanical functionality.



Gene therapy is a highly disruptive technology that can enable the sustained delivery and production of therapeutic candidate gene sequences in musculoskeletal injuries over a relatively long period compared to the application of recombinant gene products displaying relatively short pharmacological half-lives. A recent technological development is to augment human musculoskeletal gene therapy approaches in vivo by providing gene-based treatments via biomaterial-assisted procedures. Biomaterial-assisted gene therapy is an example of such a procedure, which is based on the delivery of gene carriers using biocompatible, integrative, biodegradable, and mimicking materials used in tissue engineering approaches as a platform to support biological cues and provide the endogenous reparative processes in damaged musculoskeletal tissues by offering a cell-supporting scaffold in injury sites. Such technologies may offer off-the-shelf compounds that support non-invasive, patient-independent direct treatments in clinical settings compared with a more complicated, less expedient administration of genetically modified cells that requires repeated patient management.



The proposed symposium is currently a hot research topic within the Biomaterials community that will attract significant interest from researchers, industry and clinicians working in the areas gene therapy, nanomedicine, biomaterials science, biomedical engineering and clinical translation. Within this symposium, we will focus on showcasing research that unwraps the principles of biomaterial-assisted gene therapy and providing a snapshot of the global research directed towards the opportunities and challenges associated with its translational application for the musculoskeletal disorder treatment in relevant models in vivo.

Keywords : Musculoskeletal diseases, Nanomedicine, Gene therapy

  • Session TrackBiomaterials for theranostics
  • Session TitlePlatform technology for theranostics
  • Session CodeSP-T03-0344
  • Date & Time / RoomMay 27 (Mon) 16:30~18:00 / Room 324-A
Organizer

Yong Kyu Lee (KNUT, Korea, Republic of)

Chair

Youngwook Won (University of North Texas, USA)

Hwan Kim (KNUT, Korea, Republic of)

Keynote Speaker

16:30~16:55 : Protein-based cell engineering for targeted cancer therapy Youngwook Won (University of North Texas, USA)

Invited Speaker

16:55~17:10 : A theranostic approach to high tissue parenchymal accumulation of nanoparticles Jayoung Kim (University of North Texas Health Science Center, USA)

Md. Nurunnabi (School of Pharmacy at the University of Texas at El Paso, USA)

17:25~17:40 : Theranostic Applications of Polymersomes with Dual Agent Loading in Computed Tomography and Magnetic Resonance Imaging Jessica Larsen (Clemson University, USA)

17:40~17:55 : Nano-adaptor for Antibody Delivery Jun Wang (South University of Science and Technology, China)

Description

The symposium on biocompatible biomaterials combined with therapeutic agents containing theranostics ions are welcome. The symposium on synthesizing methods of theranostics biomaterials with different methods, including (I) dry methods (solid-state and mechanochemical routes); (II) wet methods (chemical precipitation, hydrolysis, sol-gel, hydrothermal, emulsion, and sonochemical routes); (III) high-temperature processes (combustion, pyrolysis methods); (IV) approaches based on biogenic sources (biogenic wastes); and (V) combination procedures are welcome. The application of these biomaterials for cancer therapy, including drug delivery, photothermal/photodynamic therapy, imaging, etc.The present symposium topic aims to provide an invaluable collection of contributions and a platform for a scientific discussion focused on the role of different types of biocompatible biomaterials.

Keywords : therapeutic agents, theranostics biomaterials, platform

  • Session TrackBiomaterials for theranostics
  • Session TitleSelf-assembled and stimuli responsive nanobiomaterials for delivery and targeting of biological drugs
  • Session CodeSP-T03-0109
  • Date & Time / RoomMay 31 (Fri) 9:30~11:00 / Room 324-A
Organizer

Alejandro Sosnik (Technion Israel Institute of Technology Technion Research and Development Foundation Ltd, Israel)

Chair

HyunJin Kim (Inha University, Korea, Republic of)

Keynote Speaker

9:30~9:55 : Self-assembling nanobiomaterials for the safe and efficient delivery of complex nucleic acid payloads: heteroatomic tuning and supramolecular insights Omar F. Khan (University of Toronto, Canada)

Invited Speaker

9:55~10:10 : Overcoming the barrier - Topical gene therapy of skin and lung Sarah Hedtrich (Berlin Institute of Health - Charite, Germany)

Oral Presenter

10:10~10:20 : H2O2-activatable and self-immolative prodrug nanoassemblies as novel nanomedicine with cooperative therapeutic actions Dongwon Lee (Jeonbuk National University, Korea, Republic of)

10:20~10:30 : Stimuli-responsive polymersomes-enabled activatable therapeutic nanoreactors for tumor-specific cancer therapy Junjie Li (Kyushu University, Japan)

10:30~10:40 : PEGylated Carbon Nanohorn-Based Nanocarrier for Targeted Delivery to Enhance Phototherapy Efficacy in Cancer Treatment Fitriani Jati Rahmania (National Taiwan University of Science and Technology, Chinese Taipei)

10:40~10:50 : Mimicking amelogenesis to remineralize enamel through co-assembly of PTL fibrils and CMC/ACP Yangyang Ye (Tianjin Medical University, China)

Description

Objectives: Self-assembled polymeric nanoparticles represent one of the most promising nanotechnology platforms for the encapsulation, delivery, and targeting of small-molecule drugs (e.g., chemotherapy) and biologics (e.g., silencing RNA). Their promise stems from the great versatility and modularity to tailor features such as size, shape, spatial organization, and the encapsulated cargo's nature. The emergence of the COVID-19 pandemic paved the way for the clinical research of messenger RNA vaccines and opened new horizons in therapeutics. At the same time, the timeous and spatial delivery required to achieve efficacy relies on their integration with advanced delivery technologies. This symposium will gather experts in the field of self-assembled and stimuli-responsive nanomaterials for the delivery of biological drugs, including nucleic acids and proteins, and serve as a forum for the discussion of the most recent advances in the field with a focus on the delivery of nucleic acids and proteins and with a fully translational vision and the major challenges faced in the future to realize these strategies in the clinic.

Proposed program: The program will include a keynote lecture by Prof. Omar F. Khan, an expert in nucleic acid therapeutics, one invited lecture by Prof. Sarah Hedtrich who is an expert in gene/protein delivery to the skin, and 3 oral presentations that will be selected among the submitted abstracts. The audience of this symposium is broad and includes researchers in fields such as polymers, nanotechnology, colloidal sciences, gene and protein delivery, cancer, and immune system diseases.  

Expected outcomes and relevance to the main topic of WBC 2024: The meeting motto is "Convergence in Biomaterials: a vision for the future of healthcare". The proposed topic is in line with this motto as it requires the convergence of disciplines to design the optimal delivery platform that maximizes the efficacy of these advanced biological therapies.  

Keywords : Self-assembled nanoparticles; nucleic acid delivery; vaccines

  • Session TrackBiomaterials for tissue engineering
  • Session TitleLearning from Successful Failures in Tissue Engineering & Regenerative Medicine
  • Session CodeSP-T04-0282
  • Date & Time / RoomMay 28 (Tue) 9:30~11:00 / Room 324-B
Organizer

Sing Yian Chew (Nanyang Technological University, Singapore)

Chair

Sing Yian Chew (Nanyang Technological University, Singapore)

Catherine Le Visage (Inserm; University of Nantes, France)

Keynote Speaker

9:30~9:55 : That’s not right, it is not even wrong Michael Sefton (University of Toronto, Canada)

9:55~10:20 : Neglecting complexity when extrapolating from cell culture to the human Viola Vogel (ETH Zurich, Switzerland)

Catherine Le Visage (University of Nantes; Inserm, France, France)

Oral Presenter

10:45~10:55 : Improving stem cell differentiation potency using simulated microgravity Jeremy Teo (New York University Abu Dhabi, United Arab Emirates)

Description

The advancement of science traditionally relies heavily on the positive results and outcomes from the scientific community. Indeed, the field of Tissue Engineering & Regenerative Medicine (TERM) has advanced greatly in the past 2 decades due to positive contributions and reports in the field. On the other hand, the lack of positive experimental outcomes, such as the absence of correlation of in vitro cellular responses with in vivo treatment efficacies, is often seen as failures and frequently remains unreported. This is a great loss to the field since failures have undeniably taught us a great deal and may in fact be more helpful than the typically defined successful experimentations.



In this symposium, we have invited successful scientists to share the truth of science and how they have learnt from failures and lack of efficacy as observed in vivo and moved ahead. The symposium aims to gather scientists from different aspects of TERM to share their journey in learning from successful failures to inspire the current and next generation of scientists. 

Keywords : In vivo tissue regeneration; Biomaterials; Cell therapy

  • Session TrackBiomaterials for tissue engineering
  • Session TitleNanofiberous scaffold for tissue engineering
  • Session CodeSP-T04-0285
  • Date & Time / RoomMay 30 (Thu) 13:40~15:10 / Room 324-B
Organizer

Xiumei Mo (Donghua University, China)

Chair

Xiumei Mo (Donghua University, China)

Gary L. Bowlin (University of Memphis, USA)

Keynote Speaker

13:40~14:05 : Nanofiberous scaffolds for peripheral nerve repair Younan Xia (Georgia Institute of Technology, USA)

Invited Speaker

14:05~14:20 : Electrospun organic and inorganic nanofiber for tissue engineering Xiumei Mo (Donghua University, China)

14:20~14:35 : Semi-unstable Near-field Electrospinning: Providing Capacity for Cellular Interactions and Ingrowth within the Template Superstructure Framework Voids/Pores Gary L. Bowlin (University of Memphis, USA)

Oral Presenter

14:35~14:45 : Electronspun polycaprolactone-silk fibroin nanofiber scaffolds for the differentiation of mesenchymal stem cells into vascular cells Zhongkui Hong (Texas Tech University, USA)

14:45~14:55 : Advanced 3D Spacer Textile Scaffolds for Tubular Tissue Regeneration using an engineered nanofiber PCL-PLA core-sheath yarn Anna Doersam (University of Manchester, United Kingdom)

Description

1) Objectives or purposes

to bring nanofiber researchers from all of the world to Korea to discuss the application for tissue engineeringto bring nanofiber researchers from all of the world to Korea to discuss the application for tissue engineering.



2) Proposed program and intended audience

Native extracellular matrix(ECM) is in nanofibrous network, to biomemic the native ECM nanofibrous scaffold have been developed for tissue repairing and tissue engineering. In this symposium electrospinning, phase separation and  selfassembling nanofibers and regenerative medicine will be discussed. That include the preparation of nanofiberous scaffolds, characterization of nanofibers, biocompatibility of nanofibers, nanofibrous scaffold application in the tissue engineering of bone, cartilage, skin, blood vessel, nerve conduit, tendon and so on. Intended audience include tissue engineering researchers of  bone, cartilage, skin, blood vessel, nerve conduit, tendon and so on, electrospinning researchers and nanofiber researchers.



3) Expected outcomes and relevance to the main topic of WBC 2024

Nanofiber scaffolds for tissue engineering is most relevance to the main topic of WBC 2024 of Biomaterials for tissue engineering, the running of this symposium will give expected outcoming

Keywords : nanofiber, electrospinning

  • Session TrackBiomaterials for tissue engineering
  • Session TitleTranslational Regenerative Medicine
  • Session CodeSP-T04-0289
  • Date & Time / RoomMay 30 (Thu) 16:30~18:00 / Room 324-B
Organizer

Sang Jin Lee (Wake Forest Institute for Regenerative Medicine, USA)

Chair

Sang Jin Lee (Wake Forest Institute for Regenerative Medicine, USA)

Alvaro Mata (Nottingham University, United Kingdom)

Keynote Speaker

16:30~16:55 : Translational approaches in designing bioactive materials for regeneration of dense connective tissues Chang Hun Lee (Columbia University, USA)

Invited Speaker

16:55~17:10 : Bioengineered strategies for augmenting skeletal muscle function in rotator cuff injuries Woojin Han (Icahn School of Medicine at Mount Sinai, USA)

17:10~17:25 : Photocrosslinkable bioinks for light-based 3D bioprinting to fabricate multiscale tissue constructs Keekyung Kim (University of Calgary, Canada)

Deok-Ho Kim (Johns Hopkins Biomedical Engineering, USA)

17:40~17:55 : Pre-clinical and clinical translation of tissue engineered tendons to regenerate human extensor tendon for functional recovery Wei Liu (Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, China)

Oral Presenter

17:55~18:05 : Self-feeding living tissues via nutritional nanoparticles enables long-term stem cell functionality under anoxia Niels Willemen (University of Twente, Netherlands)

Description

This session will report on state-of-the-art regenerative medicine applications, including cell-based and scaffold-based tissue engineering approaches, by addressing science, engineering, development, regulatory, biomanufacturing, and clinical aspects of the field. The biomaterial-based scaffolding system must meet mechanical, biological, chemical, and morphological demands. While some of these demands are met by adjusting the composition and formulation of the biomaterials, advances rely on the development of a scaffolding system that can utilize the microenvironment for efficient tissue regeneration and better integration with host tissue. Generally, attendees who are involved in stem cells, biomedical engineering, cell biology, molecular biology, material science, and biofabrication may well be interested in this topic.

Keywords : Regenerative medicine, Scaffold, Translational research

  • Session TrackBiomaterials for tissue engineering
  • Session Title3D Organoids for Disease Modeling and Tissue Regeneration
  • Session CodeSP-T04-0292
  • Date & Time / RoomMay 27 (Mon) 13:00~14:30 / Room 324-B
Organizer

Yongsung Hwang (Soonchunhyang University, Korea, Republic of)

Chair

Yongsung Hwang (Soonchunhyang University, Korea, Republic of)

Yu Suk Choi (The University of Western Australia, Australia)

Keynote Speaker

13:00~13:25 : CRISPR/Cas-assisted genetics in organoids and pluripotent stem cell Bon-Kyoung Koo (Institute for Basic Science (IBS), Korea, Republic of)

Invited Speaker

13:25~13:40 : 3D-bioprinted tissue and cancer models - a revolution in preclinical drug research? Michał Wszoła (Polbionica Sp. z o.o., Poland)

Oral Presenter

13:40~13:50 : Bioengineered airway organoids using proteinaceous artificial extracellular matrix for regeneration of traumatic airway injury SeongMin Han (Kyungpook National University, Korea, Republic of)

13:50~14:00 : A seamless intervascular encapsulation device for transplantation of pancreatic islets Jonathan Brassard (McGill university, Canada)

14:00~14:10 : Bioinspired Hydrogel for Highly Effective Transplantation of Hepatic Organoids to Treat Liver Failure Dongchang Kim (Kyungpook National University, Korea, Republic of)

14:10~14:20 : Permeability of the blood brain barrier in brain organoids under normoxic and hypoxic conditions as stroke model Kathrin Kostka (University of Duisburg-Essen, Germany)

Description

Recent advances in stem cell-derived 3D human organoids have been used to study various diseases, including genetic disorders, rare and degenerative diseases, and cancers. Furthermore, the enabling organoid technology can provide researchers with new opportunities to understand the pathophysiology of human diseases. Therefore, in this session, we aim to introduce novel methods to fully recapitulate the structural and functional properties of human tissues and to highlight the emerging understanding of multiple aspects of the pathophysiology of various human diseases using patient-derived 3D organoids. In addition, this session will cover the potential applications of 3D organoids in treating devasting human diseases. In summary, this session will feature expert speakers working in the field of 3D-engineered organoids for modeling various diseases and their potential applications in regenerative medicine. 

Keywords : Organoids, Stem cells, In vitro models

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WBC 2024 SECRETARIAT

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